LIVIVO - Search results -

Search results

Result 1 - 10 of total 12

Search options

Article ; Online: Letter to the Editor regarding, "Chronic low back pain, bacterial infection, and treatment with antibiotics".

Bråten, Lars Christian Haugli / Storheim, Kjersti

The spine journal : official journal of the North American Spine Society

2021 Volume 21, Issue 7, Page(s) 1229–1230

MeSH term(s)	Anti-Bacterial Agents/adverse effects ; Bacterial Infections/drug therapy ; Humans ; Low Back Pain/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-07-10
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2037072-6
ISSN	1878-1632 ; 1529-9430
ISSN (online)	1878-1632
ISSN	1529-9430
DOI	10.1016/j.spinee.2021.03.034
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5898: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Impact of educational level and employment status on short-term and long-term pain relief from supervised exercise therapy and education: an observational study of 22 588 patients with knee and hip osteoarthritis.

Johnsen, Marianne Bakke / Roos, Ewa / Grønne, Dorte Thalund / Bråten, Lars Christian Haugli / Skou, Søren Thorgaard

BMJ open

2021 Volume 11, Issue 4, Page(s) e045156

Abstract: Objectives: To investigate the impact of educational level and employment status on change in pain intensity after treatment among patients with knee and hip osteoarthritis (OA).: Design: A prospective cohort study.: Setting and participants: We ... ...

Abstract	Objectives: To investigate the impact of educational level and employment status on change in pain intensity after treatment among patients with knee and hip osteoarthritis (OA). Design: A prospective cohort study. Setting and participants: We analysed 22 588 patients participating in the Good Life with osteoArthritis in Denmark (GLA:D). GLA:D consists of two patient education sessions and 12 supervised exercise sessions. Primary outcome: Baseline educational level and employment status were used as exposures. We investigated the impact of both exposures separately on mean change in pain intensity (visual analogue scale 0-100 mm) from baseline to immediately after treatment (approximately 3 months) and at 12 months, using linear mixed models. Results: On average, all patients improved in pain intensity. The average improvement in pain did not differ by educational level, except for one group. Patients with long-term education had less improvement after treatment (2.0 mm, 95% CI 0.8 to 3.1) and at 12 months (2.0 mm, 95% CI 0.6 to 3.4) compared with primary school only (reference). According to employment status, patients on sick leave had the greatest improvement in pain after treatment (-3.4, 95% CI -4.9 to -1.9) and at 12 months (-4.5, 95% CI -6.4 to -2.6) compared with retired patients (reference). Conclusions: On average, all patients reported improvement in pain at short-term and long-term follow-up. Change in pain intensity did not substantially differ by educational level or employment status, as the absolute differences were small and most likely not clinically important.
MeSH term(s)	Employment ; Exercise Therapy ; Humans ; Osteoarthritis, Hip/therapy ; Osteoarthritis, Knee/therapy ; Pain ; Prospective Studies
Language	English
Publishing date	2021-04-14
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2020-045156
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Longitudinal Relationship Between Reduced Modic Change Edema and Disability and Pain in Patients With Chronic Low Back Pain.

Espeland, Ansgar / Kristoffersen, Per Martin / Bråten, Lars Christian Haugli / Grøvle, Lars / Grotle, Margreth / Haugen, Anne Julsrud / Rolfsen, Mads Peder / Hellum, Christian / Zwart, John-Anker / Storheim, Kjersti / Assmus, Jörg / Vetti, Nils

Spine

2023 Volume 48, Issue 24, Page(s) 1699–1708

Abstract: Study design: Secondary analyses of a randomized trial [Antibiotics In Modic changes (MCs) study].: Objective: To assess whether or not reduced MC edema over time is related to reduced disability and pain in patients with chronic low back pain (LBP).! ...

