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  1. Article: Justice for Our Genes: The Case for Genetic Non-discrimination Regulations in the New Zealand Life Insurance Industry.

    Buckenham Boyle, Emily

    Journal of law and medicine

    2022  Volume 29, Issue 3, Page(s) 760–782

    Abstract: While most comparable jurisdictions have adopted more restrictive positions, life insurers in New Zealand remain permitted to request the disclosure of predictive genetic test results from applicants, driving up the cost to obtain life insurance for ... ...

    Abstract While most comparable jurisdictions have adopted more restrictive positions, life insurers in New Zealand remain permitted to request the disclosure of predictive genetic test results from applicants, driving up the cost to obtain life insurance for those with known susceptibilities to genetic disease. The permissive approach is now an outlier, and risks disincentivising health care and research innovation, facilitating irrational discrimination, and compounding existing health inequities. This article examines the New Zealand position through a consequentialist lens. It analyses justifications for the status quo, as well as international approaches, before concluding that genetic non-discrimination regulations governing New Zealand's life insurance industry should be introduced to enhance public wellbeing.
    MeSH term(s) Disclosure ; Genetic Testing ; Insurance, Life ; New Zealand ; Social Justice
    Language English
    Publishing date 2022-08-15
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1236328-5
    ISSN 1320-159X
    ISSN 1320-159X
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    Zs.A 4288: Show issues Location:
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  2. Article ; Online: Creating an Escape Room for Continuous Renal Replacement Therapy Validation.

    Przybyl, Heather / Boyle, Emily

    Critical care nurse

    2023  Volume 43, Issue 3, Page(s) 68–71

    MeSH term(s) Humans ; Continuous Renal Replacement Therapy ; Retrospective Studies ; Acute Kidney Injury/therapy
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632663-8
    ISSN 1940-8250 ; 0279-5442
    ISSN (online) 1940-8250
    ISSN 0279-5442
    DOI 10.4037/ccn2023243
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  3. Article ; Online: Autophagy as a caretaker of nuclear integrity.

    Boyle, Emily / Wilfling, Florian

    FEBS letters

    2023  Volume 597, Issue 22, Page(s) 2728–2738

    Abstract: Due to their essential functions, dysregulation of nuclear pore complexes (NPCs) is strongly associated with numerous human diseases, including neurodegeneration and cancer. On a cellular level, longevity of scaffold nucleoporins in postmitotic cells of ... ...

    Abstract Due to their essential functions, dysregulation of nuclear pore complexes (NPCs) is strongly associated with numerous human diseases, including neurodegeneration and cancer. On a cellular level, longevity of scaffold nucleoporins in postmitotic cells of both C. elegans and mammals renders them vulnerable to age-related damage, which is associated with an increase in pore leakiness and accumulation of intranuclear aggregates in rat brain cells. Thus, understanding the mechanisms which underpin the homeostasis of this complex, as well as other nuclear proteins, is essential. In this review, autophagy-mediated degradation pathways governing nuclear components in yeast will be discussed, with a particular focus on NPCs. Furthermore, the various nuclear degradation mechanisms identified thus far in diverse eukaryotes will also be highlighted.
    MeSH term(s) Rats ; Humans ; Animals ; Caenorhabditis elegans/metabolism ; Nuclear Pore/metabolism ; Nuclear Pore Complex Proteins/metabolism ; Cell Nucleus/metabolism ; Saccharomyces cerevisiae/metabolism ; Autophagy ; Mammals/metabolism
    Chemical Substances Nuclear Pore Complex Proteins
    Language English
    Publishing date 2023-08-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14719
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  4. Article ; Online: Autophagy as a caretaker of nuclear integrity

    Boyle, Emily / Wilfling, Florian

    FEBS Letters. 2023 Nov., v. 597, no. 22 p.2728-2738

    2023  

    Abstract: Due to their essential functions, dysregulation of nuclear pore complexes (NPCs) is strongly associated with numerous human diseases, including neurodegeneration and cancer. On a cellular level, longevity of scaffold nucleoporins in postmitotic cells of ... ...

    Abstract Due to their essential functions, dysregulation of nuclear pore complexes (NPCs) is strongly associated with numerous human diseases, including neurodegeneration and cancer. On a cellular level, longevity of scaffold nucleoporins in postmitotic cells of both C. elegans and mammals renders them vulnerable to age‐related damage, which is associated with an increase in pore leakiness and accumulation of intranuclear aggregates in rat brain cells. Thus, understanding the mechanisms which underpin the homeostasis of this complex, as well as other nuclear proteins, is essential. In this review, autophagy‐mediated degradation pathways governing nuclear components in yeast will be discussed, with a particular focus on NPCs. Furthermore, the various nuclear degradation mechanisms identified thus far in diverse eukaryotes will also be highlighted.
    Keywords autophagy ; brain ; eukaryotic cells ; homeostasis ; humans ; longevity ; neurodegenerative diseases ; nuclear pore ; nucleoporins ; rats ; yeasts
    Language English
    Dates of publication 2023-11
    Size p. 2728-2738.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14719
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  5. Article: Polymicrobial bacteremia and Strongyloides hyperinfection syndrome: Vigilance in patients on corticosteroids.

    Boyle, Evan / Coppock, Dagan

    IDCases

    2022  Volume 28, Page(s) e01520

    Abstract: Strongyloidiasis is a worldwide parasitic infection. Many who develop infection remain asymptomatic. Due to Stronygloides autoinfection cycle it can result in chronic infection over decades. Immunosuppression particularly with corticosteroids has been ... ...

    Abstract Strongyloidiasis is a worldwide parasitic infection. Many who develop infection remain asymptomatic. Due to Stronygloides autoinfection cycle it can result in chronic infection over decades. Immunosuppression particularly with corticosteroids has been associated with a rapid acceleration of the autoinfection cycle known as Strongyloides hyperinfection syndrome. The hyperinfection syndrome has severe complications and is associated with significant patient mortality. Here we report a case of hyperinfection complicated by polymicrobial bacteremia and intestinal ileus and review the literature regarding the hyperinfection syndrome.
    Language English
    Publishing date 2022-05-20
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2022.e01520
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  6. Article ; Online: Bypassing the nuclear gate: A non-canonical entry pathway for the mitochondrial pyruvate dehydrogenase complex.

    Boyle, Emily / Wilfling, Florian

    Molecular cell

    2022  Volume 82, Issue 5, Page(s) 886–888

    Abstract: Zervopoulos et al. (2022) propose a non-canonical nuclear import pathway for the functional mitochondrial pyruvate dehydrogenase complex (PDC), facilitated by dynamic MFN2-mediated tethering of mitochondria to the nuclear envelope upon exposure to ... ...

    Abstract Zervopoulos et al. (2022) propose a non-canonical nuclear import pathway for the functional mitochondrial pyruvate dehydrogenase complex (PDC), facilitated by dynamic MFN2-mediated tethering of mitochondria to the nuclear envelope upon exposure to proliferative stimuli.
    MeSH term(s) Cell Nucleus/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Pyruvate Dehydrogenase Complex/genetics ; Pyruvate Dehydrogenase Complex/metabolism
    Chemical Substances Pyruvate Dehydrogenase Complex
    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2022.02.014
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    Zs.A 5055: Show issues Location:
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  7. Article ; Online: Post-Translational Modifications and Diabetes.

    Sharma, Chiranjeev / Hamza, Abu / Boyle, Emily / Donu, Dickson / Cen, Yana

    Biomolecules

    2024  Volume 14, Issue 3

    Abstract: Diabetes and its associated complications have increasingly become major challenges for global healthcare. The current therapeutic strategies involve insulin replacement therapy for type 1 diabetes (T1D) and small-molecule drugs for type 2 diabetes (T2D). ...

    Abstract Diabetes and its associated complications have increasingly become major challenges for global healthcare. The current therapeutic strategies involve insulin replacement therapy for type 1 diabetes (T1D) and small-molecule drugs for type 2 diabetes (T2D). Despite these advances, the complex nature of diabetes necessitates innovative clinical interventions for effective treatment and complication prevention. Accumulative evidence suggests that protein post-translational modifications (PTMs), including glycosylation, phosphorylation, acetylation, and SUMOylation, play important roles in diabetes and its pathological consequences. Therefore, the investigation of these PTMs not only sheds important light on the mechanistic regulation of diabetes but also opens new avenues for targeted therapies. Here, we offer a comprehensive overview of the role of several PTMs in diabetes, focusing on the most recent advances in understanding their functions and regulatory mechanisms. Additionally, we summarize the pharmacological interventions targeting PTMs that have advanced into clinical trials for the treatment of diabetes. Current challenges and future perspectives are also provided.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Protein Processing, Post-Translational ; Phosphorylation ; Glycosylation ; Sumoylation
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14030310
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  8. Article: Bypassing the nuclear gate: A non-canonical entry pathway for the mitochondrial pyruvate dehydrogenase complex

    Boyle, Emily / Wilfling, Florian

    Molecular cell. 2022 Mar. 03, v. 82, no. 5

    2022  

    Abstract: Zervopoulos et al. (2022) propose a non-canonical nuclear import pathway for the functional mitochondrial pyruvate dehydrogenase complex (PDC), facilitated by dynamic MFN2-mediated tethering of mitochondria to the nuclear envelope upon exposure to ... ...

    Abstract Zervopoulos et al. (2022) propose a non-canonical nuclear import pathway for the functional mitochondrial pyruvate dehydrogenase complex (PDC), facilitated by dynamic MFN2-mediated tethering of mitochondria to the nuclear envelope upon exposure to proliferative stimuli.
    Keywords mitochondria ; nuclear membrane ; physiological transport ; pyruvate dehydrogenase (lipoamide)
    Language English
    Dates of publication 2022-0303
    Size p. 886-888.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2022.02.014
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  9. Article ; Online: Nitrogen pollution knows no bounds.

    Boyle, Edward

    Science (New York, N.Y.)

    2017  Volume 356, Issue 6339, Page(s) 700–701

    MeSH term(s) China ; Environmental Monitoring ; Environmental Pollution ; Nitrogen/analysis
    Chemical Substances Nitrogen (N762921K75)
    Language English
    Publishing date 2017--19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aan3242
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  10. Article ; Online: Corrigendum to "The clinical profile of people with knee osteoarthritis and a self-reported prior knee injury: A cross-sectional study of 10,973 peopleˮ [Osteoarthritis Cartilage 29 (2021) 341-345].

    Holm, P M / Roos, E M / Boyle, E / Skou, S T

    Osteoarthritis and cartilage

    2021  Volume 29, Issue 6, Page(s) 934–935

    Language English
    Publishing date 2021-03-31
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1167809-4
    ISSN 1522-9653 ; 1063-4584
    ISSN (online) 1522-9653
    ISSN 1063-4584
    DOI 10.1016/j.joca.2021.03.012
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