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Article ; Online: Plexiform tumorlet in a woman with postmenopausal endometrioid endometrial carcinoma taking tamoxifen for breast cancer: A case report.

Koufopoulos, Nektarios / Boutas, Ioannis / Dimas, Dionysios / Kontogeorgi, Adamantia / Dimitrakakis, Constantine

2022 Volume 36, Page(s) e00459

Abstract: Leiomyomas are the most common benign smooth muscle tumors of the female genital tract. Among the recognized histologic variants, one of the least common is plexiform leiomyoma. When they are small, even microscopic findings, they are referred to as ... ...

Abstract	Leiomyomas are the most common benign smooth muscle tumors of the female genital tract. Among the recognized histologic variants, one of the least common is plexiform leiomyoma. When they are small, even microscopic findings, they are referred to as plexiform tumorlets. In this report the authors describe a case of plexiform tumorlet found incidentally in the hysterectomy specimen of a 64-year-old woman with concomitant endometrioid endometrial carcinoma and a previous history of invasive lobular breast carcinoma. The endometrioid endometrial carcinoma arising on a polyps was diagnosed in a curettage specimen. In the hysterectomy specimen there was no residual endometrioid endometrial carcinoma. Six uterine leiomyomas were found. A small (3 mm) well circumscribed tumor was located in the uterine wall. Histologically it consisted of small nests, islands, cords, and tubules of relatively uniform, round to oval cells surrounded by loose stroma. The differential diagnosis was challenging, and included plexiform leiomyoma, uterine tumor resembling ovarian sex cord tumor, endometrial stromal tumor, and poorly differentiated endometrial or metastatic invasive lobular breast carcinoma. After careful morphologic evaluation and appropriate use of immunohistochemical stains the diagnosis of plexiform tumorlet was made.
Language	English
Publishing date	2022-11-02
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2800286-6
ISSN	2214-9112 ; 2214-9112
ISSN (online)	2214-9112
ISSN	2214-9112
DOI	10.1016/j.crwh.2022.e00459
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Article ; Online: Soy Isoflavones and Breast Cancer Risk: A Meta-analysis.

Boutas, Ioannis / Kontogeorgi, Adamantia / Dimitrakakis, Constantine / Kalantaridou, Sophia N

In vivo (Athens, Greece)

2022 Volume 36, Issue 2, Page(s) 556–562

Abstract: Background/aim: Soy contains genistein and daidzein isoflavones. Isoflavones are phytoestrogens, with a similarity in structure to human 17-β estradiol hormone. They imitate the action of estrogen on organs by binding and activating estrogen receptors. ... ...

Abstract	Background/aim: Soy contains genistein and daidzein isoflavones. Isoflavones are phytoestrogens, with a similarity in structure to human 17-β estradiol hormone. They imitate the action of estrogen on organs by binding and activating estrogen receptors. Numerous studies have examined the relationship between soy consumption and breast cancer but not the amount of consumption itself. We performed a systematic review of the literature in order to determine whether the amount of soy and isoflavones consumed has a positive effect in pre- and post-menopausal women. Materials and methods: Data gathering was performed following PRISMA guidelines. Narrowing down the result set for all relevant data was performed via title, abstract, full-text evaluation and the snowball procedure. The selected articles had all relevant data extracted. Analysis of the data was performed using Cochrane's Review Manager statistical analysis tool in order to draw conclusions regarding the positive effect for the amount of soy and isoflavones consumed. Results: Significant results were found when statistically analyzing data from prospective studies which compared soy isoflavones consumption, breast cancer risk and occurrence. The data were indicative of a clear inverse correlation between the amount of isoflavones consumed and breast cancer occurrence in pre- and post-menopausal women. Conclusion: The consumption of soy isoflavones can reduce the risk of breast cancer in pre-menopausal and post-menopausal women.
MeSH term(s)	Breast ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Female ; Genistein ; Humans ; Isoflavones ; Phytoestrogens ; Prospective Studies
Chemical Substances	Isoflavones ; Phytoestrogens ; Genistein (DH2M523P0H)
Language	English
Publishing date	2022-03-03
Publishing country	Greece
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.12737
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Article ; Online: The expression of Galectin-3 in endometrial cancer: a systematic review of the literature.

