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Article ; Online: The making of a classic: the 1974 Durnin-Womersley body composition paper.

Heymsfield, Steven B / Strauss, Boyd J G

2022 Volume 127, Issue 1, Page(s) 87–91

MeSH term(s)	Adipose Tissue ; Anthropometry ; Body Composition ; Skinfold Thickness
Language	English
Publishing date	2022-04-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114521003950
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Article ; Online: Evaluation of an alternative skeletal muscle index for skeletal muscle mass assessment in a group of Australian women.

Yee, Ming Li / Einoder, Sophie / Strauss, Boyd J G / Gilfillan, Christopher

Age and ageing

2022 Volume 51, Issue 2

Abstract: Background: Sarcopenia is assessed by several methods, including dual energy X-ray absorptiometry (DEXA), which provide a height-adjusted skeletal muscle index (H-SMI). A SMI 2 standard deviation below the young adult reference [1] combined with low ... ...

Abstract	Background: Sarcopenia is assessed by several methods, including dual energy X-ray absorptiometry (DEXA), which provide a height-adjusted skeletal muscle index (H-SMI). A SMI 2 standard deviation below the young adult reference [1] combined with low muscle strength or performance is used to identify sarcopenia. As height declines with age, H-SMI may underestimate low skeletal muscle mass in the older population. Our study aims to evaluate an alternative SMI and to examine its relationship to grip strength in a group of Australian women. Methods: Women from two cohorts were analysed. 2041 women had body composition data (112 had calf circumference, 137 had leg length measurements) without grip strength, and 49 women had grip strength measured (40 had body composition data).The relationship between leg length-adjusted SMI (LL-SMI) to grip strength and anthropometric variables to skeletal muscle mass by DEXA were examined by linear regression analysis. Results: Cohort 1: Older women were compared to younger women. Older women were shorter but leg length did not differ between different age groups. H-SMI was not different between groups (P = 0.528). LL-SMI was lower in older women (P = 0.002). Cohort 2: LL-SMI was significantly associated with grip strength (P = 0.048) after adjustment for age. Conclusion: Older women were shorter, while leg length did not differ from the younger group. H-SMI may obscure and may underestimate low muscle mass in older individuals. LL-SMI may be a better measure of skeletal muscle mass in older individuals. These alternate SMI would benefit from further exploration in older individuals.
MeSH term(s)	Absorptiometry, Photon ; Aged ; Australia ; Body Mass Index ; Female ; Hand Strength/physiology ; Humans ; Muscle, Skeletal/physiology ; Sarcopenia/diagnostic imaging ; Sarcopenia/epidemiology
Language	English
Publishing date	2022-06-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186788-x
ISSN	1468-2834 ; 0002-0729
ISSN (online)	1468-2834
ISSN	0002-0729
DOI	10.1093/ageing/afac002
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Zs.A 877: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Mental health diagnoses in adults with phenylketonuria: a retrospective systematic audit in a large UK single centre.

Altman, George / Hussain, Kamran / Green, Diane / Strauss, Boyd J G / Wilcox, Gisela

Orphanet journal of rare diseases

2021 Volume 16, Issue 1, Page(s) 520

Abstract: Background: Recently published European Society for Phenylketonuria (ESPKU) guidelines have recommended a lifelong diet with phenylalanine (Phe) control ≤ 600 μmol/L for phenylketonuria (PKU) patients. This study aimed to identify whether PKU adult ... ...

