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  1. AU="Brabcova, Zuzana"
  2. AU="Bayırlı Turan, Derya"
  3. AU=Sleigh James N
  4. AU="Thanee, Malinee"
  5. AU="Watchara Fongkum"

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  1. Article ; Online: Description of the three-phase contact line expansion

    Váchová Tereza / Brabcová Zuzana / Basařová Pavlína

    EPJ Web of Conferences, Vol 67, p

    2014  Volume 02121

    Abstract: Knowledge of bubble-particle interaction is important in many industrial processes such as in flotation. While the collision (first interaction sub-process) between bubbles and particles is influenced only by hydrodynamic forces, the bubble behaviour ... ...

    Abstract Knowledge of bubble-particle interaction is important in many industrial processes such as in flotation. While the collision (first interaction sub-process) between bubbles and particles is influenced only by hydrodynamic forces, the bubble behaviour during the attachment (second sub-process) is influenced both by hydrodynamic and surface forces. This work is focused on the study of the three-phase contact (TPC) line expansion during bubble adhesion on hydrophobic surface and on its experimental and mathematical description. The experiments were carried out in pure water where mobile bubble surface is expected. The rising bubble was studied in dynamic arrangement, whereas the stationary bubble was analysed in static arrangement. The attachment process was recorded using a high-speed digital camera and evaluated using image analysis. The diameter of the expanding TPC line as well as the dynamic contact angle was determined. Two approaches - the hydrodynamic and the molecular-kinetic - were used for mathematical description of the TPC line expansion. According to our results, the hydrodynamic model is suitable for the description of the initial fast phase of the expansion. The molecular-kinetic model was assessed as appropriate for almost whole range of TPC expansion. Parameters of the model were evaluated and compared for both types of arrangement.
    Keywords Physics ; QC1-999 ; Science ; Q
    Subject code 660
    Language English
    Publishing date 2014-03-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells.

    Rattigan, Kevin M / Zarou, Martha M / Brabcova, Zuzana / Prasad, Bodhayan / Zerbst, Désirée / Sarnello, Daniele / Kalkman, Eric R / Ianniciello, Angela / Scott, Mary T / Dunn, Karen / Shokry, Engy / Sumpton, David / Copland, Mhairi / Tardito, Saverio / Vande Voorde, Johan / Mussai, Francis / Cheng, Paul / Helgason, G Vignir

    EMBO reports

    2023  Volume 24, Issue 10, Page(s) e56279

    Abstract: To fuel accelerated proliferation, leukaemic cells undergo metabolic deregulation, which can result in specific nutrient dependencies. Here, we perform an amino acid drop-out screen and apply pre-clinical models of chronic phase chronic myeloid leukaemia ...

    Abstract To fuel accelerated proliferation, leukaemic cells undergo metabolic deregulation, which can result in specific nutrient dependencies. Here, we perform an amino acid drop-out screen and apply pre-clinical models of chronic phase chronic myeloid leukaemia (CML) to identify arginine as a nutrient essential for primary human CML cells. Analysis of the Microarray Innovations in Leukaemia (MILE) dataset uncovers reduced ASS1 levels in CML compared to most other leukaemia types. Stable isotope tracing reveals repressed activity of all urea cycle enzymes in patient-derived CML CD34
    MeSH term(s) Humans ; Arginine/metabolism ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism ; Apoptosis ; Stem Cells/metabolism ; Neoplastic Stem Cells/metabolism
    Chemical Substances Arginine (94ZLA3W45F)
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202256279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5433: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 41: Show issues

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  3. Article ; Online: Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells.

    Rattigan, Kevin M / Brabcova, Zuzana / Sarnello, Daniele / Zarou, Martha M / Roy, Kiron / Kwan, Ryan / de Beauchamp, Lucie / Dawson, Amy / Ianniciello, Angela / Khalaf, Ahmed / Kalkman, Eric R / Scott, Mary T / Dunn, Karen / Sumpton, David / Michie, Alison M / Copland, Mhairi / Tardito, Saverio / Gottlieb, Eyal / Vignir Helgason, G

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 4634

    Abstract: Deregulated oxidative metabolism is a hallmark of leukaemia. While tyrosine kinase inhibitors (TKIs) such as imatinib have increased survival of chronic myeloid leukaemia (CML) patients, they fail to eradicate disease-initiating leukemic stem cells (LSCs) ...

    Abstract Deregulated oxidative metabolism is a hallmark of leukaemia. While tyrosine kinase inhibitors (TKIs) such as imatinib have increased survival of chronic myeloid leukaemia (CML) patients, they fail to eradicate disease-initiating leukemic stem cells (LSCs). Whether TKI-treated CML LSCs remain metabolically deregulated is unknown. Using clinically and physiologically relevant assays, we generate multi-omics datasets that offer unique insight into metabolic adaptation and nutrient fate in patient-derived CML LSCs. We demonstrate that LSCs have increased pyruvate anaplerosis, mediated by increased mitochondrial pyruvate carrier 1/2 (MPC1/2) levels and pyruvate carboxylase (PC) activity, in comparison to normal counterparts. While imatinib reverses BCR::ABL1-mediated LSC metabolic reprogramming, stable isotope-assisted metabolomics reveals that deregulated pyruvate anaplerosis is not affected by imatinib. Encouragingly, genetic ablation of pyruvate anaplerosis sensitises CML cells to imatinib. Finally, we demonstrate that MSDC-0160, a clinical orally-available MPC1/2 inhibitor, inhibits pyruvate anaplerosis and targets imatinib-resistant CML LSCs in robust pre-clinical CML models. Collectively these results highlight pyruvate anaplerosis as a persistent and therapeutically targetable vulnerability in imatinib-treated CML patient-derived samples.
    MeSH term(s) Humans ; Pyruvic Acid ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/therapeutic use ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Acclimatization ; Biological Assay
    Chemical Substances Pyruvic Acid (8558G7RUTR) ; Imatinib Mesylate (8A1O1M485B)
    Language English
    Publishing date 2023-08-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-40222-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Near Axisymmetric Partial Wetting Using Interface-Localized Liquid Dielectrophoresis

    Brabcova, Zuzana / Brown, Carl V / Edwards, AndrewM. J / McHale, Glen / Newton, Michael I / Wells, Gary G

    Langmuir. 2016 Oct. 25, v. 32, no. 42

    2016  

    Abstract: The wetting of solid surfaces can be modified by altering the surface free energy balance between the solid, liquid, and vapor phases. Liquid dielectrophoresis (L-DEP) can produce wetting on normally nonwetting surfaces, without modification of the ... ...

    Abstract The wetting of solid surfaces can be modified by altering the surface free energy balance between the solid, liquid, and vapor phases. Liquid dielectrophoresis (L-DEP) can produce wetting on normally nonwetting surfaces, without modification of the surface topography or chemistry. L-DEP is a bulk force acting on the dipoles of a dielectric liquid and is not normally considered to be a localized effect acting at the interface between the liquid and a solid or other fluid. However, if this force is induced by a nonuniform electric field across a solid–liquid interface, it can be used to enhance and control the wetting of a dielectric liquid. Recently, it was reported theoretically and experimentally that this approach can cause a droplet of oil to spread along parallel interdigitated electrodes thus forming a stripe of liquid. Here we show that by using spiral-shaped electrodes actuated with four 90° successive phase-shifted signals, a near axisymmetric spreading of droplets can be achieved. Experimental observations show that the induced wetting can achieve film formation, an effect not possible with electrowetting. We show that the spreading is reversible thus enabling a wide range of partial wetting droplet states to be achieved in a controllable manner. Furthermore, we find that the cosine of the contact angle has a quadratic dependence on applied voltage during spreading and deduce a scaling law for the dependence of the strength of the effect on the electrode size.
    Keywords contact angle ; dielectrophoresis ; droplets ; electric field ; electric power ; electrodes ; energy balance ; Gibbs free energy ; liquids ; oils ; vapors
    Language English
    Dates of publication 2016-1025
    Size p. 10844-10850.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021%2Facs.langmuir.6b03010
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: ULK1 inhibition promotes oxidative stress-induced differentiation and sensitizes leukemic stem cells to targeted therapy.

    Ianniciello, Angela / Zarou, Martha M / Rattigan, Kevin M / Scott, Mary / Dawson, Amy / Dunn, Karen / Brabcova, Zuzana / Kalkman, Eric R / Nixon, Colin / Michie, Alison M / Copland, Mhairi / Vetrie, David / Ambler, Martin / Saxty, Barbara / Helgason, G Vignir

    Science translational medicine

    2021  Volume 13, Issue 613, Page(s) eabd5016

    Abstract: Inhibition of autophagy has been proposed as a potential therapy for individuals with cancer. However, current lysosomotropic autophagy inhibitors have demonstrated limited efficacy in clinical trials. Therefore, validation of novel specific autophagy ... ...

