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Article ; Online: Social and ethical factors in anaphylaxis.

Pur Ozyigit, Leyla / Odemyr, Mikaela / Bradatan, Elena / Brall, Caroline / Porz, Rouven / Scadding, Glenis K

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

2022 Volume 52, Issue 5, Page(s) 595–597

MeSH term(s)	Anaphylaxis/diagnosis ; Anaphylaxis/etiology ; Humans
Language	English
Publishing date	2022-04-26
Publishing country	England
Document type	Editorial
ZDB-ID	645204-8
ISSN	1365-2222 ; 0954-7894 ; 0960-2178
ISSN (online)	1365-2222
ISSN	0954-7894 ; 0960-2178
DOI	10.1111/cea.14118
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Article ; Online: Lupin, a potential "hidden" food anaphylaxis allergen: An alert from the Allergy-Vigilance Network®.

Pouessel, Guillaume / Sabouraud-Leclerc, Dominique / Beaumont, Pascale / Divaret-Chauveau, Amandine / Bradatan, Eléna / Dumond, Pascale / Karaca, Yasemin / Renaudin, Jean-Marie / Metz-Favre, Carine / Delalande, Delphine / Correard, Anne-Karine / Tscheiller, Sélina / Van der Brempt, Xavier

Allergy

2024

Language	English
Publishing date	2024-03-22
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.16107
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Article ; Online: Fatal and near‐fatal anaphylaxis: The Allergy‐Vigilance® Network data (2002–2020)

Pouessel, Guillaume / Alonzo, Sabrina / Divaret‐Chauveau, Amandine / Dumond, Pascale / Bradatan, Eléna / Liabeuf, Valérie / Beaumont, Pascale / Tscheiller, Sélina / Diesnis, Rémy / Renaudin, Jean‐Marie / Sabouraud‐Leclerc, Dominique

Allergy 2023 Jun., v. 78, no. 6, p. 1628-1638

2023 , Page(s) 1628–1638

Abstract: BACKGROUND: Having a better understanding of the risk factors of severe anaphylaxis is a crucial challenge for physicians. METHODS: To retrospectively analyse fatal/near‐fatal anaphylaxis cases recorded by the Allergy‐Vigilance® Network (2002–2020) and ... ...

Institution	the Allergy‐Vigilance® Network
Abstract	BACKGROUND: Having a better understanding of the risk factors of severe anaphylaxis is a crucial challenge for physicians. METHODS: To retrospectively analyse fatal/near‐fatal anaphylaxis cases recorded by the Allergy‐Vigilance® Network (2002–2020) and evaluate the characteristics associated with survival, age and allergens. RESULTS: Among the 3510 anaphylaxis cases documented in the network, 70 (2%) patients (males: 57%; mean age: 35.4 y) presented grade 4 (Ring‐Messmer) anaphylaxis and 25 died (19 food‐related); 33% had a history of asthma. The main allergens were food (60%; peanut, 20%; milks, 11%) involved in 25/26 cases in children and in 17/44 (39%) cases in adults. Non‐food anaphylaxis was related to drugs/latex (24%; neuromuscular blocking agents, 10%; betalactamins, 6%), Hymenoptera (16%). Three food‐related cases (one death) occurred during oral food challenge in children. Patients with a food allergy were younger (22.2 years vs. 55 years, p < .001), had more likely a history of asthma (50% vs. 7%; p < .001), a pre‐existing allergy (62% vs. 18%; p < .001) compared with other allergies. A cofactor was identified in 35 cases (50%) but predominantly in adults as opposed to children (64% vs. 27%; p = .01). The patients who died were younger (25.6 vs. 40.8 years; p = .01) than the survivors and mostly presented bronchospasm (56% vs. 29%; p = .05). Gaps in the prevention and management of anaphylaxis were noted in 15 cases (21%). CONCLUSIONS: Severe food anaphylaxis has specific features compared with other causes such as young age, asthma history and exercise. Food is also involved in severe anaphylaxis in adults that should not be underestimated.
Keywords	Hymenoptera ; anaphylaxis ; asthma ; death ; exercise ; food allergies ; latex ; peanuts ; risk
Language	English
Dates of publication	2023-06
Size	p. 1628-1638
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE ; Resource is Open Access ; Wiley License Information
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15645
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Fatal and near-fatal anaphylaxis: The Allergy-Vigilance® Network data (2002-2020).