Abstract	Background: Recently published European Society for Phenylketonuria (ESPKU) guidelines have recommended a lifelong diet with phenylalanine (Phe) control ≤ 600 μmol/L for phenylketonuria (PKU) patients. This study aimed to identify whether PKU adult patients are at a higher risk of mental health diagnoses if their 2-year average Phe level is higher than the ESPKU European guidelines. Published studies identified by a literature review showed that related studies have been published in American and European PKU study populations but not in the United Kingdom (UK) study populations. Previous studies also involved a smaller number of participants due to this being a rare disease. Results: We undertook a retrospective audit at a single large PKU centre in the UK. 244 adult PKU patients at the centre were included, 220 of which had a recorded Phe level. Approximately 75% of the patients in this study did not meet the ESPKU European guidelines for Phe control. A systematic search of the electronic patient record was undertaken looking for mental health diagnoses. Compared to two-year average Phe levels ≤ 600 μmol/L, PKU adult patients with two-year average Phe levels > 600 μmol/L were more likely to have diagnoses of low mood, depression, anxiety, or mood swings, but only low mood reached statistical significance (p < 0.05). Conclusions: PKU patients with two-year average Phenylalanine levels greater than ESPKU guidelines may be at greater risk of mental health diagnoses and symptoms. Many of these adult PKU patients will be lost to follow-up, and therefore may be receiving treatment for mental health conditions in the community. Multicentre UK studies and international collaborations are required to overcome low participant numbers in the study of this rare disease.
MeSH term(s)	Adult ; Humans ; Mental Health ; Phenylalanine ; Phenylketonurias/diagnosis ; Phenylketonurias/therapy ; Retrospective Studies ; United Kingdom
Chemical Substances	Phenylalanine (47E5O17Y3R)
Language	English
Publishing date	2021-12-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2225857-7
ISSN	1750-1172 ; 1750-1172
ISSN (online)	1750-1172
ISSN	1750-1172
DOI	10.1186/s13023-021-02138-z
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Article ; Online: Multicomponent density models for body composition: Review of the dual energy X-ray absorptiometry volume approach.

Heymsfield, Steven B / Smith, Brooke / Wong, Michael / Bennett, Jonathan / Ebbeling, Cara / Wong, Julia M W / Strauss, Boyd J G / Shepherd, John

Obesity reviews : an official journal of the International Association for the Study of Obesity

2021 Volume 22, Issue 8, Page(s) e13274

Abstract: Accurate and precise body composition estimates, notably of total body adiposity, are a vital component of in vivo physiology and metabolic studies. The reference against which other body composition approaches are usually validated or calibrated is the ... ...

Abstract	Accurate and precise body composition estimates, notably of total body adiposity, are a vital component of in vivo physiology and metabolic studies. The reference against which other body composition approaches are usually validated or calibrated is the family of methods referred to as multicomponent "body density" models. These models quantify three to six components by combining measurements of body mass, body volume, total body water, and osseous mineral mass. Body mass is measured with calibrated scales, volume with underwater weighing or air-displacement plethysmography, total body water with isotope dilution, and osseous mineral mass by dual-energy X-ray absorptiometry. Body density is then calculated for use in model as body mass/volume. Studies over the past decade introduced a new approach to quantifying body volume that relies on dual-energy X-ray absorptiometry measurements, an advance that simplifies multicomponent density model development by eliminating the need for underwater weighing or air-displacement plethysmography systems when these technologies are unavailable and makes these methods more accessible to research and clinical programs. This review critically examines these new dual-energy X-ray approaches for quantifying body volume and density, explores their shortcomings, suggests alternative derivation approaches, and introduces ideas for potential future research studies.
MeSH term(s)	Absorptiometry, Photon ; Adipose Tissue/metabolism ; Adiposity ; Body Composition ; Humans ; Obesity/metabolism ; Plethysmography
Language	English
Publishing date	2021-06-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2147980-X
ISSN	1467-789X ; 1467-7881
ISSN (online)	1467-789X
ISSN	1467-7881
DOI	10.1111/obr.13274
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Article: Multicomponent density models for body composition: Review of the dual energy X‐ray absorptiometry volume approach

Heymsfield, Steven B. / Smith, Brooke / Wong, Michael / Bennett, Jonathan / Ebbeling, Cara / Wong, Julia M. W. / Strauss, Boyd J. G. / Shepherd, John

Obesity reviews. 2021 Aug., v. 22, no. 8

2021

Abstract	Accurate and precise body composition estimates, notably of total body adiposity, are a vital component of in vivo physiology and metabolic studies. The reference against which other body composition approaches are usually validated or calibrated is the family of methods referred to as multicomponent “body density” models. These models quantify three to six components by combining measurements of body mass, body volume, total body water, and osseous mineral mass. Body mass is measured with calibrated scales, volume with underwater weighing or air‐displacement plethysmography, total body water with isotope dilution, and osseous mineral mass by dual‐energy X‐ray absorptiometry. Body density is then calculated for use in model as body mass/volume. Studies over the past decade introduced a new approach to quantifying body volume that relies on dual‐energy X‐ray absorptiometry measurements, an advance that simplifies multicomponent density model development by eliminating the need for underwater weighing or air‐displacement plethysmography systems when these technologies are unavailable and makes these methods more accessible to research and clinical programs. This review critically examines these new dual‐energy X‐ray approaches for quantifying body volume and density, explores their shortcomings, suggests alternative derivation approaches, and introduces ideas for potential future research studies.
Keywords	adiposity ; body water ; dual-energy X-ray absorptiometry ; isotope dilution technique ; obesity ; plethysmography
Language	English
Dates of publication	2021-08
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2147980-X
ISSN	1467-789X ; 1467-7881
ISSN (online)	1467-789X
ISSN	1467-7881
DOI	10.1111/obr.13274
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Article: Measuring visceral fat, subcutaneous fat and skeletal muscle area changes by computed tomography in acute pancreatitis: a retrospective, single-centre study.

Brewster, David J / Strauss, Boyd J G / Crozier, Timothy M

Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

2014 Volume 16, Issue 1, Page(s) 42–47

Abstract: Objective: To show that body composition of intensive care unit patients can be analysed with existing computed tomography (CT) images. We planned to describe changes in visceral fat area (VFA), subcutaneous fat area (SFA) and muscle area (MA) on ... ...

Abstract	Objective: To show that body composition of intensive care unit patients can be analysed with existing computed tomography (CT) images. We planned to describe changes in visceral fat area (VFA), subcutaneous fat area (SFA) and muscle area (MA) on analysis of specific CT images during acute pancreatitis requiring an ICU admission. Design, setting and participants: Retrospective analysis of body composition using existing CT images, in an ICU of a tertiary university-affiliated hospital 2005-2010, examining 21 patients with acute pancreatitis and CT imaging on two separate occasions within their hospital admission. Main outcome measures: VFA, SFA, VFA:SFA ratio and MA. Medical records were hand searched to identify ICU and hospital mortalities and other clinical outcomes. Results: Three women and 18 men had 84 CT scans analysed, from the level of the right renal hilum and L3 vertebra. The median patient age was 52 years. The median time between CT scans was 9.4 days and the mean Acute Physiology and Chronic Health Evaluation II score was 20.2. ICU mortality was 9%. Analysis showed a decrease in VFA from a median of 229.2 cm2 to 202.1 cm2 (P < 0.01) and a decrease in VFA:SFA ratio from a median of 1.20 to 1.05 (P < 0.01) during the acute illness. MA did not change significantly. Conclusions: The body composition of ICU patients can be analysed through existing CT images. Pancreatitis requiring ICU admission causes a 12% decrease in VFA.
MeSH term(s)	Aged ; Body Composition ; Female ; Follow-Up Studies ; Hospital Mortality/trends ; Humans ; Intensive Care Units ; Intra-Abdominal Fat/diagnostic imaging ; Male ; Middle Aged ; Muscle, Skeletal/diagnostic imaging ; Pancreatitis, Acute Necrotizing/diagnostic imaging ; Pancreatitis, Acute Necrotizing/mortality ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Subcutaneous Fat/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Victoria/epidemiology
Language	English
Publishing date	2014-03
Publishing country	Australia
Document type	Comparative Study ; Journal Article
ZDB-ID	2401976-8
ISSN	1441-2772
ISSN	1441-2772
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Zs.A 6672: Show issues

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Article: Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor sustain the axonal regeneration of chronically axotomized motoneurons in vivo.

