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Article: Association between Oxidative Stress with Psychological and Biochemical Variables in a Sample of Healthy Mexican People: A Cross-Sectional Study.

Saldaña-Cruz, Ana Míriam / Gallardo-Moya, Sergio Gabriel / Campos-Medina, Liliana / Brambila-Tapia, Aniel Jessica Leticia

Antioxidants (Basel, Switzerland)

2024 Volume 13, Issue 1

Abstract: Oxidative stress (OS) has been linked to cell damage and chronic disease development; however, the study of psychological factors related with OS has been limited, as has its relationship with biochemical and personal variables. Therefore, the aim of ... ...

Abstract	Oxidative stress (OS) has been linked to cell damage and chronic disease development; however, the study of psychological factors related with OS has been limited, as has its relationship with biochemical and personal variables. Therefore, the aim of this study was to evaluate the association between a wide variety of personal, psychological, and biochemical factors with OS in a sample of healthy Mexican people. A total of 134 participants, from which 70 (52%) were women, without known chronic conditions were included in the study, and the molecule 8-hydroxy-2'-deoxyguanosine (8-OHdG) was also measured as a marker of OS. We observed in the multivariate analysis of the whole sample that depressive symptoms (measured with CES-D scale) were the only psychological variable significantly associated (positively) with 8-OHdG. In addition, the following sociodemographic variables were associated with 8-OHdG: age, schooling (positively correlated), and the frequency of vitamins/antioxidant consumption (negatively correlated). The biochemical variables of erythrocytes in urine and amylase were positively correlated with 8-OHdG, while glucose was negatively correlated with it. Additional biochemical variables were associated in the multivariate analysis of each sex, including the positive correlation of LDL-cholesterol, LDH enzyme, lymphocytes, and the negative correlation of phosphorus and eosinophils in women's samples, as well as the positive correlation of potassium, uric acid, and leucocytes in urine and the negative correlation of erythrocytes and lipase in the men's samples. In conclusion, depression was the only psychological variable positively correlated with 8-OHdG after adjusting for confounders, and new associations with biochemical variables were found with some differences between sexes.
Language	English
Publishing date	2024-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox13010110
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Perceptions of Knowledge, Disease Impact and Predictive Genetic Testing in Family Members at Risk to Develop Early-Onset Alzheimer's Disease (EOAD) and Their Levels of Suicidal Ideation: A Mixed Study.

Reyes-Domínguez, Yesica Arlae / Figuera, Luis E / Brambila-Tapia, Aniel Jessica Leticia

Brain sciences

2023 Volume 13, Issue 3

Abstract: Early-onset Alzheimer's disease (EOAD) is an autosomal dominantly inherited disease, in which a founder effect has been described for A431E mutation in ... ...

Abstract	Early-onset Alzheimer's disease (EOAD) is an autosomal dominantly inherited disease, in which a founder effect has been described for A431E mutation in the
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13030501
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Article: Sex Differences in the Relationship between Personal, Psychological and Biochemical Factors with Blood Pressure in a Healthy Adult Mexican Population: A Cross-Sectional Study.

Ríos-González, Blanca Estela / Saldaña-Cruz, Ana Míriam / Gallardo-Moya, Sergio Gabriel / Brambila-Tapia, Aniel Jessica Leticia

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Hypertension is one of the main risk factors related to cardiovascular mortality, being the levels of blood pressure (BP) related to a variety of personal, anthropometric, biochemical and psychological variables; however, the study evaluating the ... ...

Abstract	Hypertension is one of the main risk factors related to cardiovascular mortality, being the levels of blood pressure (BP) related to a variety of personal, anthropometric, biochemical and psychological variables; however, the study evaluating the association of all these factors in systolic blood pressure (SBP) and diastolic blood pressure (DBP) in a sample of relatively healthy subjects has not been performed. The aim of the study was to determine the main variables associated with SBP and DPB in a sample of relatively healthy subjects. A total of 171 participants were included, in which personal, anthropometric, positive and negative psychological variables and biochemical variables were measured. We observed that men showed higher levels of SBP and DBP than women, with more differences for SBP. Among the biochemical factors and SBP, we found that albumin and monocytes were positively correlated with it, while potassium, phosphorus and eosinophils were negatively correlated with it. Additionally, schooling was a constant variable negatively correlated with SBP in all samples (global, men and women). Among psychological variables, we observed that emotional perception was negatively correlated with SBP in men's and women's samples, while autonomy was positively correlated with SBP in the men's sample; however, their association was less when compared with the personal and biochemical variables included in the multivariate model. With regard to DBP, we observed that the biochemical variables, hemoglobin, sodium, uric acid and glucose, were positively correlated with DBP in the global sample, while chloride and BUN were negatively correlated with it. In addition, many personal and behavioral variables, including BMI, age and smoking consumption frequency, also correlated with DBP in the global sample. In conclusion, BP is affected by different factors, and these affect each sex differently.
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020378
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Article: A Web Application for Biomedical Text Mining of Scientific Literature Associated with Coronavirus-Related Syndromes: Coronavirus Finder.

