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  1. Article ; Online: Aza Analogs of the TRPML1 Inhibitor Estradiol Methyl Ether (EDME).

    Rühl, Philipp / Bracher, Franz

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 21

    Abstract: Estradiol methyl ether ( ...

    Abstract Estradiol methyl ether (
    MeSH term(s) Transient Receptor Potential Channels ; Estradiol/pharmacology ; Nandrolone ; Lysosomes
    Chemical Substances Transient Receptor Potential Channels ; Estradiol (4TI98Z838E) ; Nandrolone (6PG9VR430D)
    Language English
    Publishing date 2023-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28217428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article: Correction: Synthesis of highly substituted fluorenones via metal-free TBHP-promoted oxidative cyclization of 2-(aminomethyl)biphenyls. Application to the total synthesis of nobilone.

    Jourjine, Ilya A P / Zeisel, Lukas / Krauß, Jürgen / Bracher, Franz

    Beilstein journal of organic chemistry

    2024  Volume 20, Page(s) 170–172

    Abstract: This corrects the article DOI: 10.3762/bjoc.17.181.]. ...

    Abstract [This corrects the article DOI: 10.3762/bjoc.17.181.].
    Language English
    Publishing date 2024-01-30
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2192461-2
    ISSN 1860-5397
    ISSN 1860-5397
    DOI 10.3762/bjoc.20.16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Lokale Pilzinfektionen

    Degitz, Klaus / Bracher, Franz

    [Vorträge und Arbeitsunterlagen der Fortbildungsveranstaltungen im Frühjahr 2001 in Deggendorf, Rosenheim, Bayreuth, Regensburg, Würzburg, Nürnberg, Kempten und München]

    (Schriftenreihe der Bayerischen Landesapothekerkammer ; 62 ; Vorträge und Arbeitsunterlagen der Fortbildungsveranstaltungen im Frühjahr ... / Bayerische Landesapothekerkammer, Ausschuß für Aus- und Fortbildung ; 2001)

    2001  

    Author's details von Klaus Degitz ; Franz Bracher
    Series title Schriftenreihe der Bayerischen Landesapothekerkammer ; 62
    Vorträge und Arbeitsunterlagen der Fortbildungsveranstaltungen im Frühjahr ... / Bayerische Landesapothekerkammer, Ausschuß für Aus- und Fortbildung ; 2001
    Vorträge und Arbeitsunterlagen der Fortbildungsveranstaltungen im Frühjahr ... / Bayerische Landesapothekerkammer, Ausschuss für Aus- und Fortbildung
    Collection Vorträge und Arbeitsunterlagen der Fortbildungsveranstaltungen im Frühjahr ... / Bayerische Landesapothekerkammer, Ausschuss für Aus- und Fortbildung
    Language German
    Size 83 S. : Ill., graph. Darst.
    Publisher Bayerische Landeesapothekerkammer
    Publishing place München
    Publishing country Germany
    Document type Book
    HBZ-ID HT012953731
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2001 A 1601 order for loan Magazin

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  4. Article ; Online: Coordinating activation of endo-lysosomal two-pore channels and TRP mucolipins.

    Yuan, Yu / Jaślan, Dawid / Rahman, Taufiq / Bracher, Franz / Grimm, Christian / Patel, Sandip

    The Journal of physiology

    2024  Volume 602, Issue 8, Page(s) 1623–1636

    Abstract: Two-pore channels and TRP mucolipins are ubiquitous endo-lysosomal cation channels of pathophysiological relevance. Both are ... ...

    Abstract Two-pore channels and TRP mucolipins are ubiquitous endo-lysosomal cation channels of pathophysiological relevance. Both are Ca
    MeSH term(s) Calcium Channels/metabolism ; Two-Pore Channels ; Calcium/metabolism ; Lysosomes/metabolism ; NADP/metabolism ; Osmotic Pressure ; Transient Receptor Potential Channels/metabolism
    Chemical Substances Calcium Channels ; Two-Pore Channels ; Calcium (SY7Q814VUP) ; NADP (53-59-8) ; Transient Receptor Potential Channels
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP283829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Methods for Arylethylation of Amines and Heteroarenes

    Bracher, Franz

    SynOpen

    2018  Volume 02, Issue 02, Page(s) 96–104

    Abstract: Compared with standard N-methylation, benzylation, and alkylation of amines and N-heterocycles, N-arylethylation is significantly more challenging. In this Review the available methods for N-arylethylation are summarized, with a special focus on ... ...