Pouessel, Guillaume / Alonzo, Sabrina / Divaret-Chauveau, Amandine / Dumond, Pascale / Bradatan, Eléna / Liabeuf, Valérie / Beaumont, Pascale / Tscheiller, Sélina / Diesnis, Rémy / Renaudin, Jean-Marie / Sabouraud-Leclerc, Dominique

Allergy

2023 Volume 78, Issue 6, Page(s) 1628–1638

Abstract: Background: Having a better understanding of the risk factors of severe anaphylaxis is a crucial challenge for physicians.: Methods: To retrospectively analyse fatal/near-fatal anaphylaxis cases recorded by the Allergy-Vigilance® Network (2002-2020) ... ...

Abstract	Background: Having a better understanding of the risk factors of severe anaphylaxis is a crucial challenge for physicians. Methods: To retrospectively analyse fatal/near-fatal anaphylaxis cases recorded by the Allergy-Vigilance® Network (2002-2020) and evaluate the characteristics associated with survival, age and allergens. Results: Among the 3510 anaphylaxis cases documented in the network, 70 (2%) patients (males: 57%; mean age: 35.4 y) presented grade 4 (Ring-Messmer) anaphylaxis and 25 died (19 food-related); 33% had a history of asthma. The main allergens were food (60%; peanut, 20%; milks, 11%) involved in 25/26 cases in children and in 17/44 (39%) cases in adults. Non-food anaphylaxis was related to drugs/latex (24%; neuromuscular blocking agents, 10%; betalactamins, 6%), Hymenoptera (16%). Three food-related cases (one death) occurred during oral food challenge in children. Patients with a food allergy were younger (22.2 years vs. 55 years, p < .001), had more likely a history of asthma (50% vs. 7%; p < .001), a pre-existing allergy (62% vs. 18%; p < .001) compared with other allergies. A cofactor was identified in 35 cases (50%) but predominantly in adults as opposed to children (64% vs. 27%; p = .01). The patients who died were younger (25.6 vs. 40.8 years; p = .01) than the survivors and mostly presented bronchospasm (56% vs. 29%; p = .05). Gaps in the prevention and management of anaphylaxis were noted in 15 cases (21%). Conclusions: Severe food anaphylaxis has specific features compared with other causes such as young age, asthma history and exercise. Food is also involved in severe anaphylaxis in adults that should not be underestimated.
MeSH term(s)	Child ; Male ; Adult ; Humans ; Anaphylaxis/etiology ; Anaphylaxis/complications ; Retrospective Studies ; Food Hypersensitivity/complications ; Food Hypersensitivity/epidemiology ; Food/adverse effects ; Allergens ; Asthma/etiology ; Asthma/complications
Chemical Substances	Allergens
Language	English
Publishing date	2023-01-24
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15645
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tolerance and growth in children with cow's milk allergy fed a thickened extensively hydrolyzed casein-based formula.

Dupont, Christophe / Bradatan, Elena / Soulaines, Pascale / Nocerino, Rita / Berni-Canani, Roberto

BMC pediatrics

2016 Volume 16, Page(s) 96

Abstract: Background: In case of cow's milk allergy (CMA), pediatric guidelines recommend for children the use of extensively hydrolyzed formulas (eHFs) as elimination diet. According to the American Academy of Pediatrics, the hypoallergenicity of each specific ... ...

Abstract	Background: In case of cow's milk allergy (CMA), pediatric guidelines recommend for children the use of extensively hydrolyzed formulas (eHFs) as elimination diet. According to the American Academy of Pediatrics, the hypoallergenicity of each specific eHF should be tested in subjects with CMA. Methods: A prospective, multicenter trial was performed to assess the tolerance/hypoallergenicity of a thickened casein-based eHF (eHCF, Allernova AR®, United Pharmaceuticals, France) in infants aged <12 months with CMA proven by a double-blind placebo-controlled food challenge. Its efficacy, measured through allergy symptoms monitoring and Cow's Milk-related Symptom Score (CoMiSS) calculation, and safety were evaluated during a 4-month feeding period. Growth z-scores were computed based on WHO anthropometric data. Results: Thirty infants (mean age: 4.8 ± 3.0 months) with CMA proven by a DBPCFC tolerated the eHCF during the 4-month study. The CoMiSS, crying and regurgitation scores significantly decreased by 4.2 ± 4.0, 0.9 ±1.2 and 0.7 ± 1.1 respectively, after 14 days of feeding (p < 0.001). The Scoring Atopic Dermatitis index, of 33.2 ± 14.8 at inclusion in 9 patients, significantly decreased by 15.5 ± 6.7 and 21.1 ± 11.2, after 14 and 45 days of feeding, respectively (p < 0.001). The percentage of infants having normal stool consistency (soft or formed stools) significantly improved from 66.7 % (20/30) at inclusion to 90.0 % (27/30) after 14 days of feeding (p = 0.020). The growth z-scores, negative at study inclusion, significantly improved over the 4-month study. No adverse event was related to the eHCF. Conclusion: The thickened eHCF was tolerated by more than 90 % of included allergic infants with 95 % confidence interval and can therefore be considered as hypoallergenic in accordance with current guidelines. The improvement of growth indices and absence of related adverse events confirmed its safety. Results of this trial back the use of the tested thickened eHCF as an efficient and safe alternative in children with CMA. Trial registration: ClinicalTrials.gov, number NCT02351531 , registered on 27 January 2015.
Language	English
Publishing date	2016-07-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-016-0637-3
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Article ; Online: Safety of a New Amino Acid Formula in Infants Allergic to Cow's Milk and Intolerant to Hydrolysates.

Dupont, Christophe / Kalach, Nicolas / Soulaines, Pascale / Bradatan, Elena / Lachaux, Alain / Payot, François / De Blay, Frédéric / Guénard-Bilbault, Lydie / Hatahet, Riad / Mulier, Sandra / Kapel, Nathalie / Waligora-Dupriet, Anne-Judith / Butel, Marie-José

Journal of pediatric gastroenterology and nutrition

2015 Volume 61, Issue 4, Page(s) 456–463

Abstract: Objectives: Amino acid-based formulas (AAFs) are recommended for children with cow's-milk allergy (CMA) failing to respond to extensively hydrolysed formulas (eHFs). We evaluated the effects of a new thickened AAF (TAAF, Novalac), containing a pectin- ... ...

Abstract	Objectives: Amino acid-based formulas (AAFs) are recommended for children with cow's-milk allergy (CMA) failing to respond to extensively hydrolysed formulas (eHFs). We evaluated the effects of a new thickened AAF (TAAF, Novalac), containing a pectin-based thickener, and a reference AAF (RAAF, Neocate) on allergy symptoms and safety, through blood biochemistry analysis and growth. Methods: Infants (ages < 18 months) with CMA symptoms failing to respond to eHFs were randomised in a double-blind manner to receive TAAF or RAAF for 3 months. All of the infants were then fed TAAF for 3 additional months. Paediatric visits occurred at 1, 3, and 6 months. Blood samples were collected at inclusion and 3 months. Results: Results at 1 month were previously described. The 75 infants with proven CMA and eHF intolerance tolerated their allocated formula. At 3 months, the dominant allergic symptom had disappeared in 76.2% of the infants with TAAF and in 51.5% of the infants with RAAF (P = 0.026). The Scoring Atopic Dermatitis Index significantly improved more with TAAF than with RAAF (-27.3 ± 2.3 vs -20.8 ± 2.2, P = 0.048). Of the infants, 92.9% had normal stools (soft or formed consistency) with TAAF vs 75.8% with RAAF (P = 0.051). More infants in TAAF group had better quality of nighttime sleep (P = 0.036) and low frequency of irritability signs (P < 0.001). With both formulas, all of the biochemical parameters were within normal ranges. There were no differences between the 2 groups in any of the anthropometric z scores. Conclusions: The new TAAF was tolerated by all of the infants with CMA and intolerance to eHFs. Anthropometric and clinical data showed that both formulas were safe.
MeSH term(s)	Amino Acids/administration & dosage ; Amino Acids/adverse effects ; Amino Acids/analysis ; Amino Acids/chemistry ; Belgium ; Biomarkers/analysis ; Carbohydrates/adverse effects ; Carbohydrates/chemistry ; Child Development ; Cohort Studies ; Dietary Fats/adverse effects ; Dietary Fiber/administration & dosage ; Dietary Fiber/analysis ; Double-Blind Method ; Eosinophil-Derived Neurotoxin/analysis ; Feces/chemistry ; Feces/microbiology ; Female ; France ; Gastrointestinal Microbiome/immunology ; Humans ; Infant ; Infant Behavior ; Infant Formula/chemistry ; Infant Nutritional Physiological Phenomena ; Male ; Milk Hypersensitivity/diet therapy ; Milk Hypersensitivity/immunology ; Milk Hypersensitivity/microbiology ; Milk Hypersensitivity/physiopathology ; Pectins/chemistry ; Protein Hydrolysates/adverse effects ; Viscosity
Chemical Substances	Amino Acids ; Biomarkers ; Carbohydrates ; Dietary Fats ; Dietary Fiber ; Neocate ; Pectins ; Protein Hydrolysates ; Eosinophil-Derived Neurotoxin (EC 3.1.-) ; RNASE2 protein, human (EC 3.1.27.5)
Language	English
Publishing date	2015-10
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000000803
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Article ; Online: A thickened amino-acid formula in infants with cow's milk allergy failing to respond to protein hydrolysate formulas: a randomized double-blind trial.