Armenta-Medina, Dagoberto / Brambila-Tapia, Aniel Jessica Leticia / Miranda-Jiménez, Sabino / Rodea-Montero, Edel Rafael

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 4

Abstract: In this study, a web application was developed that comprises scientific literature associated with ... ...

Abstract	In this study, a web application was developed that comprises scientific literature associated with the
Language	English
Publishing date	2022-04-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12040887
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Article ; Online: Association between Emotional Intelligence and Stress Coping Strategies According to Sex in Mexican General Population.

Macías-Espinoza, Fabiola / Brambila-Tapia, Aniel Jessica Leticia / Reyes-Domínguez, Yesica Arlae / Ramírez-García, María Luisa

International journal of environmental research and public health

2022 Volume 19, Issue 12

Abstract: Emotional intelligence has been associated with adaptive coping in the adolescent and young population; however, the association of specific dimensions of emotional intelligence with each coping strategy has not been associated in general nor by each sex ...

Abstract	Emotional intelligence has been associated with adaptive coping in the adolescent and young population; however, the association of specific dimensions of emotional intelligence with each coping strategy has not been associated in general nor by each sex separately. Therefore, the aim of the study was to determine such an association. The general population was invited to perform an electronic questionnaire via social networks. A sample of 984 individuals were included, from which 62.1% were women, in whom we detected higher levels of emotional attention, and lower levels of emotional clarity and emotional repair, as well as increased levels of stress, depression and anxiety than men. In the bivariate correlations we observed significant positive correlations between emotional attention with stress, depression and anxiety, and significant negative correlations between emotional clarity and emotional repair with the three negative psychological variables, in both sexes. Adaptive coping strategies (mainly active coping and planning) showed positive correlations with emotional attention, emotional clarity and repair, being higher for emotional clarity and repair in both sexes. In addition, these two subscales also showed low negative correlations between some maladaptive strategies in both sexes, which suggests that interventions addressed to increase these emotional abilities could be useful in increasing adaptive coping.
MeSH term(s)	Adaptation, Psychological ; Emotional Intelligence ; Female ; Humans ; Male ; Mexico ; Sex Factors ; Stress, Psychological/psychology ; Surveys and Questionnaires
Language	English
Publishing date	2022-06-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19127318
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Sex Differences in the Atherogenic Risk Index in Healthy Mexican Population and Its Relationship with Anthropometric and Psychological Factors.

Brambila-Tapia, Aniel Jessica Leticia / Dávalos-Rodríguez, Ingrid Patricia / Méndez-García, Carlos Adán / Bárcenas-Robles, Frida Isadora / Gutiérrez-Hurtado, Itzae Adonai

Journal of personalized medicine

2023 Volume 13, Issue 10

Abstract: Dyslipidemia is a risk factor for cardiovascular disease and mortality; however, the association of this variable with a wide range of personal and psychological variables has not been researched. Therefore, the aim of this study was to compare lipid ... ...

Abstract	Dyslipidemia is a risk factor for cardiovascular disease and mortality; however, the association of this variable with a wide range of personal and psychological variables has not been researched. Therefore, the aim of this study was to compare lipid levels and anthropometric measures between sexes and to determine the association between personal and psychological variables with the atherogenic risk index (ARI). An adult population which auto-reported as healthy was invited to participate via social media and in person. They filled out a questionnaire with personal and psychological variables; in addition, the body mass index (BMI) and waist-to-hip ratio (WHR) were measured, and a blood sample was obtained to determine serum lipids. A total of 172 participants were included, from which 92 (53.49%) were women; both sexes were comparable in age and most sociodemographic values. Men showed significantly higher levels of total cholesterol, LDL cholesterol, triglycerides, ARI, and lower levels of HDL cholesterol. The men also showed higher values of WHR than the women. In the bivariate analysis, ARI showed the highest correlation with WHR (r = 0.664) in the men and with BMI (r = 0.619) in the women. In the multivariate analysis, the quality of food intake was negatively correlated with ARI in the global and women's samples, and the psychological variables of assertiveness and positive relations with others were negatively correlated with ARI in women, while purpose in life was negatively correlated with ARI in men. In conclusion, the higher levels of serum lipids and ARI in men can be explained by the higher values of WHR in this sex. Behavioral and psychological variables could be protective factors for high ARI.
Language	English
Publishing date	2023-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13101452
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Brief COPE Short Version (Mini-COPE): A Proposal of Item and Factorial Reduction in Mexican Population.

Brambila-Tapia, Aniel Jessica Leticia / Martínez-Arriaga, Reyna Jazmin / González-Cantero, Joel Omar / González-Becerra, Victor Hugo / Reyes-Domínguez, Yesica Arlae / Ramírez-García, María Luisa / Macías-Espinoza, Fabiola

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 8

Abstract: The factorial reduction of Brief COPE has not been successfully replicated by independent studies, and few have been performed in Spanish-speaking populations; therefore, the objective of this study was to perform a factorial reduction of the instrument ... ...

Abstract	The factorial reduction of Brief COPE has not been successfully replicated by independent studies, and few have been performed in Spanish-speaking populations; therefore, the objective of this study was to perform a factorial reduction of the instrument in a large sample of the Mexican population and perform a convergent and divergent validity of the factors obtained. We distributed a questionnaire via social networks with sociodemographic and psychological variables, including the Brief COPE and the scales of the CPSS, GAD-7, and CES-D to measure stress, anxiety, and depression. A total of 1283 persons were included, most of whom (64.8%) were women and had a bachelor's degree (55.2%). After performing the exploratory factorial analysis, we did not find a model with an adequate fit and a reduced number of factors; therefore, we decided to reduce the number of items according to the most representative ones of adaptive, maladaptive, and emotional coping strategies. The resulting model with three factors showed good fit parameters and good internal consistency of the factors. In addition, the nature and naming of the factors were confirmed by convergent and divergent validity, with significant negative correlations between factor 1 (active/adaptive) and stress, depression, and anxiety, significant positive correlations between factor 2 (avoidant/maladaptive) and these three variables, and no significant correlation between factor 3 (emotional/neutral) and stress or depression. This shortened version of the brief COPE (Mini-COPE) is a good option to evaluate adaptive and maladaptive coping strategies in Spanish-speaking populations.
Language	English
Publishing date	2023-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11081070
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Article: Association between Psychological, Biochemical and Personal Factors with the Inflammatory Marker High-Sensitive C Reactive Protein (Hs-CRP) in Mexican Healthy Population.

Brambila-Tapia, Aniel Jessica Leticia / Jacquez-Castañeda, Ana Lilia / Carrillo-Delgadillo, Laura Arely / Dávila-Flores, Jessica Natalia / Macías-Espinoza, Fabiola / Ramírez-De Los Santos, Saúl / Gutiérrez-Hurtado, Itzae Adonai

Journal of personalized medicine

2023 Volume 13, Issue 5

Abstract: In the last decades, it has been shown that inflammatory processes play a role in the development of mental and physical problems; although some studies have researched the relationship between inflammation and psychological variables, the inclusion of ... ...

Abstract	In the last decades, it has been shown that inflammatory processes play a role in the development of mental and physical problems; although some studies have researched the relationship between inflammation and psychological variables, the inclusion of biochemical variables as possible confounders has been limited. Therefore, the aim of this study was to determine whether psychological variables are associated with the inflammatory marker, highly sensitive CRP (hs-CRP), after controlling for personal and biochemical variables in the Mexican population. The study was performed at the University of Guadalajara facilities, during the second half of 2022. Healthy subjects were invited to participate in the study, which consisted of the measurement of personal, psychological, and biochemical variables. We included 172 participants, 92 (52.9%) of which were women; the median (range) of age of the whole sample was 22 (18-69) years old. In the bivariate analysis, significant positive correlations were observed between hs-CRP and body mass index (BMI) and waist/hip ratio (WHR) in both sexes, together with leukocytes, uric acid, low-density lipoprotein (LDL), triglycerides, and the liver enzymes gamma glutamyl transferase (GGT) and alkaline phosphatase (ALP). In the multivariate regression analysis of the global and men's samples, anxiety was positively associated with hs-CRP, while depression and positive relations with others were negatively associated with hs-CRP. In conclusion, psychological variables influence inflammation mainly in men, and anxiety was the main contributor; in addition, positive relation with others is a variable that should be further explored as a psychological protector of inflammation in both sexes.
Language	English
Publishing date	2023-05-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13050876
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Sex Differences in Mental Status and Coping Strategies among Adult Mexican Population: A Cross-Sectional Study.

