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  1. Article ; Online: Providing assessable information on effectiveness of maintenance treatments for bipolar disorder to psychiatrists and patients.

    Bowden, Charles L

    Evidence-based mental health

    2015  Volume 18, Issue 2, Page(s) 58

    Language English
    Publishing date 2015-05
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2009065-1
    ISSN 1468-960X ; 1362-0347
    ISSN (online) 1468-960X
    ISSN 1362-0347
    DOI 10.1136/eb-2014-102014
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  2. Article: Expand the applicability and acceptability of CBT approaches in mood disorders.

    Bowden, Charles L

    World psychiatry : official journal of the World Psychiatric Association (WPA)

    2014  Volume 13, Issue 3, Page(s) 261–262

    Language English
    Publishing date 2014-10-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2236130-3
    ISSN 2051-5545 ; 1723-8617
    ISSN (online) 2051-5545
    ISSN 1723-8617
    DOI 10.1002/wps.20165
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  3. Article: Pharmacological treatments for bipolar disorder: present recommendations and future prospects.

    Bowden, Charles L

    Current topics in behavioral neurosciences

    2014  Volume 5, Page(s) 263–283

    Abstract: In selecting and adapting medications to treat the specific clinical features of a patient with bipolar disorder (BPD) over time, a foundation strategy is to have good working knowledge of up-to-date practice guidelines. The World Federation of Societies ...

    Abstract In selecting and adapting medications to treat the specific clinical features of a patient with bipolar disorder (BPD) over time, a foundation strategy is to have good working knowledge of up-to-date practice guidelines. The World Federation of Societies of Biological Psychiatry Guidelines has the reasoned advantage of weighing safety/tolerability as high as efficacy. Most successful treatments for BPD start to separate from placebo within 1 week; most differences between regimens occur within the first 4 weeks. This observation extrapolates to a strategy of discontinuing or adding a second drug for symptoms unimproved within 1 month of treatment initiation. The weight of evidence argues against starting treatment with combination regimens, despite evidence that over time most patients do receive combination drug regimens and appear to tolerate them well. The current design paradigm for adjunctive trials generally strongly weights trials in favor of the sponsor drug.Well managed, BPD is often compatible with fully good health, both symptomatically and functionally. Consequently, for whatever regimens are found to accomplish excellent symptom control, it is important to achieve regimens that are well tolerated by all bodily systems. This chapter emphasizes the tactics needed to accomplish this specific to individual medications. The chapter also addresses the serious, broad failure of pharmaceutical companies to develop new drugs with novel mechanisms for BPD therapy and proposes a series of steps that might reenergize drug development to the benefit of psychiatrists and patients alike.
    MeSH term(s) Bipolar Disorder/drug therapy ; Humans ; Placebo Effect
    Language English
    Publishing date 2014-09-18
    Publishing country Germany
    Document type Journal Article
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2010_73
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  4. Article ; Online: KIOS: A smartphone app for self-monitoring for patients with bipolar disorder.

    Pahwa, Mehak / McElroy, Susan L / Priesmeyer, Richard / Siegel, Gregg / Siegel, Phyllis / Nuss, Sharon / Bowden, Charles L / El-Mallakh, Rif S

    Bipolar disorders

    2023  Volume 26, Issue 1, Page(s) 84–92

    Abstract: Objectives: This study examined the use of a self-monitoring/self-management smartphone application (app) for patients with bipolar disorder. The app was specifically designed with patient-centered computational software system based on concepts from ... ...

    Abstract Objectives: This study examined the use of a self-monitoring/self-management smartphone application (app) for patients with bipolar disorder. The app was specifically designed with patient-centered computational software system based on concepts from nonlinear systems (chaos) theory.
    Methods: This was a randomized, active comparator study of use of the KIOS app compared to an existing free app that has high utilization rates known as eMoods, over 52 weeks, and performed in three academic centers. Patients were evaluated monthly utilizing the Bipolar Inventory of Symptoms Schedule (BISS). The primary outcome measure was the persistence of using the app over the year of the study.
    Results: Patients assigned to KIOS persisted in the study longer than those assigned to eMoods; 57 patients (87.70%) in the KIOS group versus 42 (73.69%) in the eMoods group completed the study (p = 0.03). By 52 weeks, significantly more of KIOS group (84.4%) versus eMoods group (54%) entered data into their programs (χ
    Conclusions: This is the first randomized comparison study comparing two apps for the self-monitoring/self-management of bipolar disorder. The study revealed greater patient satisfaction and greater adherence to a patient-centered software program (KIOS) than a monitoring program that does not provide feedback (eMoods).
    MeSH term(s) Humans ; Mobile Applications ; Bipolar Disorder ; Self-Management ; Smartphone
    Language English
    Publishing date 2023-06-20
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.13362
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  5. Article ; Online: The role of ziprasidone in adjunctive use with lithium or valproate in maintenance treatment of bipolar disorder.

    Bowden, Charles L

    Neuropsychiatric disease and treatment

    2011  Volume 7, Page(s) 87–92

    Abstract: Objectives: This article addresses the clinical role for ziprasidone used adjunctively with a mood stabilizer in maintenance treatment of bipolar disorder. This review also addresses the strengths and limitations of design features in adjunctive studies ...

    Abstract Objectives: This article addresses the clinical role for ziprasidone used adjunctively with a mood stabilizer in maintenance treatment of bipolar disorder. This review also addresses the strengths and limitations of design features in adjunctive studies of second-generation antipsychotic drugs added to mood stabilizers.
    Methods: The principal study relevant to this review enrolled subjects who were ≥18 years of age, experiencing a recent or current manic or mixed bipolar I episode, with at least moderately severe current manic symptoms. To meet criteria for randomization to 6 months maintenance treatment, patients had to have failed a short course of treatment with either lithium or valproate and achieved benefit with added ziprasidone for 8 consecutive weeks.
    Results: Time to intervention for a new mood episode as well as time to discontinuation for any reason was significantly longer with adjunctive ziprasidone treatment than with monotherapy treatment with mood stabilizer. Three dosages of ziprasidone augmentation were studied. Patients treated with 120 mg/day had better efficacy and overall outcomes than did patients who received 80 or 160 mg/day of ziprasidone.
    Conclusions: Good evidence exists that adjunctive ziprasidone will likely provide greater overall efficacy coupled with good tolerability for at least a 6-month period than a strategy of continued monotherapy with a mood stabilizer. Changes in open phases of maintenance studies to reduce study enrichment, in study endpoints, and in statistical approaches to analysis of data are warranted.
    Language English
    Publishing date 2011-03-07
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S9932
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  6. Article ; Online: The use of antidepressants in bipolar disorder patients with depression.

    Bowden, Charles L / Singh, Vivek

    Expert opinion on pharmacotherapy

    2016  Volume 17, Issue 1, Page(s) 17–25

    Abstract: Introduction: The proportion of time that bipolar patients experience depressive symptoms and clinical states, with associated psychosocial impairment and elevated risk of suicide, is significantly greater than the time spent in manic/hypomanic forms of ...

    Abstract Introduction: The proportion of time that bipolar patients experience depressive symptoms and clinical states, with associated psychosocial impairment and elevated risk of suicide, is significantly greater than the time spent in manic/hypomanic forms of bipolar disorders. Yet, manic states and symptoms have been the focus and interest of most clinical research over the past quarter century. Not a single antidepressant approved for treatment of major depressive disorder, as monotherapy, has received regulatory approval for treatment of bipolar depression as monotherapy, despite their common use in bipolar depression.
    Areas covered: We reviewed randomized studies, particularly ones initially intended for registration purposes, and systematic treatment guidelines, in development of this guide to treatment decision and implementation of interventions for depression in bipolar disorders.
    Expert opinion: The Expert Opinion section emphasizes strategies, not individual agents. The efficacious performance of mood stabilizers and second-generation antipsychotics as a component of the strategy is strongly supported by published studies. However, this section relies largely on secondary publications and our combined clinical experience, as few randomized, blinded studies have had, as their focus, the comparison of combined regimens for depression. This article summarizes the design features and results of studies dealing with depressive features and intervention strategies for bipolar disorders. The emphasis of the recommendations is on pragmatic treatment decisions that clinicians can make to enhance the probability of both short and long term benefits for patients.
    MeSH term(s) Antidepressive Agents/therapeutic use ; Antipsychotic Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Bipolar Disorder/psychology ; Depression/complications ; Depression/drug therapy ; Depressive Disorder, Major/drug therapy ; Drug Therapy, Combination ; Humans ; Randomized Controlled Trials as Topic ; Suicide
    Chemical Substances Antidepressive Agents ; Antipsychotic Agents
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1517/14656566.2016.1104299
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  7. Article ; Online: Treatment strategies for bipolar depression.