Dupont, Christophe / Kalach, Nicolas / Soulaines, Pascale / Bradatan, Elena / Lachaux, Alain / Payot, François / de Blay, Frédéric / Guénard-Bilbault, Lydie / Hatahet, Riad / Mulier, Sandra

Paediatric drugs

2014 Volume 16, Issue 6, Page(s) 513–522

Abstract: Introduction: Amino-acid-based formulas (AAFs) are recommended for children with cow's milk protein allergy (CMPA) failing to respond to extensively hydrolyzed formulas (eHFs).: Objective: This study aimed to assess the tolerance/hypoallergenicity ... ...

Abstract	Introduction: Amino-acid-based formulas (AAFs) are recommended for children with cow's milk protein allergy (CMPA) failing to respond to extensively hydrolyzed formulas (eHFs). Objective: This study aimed to assess the tolerance/hypoallergenicity and efficacy of a thickened AAF (TAAF) in these infants. Methods: This multicenter, double-blind, randomized controlled trial (NCT01940068) compared 3-month feeding with a pectin-based TAAF (Novalac(®), United Pharmaceuticals, Paris, France) and a commercially available "reference" AAF (RAAF; Neocate(®), Nutricia, Germany) in infants aged <18 months with CMPA and persistent allergy symptoms with eHF feeding. Reported here are the results of an interim analysis after 1 month of feeding. Results: Of the 86 infants randomized, CMPA with eHF intolerance was confirmed in 75 infants; all of them tolerated the allocated AAFs. The major allergic symptom disappeared within 1 month in 61.9 and 51.5 % and regurgitations disappeared in 66.7 and 42.3 % of infants who received TAAF and RAAF, respectively. Infants had significantly more normal stools (soft or formed consistency) with the TAAF (90.5 vs. 66.7 %; p = 0.011). From baseline, daily family life significantly improved with both AAFs: crying time decreased by 97.3 (p < 0.001) and 28.6 min (p = 0.014) and sleeping time increased by 64.6 (p = 0.009) and 29.0 min with TAAF and RAAF, respectively. At day 30, weight and body mass index z-score gains were 0.1 and 0.2 with TAAF and 0.2 and 0.0 with RAAF. Conclusion: Both AAFs were well tolerated by infants with CMPA and eHF intolerance and ensured appropriate growth, with the TAAF providing additional comfort.
MeSH term(s)	Amino Acids/administration & dosage ; Amino Acids/adverse effects ; Animals ; Carbohydrates/administration & dosage ; Carbohydrates/adverse effects ; Cattle ; Dietary Fats/administration & dosage ; Dietary Fats/adverse effects ; Double-Blind Method ; Female ; Humans ; Infant ; Infant Formula/administration & dosage ; Male ; Milk Hypersensitivity/therapy ; Protein Hydrolysates/administration & dosage ; Protein Hydrolysates/adverse effects
Chemical Substances	Amino Acids ; Carbohydrates ; Dietary Fats ; Neocate ; Protein Hydrolysates
Language	English
Publishing date	2014-12
Publishing country	Switzerland
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1492748-2
ISSN	1179-2019 ; 1174-5878
ISSN (online)	1179-2019
ISSN	1174-5878
DOI	10.1007/s40272-014-0097-x
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Article ; Online: Social and ethical factors in anaphylaxis.

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Article ; Online: Lupin, a potential "hidden" food anaphylaxis allergen: An alert from the Allergy-Vigilance Network®.

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Article ; Online: Fatal and near‐fatal anaphylaxis: The Allergy‐Vigilance® Network data (2002–2020)

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Article ; Online: Fatal and near-fatal anaphylaxis: The Allergy-Vigilance® Network data (2002-2020).

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Article ; Online: Tolerance and growth in children with cow's milk allergy fed a thickened extensively hydrolyzed casein-based formula.

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Article ; Online: Safety of a New Amino Acid Formula in Infants Allergic to Cow's Milk and Intolerant to Hydrolysates.

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Article ; Online: A thickened amino-acid formula in infants with cow's milk allergy failing to respond to protein hydrolysate formulas: a randomized double-blind trial.

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