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Book ; Thesis: Die Identifikation von Schwachstellen der Informationssicherheit als Ausgangspunkt für die Prävention und Erkennung geschäftsschädigenden Informatikmissbrauchs

Brandao, Rui P

2001

Author's details	vorgelegt von Rui P. Brandao
Keywords	Datensicherheit ; Sicherheitsgewerbe ; Wirtschaftskriminalität ; Immaterialgüterrechte ; Geschäftsgeheimnis
Language	German ; English
Size	XXIV, 289 S, graph. Darst, 21 cm
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Zürich, 2001
Note	Zsfassung in engl. Sprache
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Thesis: Die Identifikation von Schwachstellen der Informationssicherheit als Ausgangspunkt für die Prävention und Erkennung geschäftsschädigenden Informatikmissbrauchs

Brandao, Rui P

2001

Author's details	vorgelegt von Rui P. Brandao
Keywords	Datensicherheit ; Sicherheitsgewerbe ; Wirtschaftskriminalität ; Immaterialgüterrechte ; Geschäftsgeheimnis
Language	German ; English
Size	XXIV, 289 S, graph. Darst, 21 cm
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Zürich, 2001
Note	Zsfassung in engl. Sprache
Database	ECONomics Information System

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Article: Comparison of Poaceae pollen counts recorded at sites in Portugal, Spain and the UK

Rodríguez, Santiago Fernández / Adams-Groom, Beverley / Palacios, Inmaculada Silva / Caeiro, Elsa / Brandao, Rui / Ferro, Raquel / Garijo, Ángela Gonzalo / Smith, Matt / Molina, Rafael Tormo

Aerobiologia. 2015 Mar., v. 31, no. 1

2015

Abstract: The main aim of this study was to analyse the temporal and spatial variations in grass (Poaceae) pollen counts (2005–2011) recorded in Évora (Portugal), Badajoz (Spain) and Worcester (UK). Weekly average data were examined using nonparametric statistics ... ...

Abstract	The main aim of this study was to analyse the temporal and spatial variations in grass (Poaceae) pollen counts (2005–2011) recorded in Évora (Portugal), Badajoz (Spain) and Worcester (UK). Weekly average data were examined using nonparametric statistics to compare differences between places. On average, Évora recorded the earliest start dates of the Poaceae pollen seasons and Worcester the latest. The intensity of the Poaceae pollen season varied between sites, with Worcester usually recording the least and Évora the most grass pollen in a season. Mean durations of grass pollen seasons were 77 days in Évora, 78 days in Badajoz and 59 days in Worcester. Overall, longer Poaceae pollen seasons coincided with earlier pollen season start dates. Weekly pollen data, from March to September, from the three pollen-monitoring stations studied were compared. The best fit and most statistically significant correlations were obtained by moving Worcester data backward by 4 weeks (Évora, r = 0.810, p < 0.001) and 5 weeks (Badajoz, r = 0.849, p < 0.001). Weekly data from Worcester therefore followed a similar pattern to that of Badajoz and Évora but at a distance of more than 1,500 km and 4–5 weeks later. The sum of pollen recorded in a season was compared with monthly rainfall between January and May. The strongest positive relationship between season intensity and rainfall was between the annual sum of Poaceae pollen recorded in the season at Badajoz and Évora and total rainfall during January and February. Winter rainfall noticeably affects the intensity of Poaceae pollen seasons in Mediterranean areas, but this was not as important in Worcester.
Keywords	Poaceae ; grasses ; pollen ; rain ; rain intensity ; statistics ; Mediterranean region ; Portugal ; Spain ; United Kingdom
Language	English
Dates of publication	2015-03
Size	p. 1-10.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	1499126-3
ISSN	1573-3025 ; 0393-5965
ISSN (online)	1573-3025
ISSN	0393-5965
DOI	10.1007/s10453-014-9338-2
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Misdosing of Non-Vitamin K Antagonist Oral Anticoagulants in Primary Care.

Cardoso, Carlos Seiça / Sousa, João André / Simões, Pedro / Silva, Beatriz / Albuquerque, Ana / Esperança, Ana / Cibrão, Ana / Correia, Artur / Gonçalves, Joana / Mortágua, Joana / Almeida, José Eduardo / Oliveira, Leonor / Garcia, José / Duarte, Mariana / Loureiro, Mariana / Costa E Silva, Marta / Fraga, Marta / Lopes, Paulo / Brandão, Rui /

Miguel, Susana / Queirós, Teresa / Santo, Gustavo / Silva, Fernando / Sargento-Freitas, João

Clinical therapeutics

2020 Volume 42, Issue 6, Page(s) 1132–1136.e1

Abstract: Purpose: Prescription patterns of non-vitamin K antagonist oral anticoagulants (NOACs) are unknown among primary care physicians, where most patients with nonvalvular atrial fibrillation (NVAF) are diagnosed and followed up. The goal of this study was ... ...

