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Article ; Online: Digital biomarkers of mobility and quality of life in Parkinson's disease based on a wearable motion analysis LAB.

Gonçalves, Helena R / Branquinho, André / Pinto, Joana / Rodrigues, Ana Margarida / Santos, Cristina P

Computer methods and programs in biomedicine

2023 Volume 244, Page(s) 107967

Abstract: Background and objective: Functional mobility, an indicator of the quality of life (QoL), requires fast and flexible changes during motion, which are limited in Parkinson's disease (PD). Recent body-worn sensors have emerged in the last decades as ... ...

Abstract	Background and objective: Functional mobility, an indicator of the quality of life (QoL), requires fast and flexible changes during motion, which are limited in Parkinson's disease (PD). Recent body-worn sensors have emerged in the last decades as potential solutions to produce digital biomarkers able to quantify mobility outside routine consultations and during real-life scenarios for multiple days at a time. The proposed research aims to study the ability of a wearable motion analysis lab, developed by our team, to produce digital biomarkers of mobility and QoL levels in patients with PD. Methods: A cross-sectional study was followed, including 40 patients stratified into three subgroups according to a clinic motor examination and a QoL questionnaire. Results: The achieved outcomes demonstrate the ability of the proposed high-tech solution to measure prototypical gait impairments and discriminate motor condition (AUC=0,890) and patients' QoL levels (AUC=0,950). Also, from the measured multiple gait-associated parameters, we identified the variables with the most potential to be applied as digital biomarkers of mobility (67 % of the metrics) and QoL (72 % of the metrics) in PD. Conclusions: Overall, we confirmed our hypothesis of using our body-worn sensor-based solution for passive or active monitoring of mobility and QoL in PD to produce objective, feasible, and continuous digital biomarkers.
MeSH term(s)	Humans ; Parkinson Disease/diagnosis ; Quality of Life ; Cross-Sectional Studies ; Biomarkers ; Wearable Electronic Devices
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-12-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632564-6
ISSN	1872-7565 ; 0169-2607
ISSN (online)	1872-7565
ISSN	0169-2607
DOI	10.1016/j.cmpb.2023.107967
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Article: The impact of remote work on worker's health.

Roque, Alexandra Lima / Pimenta, Silvia Maria / Ribeiro, Rita / Branquinho, Ana / Valente, Teresa Martinho / Perea, Elvira Rodriguez / Fonnegra, Juan Carlos

Revista brasileira de medicina do trabalho : publicacao oficial da Associacao Nacional de Medicina do Trabalho-ANAMT

2023 Volume 20, Issue 4, Page(s) 691–695

Abstract: Remote work was brought to the forefront with the arrival of the COVID-19 public health emergency. Although there is no evidence of a direct cause-and-effect relationship between venous disease and work, the current medical consensus is that work can ... ...

Abstract	Remote work was brought to the forefront with the arrival of the COVID-19 public health emergency. Although there is no evidence of a direct cause-and-effect relationship between venous disease and work, the current medical consensus is that work can severely intensify its progression. Here, we report the case of a worker at a financial institution, who had been working remotely for around one year and had stopped exercising regularly for the same period. In January 2021, he presented intense pain and marked edema in the soleus area of the right lower limb, which prompted a visit to the emergency department. Laboratory analyses showed slight increases in d-dimer (720 ng/mL) and C-reactive protein (5 mg/dL) levels. A venous Doppler ultrasound of the lower limbs revealed the presence of an occlusive thrombus in the right soleus veins, reaching the right popliteal vein with associated venous dilation. The diagnosis of right, popliteal-distal acute deep vein thrombosis was thus reached. It is clearly impossible to change some of the risk factors of chronic venous insufficiency; however, other aspects such as obesity and working conditions can be the object of preventive actions that generate changes. We thus highlight the importance and possibility of a multidisciplinary approach to this theme, which could evolve into the establishment of a protocol for the prevention and treatment of venous diseases according to each job position.
Language	English
Publishing date	2023-02-13
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	2735204-3
ISSN	1679-4435
ISSN	1679-4435
DOI	10.47626/1679-4435-2022-828
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Article: Multidisciplinary Approach to Spinal Metastases and Metastatic Spinal Cord Compression-A New Integrative Flowchart for Patient Management.

Esperança-Martins, Miguel / Roque, Diogo / Barroso, Tiago / Abrunhosa-Branquinho, André / Belo, Diogo / Simas, Nuno / Costa, Luis

Cancers

2023 Volume 15, Issue 6

Abstract: Metastatic spine disease (MSD) and metastatic spinal cord compression (MSCC) are major causes of permanent neurological damage and long-term disability for cancer patients. The development of MSD is pathophysiologically framed by a cooperative ... ...

Abstract	Metastatic spine disease (MSD) and metastatic spinal cord compression (MSCC) are major causes of permanent neurological damage and long-term disability for cancer patients. The development of MSD is pathophysiologically framed by a cooperative interaction between general mechanisms of bone growth and specific mechanisms of spinal metastases (SM) expansion. SM most commonly affects the thoracic spine, even though multiple segments may be affected concomitantly. The great majority of SM are extradural, while intradural-extramedullary and intramedullary metastases are less frequently seen. The management of patients with SM is particularly complex and challenging, with multiple factors-such as the spinal stability status, primary tumor radio and chemosensitivity, cancer biological burden, patient performance status and comorbidities, and patient's oncological prognosis-influencing the clinical decision-making process. Different frameworks were developed in order to systematize and support this process. A multidisciplinary, personalized approach, enriched by the expertise of each involved specialty, is crucial. We reviewed the most recent evidence and proposed an updated algorithmic approach to patients with MSD according to the clinical scenario of each patient. A flowchart-based approach offers an evidence-based management of MSD, providing a valuable clinical decision tool in a context of high uncertainty and quick-acting need.
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15061796
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Book ; Online: Design and Experimental Evaluation of a Bluetooth 5.1 Antenna Array for Angle-of-Arrival Estimation

Paulino, Nuno / Pessoa, Luís M. / Branquinho, André / Gonçalves, Edgar

2022

Abstract: On the of the applications in the realm of the Internet-of-Things (IoT) is real-time localization of assets in specific application environments where satellite based global positioning is unviable. Numerous approaches for localization relying on ... ...

Abstract	On the of the applications in the realm of the Internet-of-Things (IoT) is real-time localization of assets in specific application environments where satellite based global positioning is unviable. Numerous approaches for localization relying on wireless sensor mesh systems have been evaluated, but the recent Bluetooth Low Energy (BLE) 5.1 direction finding features based on Angle-of-Arrival (AoA) promise a low-cost solution for this application. In this paper, we present an implementation of a BLE 5.1 based circular antenna array, and perform two experimental evaluations over the quality of the retrieved data sampled from the array: in an anechoic chamber, and in a real-world environment using a setup composed of four BLE beacons.
Keywords	Electrical Engineering and Systems Science - Signal Processing
Publishing date	2022-04-26
Publishing country	us
Document type	Book ; Online
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Article: A Tailored Approach for Appendicular Impending and Pathologic Fractures in Solid Cancer Metastases.

Soares do Brito, Joaquim / Lopes-Brás, Raquel / Abrunhosa-Branquinho, André / Fernandes, Isabel / Gomes, Inês / Casimiro, Sandra / Costa, Luís

Cancers

2022 Volume 14, Issue 4

Abstract: Advances in medical and surgical treatment have played a major role in increasing the survival rates of cancer patients with metastatic bone disease. The clinical course of patients with bone metastases is often impaired by bone complications, such as ... ...

Abstract	Advances in medical and surgical treatment have played a major role in increasing the survival rates of cancer patients with metastatic bone disease. The clinical course of patients with bone metastases is often impaired by bone complications, such as bone fractures, which have a substantial negative impact on clinical outcomes. To optimize clinical results and prevent a detrimental impact on patients' health, a tailored approach should be defined for any given patient. The optimal management of impending or pathologic fractures is unknown and relies on a multidisciplinary approach to tailor clinical decisions to each individual patient. The ability to control systemic disease, the extent, location and nature of bone metastases, and the biology of the underlying tumor, are the main factors that will define the strategy to follow. The present review covers the most recent data regarding impending and pathologic fractures in patients with bone metastases, and discusses the medical and surgical management of patients presenting with metastatic bone disease in different clinical settings.
Language	English
Publishing date	2022-02-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14040893
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Article ; Online: Validation of the Ottawa ankle rules: Strategies for increasing specificity.

Morais, Bruno / Branquinho, André / Barreira, Mariana / Correia, Joana / Machado, Marino / Marques, Nuno / Ferrão, Ana / Nóbrega, João / Teixeira, Frederico / Diogo, Nuno

Injury

2021 Volume 52, Issue 4, Page(s) 1017–1022

Abstract: Introduction: The majority of patients with ankle injuries undergo radiological examinations of the foot, ankle or both. The objective of this study was in the first place to validate the Ottawa Ankle Rules (OARs) for the population of our centre. ... ...

Abstract	Introduction: The majority of patients with ankle injuries undergo radiological examinations of the foot, ankle or both. The objective of this study was in the first place to validate the Ottawa Ankle Rules (OARs) for the population of our centre. Secondly, an attempt was made to identify parameters that contribute to improve the specificity of the method, with a view to reduce the need for patients to be exposed to radiation as well as optimizing the expenses of the Emergency Ward (EW). Materials and methods: This was a prospective study conducted during a 9-month period. The study population included 148 patients, in 54 (36%) of the patients a fracture was present on the exams performed. Patients were submitted to a sequential protocol in the EW with a form completion, evaluation of OARs, application of the Visual Analog Pain Scale (VAS) and radiographic exams. Results: We found a sensitivity of OARs in ankle injuries of 100%, specificity of 26% and in midfoot injuries of 100% and 62% respectively. All patients with fractures had a VAS of 5 or more points in any of the tested sites. With the VAS criterium, we found a significant increase of global specificity (38% vs 15%), as well as when applied only to the ankle (26% to 47%) or to midfoot trauma (62% to 67%). In both, there would have been a 100% reduction of CT scans. Patients with a fracture or with fractures who required surgical treatment had a mean VAS significantly higher than patients with no fracture or fractures submitted to conservative treatment respectively. Although there was a lower percentage of fractures in the group of injuries in Work Accidents (31% vs 37% Sports Activity and 38% Leisure Activity), there was a statistically significant increase in the sum of average VAS in Accidents at Work vs Leisure Activities and vs Sports Activities. Conclusion: We seek to confirm the usefulness of OARs for our population and we investigated strategies to further reduce the need for unnecessary radiographs. The introduction of parameters for grading pain and adapting to the context of the accident seem promising.
MeSH term(s)	Ankle ; Ankle Injuries/diagnostic imaging ; