LIVIVO - Search results -

Search results

Result 1 - 10 of total 10

Search options

Article ; Online: Regulatory cytokine function in the respiratory tract.

Branchett, William J / Lloyd, Clare M

2019 Volume 12, Issue 3, Page(s) 589–600

Abstract: The respiratory tract is an important site of immune regulation; required to allow protective immunity against pathogens, while minimizing tissue damage and avoiding aberrant inflammatory responses to inhaled allergens. Several cell types work in concert ...

Abstract	The respiratory tract is an important site of immune regulation; required to allow protective immunity against pathogens, while minimizing tissue damage and avoiding aberrant inflammatory responses to inhaled allergens. Several cell types work in concert to control pulmonary immune responses and maintain tolerance in the respiratory tract, including regulatory and effector T cells, airway and interstitial macrophages, dendritic cells and the airway epithelium. The cytokines transforming growth factor β, interleukin (IL-) 10, IL-27, and IL-35 are key coordinators of immune regulation in tissues such as the lung. Here, we discuss the role of these cytokines during respiratory infection and allergic airway disease, highlighting the critical importance of cellular source and immunological context for the effects of these cytokines in vivo.
MeSH term(s)	Animals ; Cytokines/metabolism ; Dendritic Cells/immunology ; Homeostasis ; Humans ; Hypersensitivity/immunology ; Immune Tolerance ; Lung/immunology ; Respiratory Mucosa/immunology ; Respiratory System/immunology ; Respiratory Tract Infections/immunology ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Cytokines
Language	English
Publishing date	2019-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2411370-0
ISSN	1935-3456 ; 1933-0219
ISSN (online)	1935-3456
ISSN	1933-0219
DOI	10.1038/s41385-019-0158-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6796: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Experimental Mouse Models of Asthma and Analysis of CD4 T Cells.

Branchett, William J / Walker, Simone A / Lloyd, Clare M

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2285, Page(s) 329–348

Abstract: Asthma is a highly prevalent lung disease, characterized by airway dysfunction and chronic inflammation. Asthma occurs in both children and adults, but frequently originates in early life. Heterogeneous asthma phenotypes exist, but Th2 cells are key ... ...

Abstract	Asthma is a highly prevalent lung disease, characterized by airway dysfunction and chronic inflammation. Asthma occurs in both children and adults, but frequently originates in early life. Heterogeneous asthma phenotypes exist, but Th2 cells are key players in a large proportion of cases, while other CD4+ T cell subsets are also implicated in driving and limiting pathology. In this chapter, we describe methods for establishing allergic airway disease to model asthma in adult and neonatal mice, along with protocols for measuring key disease parameters and quantifying and phenotyping CD4+ T cell subtypes.
MeSH term(s)	Age Factors ; Animals ; Asthma/immunology ; Asthma/metabolism ; Asthma/pathology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cell Separation ; Cells, Cultured ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Flow Cytometry ; Immunohistochemistry ; Lung/immunology ; Lung/metabolism ; Lung/pathology ; Male ; Mice, Inbred BALB C ; Phenotype ; Research Design ; Workflow ; Mice
Chemical Substances	Cytokines
Language	English
Publishing date	2021-04-09
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1311-5_25
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article: Transcriptomic analysis reveals diverse gene expression changes in airway macrophages during experimental allergic airway disease.

Branchett, William J / O'Garra, Anne / Lloyd, Clare M

Wellcome open research

2020 Volume 5, Page(s) 101

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-06-22
Publishing country	England
Document type	Journal Article
ISSN	2398-502X
ISSN	2398-502X
DOI	10.12688/wellcomeopenres.15875.2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis.

Alvarez-Martinez, Marisol / Cox, Luke S / Pearson, Claire F / Branchett, William J / Chakravarty, Probir / Wu, Xuemei / Slawinski, Hubert / Al-Dibouni, Alaa / Samelis, Vasileios A / Gabryšová, Leona / Priestnall, Simon L / Suárez-Bonnet, Alejandro / Mikolajczak, Anna / Briscoe, James / Powrie, Fiona / O'Garra, Anne

Nature immunology

2024

Abstract: Intestinal immune responses to microbes are controlled by the cytokine IL-10 to avoid immune pathology. Here, we use single-cell RNA sequencing of colon lamina propria leukocytes (LPLs) along with RNA-seq and ATAC-seq of purified ... ...

Abstract	Intestinal immune responses to microbes are controlled by the cytokine IL-10 to avoid immune pathology. Here, we use single-cell RNA sequencing of colon lamina propria leukocytes (LPLs) along with RNA-seq and ATAC-seq of purified CD4
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-024-01814-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Pulmonary Group 2 Innate Lymphoid Cell Phenotype Is Context Specific: Determining the Effect of Strain, Location, and Stimuli.

Entwistle, Lewis J / Gregory, Lisa G / Oliver, Robert A / Branchett, William J / Puttur, Franz / Lloyd, Clare M

Frontiers in immunology

2020 Volume 10, Page(s) 3114

Abstract: Group 2 innate lymphoid cells (ILC2s) are enriched at mucosal sites, including the lung, and play a central role in type 2 immunity and maintaining tissue homeostasis. As a result, since their discovery in 2010, research into ILC2s has increased markedly. ...

Abstract	Group 2 innate lymphoid cells (ILC2s) are enriched at mucosal sites, including the lung, and play a central role in type 2 immunity and maintaining tissue homeostasis. As a result, since their discovery in 2010, research into ILC2s has increased markedly. Numerous strategies have been used to define ILC2s by flow cytometry, often utilizing different combinations of surface markers despite their expression being variable and context-dependent. In this study, we sought to generate a comprehensive characterization of pulmonary ILC2s, identifying stable and context specific markers from different pulmonary compartments following different airway exposures in different strains of mice. Our analysis revealed that pulmonary ILC2 surface marker phenotype is heterogeneous and is influenced by mouse strain, pulmonary location,
MeSH term(s)	Allergens/immunology ; Animals ; Biomarkers ; Female ; Immunity, Innate ; Immunohistochemistry ; Immunophenotyping ; Interleukin-33/metabolism ; Lymphocyte Count ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Species Specificity
Chemical Substances	Allergens ; Biomarkers ; Interleukin-33
Language	English
Publishing date	2020-01-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.03114
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Airway macrophage-intrinsic TGF-β1 regulates pulmonary immunity during early-life allergen exposure.

Branchett, William J / Cook, James / Oliver, Robert A / Bruno, Nicoletta / Walker, Simone A / Stölting, Helen / Mack, Matthias / O'Garra, Anne / Saglani, Sejal / Lloyd, Clare M

The Journal of allergy and clinical immunology

2021 Volume 147, Issue 5, Page(s) 1892–1906

Abstract: Background: Early life represents a major risk window for asthma development. However, the mechanisms controlling the threshold for establishment of allergic airway inflammation in early life are incompletely understood. Airway macrophages (AMs) ... ...

Abstract	Background: Early life represents a major risk window for asthma development. However, the mechanisms controlling the threshold for establishment of allergic airway inflammation in early life are incompletely understood. Airway macrophages (AMs) regulate pulmonary allergic responses and undergo TGF-β-dependent postnatal development, but the role of AM maturation factors such as TGF-β in controlling the threshold for pathogenic immune responses to inhaled allergens remains unclear. Objective: Our aim was to test the hypothesis that AM-derived TGF-β1 regulates pathogenic immunity to inhaled allergen in early life. Methods: Conditional knockout (Tgfb1 Results: AM-intrinsic TGF-β1 was redundant for initial population of the neonatal lung with AMs, but AMs from Tgfb1 Conclusion: Our results highlight a causal relationship between AM maturity, chemokines, and pathogenic immunity to environmental stimuli in early life and identify TGF-β1 as a key regulator of this.
MeSH term(s)	Allergens/immunology ; Animals ; Chemokines/immunology ; Hypersensitivity/immunology ; Lung/immunology ; Macrophages, Alveolar/immunology ; Mice, Inbred C57BL ; Mice, Knockout ; Pyroglyphidae/immunology ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/immunology ; Mice
Chemical Substances	Allergens ; Chemokines ; Transforming Growth Factor beta1
Language	English
Publishing date	2021-02-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2021.01.026
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.92: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis.

Tabone, Olivier / Verma, Raman / Singhania, Akul / Chakravarty, Probir / Branchett, William J / Graham, Christine M / Lee, Jo / Trang, Tran / Reynier, Frederic / Leissner, Philippe / Kaiser, Karine / Rodrigue, Marc / Woltmann, Gerrit / Haldar, Pranabashis / O'Garra, Anne

The Journal of experimental medicine

2021 Volume 218, Issue 10

Abstract: Blood transcriptomics have revealed major characteristics of the immune response in active TB, but the signature early after infection is unknown. In a unique clinically and temporally well-defined cohort of household contacts of active TB patients that ... ...

Abstract	Blood transcriptomics have revealed major characteristics of the immune response in active TB, but the signature early after infection is unknown. In a unique clinically and temporally well-defined cohort of household contacts of active TB patients that progressed to TB, we define minimal changes in gene expression in incipient TB increasing in subclinical and clinical TB. While increasing with time, changes in gene expression were highest at 30 d before diagnosis, with heterogeneity in the response in household TB contacts and in a published cohort of TB progressors as they progressed to TB, at a bulk cohort level and in individual progressors. Blood signatures from patients before and during anti-TB treatment robustly monitored the treatment response distinguishing early and late responders. Blood transcriptomics thus reveal the evolution and resolution of the immune response in TB, which may help in clinical management of the disease.
MeSH term(s)	Antitubercular Agents/therapeutic use ; Biological Evolution ; Contact Tracing ; Female ; Gene Expression ; Humans ; Male ; Prospective Studies ; Risk Factors ; Sequence Analysis, RNA ; Treatment Outcome ; Tuberculosis, Pulmonary/diagnostic imaging ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/genetics ; Tuberculosis, Pulmonary/immunology
Chemical Substances	Antitubercular Agents
Language	English
Publishing date	2021-09-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20210915
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 45: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthma.

Branchett, William J / Stölting, Helen / Oliver, Robert A / Walker, Simone A / Puttur, Franz / Gregory, Lisa G / Gabryšová, Leona / Wilson, Mark S / O'Garra, Anne / Lloyd, Clare M

The Journal of allergy and clinical immunology

2019 Volume 145, Issue 2, Page(s) 666–678.e9

Abstract: Background: Although originally defined as a type 2 (T2) immune-mediated condition, non-T2 cytokines, such as IFN-γ and IL-17A, have been implicated in asthma pathogenesis, particularly in patients with severe disease. IL-10 regulates T: Objective: ... ...

Abstract	Background: Although originally defined as a type 2 (T2) immune-mediated condition, non-T2 cytokines, such as IFN-γ and IL-17A, have been implicated in asthma pathogenesis, particularly in patients with severe disease. IL-10 regulates T Objective: We sought to determine how IL-10 regulates the balance of T Methods: Allergic airway disease was induced in wild-type, IL-10 reporter, and conditional IL-10 or IL-10 receptor α (IL-10Rα) knockout mice by means of repeated intranasal administration of house dust mite (HDM). IL-10 and IFN-γ signaling were disrupted by using blocking antibodies. Results: Repeated HDM inhalation induced a mixed IL-13/IL-17A response and accumulation of IL-10-producing forkhead box P3-negative effector CD4 Conclusions: IL-10 from effector T cells signals to CD11c
MeSH term(s)	Allergens/immunology ; Animals ; Asthma/immunology ; Disease Models, Animal ; Female ; Hypersensitivity/immunology ; Interferon-gamma/immunology ; Interleukin-10/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myeloid Cells/immunology ; Pyroglyphidae/immunology ; T-Lymphocytes, Helper-Inducer/immunology
Chemical Substances	Allergens ; IL10 protein, mouse ; Interleukin-10 (130068-27-8) ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2019-08-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2019.08.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.92: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13

Science immunology

2018 Volume 3, Issue 27

Abstract: Airway hyperresponsiveness (AHR) is a critical feature of wheezing and asthma in children, but the initiating immune mechanisms remain unconfirmed. We demonstrate that both recombinant interleukin-33 (rIL-33) and allergen [house dust mite (HDM) ... ...

