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  1. Article: COVID-19 impairs oxygen delivery by altering red blood cell hematological, hemorheological, and oxygen transport properties.

    Rogers, Stephen C / Brummet, Mary / Safari, Zohreh / Wang, Qihong / Rowden, Tobi / Boyer, Tori / Doctor, Allan

    Frontiers in physiology

    2024  Volume 14, Page(s) 1320697

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1320697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Coagulation potential and the integrated omics of extracellular vesicles from COVID-19 positive patient plasma.

    Setua, Saini / Thangaraju, Kiruphagaran / Dzieciatkowska, Monika / Wilkerson, Rebecca B / Nemkov, Travis / Lamb, Derek R / Tagaya, Yutaka / Boyer, Tori / Rowden, Tobi / Doctor, Allan / D'Alessandro, Angelo / Buehler, Paul W

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 22191

    Abstract: Extracellular vesicles (EVs) participate in cell-to-cell communication and contribute toward homeostasis under physiological conditions. But EVs can also contribute toward a wide array of pathophysiology like cancer, sepsis, sickle cell disease, and ... ...

    Abstract Extracellular vesicles (EVs) participate in cell-to-cell communication and contribute toward homeostasis under physiological conditions. But EVs can also contribute toward a wide array of pathophysiology like cancer, sepsis, sickle cell disease, and thrombotic disorders. COVID-19 infected patients are at an increased risk of aberrant coagulation, consistent with elevated circulating levels of ultra-high molecular weight VWF multimers, D-dimer and procoagulant EVs. The role of EVs in COVID-19 related hemostasis may depend on cells of origin, vesicular cargo and size, however this is not well defined. We hypothesized that the procoagulant potential of EV isolates from COVID-19 (+) patient plasmas could be defined by thrombin generation assays. Here we isolated small EVs (SEVs) and large EVs (LEVs) from hospitalized COVID-19 (+) patient (n = 21) and healthy donor (n = 20) plasmas. EVs were characterized by flow cytometry, Transmission electron microscopy, nanoparticle tracking analysis, plasma thrombin generation and a multi-omics approach to define coagulation potential. These data were consistent with differences in EV metabolite, lipid, and protein content when compared to healthy donor plasma isolated SEVs and LEVs. Taken together, the effect of EVs on plasma procoagulant potential as defined by thrombin generation and supported by multi-omics is enhanced in COVID-19. Further, we observe that this effect is driven both by EV size and phosphatidyl serine.
    MeSH term(s) Humans ; Thrombin/metabolism ; COVID-19/complications ; Extracellular Vesicles/metabolism ; Blood Coagulation ; Thrombosis/metabolism
    Chemical Substances Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2022-12-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-26473-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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