Boyd, J G / Gordon, T

Experimental neurology

2003 Volume 183, Issue 2, Page(s) 610–619

Abstract: In contrast to injuries in the central nervous system, injured peripheral neurons will regenerate their axons. However, axotomized motoneurons progressively lose their ability to regenerate their axons, following peripheral nerve injury often resulting ... ...

Abstract	In contrast to injuries in the central nervous system, injured peripheral neurons will regenerate their axons. However, axotomized motoneurons progressively lose their ability to regenerate their axons, following peripheral nerve injury often resulting in very poor recovery of motor function. A decline in neurotrophic support may be partially responsible for this effect. The initial upregulation of glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) by Schwann cells of the distal nerve stump after nerve injury has led to the speculation that they are important for motor axonal regeneration. However, few experiments directly measure the effects of exogenous BDNF or GDNF on motor axonal regeneration. This study provided the first direct and quantitative evidence that long-term continuous treatment with exogenous GDNF significantly increased the number of motoneurons which regenerate their axons, completely reversing the negative effects of chronic axotomy. The beneficial effect of GDNF was not dose-dependent. A combination of exogenous GDNF and BDNF on motor axonal regeneration was significantly greater than either factor alone, and this effect was most pronounced following long-term continuous treatment. The ability of GDNF, either alone or in combination with BDNF, to increase the number of motoneurons that regenerated their axons correlated well with an increase in axon sprouting within the distal nerve stump. Thus long-term continuous treatment with neurotrophic factors, such as GDNF and BDNF, can be used as a viable treatment to sustain motor axon regeneration.
MeSH term(s)	Animals ; Axons/drug effects ; Axons/physiology ; Axotomy ; Brain-Derived Neurotrophic Factor/administration & dosage ; Brain-Derived Neurotrophic Factor/pharmacology ; Dose-Response Relationship, Drug ; Drug Synergism ; Female ; Glial Cell Line-Derived Neurotrophic Factor ; Infusion Pumps, Implantable ; Motor Neurons/drug effects ; Motor Neurons/physiology ; Nerve Growth Factors/administration & dosage ; Nerve Growth Factors/pharmacology ; Nerve Regeneration/drug effects ; Rats ; Rats, Sprague-Dawley ; Treatment Outcome
Chemical Substances	Brain-Derived Neurotrophic Factor ; Gdnf protein, rat ; Glial Cell Line-Derived Neurotrophic Factor ; Nerve Growth Factors
Language	English
Publishing date	2003-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207148-4
ISSN	1090-2430 ; 0014-4886
ISSN (online)	1090-2430
ISSN	0014-4886
DOI	10.1016/s0014-4886(03)00183-3
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Article: A dose-dependent facilitation and inhibition of peripheral nerve regeneration by brain-derived neurotrophic factor.

Boyd, J G / Gordon, T

The European journal of neuroscience

2002 Volume 15, Issue 4, Page(s) 613–626

Abstract: The time-dependent decline in the ability of motoneurons to regenerate their axons after axotomy is one of the principle contributing factors to poor functional recovery after peripheral nerve injury. A decline in neurotrophic support may be partially ... ...

Abstract	The time-dependent decline in the ability of motoneurons to regenerate their axons after axotomy is one of the principle contributing factors to poor functional recovery after peripheral nerve injury. A decline in neurotrophic support may be partially responsible for this effect. The up-regulation of BDNF after injury, both in denervated Schwann cells and in axotomized motoneurons, suggests its importance in motor axonal regeneration. In adult female Sprague-Dawley rats, we counted the number of freshly injured or chronically axotomized tibial motoneurons that had regenerated their axons 1 month after surgical suture to a freshly denervated common peroneal distal nerve stump. Motor axonal regeneration was evaluated by applying fluorescent retrograde neurotracers to the common peroneal nerve 20 mm distal to the injury site and counting the number of fluorescently labelled motoneurons in the T11-L1 region of the spinal cord. We report that low doses of BDNF (0.5-2 microg/day for 28 days) had no detectable effect on axonal regeneration after immediate nerve repair, but promoted axonal regeneration of motoneurons whose regenerative capacity was reduced by chronic axotomy 2 months prior to nerve resuture, completely reversing the negative effects of delayed nerve repair. In contrast, high doses of BDNF (12-20 microg/day for 28 days) significantly inhibited motor axonal regeneration, after both immediate nerve repair and nerve repair after chronic axotomy. The inhibitory actions of high dose BDNF could be reversed by functional blockade of p75 receptors, thus implicating these receptors as mediators of the inhibitory effects of high dose exogenous BDNF.
MeSH term(s)	Animals ; Axons/drug effects ; Axons/metabolism ; Axons/ultrastructure ; Brain-Derived Neurotrophic Factor/metabolism ; Brain-Derived Neurotrophic Factor/pharmacology ; Cell Size/drug effects ; Cell Size/physiology ; Chronic Disease ; Dose-Response Relationship, Drug ; Drug Delivery Systems/adverse effects ; Female ; Fluorescent Dyes ; Motor Neurons/cytology ; Motor Neurons/drug effects ; Motor Neurons/metabolism ; Nerve Regeneration/drug effects ; Nerve Regeneration/physiology ; Peripheral Nerve Injuries ; Peripheral Nerves/drug effects ; Peripheral Nerves/surgery ; Rats ; Rats, Sprague-Dawley ; Receptor, Nerve Growth Factor/antagonists & inhibitors ; Receptor, Nerve Growth Factor/immunology ; Receptor, Nerve Growth Factor/metabolism ; Time Factors
Chemical Substances	Brain-Derived Neurotrophic Factor ; Fluorescent Dyes ; Receptor, Nerve Growth Factor
Language	English
Publishing date	2002-02
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1046/j.1460-9568.2002.01891.x
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Zs.A 2548: Show issues

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Article ; Online: Selective Loss of Levator Ani and Leg Muscle Volumes in Men Undergoing Androgen Deprivation Therapy.

Cheung, Ada S / Cunningham, Christopher / Ko, Dong-Kyoon Daniel / Ly, Vivian / Gray, Hans / Hoermann, Rudolf / Strauss, Boyd J G / Bani Hassan, Ebrahim / Duque, Gustavo / Ebeling, Peter / Pandy, Marcus G / Zajac, Jeffrey D / Grossmann, Mathis

The Journal of clinical endocrinology and metabolism

2018 Volume 104, Issue 6, Page(s) 2229–2238

Abstract: Context: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a selective loss of leg muscle function during walking. Rodent models of ADT have demonstrated that the levator ani is exquisitely androgen sensitive.: Objective: To ... ...

Abstract	Context: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a selective loss of leg muscle function during walking. Rodent models of ADT have demonstrated that the levator ani is exquisitely androgen sensitive. Objective: To determine whether the high androgen responsiveness of the levator ani muscle documented in rodents is evolutionarily conserved and ADT is associated with a selective loss in leg muscle volume. Design: Prospective longitudinal case-control study. Setting: Tertiary referral hospital. Participants: Thirty-four men newly beginning ADT and 29 age-matched controls with PCa. Main outcome measures: The muscle volumes in liters of the levator ani and primary muscles involved in walking (iliopsoas, quadriceps, gluteus maximus, gluteus medius, calf). Results: Compared with controls, during a 12-month period, men receiving ADT experienced a mean reduction in total testosterone from 14.1 to 0.4 nmol/L and demonstrated greater decreases in levator ani [mean adjusted difference (MAD), -0.005 L; 95% CI, -0.007 to -0.002; P = 0.002; -16% of initial median value], gluteus maximus (MAD, -0.032 L; 95% CI, -0.063 to -0.002; P = 0.017; -5% of initial median value), iliopsoas (MAD, -0.005 L; 95% CI, -0.001 to 0.000; P = 0.013; -5% of initial median value), and quadriceps (MAD, -0.050 L; 95% CI, -0.088 to -0.012; P = 0.031; -3% of initial median value). No substantial differences were observed in the gluteus medius and calf muscles. Conclusions: The androgen responsiveness of the levator ani appears to be evolutionarily conserved in humans. ADT selectively decreases the volume of muscles that support body weight. Interventional strategies to reduce ADT-related sarcopenia and sexual dysfunction should assess whether targeting these muscle groups, including the pelvic floor, will improve clinical outcomes.
MeSH term(s)	Aged ; Androgen Antagonists/adverse effects ; Body Composition/drug effects ; Humans ; Leg ; Male ; Middle Aged ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/pathology ; Prospective Studies ; Sarcopenia/chemically induced ; Sexual Dysfunction, Physiological/chemically induced
Chemical Substances	Androgen Antagonists
Language	English
Publishing date	2018-12-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/jc.2018-01954
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Article: The neurotrophin receptors, trkB and p75, differentially regulate motor axonal regeneration.

Boyd, J G / Gordon, T

Journal of neurobiology

2001 Volume 49, Issue 4, Page(s) 314–325

Abstract: Neurotrophic factors that support neuronal survival are implicated in axonal regeneration after injury. Specifically, a strong role for BDNF in motor axonal regeneration has been suggested based on its pattern of expression after injury, as well as the ... ...

Abstract	Neurotrophic factors that support neuronal survival are implicated in axonal regeneration after injury. Specifically, a strong role for BDNF in motor axonal regeneration has been suggested based on its pattern of expression after injury, as well as the expression of its receptors, trkB and p75. Despite considerable in vitro evidence, which demonstrate specific and distinct physiological responses elicited following trkB and p75 activation, relatively little is known about the function of these receptors in vivo. To investigate the roles of the trkB and p75 receptors in motor axonal regeneration, we have used a tibial (TIB)- common peroneal (CP) cross suture paradigm in p75 homozygous (-/-) knockout mice, trkB heterozygous (+/-) knockout mice, as well as in their wild-type controls. Contralateral intact TIB motoneurons, and axotomized TIB motoneurons that regenerated their axons 10 mm into the CP distal nerve stump were identified by fluorescent retrograde tracers and counted in the T11-L1 spinal segments. Regeneration was evaluated 2, 3, 4, 6, and 8 weeks after nerve repair. Compared to wild-type animals, there are significantly fewer intact TIB motoneurons in p75 (-/-), but not trkB (+/-) mice. The number of motoneurons that regenerated their axons was significantly increased in the p75 (-/-) knockout mice, but significantly attenuated in the trkB (+/-) mice compared to wild-type controls. These results suggest that p75 is important for motoneuronal survival during development, but p75 expression after injury serves to inhibit motor axonal regeneration. In addition, full expression of trkB is critical for complete axonal regeneration to proceed.
MeSH term(s)	Animals ; Axons/physiology ; Axotomy ; Cell Count ; Cell Survival/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Motor Neurons/physiology ; Nerve Regeneration/physiology ; Perfusion ; Receptor, Nerve Growth Factor/physiology ; Receptor, trkB/physiology ; Receptors, Nerve Growth Factor/physiology ; Reverse Transcriptase Polymerase Chain Reaction ; Tibial Nerve/cytology ; Tibial Nerve/physiology
Chemical Substances	Receptor, Nerve Growth Factor ; Receptors, Nerve Growth Factor ; Receptor, trkB (EC 2.7.10.1)
Language	English
Publishing date	2001-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	300903-8
ISSN	1097-4695 ; 0022-3034
ISSN (online)	1097-4695
ISSN	0022-3034
DOI	10.1002/neu.10013
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