Abstract	Purpose: Prescription patterns of non-vitamin K antagonist oral anticoagulants (NOACs) are unknown among primary care physicians, where most patients with nonvalvular atrial fibrillation (NVAF) are diagnosed and followed up. The goal of this study was to evaluate overdosing and underdosing of NOACs in patients with NVAF followed up in primary care and determine their clinical predictors. Methods: This multicenter cross-sectional study included all patients with NVAF followed up in 13 primary care units in the center region of Portugal. Patients receiving antithrombotic regimens other than NOACs and patients with missing data were excluded. Findings: The study included 858 patients with NVAF on an NOAC regimen. Overall, 30.3% were prescribed an off-label dosage (25.4% with infratherapeutic dosing [ITD] and 4.9% with supratherapeutic dosing). Chronic kidney disease (odds ratio, 14.0; 95% CI, 5.4-36.5; P < 0.001) and female sex (odds ratio, 2.6; 95% CI, 1.2-5.7; P < 0.001) were independent predictors of supratherapeutic dosing. We also found a significant effect of chronic kidney disease on ITD (odds ratio, 0.22; 95% CI, 0.258-0.678; P < 0.001). Implications: In primary care, NOACs are frequently prescribed with unadjusted dosages, generally infratherapeutic. Attention should be paid to women and patients with chronic kidney disease.
MeSH term(s)	Administration, Oral ; Aged ; Aged, 80 and over ; Anticoagulants/administration & dosage ; Atrial Fibrillation/drug therapy ; Cross-Sectional Studies ; Female ; Humans ; Male ; Medication Errors ; Middle Aged ; Portugal ; Practice Patterns, Physicians' ; Primary Health Care ; Renal Insufficiency, Chronic/drug therapy
Chemical Substances	Anticoagulants
Language	English
Publishing date	2020-06-05
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	603113-4
ISSN	1879-114X ; 0149-2918
ISSN (online)	1879-114X
ISSN	0149-2918
DOI	10.1016/j.clinthera.2020.04.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Identification of potential sources of airborne Olea pollen in the Southwest Iberian Peninsula

Fernández-Rodríguez, Santiago / Skjøth, Carsten Ambelas / Tormo-Molina, Rafael / Brandao, Rui / Caeiro, Elsa / Silva-Palacios, Inmaculada / Gonzalo-Garijo, Ángela / Smith, Matt

International journal of biometeorology. 2014 Apr., v. 58, no. 3

2014

Abstract: This study aims to determine the potential origin of Olea pollen recorded in Badajoz in the Southwest of the Iberian Peninsula during 2009–2011. This was achieved using a combination of daily average and diurnal (hourly) airborne Olea pollen counts ... ...

Abstract	This study aims to determine the potential origin of Olea pollen recorded in Badajoz in the Southwest of the Iberian Peninsula during 2009–2011. This was achieved using a combination of daily average and diurnal (hourly) airborne Olea pollen counts recorded at Badajoz (south-western Spain) and Évora (south-eastern Portugal), an inventory of olive groves in the studied area and air mass trajectory calculations computed using the HYSPLIT model. Examining olive pollen episodes at Badajoz that had distinctly different diurnal cycles in olive pollen in relation to the mean, allowed us to identify three different scenarios where olive pollen can be transported to the city from either distant or nearby sources during conditions with slow air mass movements. Back trajectory analysis showed that olive pollen can be transported to Badajoz from the West on prevailing winds, either directly or on slow moving air masses, and from high densities of olive groves situated to the Southeast (e.g. Andalucía). Regional scale transport of olive pollen can result in increased nighttime concentrations of this important aeroallergen. This could be particularly important in Mediterranean countries where people can be outdoors during this time due to climate and lifestyle. Such studies that examine sources and the atmospheric transport of pollen are valuable for allergy sufferers and health care professionals because the information can be incorporated into forecasts, the outputs of which are used for avoiding exposure to aeroallergens and planning medication. The results of studies of this nature can also be used for examining gene flow in this important agricultural crop.
Keywords	Olea ; air ; climate ; drug therapy ; gene flow ; groves ; health care workers ; hypersensitivity ; inventories ; lifestyle ; models ; olives ; pollen ; Iberian Peninsula ; Mediterranean region ; Portugal ; Spain
Language	English
Dates of publication	2014-04
Size	p. 337-348.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	127361-9
ISSN	0067-8902 ; 0020-7128
ISSN	0067-8902 ; 0020-7128
DOI	10.1007/s00484-012-0629-4
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Article: Evaluation of the efficiency of the Coriolis air sampler for pollen detection in South Europe

Gómez-Domenech, Marta / García-Mozo, Herminia / Alcázar, Pura / Brandao, Rui / Caeiro, Elsa / Munhoz, Vinicius / Galán, Carmen

Aerobiologia. 2010 June, v. 26, no. 2

2010

Abstract: The Coriolis δ air sampler is a new volumetric air sampler, dedicated to outdoor monitoring of airborne biological particles, including pollen and spores. In the present work, the performance of the Coriolis in the collection of pollen grains was ... ...

Abstract	The Coriolis δ air sampler is a new volumetric air sampler, dedicated to outdoor monitoring of airborne biological particles, including pollen and spores. In the present work, the performance of the Coriolis in the collection of pollen grains was evaluated in comparison with a Hirst spore trap, the most frequently used trap in aerobiological studies, in two cities of South Europe, Evora (Portugal) and Córdoba (Spain). Both concentration values are compared, and statistical analysis was carried out. The present study indicated that, in general, pollen counts for all taxa detected with the Hirst trap were higher than those detected with the Coriolis δ in both cities. In Córdoba, significant differences were detected for all taxa except for Cupressus, Olea and Pinus, while in Evora significant differences were noted for all except Pinus and Poaceae. Differences were particularly marked in species flowering during April and May. In spite of theses differences, Spearman correlation test results showed that the relationship between Hirst and Coriolis curves was always positive and significant (p > 0.01). Regards to the number of detected taxa, the results showed greater diversity for the Hirst sampler in both cities.
Keywords	pollen
Language	English
Dates of publication	2010-06
Size	p. 149-155.
Publisher	Springer Netherlands
Publishing place	Dordrecht
Document type	Article
ZDB-ID	1499126-3
ISSN	1573-3025 ; 0393-5965
ISSN (online)	1573-3025
ISSN	0393-5965
DOI	10.1007/s10453-009-9152-4
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Article ; Online: Adult Acne: Prevalence and Portrayal in Primary Healthcare Patients, in the Greater Porto Area, Portugal.

Semedo, Diogo / Ladeiro, Filipa / Ruivo, Mariana / D'Oliveira, Carlos / De Sousa, Filipa / Gayo, Mariana / Lima, Clara / Magalhães, Frederico / Brandão, Rui / Branco, Maria / Da Silva, Isabel / Batista, Joana / Amado, João / Massa, António / Neves-Amado, João

Acta medica portuguesa

2016 Volume 29, Issue 9, Page(s) 507–513

Abstract: Introduction: Though typically found in adolescents, acne frequently affects the adult population. In Portugal, no representative studies about acne prevalence in greater populational areas are known. This study had the following objectives: calculate ... ...

Abstract	Introduction: Though typically found in adolescents, acne frequently affects the adult population. In Portugal, no representative studies about acne prevalence in greater populational areas are known. This study had the following objectives: calculate acne prevalence in primary healthcare patients; its characteristics, including risk factors for onset and worsening; collect information concerning selfmedication and/or prescribed treatment. Material and methods: Application of a questionnaire and physical examination into a convenience sample, composed by adults from20 - 60 years old that visited, in random days, five primary healthcare centers of the Greater Porto area. Results: From the 1,055 evaluated adults, acne prevalence was estimated at 61.5%. Only 36.8% of acne suffering adults was awareof their condition. More than half of tobacco users (62.3%) had acne. Just 25% of acne sufferers sought treatment. The most affected areas were the malars, differing from the younger disease form. Discussion: Acne prevalence was relatively higher than other studies. The results of this study have confirmed that acne seems to be related with increased calorie intake, tobacco smoking, whole milk and fat-reduced milk consumption, hirsutism, alopecia and seborrhea. Conclusion: In the primary healthcare set, more than half of adults were acne sufferers. These numbers show how important primary healthcare services can be in preventing and intervening when managing acne-related risk factors and psychosocial consequences.
Language	English
Publishing date	2016-09
Publishing country	Portugal
Document type	Journal Article
ZDB-ID	603078-6
ISSN	1646-0758 ; 0870-399X
ISSN (online)	1646-0758
ISSN	0870-399X
DOI	10.20344/amp.6626
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Article ; Online: Identification of potential sources of airborne Olea pollen in the Southwest Iberian Peninsula.

Fernández-Rodríguez, Santiago / Skjøth, Carsten Ambelas / Tormo-Molina, Rafael / Brandao, Rui / Caeiro, Elsa / Silva-Palacios, Inmaculada / Gonzalo-Garijo, Angela / Smith, Matt

International journal of biometeorology

2013 Volume 58, Issue 3, Page(s) 337–348

Abstract: This study aims to determine the potential origin of Olea pollen recorded in Badajoz in the Southwest of the Iberian Peninsula during 2009-2011. This was achieved using a combination of daily average and diurnal (hourly) airborne Olea pollen counts ... ...

Abstract	This study aims to determine the potential origin of Olea pollen recorded in Badajoz in the Southwest of the Iberian Peninsula during 2009-2011. This was achieved using a combination of daily average and diurnal (hourly) airborne Olea pollen counts recorded at Badajoz (south-western Spain) and Évora (south-eastern Portugal), an inventory of olive groves in the studied area and air mass trajectory calculations computed using the HYSPLIT model. Examining olive pollen episodes at Badajoz that had distinctly different diurnal cycles in olive pollen in relation to the mean, allowed us to identify three different scenarios where olive pollen can be transported to the city from either distant or nearby sources during conditions with slow air mass movements. Back trajectory analysis showed that olive pollen can be transported to Badajoz from the West on prevailing winds, either directly or on slow moving air masses, and from high densities of olive groves situated to the Southeast (e.g. Andalucía). Regional scale transport of olive pollen can result in increased nighttime concentrations of this important aeroallergen. This could be particularly important in Mediterranean countries where people can be outdoors during this time due to climate and lifestyle. Such studies that examine sources and the atmospheric transport of pollen are valuable for allergy sufferers and health care professionals because the information can be incorporated into forecasts, the outputs of which are used for avoiding exposure to aeroallergens and planning medication. The results of studies of this nature can also be used for examining gene flow in this important agricultural crop.
MeSH term(s)	Air Pollutants/analysis ; Air Pollution/statistics & numerical data ; Allergens/analysis ; Atmosphere/analysis ; Atmosphere/chemistry ; Cities/statistics & numerical data ; Climate ; Computer Simulation ; Environmental Monitoring/methods ; Models, Statistical ; Olea/chemistry ; Pollen/chemistry ; Portugal ; Seasons ; Spatio-Temporal Analysis ; Wind
Chemical Substances	Air Pollutants ; Allergens
Language	English
Publishing date	2013-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280324-0
ISSN	1432-1254 ; 0020-7128
ISSN (online)	1432-1254
ISSN	0020-7128
DOI	10.1007/s00484-012-0629-4
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Article ; Online: Variation of the group 5 grass pollen allergen content of airborne pollen in relation to geographic location and time in season.

The Journal of allergy and clinical immunology

2015 Volume 136, Issue 1, Page(s) 87–95.e6

Abstract: Background: Allergies to grass pollen are the number one cause of outdoor hay fever. The human immune system reacts with symptoms to allergen from pollen.: Objective: We investigated the natural variability in release of the major group 5 allergen ... ...

Abstract	Background: Allergies to grass pollen are the number one cause of outdoor hay fever. The human immune system reacts with symptoms to allergen from pollen. Objective: We investigated the natural variability in release of the major group 5 allergen from grass pollen across Europe. Methods: Airborne pollen and allergens were simultaneously collected daily with a volumetric spore trap and a high-volume cascade impactor at 10 sites across Europe for 3 consecutive years. Group 5 allergen levels were determined with a Phl p 5-specific ELISA in 2 fractions of ambient air: particulate matter of greater than 10 μm in diameter and particulate matter greater than 2.5 μm and less than 10 μm in diameter. Mediator release by ambient air was determined in FcεRI-humanized basophils. The origin of pollen was modeled and condensed to pollen potency maps. Results: On average, grass pollen released 2.3 pg of Phl p 5 per pollen. Allergen release per pollen (potency) varied substantially, ranging from less than 1 to 9 pg of Phl p 5 per pollen (5% to 95% percentile). The main variation was locally day to day. Average potency maps across Europe varied between years. Mediator release from basophilic granulocytes correlated better with allergen levels per cubic meter (r(2) = 0.80, P < .001) than with pollen grains per cubic meter (r(2) = 0.61, P < .001). In addition, pollen released different amounts of allergen in the non-pollen-bearing fraction of ambient air, depending on humidity. Conclusion: Across Europe, the same amount of pollen released substantially different amounts of group 5 grass pollen allergen. This variation in allergen release is in addition to variations in pollen counts. Molecular aerobiology (ie, determining allergen in ambient air) might be a valuable addition to pollen counting.
MeSH term(s)	Air/analysis ; Basophils/physiology ; Cell Degranulation ; Europe ; Humans ; Humidity ; Particulate Matter/analysis ; Plant Proteins/analysis ; Poaceae/immunology ; Pollen/chemistry ; Receptors, IgE/genetics ; Receptors, IgE/metabolism ; Rhinitis, Allergic, Seasonal/epidemiology ; Rhinitis, Allergic, Seasonal/immunology ; Seasons
Chemical Substances	FcepsilonRI gamma-chain, human ; Particulate Matter ; Phl p V protein, Phleum pratense ; Plant Proteins ; Receptors, IgE
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2015.01.049
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Article: Release of Bet v 1 from birch pollen from 5 European countries. Results from the HIALINE study

Buters, Jeroen T.M / Thibaudon, Michel / Smith, Matt / Kennedy, Roy / Rantio-Lehtimäki, Auli / Albertini, Roberto / Reese, Gerald / Weber, Bernhard / Galan, Carmen / Brandao, Rui / Antunes, Celia M / Jäger, Siegfried / Berger, Uwe / Celenk, Sevcan / Grewling, Łukasz / Jackowiak, Bogdan / Sauliene, Ingrida / Weichenmeier, Ingrid / Pusch, Gudrun /

Sarioglu, Hakan / Ueffing, Marius / Behrendt, Heidrun / Prank, Marje / Sofiev, Mikhail / Cecchi, Lorenzo

Atmospheric environment. 2012 Aug., v. 55

2012

Abstract: Exposure to allergens is pivotal in determining sensitization and allergic symptoms in individuals. Pollen grain counts in ambient air have traditionally been assessed to estimate airborne allergen exposure. However, the exact allergen content of ambient ...

Institution	The HIALINE working group
Abstract	Exposure to allergens is pivotal in determining sensitization and allergic symptoms in individuals. Pollen grain counts in ambient air have traditionally been assessed to estimate airborne allergen exposure. However, the exact allergen content of ambient air is unknown. We therefore monitored atmospheric concentrations of birch pollen grains and the matched major birch pollen allergen Bet v 1 simultaneously across Europe within the EU-funded project HIALINE (Health Impacts of Airborne Allergen Information Network). Pollen count was assessed with Hirst type pollen traps at 10 l min⁻¹ at sites in France, United Kingdom, Germany, Italy and Finland. Allergen concentrations in ambient air were sampled at 800 l min⁻¹ with a Chemvol® high-volume cascade impactor equipped with stages PM > 10 μm, 10 μm > PM > 2.5 μm, and in Germany also 2.5 μm > PM > 0.12 μm. The major birch pollen allergen Bet v 1 was determined with an allergen specific ELISA. Bet v 1 isoform patterns were analyzed by 2D-SDS-PAGE blots and mass spectrometric identification. Basophil activation was tested in an FcɛR1-humanized rat basophil cell line passively sensitized with serum of a birch pollen symptomatic patient. Compared to 10 previous years, 2009 was a representative birch pollen season for all stations. About 90% of the allergen was found in the PM > 10 μm fraction at all stations. Bet v 1 isoforms pattern did not vary substantially neither during ripening of pollen nor between different geographical locations. The average European allergen release from birch pollen was 3.2 pg Bet v 1/pollen and did not vary much between the European countries. However, in all countries a >10-fold difference in daily allergen release per pollen was measured which could be explained by long-range transport of pollen with a deviating allergen release. Basophil activation by ambient air extracts correlated better with airborne allergen than with pollen concentration. Although Bet v 1 is a mixture of different isoforms, its fingerprint is constant across Europe. Bet v 1 was also exclusively linked to pollen. Pollen from different days varied >10-fold in allergen release. Thus exposure to allergen is inaccurately monitored by only monitoring birch pollen grains. Indeed, a humanized basophil activation test correlated much better with allergen concentrations in ambient air than with pollen count. Monitoring the allergens themselves together with pollen in ambient air might be an improvement in allergen exposure assessment.
Keywords	Betula ; air ; allergens ; atmospheric chemistry ; blood serum ; enzyme-linked immunosorbent assay ; exposure assessment ; mass spectrometry ; monitoring ; patients ; pollen ; rats ; ripening ; spore traps ; Finland ; France ; Germany ; Italy ; United Kingdom
Language	English
Dates of publication	2012-08
Size	p. 496-505.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	216368-8
ISSN	0004-6981 ; 1352-2310
ISSN	0004-6981 ; 1352-2310
DOI	10.1016/j.atmosenv.2012.01.054
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