Boutas, Ioannis / Kontogeorgi, Adamantia / Dimitrakakis, Constantine / Kalantaridou, Sophia N

Molecular biology reports

2021 Volume 48, Issue 7, Page(s) 5699–5705

Abstract: Background: Galectin-3 is part of a protein group called lectins and acts as a multifunctional glycoprotein due to its expression location. Galectin-3 is expressed by different human tissues. It plays a significant role in carcinogenesis and the ... ...

Abstract	Background: Galectin-3 is part of a protein group called lectins and acts as a multifunctional glycoprotein due to its expression location. Galectin-3 is expressed by different human tissues. It plays a significant role in carcinogenesis and the selection of tumor-related physiological and pathological activities. Galectin-3 has been utilized through the years as a diagnostic and prognostic marker for various types of cancers. Methods and results: This review describes the outcomes of some studies on the matter that were selected appropriately through a review of the existing literature. These studies examined the levels of Galectin-3 expression in endometrial carcinomas, the outcomes, and the prognosis of these carcinomas. Two of the studies concluded that high expression of Galectin-3 is associated with a tumor's histological grade, type and depth. This enhanced nuclear Galectin-3 expression might assist in progression to atypia and neoplasia. The other three on the contrary concluded that malignant tumors had a decreased expression of Galectin-3 and that Galectin-3 played a suppressive role in tumor growth. Conclusions: The part Galectin-3 might potentially have in metastasis of cancers and the offering of a better prognosis for patients is of high importance. To date, there is minimal literature regarding the effects of Galectin-3 and more research is required.
MeSH term(s)	Biomarkers ; Blood Proteins/genetics ; Blood Proteins/metabolism ; Disease Management ; Disease Susceptibility ; Endometrial Neoplasms/diagnosis ; Endometrial Neoplasms/etiology ; Endometrial Neoplasms/metabolism ; Endometrial Neoplasms/therapy ; Female ; Galectins/genetics ; Galectins/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Signal Transduction
Chemical Substances	Biomarkers ; Blood Proteins ; Galectins ; LGALS3 protein, human
Language	English
Publishing date	2021-07-09
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-021-06536-1
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Article: Fibroadenoma Arising in Axillary Ectopic Breast Tissue. A Diagnostic Challenge.

Koufopoulos, Nektarios / Dimas, Dionysios T / Boutas, Ioannis / Kontogeorgi, Adamantia / Sitara, Kyparissia / Sourla, Antigoni / Kittas, Christos / Missitzis, Ioannis L

Cureus

2023 Volume 15, Issue 3, Page(s) e36594

Abstract: Ectopic or accessory breast tissue may occur in primitive embryonic milk lines or locations other than the milk line. The same pathology arising in breast tissue may occur less frequently in ectopic breast tissue. Fibroadenomas rarely occur in ectopic ... ...

Abstract	Ectopic or accessory breast tissue may occur in primitive embryonic milk lines or locations other than the milk line. The same pathology arising in breast tissue may occur less frequently in ectopic breast tissue. Fibroadenomas rarely occur in ectopic breast tissue, with less than 50 reported cases in the English literature, despite being the most common benign breast neoplasms. Diagnosing fibroadenoma in ectopic breast tissue can be challenging due to the lack of clinical suspicion and the atypical findings in imaging studies. Treatment consists of surgical excision. In this manuscript, we present a case of a 24-year-old patient with a fibroadenoma of the left axilla arising in bilateral axillary ectopic breast tissue, and we comprehensively review the literature.
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.36594
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Article: Breast Cancer and Fertility Preservation in Young Female Patients: A Systematic Review of the Literature.

Boutas, Ioannis / Kontogeorgi, Adamantia / Koufopoulos, Nektarios / Dimas, Dionysios T / Sitara, Kyparissia / Kalantaridou, Sophia N / Dimitrakakis, Constantine

Clinics and practice

2023 Volume 13, Issue 6, Page(s) 1413–1426

Abstract: Introduction: Breast cancer affects almost 1.5 million women worldwide below the age of 45 years each year. Many of these women will be advised to undergo adjuvant chemotherapy to minimize the risk of death or recurrence of the tumor. For these patients, ...

Abstract	Introduction: Breast cancer affects almost 1.5 million women worldwide below the age of 45 years each year. Many of these women will be advised to undergo adjuvant chemotherapy to minimize the risk of death or recurrence of the tumor. For these patients, chemotherapy is a known cause of infertility, as it can damage primordial follicles, which can lead to early menopause or premature ovarian insufficiency. This systematic review aims to synthesize the current evidence of the most suitable treatments for fertility preservation. Methodology: This review was performed following the PRISMA guidelines. The authors conducted an extensive search from the last 15 years. Relevant studies were pursued in PubMed, Embase, and the Cochrane Library up until 31 July 2023. A total of seven eligible studies were identified. Results: From the reviewed literature, ovarian suppression with gonadotropin-releasing hormone agonists showed promising results in preserving fertility for breast cancer patients undergoing chemotherapy. Additionally, oocyte and embryo cryopreservation demonstrated successful outcomes, with embryo cryopreservation being the most effective option. Notably, the slow-freezing and vitrification methods were both effective in preserving embryos, with vitrification showing superior results in clinical-assisted reproductive technologies. Ovarian tissue cryopreservation emerged as a viable option for prepubertal girls and those unable to undergo conventional ovarian stimulation. The potential of in vitro maturation (IVM) as an alternative method presents a promising avenue for future fertility preservation research. Discussion: The most suitable treatments for fertility preservation in young patients is the temporary suppression with luteinizing hormone-releasing analogs, while the patient undergoes chemotherapy and cryopreservation. For cryopreservation, the physicians might deem it necessary to either cryopreserve ovarian tissue taken from the patient before any treatment or cryopreserve embryos/oocytes. Cryopreservation of oocytes and/or embryos is the most effective solution for fertility preservation in women of reproductive age, who have a sufficient ovarian reserve and are diagnosed with breast cancer, regardless of the histological type of the tumor. Because approximately 50% of young breast cancer patients are interested in becoming pregnant right after completion of therapy, the evolution and development of fertility preservation techniques promise to be very exciting.
Language	English
Publishing date	2023-11-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2605724-4
ISSN	2039-7283 ; 2039-7275
ISSN (online)	2039-7283
ISSN	2039-7275
DOI	10.3390/clinpract13060127
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Article ; Online: Reverse Onco-Cardiology: What Is the Evidence for Breast Cancer? A Systematic Review of the Literature.

Boutas, Ioannis / Kontogeorgi, Adamantia / Kalantaridou, Sophia N / Dimitrakakis, Constantine / Patsios, Panagiotis / Kalantzi, Maria / Xanthos, Theodoros

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: Breast cancer and cardiovascular diseases (CVD) represent significant global health challenges, with CVD being the leading cause of mortality and breast cancer, showing a complex pattern of incidence and mortality. We explore the intricate interplay ... ...

Abstract	Breast cancer and cardiovascular diseases (CVD) represent significant global health challenges, with CVD being the leading cause of mortality and breast cancer, showing a complex pattern of incidence and mortality. We explore the intricate interplay between these two seemingly distinct medical conditions, shedding light on their shared risk factors and potential pathophysiological connections. A specific connection between hypertension (HTN), atrial fibrillation (AF), myocardial infarction (MI), and breast cancer was evaluated. HTN is explored in detail, emphasizing the role of aging, menopause, insulin resistance, and obesity as common factors linking HTN and breast cancer. Moreover, an attempt is made to identify the potential impact of antihypertensive medications and highlight the increased risk of breast cancer among those women, with a focus on potential mechanisms. A summary of key findings underscores the need for a multisystem approach to understanding the relationship between CVD and breast cancer is also explored with a highlight for all the gaps in current research, such as the lack of clinical observational data on MI and breast cancer in humans and the need for studies specifically designed for breast cancer. This paper concludes that there should be a focus on potential clinical applications of further investigation in this field, including personalized prevention and screening strategies for women at risk. Overall, the authors attempt to provide a comprehensive overview of the intricate connections between breast cancer and cardiovascular diseases, emphasizing the importance of further research in this evolving field of cardio-oncology.
MeSH term(s)	Humans ; Female ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Hypertension/epidemiology ; Cardiology ; Risk Factors ; Myocardial Infarction
Language	English
Publishing date	2023-11-19
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216500
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Article ; Online: Antimüllerian Hormone as a Tool to Predict the Age at Menopause.

Chatziandreou, Efstathia / Eustathiou, Andreas / Augoulea, Areti / Armeni, Eleni / Mili, Nikoletta / Boutas, Ioannis / Tsoltos, Nikolaos / Kapetanaki, Antigoni / Kalantaridou, Sofia

Geriatrics (Basel, Switzerland)

2023 Volume 8, Issue 3

Abstract: This study aimed to assess an eligible cut-off value of anti-Müllerian hormone (AMH) to detect ovarian senescence in a group of premenopausal Greek women to evaluate the possible link between AMH-values and the severity of climacteric symptoms during a ... ...

Abstract	This study aimed to assess an eligible cut-off value of anti-Müllerian hormone (AMH) to detect ovarian senescence in a group of premenopausal Greek women to evaluate the possible link between AMH-values and the severity of climacteric symptoms during a follow-up of 24 months. This study included 180 women (group A, 96 women of late reproductive stage/early perimenopause; group B, 84 women in late perimenopause). We measured AMH blood levels and assessed climacteric symptoms using the Greene scale. Log-AMH is inversely associated with postmenopausal status. The AMH cut-off of 0.012 ng/mL predicts the postmenopausal status with a sensitivity of 24.2% and specificity of 30.5%. The postmenopausal stage associated with age (OR = 1.320, 95%CI: 1.084-1.320) and AMH (values ≥ vs. <0.012 ng/mL, OR = 0.225, 95%CI: 0.098-0.529,
Language	English
Publishing date	2023-05-19
Publishing country	Switzerland
Document type	Journal Article
ISSN	2308-3417
ISSN (online)	2308-3417
DOI	10.3390/geriatrics8030057
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Article: The Correlation Between Progesterone and Mammographic Density in Postmenopausal Women: A Systematic Review of the Literature and Meta-Analysis.

Boutas, Ioannis / Kontogeorgi, Adamantia / Koufopoulos, Nektarios I / Pouliakis, Abraham / Dimitrakakis, Constantine / Dimas, Dionysios T / Sitara, Kyparissia / Kalantaridou, Sophia / Durmusoglu, Fatih

Cureus

2023 Volume 15, Issue 9, Page(s) e45597

Abstract: Higher mammographic breast density in premenopausal and postmenopausal women is related to a higher breast cancer risk. In this review, we analyze the correlation between estrogen, progesterone, and mammographic density in postmenopausal women and ... ...

Abstract	Higher mammographic breast density in premenopausal and postmenopausal women is related to a higher breast cancer risk. In this review, we analyze the correlation between estrogen, progesterone, and mammographic density in postmenopausal women and clarify whether these findings are consistent across different types of mammographic breast density. We extracted data concerning mammographic density increases in the populations treated with estrogen-only hormone replacement therapy and those treated with estrogen and progestin hormone replacement therapy. Postmenopausal women treated with estrogen and progesterone regimens had a statistically significant lesser mammographic density increase than estrogen-only hormone replacement therapy regimens.
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.45597
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Article: The expression of Galectin-3 in endometrial cancer: a systematic review of the literature

Boutas, Ioannis / Kontogeorgi, Adamantia / Dimitrakakis, Constantine / Kalantaridou, Sophia N.

Molecular biology reports. 2021 July, v. 48, no. 7

2021

Abstract: BACKGROUND: Galectin-3 is part of a protein group called lectins and acts as a multifunctional glycoprotein due to its expression location. Galectin-3 is expressed by different human tissues. It plays a significant role in carcinogenesis and the ... ...

Abstract	BACKGROUND: Galectin-3 is part of a protein group called lectins and acts as a multifunctional glycoprotein due to its expression location. Galectin-3 is expressed by different human tissues. It plays a significant role in carcinogenesis and the selection of tumor-related physiological and pathological activities. Galectin-3 has been utilized through the years as a diagnostic and prognostic marker for various types of cancers. METHODS AND RESULTS: This review describes the outcomes of some studies on the matter that were selected appropriately through a review of the existing literature. These studies examined the levels of Galectin-3 expression in endometrial carcinomas, the outcomes, and the prognosis of these carcinomas. Two of the studies concluded that high expression of Galectin-3 is associated with a tumor’s histological grade, type and depth. This enhanced nuclear Galectin-3 expression might assist in progression to atypia and neoplasia. The other three on the contrary concluded that malignant tumors had a decreased expression of Galectin-3 and that Galectin-3 played a suppressive role in tumor growth. CONCLUSIONS: The part Galectin-3 might potentially have in metastasis of cancers and the offering of a better prognosis for patients is of high importance. To date, there is minimal literature regarding the effects of Galectin-3 and more research is required.
Keywords	carcinogenesis ; endometrium ; galectins ; glycoproteins ; histology ; humans ; metastasis ; molecular biology ; prognosis ; systematic review ; uterine neoplasms
Language	English
Dates of publication	2021-07
Size	p. 5699-5705.
Publishing place	Springer Netherlands
Document type	Article
Note	Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-021-06536-1
Database	NAL-Catalogue (AGRICOLA)

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Article: The expression of Galectin-3 in breast cancer and its association with metastatic disease: a systematic review of the literature

Boutas, Ioannis / Potiris, Anastasios / Makrakis, Evangelos / Messaropoulos, Pantelis / Papaioannou, Georgios-Konstantinos / Kalantaridou, Sophia Ν

Molecular biology reports. 2021 Jan., v. 48, no. 1

2021

Abstract: Breast cancer is the most common form of cancer and the second highest cause of cancer mortality in female patients. The significance of the expression of Galectin-3 has been correlated with various malignancy types and in data from several research ... ...

Abstract	Breast cancer is the most common form of cancer and the second highest cause of cancer mortality in female patients. The significance of the expression of Galectin-3 has been correlated with various malignancy types and in data from several research papers, the expression of Galectin-3 has been associated with the progression and metastasis of breast cancer. In the present study, the authors’ goal is to identify whether the expression of Galectin-3 in breast cancer can be associated with the presence and/or recurrence of a metastatic disease. Both Scopus and PubMed databases were utilized, by inputting the following combination of keywords: (((Breast) AND Metastasis)) AND ((Galectin 3) OR Galectin-3). The time of publication and text availability were not considered when searching the databases and all relevant articles in English were initially accepted. We included one case-control study, three retrospective case studies and one retrospective cohort study. In two of the included studies, the levels in concentration of Galectin-3 were not correlated with a significant difference in prognosis. In two studies, the lacking in expression of Galectin-3 was associated with a worse prognosis and in one of the studies selected, the elevated levels of Galectin-3 were correlated with recurrence of disease in triple negative breast cancer cases. For most of the studies selected for this review, the results were contradictory in regard to the role of Galectin-3 for prognosis and metastatic potential in female breast cancer patients. It is still unclear, whether Galectin-3 can be used as a prognostic marker for advanced breast cancer disease.
Keywords	breast neoplasms ; breasts ; case-control studies ; cohort studies ; females ; galectins ; metastasis ; molecular biology ; mortality ; prognosis ; systematic review
Language	English
Dates of publication	2021-01
Size	p. 807-815.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-020-06122-x
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