    Bowden, Charles L

    The Journal of clinical psychiatry

    2010  Volume 71, Issue 5, Page(s) e10

    Abstract: Resolving acute bipolar mood episodes is only one part of an overall strategy for treating bipolar disorder. Successful prevention of mood episode relapse, particularly bipolar depressive episodes, through effective continuation and maintenance therapies ...

    Abstract Resolving acute bipolar mood episodes is only one part of an overall strategy for treating bipolar disorder. Successful prevention of mood episode relapse, particularly bipolar depressive episodes, through effective continuation and maintenance therapies can greatly improve patient functioning and outcomes. Little evidence is available to guide decisions on the treatment of bipolar depression, especially in the maintenance phase, and additional research into effective options is urgently needed. General strategies for treating patients with bipolar disorder include continuing the acute pharmacotherapeutic regimen into the maintenance phase and considering tolerability.
    MeSH term(s) Bipolar Disorder/therapy ; Humans
    Language English
    Publishing date 2010-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.8125tx2c
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  8. Article ; Online: Diagnosis, treatment, and recovery maintenance in bipolar depression.

    Bowden, Charles L

    The Journal of clinical psychiatry

    2010  Volume 71, Issue 1, Page(s) e01

    Abstract: Misdiagnosis of bipolar disorder and inappropriate pharmacotherapeutic treatment is common. Clinicians should screen for manic/hypomanic symptoms during depressive episodes to differentiate bipolar depression from other depressive disorders. Depression ... ...

    Abstract Misdiagnosis of bipolar disorder and inappropriate pharmacotherapeutic treatment is common. Clinicians should screen for manic/hypomanic symptoms during depressive episodes to differentiate bipolar depression from other depressive disorders. Depression is the dominant pole of bipolar disorder, and effective maintenance therapy must prevent depressive episode recurrence. Few pharmacologic treatments have evidence supporting both short- and long-term efficacy for bipolar depression. Clinicians must consider the existing evidence on the long-term efficacy of various pharmacologic and psychosocial interventions for preventing and treating bipolar mood episodes.
    MeSH term(s) Antidepressive Agents/therapeutic use ; Antimanic Agents/therapeutic use ; Bipolar Disorder/diagnosis ; Bipolar Disorder/drug therapy ; Bipolar Disorder/therapy ; Humans ; Secondary Prevention
    Chemical Substances Antidepressive Agents ; Antimanic Agents
    Language English
    Publishing date 2010-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.8125cc5c
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  9. Article ; Online: Cognitive Dysfunction in Bipolar Disorder: A Guide for Cliniciansedited by Goldberg Joseph F. and Burdick Katherine E. . Foreword by Goodwin Frederick K. . Washington, D.C. American Psychiatric Publishing, Inc. , 2008 , 316 pp., $45.00.

    Bowden, Charles L

    The American journal of psychiatry

    2010  Volume 167, Issue 2, Page(s) 222

    Language English
    Publishing date 2010-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2009.09060774
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  10. Article: Comorbidities with bipolar disorders: significance, recognition, and management.

    Bowden, Charles L

    CNS spectrums

    2010  Volume 15, Issue 2 Suppl 3, Page(s) 8–9; discussion 17

    MeSH term(s) Antisocial Personality Disorder/complications ; Anxiety Disorders/complications ; Bipolar Disorder/complications ; Bipolar Disorder/therapy ; Comorbidity ; Humans ; Male ; Middle Aged ; Substance-Related Disorders/complications ; United States
    Language English
    Publishing date 2010-04-22
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2008418-3
    ISSN 2165-6509 ; 1092-8529
    ISSN (online) 2165-6509
    ISSN 1092-8529
    DOI 10.1017/s1092852900027760
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