LIVIVO - Search results -

Search results

Result 1 - 10 of total 13

Search options

Article ; Online: Behavioral and neuroinflammatory changes caused by glyphosate: Base herbicide in mice offspring.

de Castro Vieira Carneiro, Carla Larissa / Chaves, Edna Maria Camelo / Neves, Kelly Rose Tavares / Braga, Marcus Davis Machado / Assreuy, Ana Maria Sampaio / de Moraes, Maria Elisabete Amaral / Aragão, Gislei Frota

Birth defects research

2022 Volume 115, Issue 4, Page(s) 488–497

Abstract: Background: Glyphosate is a pesticide considered of low toxicity, but scientific evidences show it can be harmful to health. This study aimed to evaluate the toxicity in mice offspring exposed to glyphosate-based herbicide (GBH) during the intrauterine ... ...

Abstract	Background: Glyphosate is a pesticide considered of low toxicity, but scientific evidences show it can be harmful to health. This study aimed to evaluate the toxicity in mice offspring exposed to glyphosate-based herbicide (GBH) during the intrauterine period. Methods: Female matrices received glyphosate 0.3 mg/kg daily per oral throughout the gestational period, which was variable between 18 and 22 days. From the 25th until the 28th days post-birth, mice offspring were subjected to behavioral tests, and the prefrontal cortex was processed for immunohistochemical analysis. Results: Two significant behavioral changes were observed: anxiety in the GLIF0.3 group, increase in the behavior burying marbles in the marble-burying test and hyperactivity, expressed by the significant increase of the crossing number in the open field test. The increased microglia, TNF-alpha, and astrocyte expression were also observed in the prefrontal cortex of offspring treated with GLIF0.3. Conclusion: Exposure to GBH during mice intrauterine development induces hyperactive and anxious behavior, evidencing neuroinflammation.
MeSH term(s)	Animals ; Mice ; Female ; Herbicides/toxicity ; Neuroinflammatory Diseases ; Glycine/toxicity ; Behavior, Animal ; Glyphosate
Chemical Substances	Herbicides ; Glycine (TE7660XO1C)
Language	English
Publishing date	2022-12-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2104792-3
ISSN	2472-1727
ISSN (online)	2472-1727
DOI	10.1002/bdr2.2138
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 749: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Risk factors for renal impairment in patients with hematological cancer receiving antineoplastic treatment.

Travassos, Priscila Nunes Costa / de Barros Silva, Paulo Goberlânio / Freitas, Milena Oliveira / Braga, Marcus Davis Machado / Duarte, Fernando Barroso / de Oliveira Maia, Jéssica Karen / Pitombeira, Helena / de Sousa, Jacqueline Holanda / Alves, Ana Paula Negreiros Nunes

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2022 Volume 30, Issue 9, Page(s) 7271–7280

Abstract: Purpose: Antineoplastic treatments, mainly chemotherapy, affect the kidneys, causing toxicity, and can trigger acute and chronic kidney injuries. This study aimed to analyze the prevalence of renal disorders in patients with oncohematological neoplasms ... ...

Abstract	Purpose: Antineoplastic treatments, mainly chemotherapy, affect the kidneys, causing toxicity, and can trigger acute and chronic kidney injuries. This study aimed to analyze the prevalence of renal disorders in patients with oncohematological neoplasms receiving antineoplastic treatment. Methods: This retrospective cohort study included 75 patients with hematological cancer who underwent chemotherapy between 2012 and 2018 in the Hematology Sector of the Walter Cantídeo University Hospital of the Federal University of Ceará. Sociodemographic and clinical data, blood biochemical assessment findings, and glomerular filtration rate (GFR) were analyzed using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The data were tabulated; transferred to the Statistical Package for the Social Sciences software, version 20.0; and analyzed using Pearson's chi-square test or Fisher's exact test for categorical variables followed by a multinomial logistic regression model (p < 0.05). Results: The prevalence of renal disorders was 52.4% according to the CKD-EPI equation for GFR events. There was a significant association between the decrease in GFRs and the following variables: female sex (p = 0.002), diagnosis of multiple myeloma (p = 0.008), start of treatment within 40 days (p = 0.005), and the following antineoplastic treatments: cyclophosphamide, vincristine, and prednisone (p = 0.026); irarubicin (p = 0.032); azacytidine, dexamethasone, and cyclophosphamide (p < 0.001); zoledronic acid (p < 0.001); and pamidronate (p = 0.012). CALGB 8811 (p < 0.001) was inversely associated with a reduction in the GFR. Conclusions: The prevalence of renal disorders was high in patients with oncohematological neoplasms receiving antineoplastic treatment. This requires periodic monitoring of the evaluation of renal function since reductions in GFRs were significantly associated with different treatment protocols used.
MeSH term(s)	Antineoplastic Agents/adverse effects ; Creatinine ; Cyclophosphamide ; Female ; Glomerular Filtration Rate ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/drug therapy ; Hematologic Neoplasms/epidemiology ; Humans ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Retrospective Studies ; Risk Factors
Chemical Substances	Antineoplastic Agents ; Cyclophosphamide (8N3DW7272P) ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2022-05-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-022-07159-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3697: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Melioidose numa pequena comunidade rural do Ceará.

Braga, Marcus Davis Machado / de Almeida, Paulo Roberto Carvalho

Revista da Sociedade Brasileira de Medicina Tropical

2005 Volume 38, Issue 4, Page(s) 361

Title translation	Melioidosis in a little rural community of Ceará State.
MeSH term(s)	Animals ; Brazil ; Humans ; Melioidosis ; Publishing ; Rural Population
Language	Portuguese
Publishing date	2005-08-03
Publishing country	Brazil
Document type	Comment ; Letter
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/s0037-86822005000400019
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2726: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Primeira descrição de um caso autopsiado de melioidose no Estado do Ceará

Braga, Marcus Davis Machado / Almeida, Paulo Roberto Carvalho de

Revista da Sociedade Brasileira de Medicina Tropical

2005 Volume 38, Issue 1, Page(s) 58–60

Abstract: An autopsied case is reported concerning fulminant sepsis with predominantly pulmonary lesions, caused by Burkholderia pseudomallei, etiologic agent of melioidosis, originating from interior of Ceará State, Northeastern Brazil where there had been no ... ...

Title translation	First description of an autopsied case of melioidosis in Ceará State.
Abstract	An autopsied case is reported concerning fulminant sepsis with predominantly pulmonary lesions, caused by Burkholderia pseudomallei, etiologic agent of melioidosis, originating from interior of Ceará State, Northeastern Brazil where there had been no previous cases reported. Autopsy findings and differential diagnosis are discussed.
MeSH term(s)	Adolescent ; Autopsy ; Brazil ; Burkholderia pseudomallei/isolation & purification ; Fatal Outcome ; Female ; Humans ; Male ; Melioidosis/pathology ; Sepsis/microbiology ; Sepsis/pathology
Language	Portuguese
Publishing date	2005-01-18
Publishing country	Brazil
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/s0037-86822005000100012
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2726: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Primeira descrição de um caso autopsiado de melioidose no Estado do Ceará

Braga Marcus Davis Machado / Almeida Paulo Roberto Carvalho de

Revista da Sociedade Brasileira de Medicina Tropical, Vol 38, Iss 1, Pp 58-

2005 Volume 60

Abstract: Relata-se um caso autopsiado de paciente acometida por sepse fulminante com lesões predominantemente pulmonares, causada pela Burkholderia pseudomallei, agente etiológico da melioidose, proveniente de município do interior do Ceará, estado do nordeste do ...

Abstract	Relata-se um caso autopsiado de paciente acometida por sepse fulminante com lesões predominantemente pulmonares, causada pela Burkholderia pseudomallei, agente etiológico da melioidose, proveniente de município do interior do Ceará, estado do nordeste do Brasil onde ainda não tinham sido descritos casos da doença. São discutidos os achados da autópsia e os diagnósticos diferenciais.
Keywords	Melioidose ; Sepse fulminante ; Broncopneumonia ; Ceará ; Brasil ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	Portuguese
Publishing date	2005-01-01T00:00:00Z
Publisher	Sociedade Brasileira de Medicina Tropical - SBMT
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Melioidose numa pequena comunidade rural do Ceará

Braga Marcus Davis Machado / Almeida Paulo Roberto Carvalho de

Revista da Sociedade Brasileira de Medicina Tropical, Vol 38, Iss 4, Pp 361-

2005 Volume 361

Keywords	Arctic medicine. Tropical medicine ; RC955-962
Language	English
Publishing date	2005-01-01T00:00:00Z
Publisher	Sociedade Brasileira de Medicina Tropical (SBMT)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Renal dysfunction and inflammatory markers in hypertensive patients seen in a university hospital.

Braga, Fátima Lúcia Machado / Arruda, Ilma Kruze Grande de / Diniz, Alcides da Silva / Cabral, Poliana Coelho / Lemos, Maria da Conceição Chaves de / Braga, Marcus Davis Machado / Chaves, Hilton de Castro

Arquivos brasileiros de cardiologia

2013 Volume 100, Issue 6, Page(s) 538–545

Abstract: Background: Today, chronic kidney diseases represent a great challenge to public health as regards the acquisition of knowledge to support interventions that can slow the progression of renal function loss.: Objective: To analyze the magnitude of the ...

Abstract	Background: Today, chronic kidney diseases represent a great challenge to public health as regards the acquisition of knowledge to support interventions that can slow the progression of renal function loss. Objective: To analyze the magnitude of the renal function deficit in hypertensive adult patients and its relationship with the following inflammatory markers: high-sensitivity C reactive protein, erythrocyte sedimentation rate, and neutrophil/lymphocyte ratio. Methods: Cross-sectional study including 1,273 adult hypertensive patients of both genders, of whom 1,052 had renal function deficit, and 221 had no deficit, as diagnosed by the Modification of Diet in Renal Disease equation. The odds ratio (OR) and the prevalence ratio (PR) were used to determine the probability of the occurrence of inflammatory activity in renal disease. Results: Renal function deficit was diagnosed in 82.6% of the patients assessed, and most of the sample (70.8%) was classified as in stage 2 of chronic kidney disease. In the regression model, metabolic syndrome (PR adjusted = 1.09 [95%CI: 1.04-1.14]), high-sensitivity C reactive protein (PR adjusted = 1.54 [95%CI: 1.40-1.69]) and erythrocyte sedimentation rate (PR adjusted = 1.20 [95%CI: 1.12-1.28]) remained independently associated with the renal function deficit. However, considering the individuals classified as in stage 2 of renal function deficit, the chance of abnormalities in inflammatory markers were OR = 10.25 (95%CI: 7.00-15.05) for high-sensitivity C reactive protein, OR = 8.50 (95%CI: 5.70-12.71) for neutrophil/lymphocyte ratio, and OR = 7.18 (95%CI: 4.87-10.61) for erythrocyte sedimentation rate. Conclusion: The results show an association of inflammatory activity and metabolic syndrome with renal function deficit.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Blood Sedimentation ; C-Reactive Protein/analysis ; Cross-Sectional Studies ; Female ; Glomerular Filtration Rate ; Hospitals, University ; Humans ; Hypertension/blood ; Hypertension/physiopathology ; Inflammation/blood ; Lymphocytes ; Male ; Metabolic Syndrome/physiopathology ; Middle Aged ; Neutrophils ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/physiopathology ; Risk Factors ; Statistics, Nonparametric
Chemical Substances	Biomarkers ; C-Reactive Protein (9007-41-4)
Language	Portuguese
Publishing date	2013-06
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.5935/abc.20130102
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 548: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Malária cerebral no Ceará: relato de caso.

Braga, Marcus Davis Machado / Alcântara, Geritza Chagas / da Silva, Cristiane Nobre / Nascimento, Cyntia Gioconda Honorato

Revista da Sociedade Brasileira de Medicina Tropical

2004 Volume 37, Issue 1, Page(s) 53–55

Abstract: Starting from a case of cerebral malaria in Ceará, the authors get the attention for that possibility of this occurrence in no-endemic zone, due to the retard of the diagnosis. Besides the serious implications of the disease, uncommon for this determined ...

Title translation	Cerebral Malaria in Ceará: a case report.
Abstract	Starting from a case of cerebral malaria in Ceará, the authors get the attention for that possibility of this occurrence in no-endemic zone, due to the retard of the diagnosis. Besides the serious implications of the disease, uncommon for this determined species, Plasmodium vivax, it is observed the probable existence of mixed infection and the potential dissemination with the presence of the sand fly transmitter.
MeSH term(s)	Adult ; Animals ; Antimalarials/therapeutic use ; Chloroquine/therapeutic use ; Humans ; Malaria, Cerebral/diagnosis ; Malaria, Cerebral/drug therapy ; Mefloquine/therapeutic use ; Plasmodium vivax ; Primaquine/therapeutic use
Chemical Substances	Antimalarials ; Chloroquine (886U3H6UFF) ; Primaquine (MVR3634GX1) ; Mefloquine (TML814419R)
Language	Portuguese
Publishing date	2004-03-19
Publishing country	Brazil
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/s0037-86822004000100014
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2726: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Malária cerebral no Ceará

Braga Marcus Davis Machado / Alcântara Geritza Chagas / Silva Cristiane Nobre da / Nascimento Cyntia Gioconda Honorato

Revista da Sociedade Brasileira de Medicina Tropical, Vol 37, Iss 1, Pp 53-

relato de caso

2004 Volume 55

Abstract: A partir de um caso de malária cerebral no Ceará observa-se a possibilidade dessa ocorrência em zona não endêmica, secundária a retardo diagnóstico. Além da gravidade da doença, incomum para a espécie determinada, Plasmodium vivax, verifica-se a possível ...

Abstract	A partir de um caso de malária cerebral no Ceará observa-se a possibilidade dessa ocorrência em zona não endêmica, secundária a retardo diagnóstico. Além da gravidade da doença, incomum para a espécie determinada, Plasmodium vivax, verifica-se a possível existência de infecção mista e sua potencial disseminação na presença do vetor.
Keywords	Malária cerebral ; Malária atípica ; Malária importada ; Malária no Ceará ; Brasil ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	Portuguese
Publishing date	2004-01-01T00:00:00Z
Publisher	Sociedade Brasileira de Medicina Tropical - SBMT
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Purification and biological activity of the thrombin-like substance isolated from Bothrops insularis venom.

Braga, Marcus Davis Machado / Martins, Alice Maria Costa / de Menezes, Dalgimar Bezerra / Barbosa, Paulo Sergio Ferreira / Evangelista, Janaina Serra Azul Monteiro / Toyama, Marcos Hikari / Toyama, Daniela Oliveira / Fonteles, Manassés Claudino / Monteiro, Helena Serra Azul

Toxicon : official journal of the International Society on Toxinology

2007 Volume 49, Issue 3, Page(s) 329–338

Abstract: The venom of Bothrops insularis snake, known in Brazil as jararaca ilhoa, contains a variety of proteolytic enzymes such as a thrombin-like substance that is responsible for various pharmacological effects. B. insularis venom chromatography profile ... ...

Abstract	The venom of Bothrops insularis snake, known in Brazil as jararaca ilhoa, contains a variety of proteolytic enzymes such as a thrombin-like substance that is responsible for various pharmacological effects. B. insularis venom chromatography profile showed an elution of seven main fractions. The thrombin-like activity was detected in fractions I and III, the latter being subjected to two other chromatographic procedures, so to say DEAE and Hi Trap Benzamidine. The purity degree of this fraction was confirmed by analytical reverse phase HPLC, which displayed only one main fraction confirmed by SDS-PAGE constituting fraction III. About 5 microg of fraction III protein potentiated the secretion of insulin induced by 2.8 mM of glucose in rats isolated pancreatic beta-cells treated; the increase being around 3-fold higher than its respective control. B. insularis lectin (BiLec; 10 microg/mL) was also studied as to its effect on the renal function of isolated perfused rat kidneys with the use of six Wistar rats. BiLec increased perfusion pressure (PP), renal vascular resistance (RVR), urinary flow (UF) and glomerular filtration rate (GFR). Sodium (%TNa+) and chloride tubular reabsorption (%TCl-) decreased at 120 min, without alteration in potassium transport. In conclusion, the thrombin-like substance isolated from B. insularis venom induced an increase in insulin secretion, in vitro, and transiently altered vascular, glomerular and tubular parameters in the isolated rat kidney.
MeSH term(s)	Animals ; Blood Coagulation/drug effects ; Bothrops ; Cells, Cultured ; Chlorides/metabolism ; Chromatography, High Pressure Liquid ; Crotalid Venoms/chemistry ; Crotalid Venoms/isolation & purification ; Crotalid Venoms/pharmacology ; Electrophoresis, Polyacrylamide Gel ; Glomerular Filtration Rate/drug effects ; Hemostatics/chemistry ; Hemostatics/isolation & purification ; Hemostatics/pharmacology ; Insulin/metabolism ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Insulin-Secreting Cells/pathology ; Kidney/blood supply ; Kidney/drug effects ; Kidney/pathology ; Kidney Tubules/drug effects ; Kidney Tubules/metabolism ; Lectins/pharmacology ; Male ; Perfusion ; Rats ; Rats, Wistar ; Urination/drug effects ; Vascular Resistance/drug effects
Chemical Substances	Chlorides ; Crotalid Venoms ; Hemostatics ; Insulin ; Lectins
Language	English
Publishing date	2007-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2006.10.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 501: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito