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  1. Article ; Online: Possibilities and limitations of an

    Braham, Maaike V J / Alblas, Jacqueline / Dhert, Wouter J A / Öner, F Cumhur / Minnema, Monique C

    Haematologica

    2019  Volume 104, Issue 11, Page(s) e523–e526

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bone Marrow/pathology ; Combined Modality Therapy/adverse effects ; Combined Modality Therapy/methods ; Humans ; Molecular Targeted Therapy ; Multiple Myeloma/mortality ; Multiple Myeloma/pathology ; Multiple Myeloma/therapy ; Prognosis ; Treatment Outcome
    Language English
    Publishing date 2019-04-19
    Publishing country Italy
    Document type Letter
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2018.213355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.76: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A Human Hematopoietic Niche Model Supporting Hematopoietic Stem and Progenitor Cells In Vitro.

    Braham, Maaike V J / Li Yim, Amélie S P / Garcia Mateos, Jara / Minnema, Monique C / Dhert, Wouter J A / Öner, F Cumhur / Robin, Catherine / Alblas, Jacqueline

    Advanced healthcare materials

    2019  Volume 8, Issue 10, Page(s) e1801444

    Abstract: Niches in the bone marrow regulate hematopoietic stem and progenitor cell (HSPC) fate and behavior through cell-cell interactions and soluble factor secretion. The niche-HSPC crosstalk is a very complex process not completely elucidated yet. To aid ... ...

    Abstract Niches in the bone marrow regulate hematopoietic stem and progenitor cell (HSPC) fate and behavior through cell-cell interactions and soluble factor secretion. The niche-HSPC crosstalk is a very complex process not completely elucidated yet. To aid further investigation of this crosstalk, a functional in vitro 3D model that closely represents the main supportive compartments of the bone marrow is developed. Different combinations of human stromal cells and hydrogels are tested for their potential to maintain CD34
    MeSH term(s) Adipogenesis/drug effects ; Alginates/chemistry ; Antigens, CD34/metabolism ; Cell Culture Techniques ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Collagen/chemistry ; Drug Combinations ; Endothelial Cells/cytology ; Endothelial Cells/metabolism ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Laminin/chemistry ; Osteogenesis/drug effects ; Proteoglycans/chemistry ; Stem Cell Niche
    Chemical Substances Alginates ; Antigens, CD34 ; Drug Combinations ; Hydrogels ; Laminin ; Proteoglycans ; matrigel (119978-18-6) ; Collagen (9007-34-5)
    Language English
    Publishing date 2019-04-03
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.201801444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6966: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Endosteal and Perivascular Subniches in a 3D Bone Marrow Model for Multiple Myeloma.

    Braham, Maaike V J / Ahlfeld, Tilman / Akkineni, A Rahul / Minnema, Monique C / Dhert, Wouter J A / Öner, F Cumhur / Robin, Catherine / Lode, Anja / Gelinsky, Michael / Alblas, Jacqueline

    Tissue engineering. Part C, Methods

    2018  Volume 24, Issue 5, Page(s) 300–312

    Abstract: The bone marrow microenvironment is the preferred location of multiple myeloma, supporting tumor growth and development. It is composed of a collection of interacting subniches, including the endosteal and perivascular niche. Current in vitro models ... ...

    Abstract The bone marrow microenvironment is the preferred location of multiple myeloma, supporting tumor growth and development. It is composed of a collection of interacting subniches, including the endosteal and perivascular niche. Current in vitro models mimic either of these subniches. By developing a model combining both niches, this study aims to further enhance the ability to culture primary myeloma cells in vitro. Also, the dependency of myeloma cells on each niche was studied. A 3D bone marrow model containing two subniches was created using 3D bioprinting technology. We used a bioprintable pasty calcium phosphate cement (CPC) scaffold with seeded osteogenic multipotent mesenchymal stromal cells (O-MSCs) to model the endosteal niche, and Matrigel containing both endothelial progenitor cells (EPCs) and MSCs to model the perivascular niche. Within the model containing one or both of the niches, primary CD138
    MeSH term(s) Bone Cements/pharmacology ; Bone Marrow/blood supply ; Calcium Phosphates/pharmacology ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Survival/drug effects ; Cellular Microenvironment ; Endothelial Progenitor Cells/drug effects ; Endothelial Progenitor Cells/metabolism ; Humans ; Mesenchymal Stem Cells/cytology ; Models, Biological ; Multiple Myeloma/pathology ; Osteogenesis/drug effects ; Tissue Scaffolds/chemistry
    Chemical Substances Bone Cements ; Calcium Phosphates ; calcium phosphate (97Z1WI3NDX)
    Language English
    Publishing date 2018-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2420585-0
    ISSN 1937-3392 ; 1937-3384
    ISSN (online) 1937-3392
    ISSN 1937-3384
    DOI 10.1089/ten.TEC.2017.0467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5500/C: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Cellular immunotherapy on primary multiple myeloma expanded in a 3D bone marrow niche model.

    Braham, Maaike V J / Minnema, Monique C / Aarts, Tineke / Sebestyen, Zsolt / Straetemans, Trudy / Vyborova, Anna / Kuball, Jurgen / Öner, F Cumhur / Robin, Catherine / Alblas, Jacqueline

    Oncoimmunology

    2018  Volume 7, Issue 6, Page(s) e1434465

    Abstract: Bone marrow niches support multiple myeloma, providing signals and cell-cell interactions essential for disease progression. A 3D bone marrow niche model was developed, in which supportive multipotent mesenchymal stromal cells and their osteogenic ... ...

    Abstract Bone marrow niches support multiple myeloma, providing signals and cell-cell interactions essential for disease progression. A 3D bone marrow niche model was developed, in which supportive multipotent mesenchymal stromal cells and their osteogenic derivatives were co-cultured with endothelial progenitor cells. These co-cultured cells formed networks within the 3D culture, facilitating the survival and proliferation of primary CD138
    Language English
    Publishing date 2018-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.1080/2162402X.2018.1434465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Differences in IgG autoantibody Fab glycosylation across autoimmune diseases.

    Koers, Jana / Sciarrillo, Rocco / Derksen, Ninotska I L / Vletter, Esther M / Fillié-Grijpma, Yvonne E / Raveling-Eelsing, Elisabeth / Graça, Nuno A G / Leijser, Thiemo / Pas, Hendri H / Laura van Nijen-Vos, L / Braham, Maaike V J / Buisman, Anne-Marie / de Jong, Jan / Schriek, Angela I / Tio-Gillen, Anne P / Teng, Y K Onno / Steenhuis, Maurice / Swaneveld, Francis H / de Taeye, Steven W /
    van Gils, Marit J / Verschuuren, Jan J G M / Rutgers, Bram / Heeringa, Peter / Horváth, Barbara / Jacobs, Bart C / de Leeuw, Karina / Franssen, Casper F M / Veyradier, Agnès / Coppo, Paul / Gelderman, Kyra A / Marieke van Ham, S / van Els, Cécile A C M / van der Woude, Diane / Huizinga, Ruth / Huijbers, Maartje G / Kuijpers, Taco W / Toes, Rene E M / Bos, Nicolaas A / Rispens, Theo

    The Journal of allergy and clinical immunology

    2023  Volume 151, Issue 6, Page(s) 1646–1654

    Abstract: Background: Increased prevalence of autoantibody Fab glycosylation has been demonstrated for several autoimmune diseases.: Objectives: To study whether elevated Fab glycosylation is a common feature of autoimmunity, this study investigated Fab ... ...

    Abstract Background: Increased prevalence of autoantibody Fab glycosylation has been demonstrated for several autoimmune diseases.
    Objectives: To study whether elevated Fab glycosylation is a common feature of autoimmunity, this study investigated Fab glycosylation levels on serum IgG and its subclasses for autoantibodies associated with a range of different B cell-mediated autoimmune diseases, including rheumatoid arthritis, myasthenia gravis subtypes, pemphigus vulgaris, antineutrophil cytoplasmic antibody-associated vasculitis, systemic lupus erythematosus, anti-glomerular basement membrane glomerulonephritis, thrombotic thrombocytopenic purpura, and Guillain-Barré syndrome.
    Methods: The level of Fab glycosylated IgG antibodies was assessed by lectin affinity chromatography and autoantigen-specific immunoassays.
    Results: In 6 of 10 autoantibody responses, in 5 of 8 diseases, the investigators found increased levels of Fab glycosylation on IgG autoantibodies that varied from 86% in rheumatoid arthritis to 26% in systemic lupus erythematosus. Elevated autoantibody Fab glycosylation was not restricted to IgG
    Conclusions: These data indicate that in chronic but not acute B cell-mediated autoimmune diseases, disease-specific autoantibodies are enriched for Fab glycans.
    MeSH term(s) Humans ; Autoimmune Diseases ; Autoantibodies ; Myasthenia Gravis ; Arthritis, Rheumatoid ; Immunoglobulin G ; Lupus Erythematosus, Systemic ; Autoantigens
    Chemical Substances Autoantibodies ; Immunoglobulin G ; Autoantigens
    Language English
    Publishing date 2023-01-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.10.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.92: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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