Article ; Online: Intestinal permeability correlates with disease activity and DNA methylation changes in lupus patients.
Clinical immunology (Orlando, Fla.)
2024 Volume 262, Page(s) 110173
Abstract: Objective: Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease that can involve various organ systems. Several studies have suggested that increased intestinal permeability may play a role in the pathogenesis of lupus. The aim of ...
| Abstract | Objective: Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease that can involve various organ systems. Several studies have suggested that increased intestinal permeability may play a role in the pathogenesis of lupus. The aim of this study was to elucidate the relationship between intestinal permeability, disease activity, and epigenetic changes in lupus patients. Methods: A total of 25 female lupus patients were included in this study. Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores were used as indicator of disease activity. Plasma zonulin levels were measured, using an ELISA, as a marker of intestinal permeability. Genome-wide DNA methylation patterns were assessed in neutrophils for 19 of the lupus patients using the Infinium MethylationEPIC array. Linear regression and Pearson's correlation were used to evaluate the correlation between zonulin concentrations and SLEDAI scores. The relationship between DNA methylation levels and zonulin concentrations was assessed using beta regression, linear regression, and Pearson's correlation, adjusting for age and race. Results: Intestinal permeability positively correlated with disease activity in lupus patients (p-value = 7.60 × 10 Conclusion: Our data suggest a correlation between increased intestinal permeability and disease activity in lupus patients. Further, increased intestinal permeability might be associated with epigenetic changes that could play a role in the pathogenesis of lupus. |
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| MeSH term(s) | Humans ; Female ; DNA Methylation ; Intestinal Barrier Function ; Epigenesis, Genetic ; Lupus Erythematosus, Systemic/genetics ; Case-Control Studies |
| Language | English |
| Publishing date | 2024-03-08 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1459903-x |
| ISSN | 1521-7035 ; 1521-6616 |
| ISSN (online) | 1521-7035 |
| ISSN | 1521-6616 |
| DOI | 10.1016/j.clim.2024.110173 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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