    Abstract Inhibition of autophagy has been proposed as a potential therapy for individuals with cancer. However, current lysosomotropic autophagy inhibitors have demonstrated limited efficacy in clinical trials. Therefore, validation of novel specific autophagy inhibitors using robust preclinical models is critical. In chronic myeloid leukemia (CML), minimal residual disease is maintained by persistent leukemic stem cells (LSCs), which drive tyrosine kinase inhibitor (TKI) resistance and patient relapse. Here, we show that deletion of autophagy-inducing kinase ULK1 (unc-51–like autophagy activating kinase 1) reduces growth of cell line and patient-derived xenografted CML cells in mouse models. Using primitive cells, isolated from individuals with CML, we demonstrate that pharmacological inhibition of ULK1 selectively targets CML LSCs ex vivo and in vivo, when combined with TKI treatment. The enhanced TKI sensitivity after ULK1-mediated autophagy inhibition is driven by increased mitochondrial respiration and loss of quiescence and points to oxidative stress–induced differentiation of CML LSCs, proposing an alternative strategy for treating patients with CML.
    MeSH term(s) Autophagy ; Autophagy-Related Protein-1 Homolog/metabolism ; Cell Differentiation ; Oxidative Stress ; Stem Cells/metabolism
    Chemical Substances Autophagy-Related Protein-1 Homolog (EC 2.7.11.1)
    Language English
    Publishing date 2021-09-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abd5016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6941: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Near Axisymmetric Partial Wetting Using Interface-Localized Liquid Dielectrophoresis.

    Brabcova, Zuzana / McHale, Glen / Wells, Gary G / Brown, Carl V / Newton, Michael I / Edwards, Andrew M J

    Langmuir : the ACS journal of surfaces and colloids

    2016  Volume 32, Issue 42, Page(s) 10844–10850

    Abstract: The wetting of solid surfaces can be modified by altering the surface free energy balance between the solid, liquid, and vapor phases. Liquid dielectrophoresis (L-DEP) can produce wetting on normally nonwetting surfaces, without modification of the ... ...

    Abstract The wetting of solid surfaces can be modified by altering the surface free energy balance between the solid, liquid, and vapor phases. Liquid dielectrophoresis (L-DEP) can produce wetting on normally nonwetting surfaces, without modification of the surface topography or chemistry. L-DEP is a bulk force acting on the dipoles of a dielectric liquid and is not normally considered to be a localized effect acting at the interface between the liquid and a solid or other fluid. However, if this force is induced by a nonuniform electric field across a solid-liquid interface, it can be used to enhance and control the wetting of a dielectric liquid. Recently, it was reported theoretically and experimentally that this approach can cause a droplet of oil to spread along parallel interdigitated electrodes thus forming a stripe of liquid. Here we show that by using spiral-shaped electrodes actuated with four 90° successive phase-shifted signals, a near axisymmetric spreading of droplets can be achieved. Experimental observations show that the induced wetting can achieve film formation, an effect not possible with electrowetting. We show that the spreading is reversible thus enabling a wide range of partial wetting droplet states to be achieved in a controllable manner. Furthermore, we find that the cosine of the contact angle has a quadratic dependence on applied voltage during spreading and deduce a scaling law for the dependence of the strength of the effect on the electrode size.
    Language English
    Publishing date 2016-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.6b03010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Daleko od stromu

    Brabcová, Zuzana

    1991  

    Author's details Zuzana Brabcová
    Language Czech
    Size 148 p., 21 cm
    Edition 1. vyd.
    Publisher Československý spisovatel
    Publishing place Praha
    Document type Book
    Note Übers.: Unweit vom Baum
    ISBN 8020203044 ; 9788020203045
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book: Weit vom Baum

    Brabcová, Zuzana / Lustyková, Lea

    Roman

    (rororo : Literatur ; 13252)

    1993  

    Title translation Daleko od stromu <dt.>
    Author's details Zuzana Brabcová. Aus dem Tschech. von Lea Lustyková
    Series title rororo : Literatur ; 13252
    Keywords Jugend ; Prag
    Language German
    Size 248 S.
    Publisher Rowohlt-Taschenbuch-Verl
    Publishing place Reinbek bei Hamburg
    Document type Book
    Note Lizenz des Rowohlt-Berlin-Verl., Berlin
    ISBN 3499132524 ; 9783499132520
    Database Former special subject collection: coastal and deep sea fishing

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  9. Book: Weit vom Baum

    Brabcová, Zuzana / Lustyková, Lea

    Roman

    1991  

    Title translation Daleko od stromu <dt.>
    Author's details Zuzana Brabcová. Aus dem Tschech. von Lea Lustyková
    Language German
    Size 248 S., 21 cm
    Edition 1. Aufl
    Publisher Rowohlt
    Publishing place Berlin
    Document type Book
    ISBN 3871340138 ; 9783871340130
    Database Former special subject collection: coastal and deep sea fishing

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