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  1. Article ; Online: A case report of rapid diagnosis of atrial-oesophageal fistula by transthoracic echocardiogram with agitated saline injection.

    Galante, Ori / Braiman, Dana / Haim, Moti / Kobal, Sergio L

    European heart journal. Case reports

    2023  Volume 7, Issue 6, Page(s) ytad254

    Abstract: Background: Catheter ablation is a common treatment for atrial fibrillation (AF). Atrial-oesophageal fistula (AOF) is a rare yet fatal complication of catheter ablation. Chest computed tomography (CT) is the diagnostic modality of choice but may be ... ...

    Abstract Background: Catheter ablation is a common treatment for atrial fibrillation (AF). Atrial-oesophageal fistula (AOF) is a rare yet fatal complication of catheter ablation. Chest computed tomography (CT) is the diagnostic modality of choice but may be undiagnostic in up to 24% of cases.
    Case summary: We present the case of a 61-year-old male who presented with pleuritic chest pain, hypotension, fever, and coffee-ground emesis 20 days after cryoablation for AF. His chest CT was undiagnostic. Atrial-oesophageal fistula was diagnosed by injecting agitated saline into the nasogastric tube during a transthoracic echocardiogram (TTE) that showed bubbles in the left atrium and ventricle.
    Discussion: In the case presented, as often happens, the diagnosis of AOF was delayed for several days, during which the patient presented with septic shock and concomitant multiorgan failure. The high mortality rate associated with AOF is partially attributable to delayed diagnosis. As prompt surgical intervention offers the best chance of survival, a high level of suspicion is of the utmost importance. We suggest contrast-enhanced TTE as a potential diagnostic tool when a rapid and definitive diagnosis is crucial and CT is inconclusive. Since this procedure is not without risk, proper risk consideration and management are necessary.
    Language English
    Publishing date 2023-05-29
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: When the brain slows the heart-herpes encephalitis and sinus arrest: a case report.

    Braiman, Dana / Konstantino, Yuval / Westreich, Roi

    European heart journal. Case reports

    2021  Volume 5, Issue 8, Page(s) ytab254

    Abstract: Background: Herpes simplex virus (HSV) encephalitis is a known cause of cognitive deterioration, neurological disturbances, and seizures though are rarely associated with sinus node dysfunction.: Case summary: We present a 54-year-old man admitted to ...

    Abstract Background: Herpes simplex virus (HSV) encephalitis is a known cause of cognitive deterioration, neurological disturbances, and seizures though are rarely associated with sinus node dysfunction.
    Case summary: We present a 54-year-old man admitted to the hospital with a 10-day history of fever, confusion, and fatigue, 1 week following a transient loss of consciousness. An initial workup suggested HSV encephalitis and the patient was started on intravenous Acyclovir. Due to his episode of syncope, a 24 h Holter electrocardiogram monitoring was performed. The Holter documented multiple episodes of sinus arrest, with a second episode of syncope noticed by the hospital staff concurrent with the last documented sinus arrest. Following antiviral treatment and resolution of the encephalitis we noticed complete resolution of sinus node dysfunction. We subsequently avoided permanent pacemaker implantation.
    Discussion: Our case of proven HSV encephalitis complicated by sinus node arrest and syncope with complete resolution following antiviral treatment suggests no indication for permanent pacemaker implantation. This approach is consistent with data from previously reported cases.
    Language English
    Publishing date 2021-08-02
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytab254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fitz-Hugh-Curtis Syndrome in the Absence of Pelvic Inflammatory Disease.

    Dayan, Roy Rafael / Braiman, Dana / Shenkman, Israel / Saidel-Odes, Lisa / Maimon, Nimrod

    The American journal of medicine

    2021  Volume 135, Issue 3, Page(s) e67–e68

    MeSH term(s) Female ; Gonorrhea/complications ; Gonorrhea/diagnosis ; Gonorrhea/drug therapy ; Hepatitis/diagnosis ; Humans ; Pelvic Inflammatory Disease/complications ; Pelvic Inflammatory Disease/diagnosis ; Pelvic Inflammatory Disease/drug therapy ; Peritonitis/diagnosis ; Peritonitis/drug therapy
    Language English
    Publishing date 2021-11-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2021.10.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.289: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: P16, Ki67, P53, and WT1 Expression in Uterine Smooth Muscle Tumors: An Adjunct in Confirming the Diagnosis of Malignancy in Ambiguous Cases.

    Delgado, Bertha / Dreiher, Jacob / Braiman, Dana / Meirovitz, Mihai / Shaco-Levy, Ruthy

    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists

    2020  Volume 40, Issue 3, Page(s) 257–262

    Abstract: The diagnosis of uterine smooth muscle tumors is sometimes difficult, as these tumors may show worrisome features, suspicious for but not diagnostic of malignancy. The recommended immunohistochemical panel in this setting is currently under debate. In ... ...

    Abstract The diagnosis of uterine smooth muscle tumors is sometimes difficult, as these tumors may show worrisome features, suspicious for but not diagnostic of malignancy. The recommended immunohistochemical panel in this setting is currently under debate. In this study, we aimed to find a panel of immunohistochemical stains that would be helpful in determining the correct diagnosis in ambiguous uterine smooth muscle tumors, with an emphasis on investigating the possible usefulness of the WT1 antibody. Uterine leiomyomas were found to be immunoreactive with WT1. Since a previous study reported on the lack of immunoreactivity of uterine leiomyosarcomas with WT1, we speculated that WT1 might be useful in this setting. We retrospectively reviewed the medical charts and slides of 91 patients: 22 with leiomyosarcoma, 15 with smooth muscle tumor of uncertain malignant potential, and 54 with leiomyoma. Immunohistochemical stains for WT1, p16, p53, and Ki67 were performed on each case. We found that immunoreactivity with p16 and Ki67 (>40% and >10% of the tumor cells, respectively) and loss of nuclear expression of WT1 (<10% of the tumor cells) were significantly more common in leiomyosarcomas (all P<0.001). Mutated p53 immunohistochemical staining pattern was significantly more prevalent in leiomyosarcomas than in leiomyomas (P<0.001). Thus, in diagnostically challenging uterine smooth muscle tumors, we recommend using an immunohistochemical panel composed of Ki67, p16, p53, and WT1. A positive result in either of the former 2 (p16 >40% and/or Ki67 >10%) has the strongest association with leiomyosarcoma (sensitivity: 95.5%, specificity=88.9%, positive predictive value=77.8%, negative predictive value=98.0%).
    MeSH term(s) Biomarkers, Tumor/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Female ; Humans ; Immunohistochemistry ; Ki-67 Antigen/metabolism ; Leiomyoma/diagnosis ; Leiomyoma/pathology ; Leiomyosarcoma/diagnosis ; Leiomyosarcoma/pathology ; Predictive Value of Tests ; Retrospective Studies ; Sensitivity and Specificity ; Smooth Muscle Tumor/diagnosis ; Smooth Muscle Tumor/pathology ; Tumor Suppressor Protein p53/metabolism ; Uterine Neoplasms/diagnosis ; Uterine Neoplasms/pathology ; Uterus/pathology ; WT1 Proteins/metabolism
    Chemical Substances Biomarkers, Tumor ; CDKN2A protein, human ; Cyclin-Dependent Kinase Inhibitor p16 ; Ki-67 Antigen ; MKI67 protein, human ; TP53 protein, human ; Tumor Suppressor Protein p53 ; WT1 Proteins ; WT1 protein, human
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604859-6
    ISSN 1538-7151 ; 0277-1691
    ISSN (online) 1538-7151
    ISSN 0277-1691
    DOI 10.1097/PGP.0000000000000688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1814: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Development of saliva-based cardiac troponin I point-of-care test using alpha-amylase depletion: a feasibility study.

    Westreich, Roi / Tsaban, Gal / Neumann, Yoav / Abu Salman, Amjad / Braver, Omri / Braiman, Dana / Zamed, Tali / Neuhaus, Zipora Feiga / Deutsch, Omer / Palmon, Aaron / Maimon, Nimrod / Zahger, Doron / Abramowitz, Yigal

    Coronary artery disease

    2023  Volume 34, Issue 5, Page(s) 351–355

    Abstract: Introduction: Cardiac troponin (cTn) is the biomarker of choice for detection of myocardial injury. There is a great need for simple point-of-care (POC) troponin testing among patients with chest pain, mainly in the prehospital setting. The purpose of ... ...

    Abstract Introduction: Cardiac troponin (cTn) is the biomarker of choice for detection of myocardial injury. There is a great need for simple point-of-care (POC) troponin testing among patients with chest pain, mainly in the prehospital setting. The purpose of this study was to evaluate the presence of cardiac troponin I (cTnI) in saliva of patients with myocardial injury using alpha-amylase depletion technique.
    Methods: Saliva samples were collected from 40 patients with myocardial injury who were tested positive for conventional high-sensitivity cardiac troponin T (cTnT) blood tests, and from 66 healthy volunteers. Saliva samples were treated for the removal of salivary alpha-amylase. Treated and untreated samples were tested with blood cTnI Rapid Diagnostic Test. Salivary cTnI levels were compared to blood cTnT levels.
    Results: Thirty-six of 40 patients with positive blood cTnT had positive salivary samples for cTnI following alpha-amylase depletion treatment (90.00% sensitivity). Moreover, three of the four negative saliva samples were obtained from patients with relatively low blood cTnT levels of 100 ng/L or less (96.88% sensitivity for 100 ng/L and above). The negative predictive value was 93.65% and rose up to 98.33% considering the 100 ng/L cutoff. Positive predictive values were 83.72% and 81.58%, respectively. Among 66 healthy volunteers and 7 samples yielded positive results (89.39% specificity).
    Conclusion: In this preliminary work, the presence of cTnI in saliva was demonstrated for the first time to be feasibly identified by a POC oriented assay. The specific salivary alpha-amylase depletion technique was shown to be crucial for the suggested assay.
    MeSH term(s) Humans ; Troponin I ; Salivary alpha-Amylases ; Feasibility Studies ; Saliva ; Troponin T ; Biomarkers ; Point-of-Care Testing
    Chemical Substances Troponin I ; Salivary alpha-Amylases (EC 3.2.1.1) ; Troponin T ; Biomarkers
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1047268-x
    ISSN 1473-5830 ; 0954-6928
    ISSN (online) 1473-5830
    ISSN 0954-6928
    DOI 10.1097/MCA.0000000000001257
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3039: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Comparison of Rate Control Efficacy between beta-blockers and Calcium Channel Blockers in Patients Hospitalized with Atrial Fibrillation.

    Sherf, Yehonatan / Avital, Dekel / Geva Robinson, Shahar / Arotsker, Natan / Waldman Radinsky, Liat / Chen Hendel, Efrat / Braiman, Dana / Hayadri, Ahab / Akselrod, Dikla / Schlaeffer-Yosef, Tal / Abu Fraiha, Yasmeen / Toledano, Ronen / Maimon, Nimrod

    The Israel Medical Association journal : IMAJ

    2022  Volume 24, Issue 11, Page(s) 752–756

    Abstract: Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia. Previous studies showed that rhythm and rate control strategies are associated with similar rates of mortality and serious morbidity. Beta blockers (BB) and calcium channel ... ...

    Abstract Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia. Previous studies showed that rhythm and rate control strategies are associated with similar rates of mortality and serious morbidity. Beta blockers (BB) and calcium channel blockers (CCB) are commonly used and the selection between these two medications depends on personal preference.
    Objectives: To compare real-time capability of BB and CCB for the treatment of rapid AF and to estimate their efficacy in reducing hospitalization duration.
    Methods: We conducted a retrospective cohort study of 306 patients hospitalized at Soroka Hospital during a 5-year period with new onset AF who were treated by a rate control strategy.
    Results: A significant difference between the two groups regarding the time (in hours) until reaching a target heart rate below 100 beats/min was observed. BB were found to decrease the heart rate after 5 hours (range 4-14) vs. 8 hours (range 4-18) for CCB (P = 0.009). Patients diagnosed with new-onset AF exhibited shorter duration of hospitalization after therapy with BB compared to CCB (median 72 vs. 96 hours, P = 0.012) in the subgroup of patients discharged with persistent AF. There was no significant difference between CCB and BB regarding the duration of hospitalization (P = 0.4) in the total patient population.
    Conclusions: BB therapy is more potent for rapid reduction of the heart rate compared to CCB and demonstrated better efficiency in shortening the duration of hospitalization in a subgroup of patients. This finding should be reevaluated in subsequent research.
    MeSH term(s) Humans ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/diagnosis ; Calcium Channel Blockers/therapeutic use ; Retrospective Studies ; Adrenergic beta-Antagonists/therapeutic use ; Hospitalization
    Chemical Substances Calcium Channel Blockers ; Adrenergic beta-Antagonists
    Language English
    Publishing date 2022-11-27
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: The Presence of Snoring as Well as its Intensity Is Underreported by Women.

    Westreich, Roi / Gozlan-Talmor, Aya / Geva-Robinson, Shahar / Schlaeffer-Yosef, Tal / Slutsky, Tzachi / Chen-Hendel, Efrat / Braiman, Dana / Sherf, Yehonatan / Arotsker, Natan / Abu-Fraiha, Yasmeen / Waldman-Radinsky, Liat / Maimon, Nimrod

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2019  Volume 15, Issue 3, Page(s) 471–476

    Abstract: Study objectives: Women are underrepresented and thus sleep conditions are underdiagnosed at sleep clinics that evaluate sleep-disordered breathing. The most common sign of obstructive sleep apnea (OSA) is snoring; therefore, it is one of the main red ... ...

    Abstract Study objectives: Women are underrepresented and thus sleep conditions are underdiagnosed at sleep clinics that evaluate sleep-disordered breathing. The most common sign of obstructive sleep apnea (OSA) is snoring; therefore, it is one of the main red flags for suspected OSA. The aim of this study is to determine whether self-reported snoring and snoring intensity by women and men correlates with snoring volume measured objectively during sleep laboratory study.
    Methods: Consecutive patients who were referred to a polysomnography (PSG) study in a university hospital over a 2-year period had their snoring volume quantified by means of a calibrated digital sound survey meter. Participants were given a questionnaire in which they were asked to rate the severity of their snoring. The correlation between objective snoring intensity as measured during PSG and the self-reported snoring intensity was evaluated.
    Results: A total of 1,913 patients were enrolled in the study. A positive correlation was found between objectively measured snoring intensity and the intensity listed by each participant in the questionnaire. Measurement of the volume of snoring revealed that women snored as loudly as men; however, 28% of the females (189/675) considered themselves to be nonsnorers compared to only 6.9% of men (
    Conclusions: In a population of individuals referred to a PSG study, although no difference in snoring intensity was found between sexes, women tend to underreport the fact that they snore and to underestimate the loudness of their snoring. Improved awareness of this discrepancy may increase women's access to sleep laboratories, and improve diagnostic rates of sleep apnea in females.
    MeSH term(s) Female ; Humans ; Male ; Middle Aged ; Polysomnography ; Self Report ; Severity of Illness Index ; Sex Factors ; Snoring/diagnosis ; Snoring/epidemiology ; Snoring/psychology ; Surveys and Questionnaires
    Language English
    Publishing date 2019-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.7678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6590: Show issues Location:
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