Abstract	Airway hyperresponsiveness (AHR) is a critical feature of wheezing and asthma in children, but the initiating immune mechanisms remain unconfirmed. We demonstrate that both recombinant interleukin-33 (rIL-33) and allergen [house dust mite (HDM) or
MeSH term(s)	Acinetobacter/immunology ; Allergens/immunology ; Alternaria/immunology ; Animals ; Animals, Newborn ; CD4-Positive T-Lymphocytes/immunology ; Female ; Interleukin-13/immunology ; Interleukin-33/genetics ; Male ; Mice, Inbred BALB C ; Mice, Knockout ; Mice, SCID ; Pyroglyphidae/immunology ; Respiratory Hypersensitivity/immunology
Chemical Substances	Allergens ; Il33 protein, mouse ; Interleukin-13 ; Interleukin-33
Language	English
Publishing date	2018-09-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.aan4128
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.

Singhania, Akul / Graham, Christine M / Gabryšová, Leona / Moreira-Teixeira, Lúcia / Stavropoulos, Evangelos / Pitt, Jonathan M / Chakravarty, Probir / Warnatsch, Annika / Branchett, William J / Conejero, Laura / Lin, Jing-Wen / Davidson, Sophia / Wilson, Mark S / Bancroft, Gregory / Langhorne, Jean / Frickel, Eva / Sesay, Abdul K / Priestnall, Simon L / Herbert, Eleanor /

Ioannou, Marianna / Wang, Qian / Humphreys, Ian R / Dodd, Jonathan / Openshaw, Peter J M / Mayer-Barber, Katrin D / Jankovic, Dragana / Sher, Alan / Lloyd, Clare M / Baldwin, Nicole / Chaussabel, Damien / Papayannopoulos, Venizelos / Wack, Andreas / Banchereau, Jacques F / Pascual, Virginia M / O'Garra, Anne

Nature communications

2019 Volume 10, Issue 1, Page(s) 2887

Abstract: Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation, we ...

Abstract	Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation, we show a breadth of immune responses in the lung. Lung immune signatures are dominated by either IFN-γ and IFN-inducible, IL-17-induced neutrophil- or allergy-associated gene expression. Type I IFN and IFN-γ-inducible, but not IL-17- or allergy-associated signatures, are preserved in the blood. While IL-17-associated genes identified in lung are detected in blood, the allergy signature is only detectable in blood CD4
MeSH term(s)	Animals ; Burkholderia pseudomallei ; Candida albicans ; Candidiasis/immunology ; Candidiasis/metabolism ; Candidiasis/microbiology ; Gene Expression Regulation/immunology ; Influenza A Virus, H3N2 Subtype ; Interferon Type I/blood ; Interferon Type I/genetics ; Interferon Type I/metabolism ; Interferon-gamma/blood ; Interferon-gamma/genetics ; Interferon-gamma/metabolism ; Lung ; Melioidosis/immunology ; Melioidosis/metabolism ; Mice ; Mice, Inbred C57BL ; Orthomyxoviridae Infections/genetics ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/metabolism ; Orthomyxoviridae Infections/virology ; Receptor, Interferon alpha-beta ; Receptors, Interferon ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Infections/metabolism ; Interferon gamma Receptor
Chemical Substances	Ifnar1 protein, mouse ; Interferon Type I ; Receptors, Interferon ; Receptor, Interferon alpha-beta (156986-95-7) ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2019-06-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-019-10601-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito