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  1. Article ; Online: Calvarial disease in secondary syphilis presenting as headache.

    Garnham, Jack / Dawe, Gemma / Bracchi, Margherita / Davies, Nicholas

    Practical neurology

    2024  Volume 24, Issue 1, Page(s) 76–77

    MeSH term(s) Humans ; Syphilis/complications ; Headache
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/pn-2023-003867
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    Zs.A 6001: Show issues Location:
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  2. Article ; Online: A case report highlighting drug-drug interactions between 3 life-saving treatments: Feminizing hormones, antiretrovirals and antituberculosis drugs.

    Suchak, Tara / Bracchi, Margherita / Mercer, Maria / Lander, Frances / Boffito, Marta

    British journal of clinical pharmacology

    2024  

    Abstract: We here present a case providing valuable insights for clinicians who deliver care to patients identifying as transgender or nonbinary. A 30-year-old trans woman presented to sexual health services requesting a routine sexual health screen and was ... ...

    Abstract We here present a case providing valuable insights for clinicians who deliver care to patients identifying as transgender or nonbinary. A 30-year-old trans woman presented to sexual health services requesting a routine sexual health screen and was subsequently diagnosed with HIV and syphilis. She started antiretrovirals for HIV (bictegravir/tenoforvir alafenamide/emtricitabine) 12 days later and was treated with benzathine penicillin G. The patient also had a positive tuberculosis (TB) ELIspot blood test result and further investigations proved the presence of active TB in the chest with mediastinal involvement. She commenced treatment for TB with quadruple therapy, including rifampicin. Due to the clinically significant interaction between rifampicin and bictegravir, the patient's antiretroviral treatment was switched to dolutegravir 50 mg twice daily in combination with tenofovir disoproxil fumarate and emtricitabine. As the patient had transitioned from male to female and was self-medicating with oestrogen-containing feminizing hormone therapy, her hormonal treatment was optimized and blood levels of oestradiol were closely monitored and titrated to manage the drug-drug interaction between rifampicin and oestrogen to ensure the latter would be maintained within the expected therapeutic range. Our case report demonstrates the importance of combining treatment of multiple conditions under 1 team ideally integrated with gender services to prevent multiple attendances and mismanagement of feminizing hormone therapies.
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Case Reports
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.16064
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  3. Article ; Online: Mycobacterial disease causing chylous effusions in two patients living with uncontrolled HIV.

    Dahill, Katherine Elizabeth / Falconer, Jonathan / Pozniak, Anton / Bracchi, Margherita

    BMJ case reports

    2023  Volume 16, Issue 7

    Abstract: Chylous effusions are a rare complication of disseminated non-tuberculous mycobacterial (NTM) infection. This is a case couplet reporting on the treatment challenge of chylous effusions secondary to NTM infection in two individuals living with advanced ... ...

    Abstract Chylous effusions are a rare complication of disseminated non-tuberculous mycobacterial (NTM) infection. This is a case couplet reporting on the treatment challenge of chylous effusions secondary to NTM infection in two individuals living with advanced HIV. Their treatment was complicated by associated immune reconstitution inflammatory syndrome. They both required intermittent paracentesis, steroid treatment and transitioning on to fat-free diets alongside NTM treatment. Only after months of this treatment regimen was successful resolution of the associated chylous effusions achieved. Chylous effusions in immunosuppressed patients living with NTM infection are rarely reported and difficult to manage. This report discusses treatment approaches and highlights the difficulties faced by the treating team.
    MeSH term(s) Humans ; Mycobacterium Infections, Nontuberculous/complications ; Exudates and Transudates ; Respiration Disorders ; HIV Infections/complications
    Language English
    Publishing date 2023-07-26
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-252000
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  4. Article ; Online: A case of pulmonary nodules in a patient living with HIV diagnosed with secondary syphilis.

    Bell, Natasha / Bracchi, Margherita / Pozniak, Anton

    BMJ case reports

    2021  Volume 14, Issue 8

    Abstract: We discuss a case of secondary syphilis with pulmonary involvement in a 45-year-old man who tested positive for HIV. He presented with dyspnoea, chest pain and a rash on his limbs and torso. A CT showed multiple bilateral necrotic lung nodules. A ... ...

    Abstract We discuss a case of secondary syphilis with pulmonary involvement in a 45-year-old man who tested positive for HIV. He presented with dyspnoea, chest pain and a rash on his limbs and torso. A CT showed multiple bilateral necrotic lung nodules. A diagnosis of pulmonary syphilis was made due to his respiratory symptoms and imaging, his serological, histopathology findings, and the resolution of symptoms on treatment with benzathine penicillin.
    MeSH term(s) HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Male ; Middle Aged ; Multiple Pulmonary Nodules/diagnostic imaging ; Penicillin G Benzathine/therapeutic use ; Syphilis/complications ; Syphilis/diagnosis ; Syphilis/drug therapy
    Chemical Substances Penicillin G Benzathine (RIT82F58GK)
    Language English
    Publishing date 2021-08-23
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-243765
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  5. Article ; Online: Nannizziopsis

    Zhao, Yi / Nozdrin, Mikhail / Dalla Pria, Alessia / Bracchi, Margherita

    European journal of case reports in internal medicine

    2021  Volume 8, Issue 11, Page(s) 3021

    Abstract: We describe the case of a 35-year-old HIV-positive male of African origin diagnosed with neurotoxoplasmosis and a : Learning points: AIDS patients at risk of multiple concomitant opportunistic infections present a significant diagnostic challenge ... ...

    Abstract We describe the case of a 35-year-old HIV-positive male of African origin diagnosed with neurotoxoplasmosis and a
    Learning points: AIDS patients at risk of multiple concomitant opportunistic infections present a significant diagnostic challenge.Unusual pathologies should also be considered in addition to the most common opportunistic pathogens, especially in the context of immune reconstitution inflammatory syndrome.
    Language English
    Publishing date 2021-11-23
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2021_003021
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  6. Article ; Online: Direct switch from an efavirenz-based regimen to intramuscular long-acting cabotegravir plus rilpivirine: A case report.

    Senkoro, Elizabeth / Bracchi, Margherita / Heskin, Joseph / Walters, Yasmin / Varadarajan, Maithili / Antoniadi, Christina / Al-Shakarchi, Yaser / Girometti, Nicolo / Boffito, Marta

    International journal of STD & AIDS

    2023  Volume 35, Issue 4, Page(s) 311–313

    Abstract: Switching from oral antiretroviral treatment to intramuscular (IM) cabotegravir (CAB) + rilpivirine (RPV) has an optional oral lead-in to ensure tolerability. The British HIV Association guidelines advise against directly switching from oral ... ...

    Abstract Switching from oral antiretroviral treatment to intramuscular (IM) cabotegravir (CAB) + rilpivirine (RPV) has an optional oral lead-in to ensure tolerability. The British HIV Association guidelines advise against directly switching from oral antiretroviral (ART) combinations containing strong/moderate cytochrome inducers like efavirenz (EFV) to IM CAB + RPV. EFV has a prolonged elimination half-life, leading to a residual induction of UGT1A1 and CYP3A4 after discontinuation. These enzymes are responsible for CAB and RPV metabolism and their induction might lead to sub-optimal concentrations of CAB and RPV, risking drug resistance. When switching from EFV to oral CAB + RPV, the ATLAS and ATLAS 2M studies showed reduced RPV concentrations but with maintained viral suppression during the oral lead-in and subsequent long-acting injectable (LAI) phases. Also, a recent pharmacokinetic modelling study indicated reduced RPV concentrations, without viral implication, when switching from EFV to IM CAB + RPV. However, there are limited real-world data on direct switching from EFV-based therapy to long-acting IM CAB + RPV. We describe a case where oral intake was impossible in a critical care scenario, switching from emitricitabine/tenofovir-DF (FTC/TDF) 200/245 mg + 600 mg EFV to IM CAB + RPV for treatment optimisation.
    MeSH term(s) Humans ; Rilpivirine/therapeutic use ; Anti-Retroviral Agents ; Alkynes ; Tenofovir ; Cyclopropanes ; Pyridones ; Benzoxazines ; Diketopiperazines
    Chemical Substances Rilpivirine (FI96A8X663) ; cabotegravir (HMH0132Z1Q) ; efavirenz (JE6H2O27P8) ; Anti-Retroviral Agents ; Alkynes ; Tenofovir (99YXE507IL) ; Cyclopropanes ; Pyridones ; Benzoxazines ; Diketopiperazines
    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1018089-8
    ISSN 1758-1052 ; 0956-4624
    ISSN (online) 1758-1052
    ISSN 0956-4624
    DOI 10.1177/09564624231217323
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    Zs.A 2829: Show issues Location:
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  7. Article ; Online: COVID-19 in patients with HIV.

    Jones, Rachael / Nelson, Mark / Bracchi, Margherita / Asboe, David / Boffito, Marta

    The lancet. HIV

    2020  Volume 7, Issue 6, Page(s) e383

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; HIV Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country Netherlands
    Document type Letter ; Comment
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(20)30139-9
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  8. Article ; Online: Indirect Human Immunodeficiency Virus Morbidity and Mortality Due to Coronavirus Disease 2019.

    Bell, Natasha / Bracchi, Margherita / Dalla Pria, Alessia / Nelson, Mark / Boffito, Marta

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 10, Page(s) 1947–1949

    MeSH term(s) COVID-19 ; HIV ; HIV Infections/epidemiology ; Humans ; Morbidity ; SARS-CoV-2
    Language English
    Publishing date 2021-02-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab128
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    Zs.MO 480: Show issues

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  9. Article ; Online: Observing the revolution: A commentary on the new GeSIDA HIV guidelines.

    Bracchi, Margherita / Pozniak, Anton

    Enfermedades infecciosas y microbiologia clinica

    2015  Volume 33, Issue 8, Page(s) 505–507

    MeSH term(s) Anti-HIV Agents ; Antiretroviral Therapy, Highly Active ; HIV Infections ; Humans
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2015-10
    Publishing country Spain
    Document type Editorial
    ZDB-ID 1070941-1
    ISSN 1578-1852 ; 0213-005X
    ISSN (online) 1578-1852
    ISSN 0213-005X
    DOI 10.1016/j.eimc.2015.08.003
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    Zs.A 3204: Show issues Location:
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  10. Article ; Online: Recent advances in HIV-associated Kaposi sarcoma.

    Dalla Pria, Alessia / Pinato, David J / Bracchi, Margherita / Bower, Mark

    F1000Research

    2019  Volume 8

    Abstract: Kaposi sarcoma (KS) is a mesenchymal tumour caused by KS-associated herpesvirus and is an AIDS-defining illness. Despite a decline in incidence since the introduction of combination anti-retroviral therapy, KS remains the most common cancer in people ... ...

    Abstract Kaposi sarcoma (KS) is a mesenchymal tumour caused by KS-associated herpesvirus and is an AIDS-defining illness. Despite a decline in incidence since the introduction of combination anti-retroviral therapy, KS remains the most common cancer in people living with HIV in sub-Saharan Africa, where it causes significant morbidity and mortality. This review reflects on recent epidemiological data as well as current management, unmet needs and future perspectives in the treatment of HIV-associated KS with particular emphasis on the potential role of immune checkpoint inhibitors.
    MeSH term(s) Africa South of the Sahara/epidemiology ; HIV Infections/complications ; HIV Infections/epidemiology ; Herpesvirus 8, Human ; Humans ; Incidence ; Sarcoma, Kaposi/epidemiology ; Sarcoma, Kaposi/therapy ; Sarcoma, Kaposi/virology
    Language English
    Publishing date 2019-06-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.17401.1
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