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  1. Article ; Online: Aberrations of DNA Repair Pathways in Prostate Cancer-The State of the Art.

    Boussios, Stergios / Sheriff, Matin

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: Prostate cancer (PC) is the second most commonly diagnosed cancer in males worldwide and the fifth most common cause of cancer-related death in men [ ... ]. ...

    Abstract Prostate cancer (PC) is the second most commonly diagnosed cancer in males worldwide and the fifth most common cause of cancer-related death in men [...].
    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/metabolism ; DNA Repair
    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Medical oncology: challenges in 2022.

    Boussios, Stergios / Sanchez, Elisabet / Sheriff, Matin

    Annals of palliative medicine

    2024  Volume 13, Issue 1, Page(s) 22–30

    MeSH term(s) Humans ; Spinal Neoplasms ; Palliative Care ; Medical Oncology
    Language English
    Publishing date 2024-01-09
    Publishing country China
    Document type Editorial
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5839
    ISSN (online) 2224-5839
    ISSN 2224-5839
    DOI 10.21037/apm-23-572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A rare case of metaplastic breast carcinoma from India: Towards precision oncology.

    Banerjee, Soirindhri / Mahajan, Ishika / Ghose, Aruni / Boussios, Stergios / Chakraborty, Shivam

    Cancer reports (Hoboken, N.J.)

    2024  Volume 7, Issue 3, Page(s) e1997

    Abstract: Background: Metaplastic Breast Cancer (MpBC) is an exceedingly rare entity, accounting for less than 1% of all malignant breast tumours. Predominantly triple-negative, they are notorious for their chemoresistance, high rates of recurrence and decreased ... ...

    Abstract Background: Metaplastic Breast Cancer (MpBC) is an exceedingly rare entity, accounting for less than 1% of all malignant breast tumours. Predominantly triple-negative, they are notorious for their chemoresistance, high rates of recurrence and decreased disease-free survival (DFS). All this contributes significantly to BC mortality and results in poor prognostic implications. Limited evidence has led to a lacuna of specific treatment guidelines for this entity and hence remains an uncharted territory for clinicians.
    Case: We report a case of a 46 year old premenopausal female with left-sided metaplastic triple negative T3N2aM0 BC with mesenchymal differentiation (high grade) whom we treated with neoadjuvant chemotherapy, primary surgery in the form of extreme oncoplasty and adjuvant radiotherapy by Telecobalt machine. Contrary to the expected aggressive course of the disease and poor prognosis of treatment, the patient is presently in remission without progression for over 2 years of follow up.
    Conclusion: Limited experience in management of this pathological entity warrants the need for more research on it, with a special focus on targeted therapy. Discussing possibilities of a tailored approach, rather than a one-size-fits-all approach may aid in paving the path for the future of MpBC treatment.
    MeSH term(s) Female ; Humans ; Middle Aged ; Precision Medicine ; Breast Neoplasms/diagnosis ; Breast Neoplasms/therapy ; Prognosis ; Carcinoma, Squamous Cell/therapy ; Disease-Free Survival
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Case Reports
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.1997
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  4. Article ; Online: Prostate cancer-what about oligometastatic disease and stereotactic ablative radiotherapy?-a narrative review.

    Mikropoulos, Christos / Saxby, Helen / Boussios, Stergios

    Annals of palliative medicine

    2023  Volume 12, Issue 3, Page(s) 646–652

    Abstract: Background and objective: Oligometastatic prostate cancer (OMPC) encompasses a heterogenous group of clinical entities defined by the timing of the development of metastases. These include de novo oligometastatic, oligorecurrent and oligoprogressive ... ...

    Abstract Background and objective: Oligometastatic prostate cancer (OMPC) encompasses a heterogenous group of clinical entities defined by the timing of the development of metastases. These include de novo oligometastatic, oligorecurrent and oligoprogressive prostate cancer (PrCa). We describe the evidence supporting the use of stereotactic ablative radiotherapy (SABR) to the oligometastases to improve patient outcomes in each of these settings.
    Methods: Published clinical trials relevant to 'OMPC' and 'SABR' where used for this narrative review.
    Key content and findings: The driving force behind this narrative review is the constantly evolving field of OMPC with an increasing number of salvage radiotherapy options changing the current treatment paradigm. We now have evidence to support that disease control can be optimised with SABR as shown in several practice changing trials including 'ORIOLE', 'STOMP' for PrCa and 'SABR-COMET' showing a survival advantage with a tumour agnostic salvage approach. We also describe the challenges with data interpretation and cost implications. Challenges include the small sample size for most reported trials, in combination with a lack of cost-efficiency analysis.
    Conclusions: SABR is a promising treatment approach for OMPC with a proven clinical benefit in some clinical settings and its use will expand in the future.
    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery ; Radiosurgery
    Language English
    Publishing date 2023-03-02
    Publishing country China
    Document type Review ; Journal Article
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5839
    ISSN (online) 2224-5839
    ISSN 2224-5839
    DOI 10.21037/apm-22-828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: State-of-the-Art Molecular Oncology in UK.

    Sandoughdaran, Saleh / Mikropoulos, Christos / Boussios, Stergios

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Molecular oncology is a rapidly evolving field that focuses on the genetic and molecular basis of cancer [ ... ]. ...

    Abstract Molecular oncology is a rapidly evolving field that focuses on the genetic and molecular basis of cancer [...].
    MeSH term(s) Humans ; Neoplasms/genetics ; Medical Oncology ; United Kingdom
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Frontiers of Molecular Biology of Cancer.

    Boussios, Stergios / Sanchez, Elisabet / Sheriff, Matin

    International journal of molecular sciences

    2023  Volume 24, Issue 24

    Abstract: Cancer is rooted in genetic background, with the expression of oncogenesis playing a pivotal role in the early stages of tumor formation [ ... ]. ...

    Abstract Cancer is rooted in genetic background, with the expression of oncogenesis playing a pivotal role in the early stages of tumor formation [...].
    MeSH term(s) Humans ; Neoplasms/genetics ; Molecular Biology ; Carcinogenesis ; Cell Transformation, Neoplastic ; Biology
    Language English
    Publishing date 2023-12-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242417187
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  7. Article ; Online: Re: Pain and Health-related Quality of Life with Olaparib Versus Physician's Choice of Next-generation Hormonal Drug in Patients with Metastatic Castration-resistant Prostate Cancer with Homologous Recombination Repair Gene Alterations (PROfound): An Open-label, Randomised, Phase 3 Trial.

    Adeleke, Sola / Ghose, Aruni / Boussios, Stergios

    European urology

    2023  Volume 84, Issue 2, Page(s) 246–247

    MeSH term(s) Humans ; Male ; Pain ; Physicians ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/pathology ; Quality of Life ; Recombinational DNA Repair
    Chemical Substances olaparib (WOH1JD9AR8)
    Language English
    Publishing date 2023-04-07
    Publishing country Switzerland
    Document type Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2023.03.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 294: Show issues

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  8. Article ; Online: Frontiers of Ovarian Carcinosarcoma.

    Ismail, Ayden / Choi, Sunyoung / Boussios, Stergios

    Current treatment options in oncology

    2023  Volume 24, Issue 12, Page(s) 1667–1682

    Abstract: Opinion statement: Ovarian carcinosarcoma (OCS), also known as a malignant mixed Müllerian tumour (MMMT), is a rare and aggressive form of cancer that accounts for less than 5% of ovarian cancers. It is characterized by high morbidity and mortality ... ...

    Abstract Opinion statement: Ovarian carcinosarcoma (OCS), also known as a malignant mixed Müllerian tumour (MMMT), is a rare and aggressive form of cancer that accounts for less than 5% of ovarian cancers. It is characterized by high morbidity and mortality rates, with a median overall survival (OS) of less than 2 years. Several factors, including advancing age, nulliparity, reduced lactation rates, decreased use of oral contraceptive pills, genetic mutations in BRCA (breast cancer) genes, and the use of assisted reproductive technology, may increase the risk of OCS. Poor prognostic factors include an advanced stage at diagnosis, older age, lymph node metastasis, suboptimal surgical cytoreduction, the presence of heterologous features on histopathology, and increased expression of vascular endothelial growth factor (VEGF), tumour protein p53, and p53 alongside Wilms tumour 1 (WT1). The main treatment approach for OCS is cytoreductive surgery followed by platinum-based chemotherapy, although immunotherapy is showing promise. Homologous recombination deficiency (HRD) testing may enhance outcomes by enabling personalized immunotherapy and targeted therapies for specific patient groups, thereby reducing unnecessary side effects and healthcare costs. However, there is currently a lack of standardised treatment regimens for OCS patients, with most studies consisting of case reports and a shortage of suitable comparator groups. This article aims to provide clinicians with information on the epidemiology, risk factors, prognostic factors, and latest therapeutic advancements in OCS.
    MeSH term(s) Female ; Humans ; Tumor Suppressor Protein p53/genetics ; Vascular Endothelial Growth Factor A ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/epidemiology ; Ovarian Neoplasms/etiology ; Carcinosarcoma/diagnosis ; Carcinosarcoma/epidemiology ; Carcinosarcoma/etiology
    Chemical Substances Tumor Suppressor Protein p53 ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057351-0
    ISSN 1534-6277 ; 1527-2729
    ISSN (online) 1534-6277
    ISSN 1527-2729
    DOI 10.1007/s11864-023-01138-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5523: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Immunotherapy Combined With Standard Therapies in Head and Neck Squamous Cell Carcinoma - A Meta-analysis.

    Eden, Daisy / Ghose, Aruni / Moschetta, Michele / Pérez-Fidalgo, José Alejandro / Rassy, Elie / Boussios, Stergios

    Anticancer research

    2024  Volume 44, Issue 3, Page(s) 861–878

    Abstract: Head and neck squamous cell carcinoma (HNSCC) is a deadly disease with a poor prognosis due to late diagnosis and limited treatment options. Immunotherapy (IT) is emerging as a promising approach, especially after the failure of standard of care ... ...

    Abstract Head and neck squamous cell carcinoma (HNSCC) is a deadly disease with a poor prognosis due to late diagnosis and limited treatment options. Immunotherapy (IT) is emerging as a promising approach, especially after the failure of standard of care therapies (STs). The objective of this systematic review and meta-analysis was to evaluate whether the addition of IT to STs improves outcomes for patients with HNSCC, including overall survival (OS), progression-free survival (PFS), and quality of life (QoL). This review employed the Population Intervention Comparison and Outcome (PICO) framework to identify relevant search terms in electronic databases, and also included supplementary hand searches. Six primary research articles were selected using the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) flow chart, and were critically appraised. Data extraction from these studies was conducted, and a meta-analysis was performed to aid in the generation of forest plots. The addition of IT to standard anticancer therapies was found to enhance patient outcomes, such as OS, PFS, and QoL. The toxicity profile of IT was acceptable, with minimal treatment-related deaths. The most frequently observed adverse events (AE) were related to the skin, followed by hematological toxicities. Based on our analysis, the addition of IT to STs is a suitable treatment option and is supported by current research. However, further studies are needed to investigate factors that influence treatment effectiveness and to develop optimal therapies. To achieve this, we recommend a comprehensive treatment approach that involves the multidisciplinary team (MDT) and patient assessment tools.
    MeSH term(s) Humans ; Head and Neck Neoplasms/therapy ; Immunotherapy ; Quality of Life ; Squamous Cell Carcinoma of Head and Neck/therapy ; Standard of Care
    Language English
    Publishing date 2024-02-29
    Publishing country Greece
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16880
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: The Application of Radiomics and AI to Molecular Imaging for Prostate Cancer.

    Tapper, William / Carneiro, Gustavo / Mikropoulos, Christos / Thomas, Spencer A / Evans, Philip M / Boussios, Stergios

    Journal of personalized medicine

    2024  Volume 14, Issue 3

    Abstract: Molecular imaging is a key tool in the diagnosis and treatment of prostate cancer (PCa). Magnetic Resonance (MR) plays a major role in this respect with nuclear medicine imaging, particularly, Prostate-Specific Membrane Antigen-based, (PSMA-based) ... ...

    Abstract Molecular imaging is a key tool in the diagnosis and treatment of prostate cancer (PCa). Magnetic Resonance (MR) plays a major role in this respect with nuclear medicine imaging, particularly, Prostate-Specific Membrane Antigen-based, (PSMA-based) positron emission tomography with computed tomography (PET/CT) also playing a major role of rapidly increasing importance. Another key technology finding growing application across medicine and specifically in molecular imaging is the use of machine learning (ML) and artificial intelligence (AI). Several authoritative reviews are available of the role of MR-based molecular imaging with a sparsity of reviews of the role of PET/CT. This review will focus on the use of AI for molecular imaging for PCa. It will aim to achieve two goals: firstly, to give the reader an introduction to the AI technologies available, and secondly, to provide an overview of AI applied to PET/CT in PCa. The clinical applications include diagnosis, staging, target volume definition for treatment planning, outcome prediction and outcome monitoring. ML and AL techniques discussed include radiomics, convolutional neural networks (CNN), generative adversarial networks (GAN) and training methods: supervised, unsupervised and semi-supervised learning.
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14030287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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