Brambila-Tapia, Aniel Jessica Leticia / Macías-Espinoza, Fabiola / González-Cantero, Joel Omar / Martínez-Arriaga, Reyna Jazmín / Reyes-Domínguez, Yesica Arlae / Ramírez-García, María Luisa

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 4

Abstract: We performed a cross-sectional study in order to determine the association between stress coping strategies and stress, depression, and anxiety, in which the Mexican population was invited to answer these variables by an electronic questionnaire. A total ...

Abstract	We performed a cross-sectional study in order to determine the association between stress coping strategies and stress, depression, and anxiety, in which the Mexican population was invited to answer these variables by an electronic questionnaire. A total of 1283 people were included, of which 64.8% were women. Women presented higher levels of stress, depression, and anxiety than men; likewise, women showed a higher frequency of some maladaptive coping strategies (behavioral disengagement and denial) and lower levels of some adaptive ones (active coping and planning); additionally, maladaptive coping strategies were positively correlated with stress and depression in both sexes: self-blame, behavioral disengagement, denial, substance use, and self-distraction. Likewise, there were negative correlations between stress and depression and the adaptive strategies: planning, active coping, acceptance, and positive reframing. For women, religion presented negative correlations with stress, depression, and anxiety, and humor showed low positive correlations with stress, anxiety, and depression. In conclusion, most adaptive and maladaptive coping strategies are common in both sexes with the exception of religion, which seems to be adaptive in women and neutral in men, and humor, which seems to be adaptive in men and maladaptive in women. In addition, emotional and instrumental support seem to be neutral in both sexes.
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11040514
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Article: MDR1 (ABCB1) polymorphisms: functional effects and clinical implications.

Brambila-Tapia, Aniel Jessica-Leticia

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

2013 Volume 65, Issue 5, Page(s) 445–454

Abstract: MDR1 gene encodes for P glycoprotein (P-gp), which plays an important role in bioavailability and cell-toxicity limitation of a wide range of drugs and xenobiotics. Three single nucleotide polymorphisms (SNPs) in the coding region (C3435T, C1236T and ... ...

Abstract	MDR1 gene encodes for P glycoprotein (P-gp), which plays an important role in bioavailability and cell-toxicity limitation of a wide range of drugs and xenobiotics. Three single nucleotide polymorphisms (SNPs) in the coding region (C3435T, C1236T and G2677T/A) are the most widely studied SNPs in MDR1 and have been related to substrate and inhibitor-dependent functional modifications in in vitro studies and reduced expression in tissues. The three SNPs exhibit the highest frequencies in Asian and Caucasians populations and the lowest in African populations. In regard to the clinical implications of MDR1 SNPs, it was found in large meta-analysis that C3435T SNP was associated with a slight increase in the susceptibility to ulcerative colitis and cancer and was related with slight modifications in tacrolimus pharmacokinetics and platinum-based chemotherapy response in lung cancer. On the other hand, C3435T SNP has shown controversial results in many other cases of disease susceptibility and drug pharmacokinetics where no meta-analyses have been performed. There is less information about C1236T and G2677T/A SNPs, which, although investigated in some diseases and drug pharmacokinetics, have a very limited number of published meta-analyses. Further studies should include analysis of the haplotype 1236T-2677T/A-3435T as well as other SNPs in MDR1, other transporters and drug metabolizers that may be related with the outcome variable.
MeSH term(s)	ATP Binding Cassette Transporter, Sub-Family B ; ATP-Binding Cassette, Sub-Family B, Member 1/genetics ; ATP-Binding Cassette, Sub-Family B, Member 1/physiology ; Antineoplastic Agents/pharmacokinetics ; Biological Transport/genetics ; Drug Resistance/genetics ; Ethnic Groups/genetics ; Exons/genetics ; Gene Frequency ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Inflammatory Bowel Diseases/genetics ; Meta-Analysis as Topic ; Neoplasms/drug therapy ; Neoplasms/genetics ; Polymorphism, Single Nucleotide
Chemical Substances	ABCB1 protein, human ; ATP Binding Cassette Transporter, Sub-Family B ; ATP-Binding Cassette, Sub-Family B, Member 1 ; Antineoplastic Agents
Language	English
Publishing date	2013-09
Publishing country	Mexico
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	138348-6
ISSN	0034-8376
ISSN	0034-8376
Database	MEDical Literature Analysis and Retrieval System OnLINE

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