    Abstract Compared with standard N-methylation, benzylation, and alkylation of amines and N-heterocycles, N-arylethylation is significantly more challenging. In this Review the available methods for N-arylethylation are summarized, with a special focus on efficiency, selectivity, availability of the required building blocks, and ecological aspects.
    Keywords arylethylation ; phenethylation ; alkylation ; reductive amination ; hydroamination ; reduction
    Language English
    Publishing date 2018-04-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2509-9396
    ISSN (online) 2509-9396
    DOI 10.1055/s-0037-1609449
    Database Thieme publisher's database

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  6. Article ; Online: A novel approach to 2-arylmethyl-2,3-dihydro-4(1

    Klaßmüller, Thomas / Tringali, Claudia / Bracher, Franz

    Natural product research

    2022  Volume 38, Issue 1, Page(s) 119–127

    Abstract: 2-Arylmethyl-2,3-dihydro-4( ... ...

    Abstract 2-Arylmethyl-2,3-dihydro-4(1
    MeSH term(s) Quinazolinones ; Alkaloids ; Cyclization
    Chemical Substances Quinazolinones ; Alkaloids
    Language English
    Publishing date 2022-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2110095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A short divergent approach to highly substituted carbazoles and β-carbolines via in situ-generated diketoindoles

    Untergehrer, Martin / Bracher, Franz

    Tetrahedron letters. 2020 Mar. 19, v. 61, no. 12

    2020  

    Abstract: Based on an aza-alkylation/Michael addition cascade reaction developed by Kim and co-workers we have developed divergent cascade reactions leading to either highly substituted 1-hydroxycarbazoles, 3-hydroxycarbazoles or β-carbolines, starting from ... ...

    Abstract Based on an aza-alkylation/Michael addition cascade reaction developed by Kim and co-workers we have developed divergent cascade reactions leading to either highly substituted 1-hydroxycarbazoles, 3-hydroxycarbazoles or β-carbolines, starting from readily accessible ortho-arylsulfonylaminobenzaldehydes. Olefination of the aldehyde functionality by aldol condensation or Wittig olefination gave reactive enone intermediates, which underwent the cascade reactions, either in two steps or in one-pot conversions, to give hydroxycarbazoles or complex β-carbolines.
    Keywords aldehydes ; carbazoles ; chemical structure ; condensation reactions
    Language English
    Dates of publication 2020-0319
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2020.151597
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 2837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: A GC-MS Protocol for the Identification of Polycyclic Aromatic Alkaloids from Annonaceae.

    Jourjine, Ilya A P / Bauernschmidt, Carolin / Müller, Christoph / Bracher, Franz

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 23

    Abstract: The Annonaceae are an old family of flowering plants belonging to the order Magnoliales, distributed mainly in tropical regions. Numerous Annonaceae species find ethnobotanical use for curing a broad range of diseases, among them cancer and infections by ...

    Abstract The Annonaceae are an old family of flowering plants belonging to the order Magnoliales, distributed mainly in tropical regions. Numerous Annonaceae species find ethnobotanical use for curing a broad range of diseases, among them cancer and infections by diverse pathogens. Hence, bioactive natural products from Annonaceae have received considerable interest in drug development. Beyond cytotoxic acetogenins, unique aporphine-derived polycyclic aromatic alkaloids are characteristic constituents of Annonaceae. Among them are unique tri- and tetracyclic aromatic alkaloids like azafluorenones, diazafluoranthenes, azaanthracenes, and azaoxoaporphines. The complex substitution pattern of these alkaloids represents a major challenge in structure elucidation of isolated natural products. Based on a broad spectrum of alkaloids available from our previous work, we present a GC-MS protocol for the identification of over 20 polycyclic aromatic alkaloids from Annonaceae. This collection of data will contribute to the future identification of the metabolite patterns of extracts from Annonaceae as an important source of novel bioactive secondary metabolites.
    Language English
    Publishing date 2022-11-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27238217
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  9. Article ; Online: Dehydrocholesterol Reductase 24 (DHCR24): Medicinal Chemistry, Pharmacology and Novel Therapeutic Options.

    Müller, Christoph / Hank, Emily / Giera, Martin / Bracher, Franz

    Current medicinal chemistry

    2021  Volume 29, Issue 23, Page(s) 4005–4025

    Abstract: During the last decade, the understanding of the biological functions of cholesterol biosynthesis intermediates has changed significantly. Particularly, the enzyme sterol dehydrocholesterol reductase 24 (DHCR24) has taken center stage as a potential drug ...

    Abstract During the last decade, the understanding of the biological functions of cholesterol biosynthesis intermediates has changed significantly. Particularly, the enzyme sterol dehydrocholesterol reductase 24 (DHCR24) has taken center stage as a potential drug target. Inhibition of DHCR24 leads to accumulation of the endogenous, biologically active metabolite cholesta-5,24-dien-3β-ol (desmosterol). Desmosterol is an endogenous agonist of the liver X receptor (LXR). LXR is a master regulator of lipid metabolism and, as such, is involved in numerous pathophysiological processes such as inflammation, atherosclerosis, cancer, diabetes mellitus (DM), multiple sclerosis (MS), nonalcoholic steatohepatitis (NASH), and the progression of viral infections. Up to now, selective pharmacological targeting of LXR without activating the sterol-response element binding proteins (SREBP) and thereby boosting endogenous lipid biosynthesis has not been achieved. In turn, no selective LXR receptor agonists leveraging its beneficial activation have yet reached the clinic. Therefore, using potent and selective inhibitors of DHCR24 leading to an accumulation of endogenous desmosterol is a promising alternative strategy for the selective activation of LXR. Here we summarize the present landscape of novel lead structures for targeting DHCR24, covering steroidal enzyme inhibitors (e.g., 20,25-diazacholesterol, SH42) as well as nonsteroidal scaffolds (e.g., amiodarone, triparanol). Further, we explain the molecular mechanisms of DHCR24 inhibition/LXR activation, discuss possible therapeutic applications, and underpin why DHCR24 is an upcoming promising drug target.
    MeSH term(s) Chemistry, Pharmaceutical ; Cholesterol/metabolism ; Dehydrocholesterols ; Desmosterol/metabolism ; Desmosterol/pharmacology ; Humans ; Liver X Receptors/metabolism ; Nerve Tissue Proteins/metabolism ; Oxidoreductases ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Sterols
    Chemical Substances Dehydrocholesterols ; Liver X Receptors ; Nerve Tissue Proteins ; Sterols ; Desmosterol (313-04-2) ; Cholesterol (97C5T2UQ7J) ; Oxidoreductases (EC 1.-) ; Oxidoreductases Acting on CH-CH Group Donors (EC 1.3.-) ; DHCR24 protein, human (EC 1.3.1.-)
    Language English
    Publishing date 2021-11-15
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867328666211115121832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4432: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Targeted profiling of 24 sulfated and non-sulfated bile acids in urine using two-dimensional isotope dilution UHPLC-MS/MS.

    Habler, Katharina / Koeppl, Bernhard / Bracher, Franz / Vogeser, Michael

    Clinical chemistry and laboratory medicine

    2021  Volume 60, Issue 2, Page(s) 220–228

    Abstract: Objectives: Bile acids serve as biomarkers for liver function and are indicators for cholestatic and hepatobiliary diseases like hepatitis, cirrhosis, and intrahepatic cholestasis of pregnancy (ICP). Sulfation and renal excretion of bile acids are ... ...

    Abstract Objectives: Bile acids serve as biomarkers for liver function and are indicators for cholestatic and hepatobiliary diseases like hepatitis, cirrhosis, and intrahepatic cholestasis of pregnancy (ICP). Sulfation and renal excretion of bile acids are important elimination steps. The power of ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) allows specific profiling of primary and secondary bile acids as well as their sulfated counterparts.
    Methods: Twenty-four sulfated and non-sulfated primary and secondary bile acids were quantified in urine with 15 corresponding stable isotope labeled internal standards by using two-dimensional UHPLC-MS/MS. The sample preparation was based on a simple dilution with a methanolic zinc sulfate solution followed by an automated online solid phase extraction clean up.
    Results: The validation results of the method fulfilled the criteria of the European Medicine Agency (EMA) "Guideline on bioanalytical method validation". To verify fitness for purpose, 40 urine samples were analyzed which showed an average of 86% sulfation, 9.1% taurine-conjugation, 14% non-conjugation, and 77% glycine-conjugation rates.
    Conclusions: Lossless one-pot sample preparation, automated sample purification, and high number of internal standards are major innovations of the presented profiling method, which may allow diagnostic application of BA profiling in the future.
    MeSH term(s) Bile Acids and Salts ; Chromatography, High Pressure Liquid/methods ; Female ; Humans ; Isotopes ; Pregnancy ; Sulfates/chemistry ; Tandem Mass Spectrometry/methods
    Chemical Substances Bile Acids and Salts ; Isotopes ; Sulfates
    Language English
    Publishing date 2021-11-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2021-1111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 121: Show issues Location:
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