Abstract	Study design: Secondary analyses of a randomized trial [Antibiotics In Modic changes (MCs) study]. Objective: To assess whether or not reduced MC edema over time is related to reduced disability and pain in patients with chronic low back pain (LBP). Summary of background data: It is not clear whether or not reduced MC edema implies improved clinical outcomes. Patients and methods: Linear regression was conducted separately in 2 subgroups with MC edema at baseline on short tau inversion recovery (STIR) or T1/T2-weighted magnetic resonance imaging, respectively. Independent variable: reduced edema (yes/no) at 1 year on STIR or T1/T2-series, respectively. Dependent variable: 1-year score on the Roland-Morris Disability Questionnaire (RMDQ), Oswestry Disability Index (ODI), or 0 to 10 numeric rating scale for LBP intensity, adjusted for the baseline score, age, smoking, body mass index, physical workload, and baseline edema on STIR (STIR analysis only). Post hoc, we, in addition, adjusted all analyses for baseline edema on STIR, treatment group (amoxicillin/placebo), and prior disc surgery-or for disc degeneration. Results: Among patients with MC edema on STIR at baseline (n = 162), reduced edema on STIR was not significantly related to the RMDQ ( B : -1.0, 95% CI: -2.8, 0.8; P = 0.27), ODI ( B :-1.4, 95% CI: -5.4, 2.6; P = 0.50), or LBP intensity scores ( B : -0.05, 95% CI: -0.8, 0.7; P = 0.90) after 1 year. Among patients with MC edema on T1/T2-series at baseline (n = 116), reduced edema on T1/T2 ( i.e ., reduced volume of the type 1 part of MCs) was not significantly related to RMDQ ( B: -1.7, 95% CI: -3.8, 0.3; P = 0.10) or ODI score ( B : -2.3, 95% CI: -7.1, 2.5; P = 0.34) but was significantly related to LBP intensity at 1 year ( B : -0.9, 95% CI: -1.8, -0.04; P = 0.04; correlation coefficient: 0.24). The post hoc analyses supported these results. Conclusion: Reduced MC edema over 1 year was not significantly associated with pain-related disability but was (on T1/T2-series) significantly but weakly related to reduced LBP intensity. Level of evidence: Level 3.
MeSH term(s)	Humans ; Amoxicillin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Chronic Pain/drug therapy ; Chronic Pain/complications ; Disabled Persons ; Intervertebral Disc Degeneration/complications ; Low Back Pain/complications
Chemical Substances	Amoxicillin (804826J2HU) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	752024-4
ISSN	1528-1159 ; 0362-2436
ISSN (online)	1528-1159
ISSN	0362-2436
DOI	10.1097/BRS.0000000000004837
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1305: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes.

Vigeland, Maria Dehli / Flåm, Siri Tennebø / Vigeland, Magnus Dehli / Espeland, Ansgar / Zucknick, Manuela / Wigemyr, Monica / Bråten, Lars Christian Haugli / Gjefsen, Elisabeth / Zwart, John-Anker / Storheim, Kjersti / Pedersen, Linda Margareth / Selmer, Kaja / Lie, Benedicte Alexandra / Gervin, Kristina / The Aim Study Group

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 7

Abstract: Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and epigenome analyses in patients ( ...

Abstract	Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and epigenome analyses in patients (
Language	English
Publishing date	2023-07-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12071217
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Cytokine Patterns as Predictors of Antibiotic Treatment Effect in Chronic Low Back Pain with Modic Changes: Subgroup Analyses of a Randomized Trial (AIM Study).

Bråten, Lars Christian Haugli / Gjefsen, Elisabeth / Gervin, Kristina / Pripp, Are Hugo / Skouen, Jan Sture / Schistad, Elina / Pedersen, Linda Margareth / Wigemyr, Monica / Selmer, Kaja Kristine / Aass, Hans Christian Dalsbotten / Goll, Guro / Brox, Jens Ivar / Espeland, Ansgar / Grøvle, Lars / Zwart, John-Anker / Storheim, Kjersti

Journal of pain research

2023 Volume 16, Page(s) 1713–1724

Abstract: Objective: Randomized trials testing the effect of antibiotics for chronic low back pain (LBP) with vertebral bone marrow changes on MRI (Modic changes) report inconsistent results. A proposed explanation is subgroups with low grade discitis where ... ...

Abstract	Objective: Randomized trials testing the effect of antibiotics for chronic low back pain (LBP) with vertebral bone marrow changes on MRI (Modic changes) report inconsistent results. A proposed explanation is subgroups with low grade discitis where antibiotics are effective, but there is currently no method to identify such subgroups. The objective of the present study was to evaluate whether distinct patterns of serum cytokine levels predict any treatment effect of oral amoxicillin at one-year follow-up in patients with chronic low back pain and Modic changes at the level of a previous lumbar disc herniation. Design: We used data from an overpowered, randomized, placebo-controlled trial (the AIM study) that tested 100 days of oral 750 mg amoxicillin vs placebo three times daily in hospital outpatients with chronic (>6 months) LBP with pain intensity ≥5 on a 0-10 numerical rating scale and Modic changes type 1 (oedema type) or 2 (fatty type). We measured serum levels of 40 inflammatory cytokines at baseline and analysed six predefined potential predictors of treatment effect based on cytokine patterns in 78 randomized patients; three analyses with recursive partitioning, one based on cluster analysis and two based on principal component analyses. The primary outcome was the Roland-Morris Disability Questionnaire score at one-year follow-up in the intention to treat population. The methodology and overall results of the AIM study were published previously. Results: The 78 patients were 25-62 years old and 47 (60%) were women. None of the three recursive partitioning analyses resulted in any suggested subgroups. Of all main analyses, the largest effect estimate (mean difference between antibiotic and placebo groups) was seen in a subgroup not predefined as of main interest (Cluster category 3+4; -2.0, 95% CI: -5.2-1.3, RMDQ points; p-value for interaction 0.54). Conclusion: Patterns of inflammatory serum cytokine levels did not predict treatment effect of amoxicillin in patients with chronic LBP and Modic changes. Clinical trial registration number: ClinicalTrials.gov (identifier: NCT02323412).
Language	English
Publishing date	2023-05-23
Publishing country	New Zealand
Document type	Case Reports ; Clinical Trial
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S406079
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Minimal important change was on the lower spectrum of previous estimates and responsiveness was sufficient for core outcomes in chronic low back pain.

Bråten, Lars Christian Haugli / Grøvle, Lars / Wigemyr, Monica / Wilhelmsen, Maja / Gjefsen, Elisabeth / Espeland, Ansgar / Haugen, Anne Julsrud / Skouen, Jan Sture / Brox, Jens Ivar / Zwart, John-Anker / Storheim, Kjersti / Ostelo, Raymond Wjg / Grotle, Margreth

Journal of clinical epidemiology

2022 Volume 151, Page(s) 75–87

Abstract: Objectives: The objective of this study was to estimate the minimal important change (MIC) and responsiveness of core patient reported outcome measures for chronic low back pain (LBP) and Modic changes.: Study design and setting: In the Antibiotics ... ...

Abstract	Objectives: The objective of this study was to estimate the minimal important change (MIC) and responsiveness of core patient reported outcome measures for chronic low back pain (LBP) and Modic changes. Study design and setting: In the Antibiotics in Modic changes (AIM) trial we measured disability (RMDQ, ODI), LBP intensity (NRS) and health-related quality of life (EQ5D) electronically at baseline, three- and 12-month follow-up. MICs were estimated using Receiver Operating Curve (ROC) curve and Predictive modeling analyses against the global perceived effect. Credibility of the estimates was assessed by a standardized set of criteria. Responsiveness was assessed by a construct and criterion approach according to COSMIN guidelines. Results: The MIC estimates of RMDQ, ODI and NRS scores varied between a 15-40% reduction, depending on including "slightly improved" in the definition of MIC or not. The MIC estimates for EQ5D were lower. The credibility of the estimates was moderate. For responsiveness, five out of six hypotheses were confirmed and AUC was >0.7 for all PROMs. Conclusion: When evaluated in a clinical trial of patients with chronic LBP and Modic changes, MIC thresholds for all PROMs were on the lower spectrum of previous estimates, varying depending on the definition of MIC. Responsiveness was sufficient.
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	639306-8
ISSN	1878-5921 ; 0895-4356
ISSN (online)	1878-5921
ISSN	0895-4356
DOI	10.1016/j.jclinepi.2022.07.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.206: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement.

Vigeland, Maria Dehli / Flåm, Siri Tennebø / Vigeland, Magnus Dehli / Espeland, Ansgar / Kristoffersen, Per Martin / Vetti, Nils / Wigemyr, Monica / Bråten, Lars Christian Haugli / Gjefsen, Elisabeth / Schistad, Elina Iordanova / Haugen, Anne Julsrud / Froholdt, Anne / Skouen, Jan Sture / Zwart, John-Anker / Storheim, Kjersti / Pedersen, Linda Margareth / Lie, Benedicte Alexandra

Scientific reports

2022 Volume 12, Issue 1, Page(s) 215

Abstract: Disability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical explanations cause huge problems both for patients and society. A subgroup of patients has Modic changes (MC), identifiable by MRI as vertebral bone marrow ... ...

Abstract	Disability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical explanations cause huge problems both for patients and society. A subgroup of patients has Modic changes (MC), identifiable by MRI as vertebral bone marrow lesions. The cause of such changes and their relationship to pain are not yet understood. We explored the pathobiology of these lesions using profiling of gene expression in blood, coupled with an edema-sensitive MRI technique known as short tau inversion recovery (STIR) imaging. STIR images and total RNA from blood were collected from 96 patients with chronic LBP and MC type I, the most inflammatory MC state. We found the expression of 37 genes significantly associated with STIR signal volume, ten genes with edema abundancy (a constructed combination of STIR signal volume, height, and intensity), and one gene with expression levels significantly associated with maximum STIR signal intensity. Gene sets related to interferon signaling, mitochondrial metabolism and defense response to virus were identified as significantly enriched among the upregulated genes in all three analyses. Our results point to inflammation and immunological defense as important players in MC biology in patients with chronic LBP.
MeSH term(s)	Adult ; Bone Marrow/diagnostic imaging ; Bone Marrow/immunology ; Chronic Pain/diagnostic imaging ; Chronic Pain/genetics ; Chronic Pain/immunology ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Humans ; Low Back Pain/diagnostic imaging ; Low Back Pain/genetics ; Low Back Pain/immunology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Predictive Value of Tests ; Randomized Controlled Trials as Topic ; Spine/diagnostic imaging ; Spine/immunology ; Transcriptome
Language	English
Publishing date	2022-01-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-04189-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Macrophage migration inhibitory factor: a potential biomarker for chronic low back pain in patients with Modic changes.

Gjefsen, Elisabeth / Gervin, Kristina / Goll, Guro / Bråten, Lars Christian Haugli / Wigemyr, Monica / Aass, Hans Christian D / Vigeland, Maria Dehli / Schistad, Elina / Pedersen, Linda Margareth / Pripp, Are Hugo / Storheim, Kjersti / Selmer, Kaja Kristine / Zwart, John Anker

RMD open

2021 Volume 7, Issue 2

Abstract: Background: Low back pain (LBP) is a leading cause of disability worldwide, but the aetiology remains poorly understood. Finding relevant biomarkers may lead to better understanding of disease mechanisms. Patients with vertebral endplate bone marrow ... ...

Abstract	Background: Low back pain (LBP) is a leading cause of disability worldwide, but the aetiology remains poorly understood. Finding relevant biomarkers may lead to better understanding of disease mechanisms. Patients with vertebral endplate bone marrow lesions visualised on MRI as Modic changes (MCs) have been proposed as a distinct LBP phenotype, and inflammatory mediators may be involved in the development of MCs. Objectives: To identify possible serum biomarkers for LBP in patients with MCs. Methods: In this case control study serum levels of 40 cytokines were compared between patients with LBP and MC type 1 (n=46) or type 2 (n=37) and healthy controls (n=50). Results: Analyses identified significantly higher levels of six out of 40 cytokines in the MC type 1 group (MC1), and five in the MC type 2 group (MC2) compared with healthy controls. Six cytokines were moderately correlated with pain. Principal component analyses revealed clustering and separation of patients with LBP and controls, capturing 40.8% of the total variance, with 10 cytokines contributing to the separation. Macrophage migration inhibitory factor (MIF) alone accounted for 92% of the total contribution. Further, receiver operating characteristics analysis revealed that MIF showed an acceptable ability to distinguish between patients and controls (area under the curve=0.79). Conclusions: These results suggest that cytokines may play a role in LBP with MCs. The clinical significance of the findings is unknown. MIF strongly contributed to clustering of patients with LBP with MCs and controls, and might be a biomarker for MCs. Ultimately, these results may guide future research on novel treatments for this patient group.
MeSH term(s)	Biomarkers ; Case-Control Studies ; Humans ; Low Back Pain/diagnosis ; Lumbar Vertebrae/diagnostic imaging ; Macrophages
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-08-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2812592-7
ISSN	2056-5933 ; 2056-5933
ISSN (online)	2056-5933
ISSN	2056-5933
DOI	10.1136/rmdopen-2021-001726
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - secondary analyses of a randomised, placebo-controlled trial (the AIM study).

Bråten, Lars Christian Haugli / Grøvle, Lars / Espeland, Ansgar / Pripp, Are Hugo / Grotle, Margreth / Helllum, Christian / Haugen, Anne Julsrud / Froholdt, Anne / Rolfsen, Mads Peder / Nygaard, Øystein Petter / Lutro, Olav / Kristoffersen, Per Martin / Anke, Audny / Schistad, Elina Iordanova / Skouen, Jan Sture / Brox, Jens Ivar / Zwart, John-Anker / Storheim, Kjersti

BMC musculoskeletal disorders

2020 Volume 21, Issue 1, Page(s) 458

Abstract: Background: Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real treatment effect in subgroups of ...

Abstract	Background: Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real treatment effect in subgroups of the study populations. The purpose of the present study was to explore potential clinical effect modifiers of 3-months oral amoxicillin treatment in patients with chronic low back pain and type I or II Modic changes at the level of a previous lumbar disc herniation. Methods: We performed analyses of effect modifiers on data from AIM, a double-blind parallel-group multicentre trial. One hundred eighty patients with chronic low back pain, previous disc herniation, Modic change type I (n = 118) or type II (n = 62) were randomised to 3-months oral treatment with 750 mg amoxicillin (n = 89) or placebo (n = 91) three times daily. The primary outcome was the Roland-Morris Disability Questionnaire (RMDQ) score (possible values 0-24) at 1-year follow-up in the intention-to-treat population. The predefined minimal clinically important between-group mean difference was 4 RMDQ points (not reached in the primary analysis of AIM). Predefined baseline characteristics were analysed as potential effect modifiers, four primary (type I Modic changes, previous disc surgery, positive pain provocation test, high CRP) and five exploratory (disturbed sleep, constant low back pain, short duration of low back pain, younger age, and male) using ANCOVA with interaction terms. Results: None of the four primary potential effect modifiers had strong evidence of modifying the treatment effect. In patients younger than 40 years the difference in mean RMDQ score between the treatment groups was - 4.0 (95%CI, - 6.9 to - 1.2), compared to - 0.5 (95%CI, - 2.3 to 1.3) in patients 40 years or older, both in favour of amoxicillin treatment (exploratory analysis). Conclusions: We did not find evidence for convincing clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes. Our results for younger age in these explorative analyses should not affect clinical treatment decisions without confirmation in future studies. Trial registration: ClinicalTrials.gov NCT02323412 , First registered 23 December 2014.
MeSH term(s)	Administration, Oral ; Anti-Bacterial Agents/therapeutic use ; Humans ; Intention ; Low Back Pain/diagnostic imaging ; Low Back Pain/drug therapy ; Lumbar Vertebrae/diagnostic imaging ; Male ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-07-13
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ISSN	1471-2474
ISSN (online)	1471-2474
DOI	10.1186/s12891-020-03422-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Association of Modic change types and their short tau inversion recovery signals with clinical characteristics- a cross sectional study of chronic low back pain patients in the AIM-study.

Bråten, Lars Christian Haugli / Schistad, Elina Iordanova / Espeland, Ansgar / Kristoffersen, Per Martin / Haugen, Anne Julsrud / Marchand, Gunn Hege / Vetti, Nils / Pripp, Are Hugo / Kadar, Thomas Istvan / Skouen, Jan Sture / Grotle, Margreth / Grøvle, Lars / Zwart, John-Anker / Brox, Jens Ivar / Storheim, Kjersti

BMC musculoskeletal disorders

2020 Volume 21, Issue 1, Page(s) 368

Abstract: Background: Modic Changes (MCs, magnetic resonance imaging (MRI) signal changes in the vertebral bone marrow extending from the vertebral endplate) may represent a subgroup of nonspecific chronic low back pain that could benefit from a specific ... ...

Abstract	Background: Modic Changes (MCs, magnetic resonance imaging (MRI) signal changes in the vertebral bone marrow extending from the vertebral endplate) may represent a subgroup of nonspecific chronic low back pain that could benefit from a specific management. The primary aim was to compare clinical characteristics between patients with type 1 versus type 2 MCs. The secondary aim was to explore associations between clinical characteristics and MC related short tau inversion recovery (STIR) signals. Methods: This cross-sectional study used baseline data prospectively collected between 2015 and 2017 on the 180 patients included in the AIM-study (Antibiotics In Modic changes), a randomized controlled trial in a Norwegian hospital out-patient setting of patients with chronic low back pain, a lumbar disc herniation within the last 2 years, low back pain intensity score ≥ 5 (on a 0-10 scale) and current type 1 or type 2 MCs at the previously herniated lumbar disc level. We used prespecified clinical characteristics including self-report measures, physiologic measures and functional measures from clinical history and examination. The diagnostic accuracy of various clinical characteristics to discriminate between patients with type 1 MCs (with or without additional type 2 MCs) and patents with type 2 MCs only (not type 1) were assessed by calculating the area under the receiver-operating curve. We assessed the correlations of clinical characteristics with details of MC related STIR signal increase. Results: No clinical characteristic differed between patients with type 1 (n = 118) versus type 2 (but not type 1) (n = 62) MCs. The clinical characteristics showed no/minor differences or no/weak correlations with MC related STIR signal increase. Patients with a positive Springing test (at any lumbar level) had slightly less volume of STIR signal increase than those with a negative test (mean difference 1.3 on a 0-48 scale, 95% CI 0.3 to 2.3). Conclusion: Clinical characteristics were similar for patients with type 1 MCs and patients with type 2 MCs, and showed no clinically relevant correlations with MC related STIR signal increase. Trial registration: ClinicalTrials.gov NCT02323412, First registered 23 December 2014.
MeSH term(s)	Adult ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Bone Marrow/diagnostic imaging ; Bone Marrow/drug effects ; Chronic Pain/diagnostic imaging ; Chronic Pain/drug therapy ; Chronic Pain/physiopathology ; Cross-Sectional Studies ; Double-Blind Method ; Female ; Humans ; Intervertebral Disc Displacement/diagnostic imaging ; Intervertebral Disc Displacement/drug therapy ; Intervertebral Disc Displacement/physiopathology ; Low Back Pain/diagnostic imaging ; Low Back Pain/drug therapy ; Low Back Pain/physiopathology ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/drug effects ; Lumbar Vertebrae/physiopathology ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Norway ; Pain Measurement ; Surveys and Questionnaires ; Time Factors ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-06-10
Publishing country	England
Document type	Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ISSN	1471-2474
ISSN (online)	1471-2474
DOI	10.1186/s12891-020-03381-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED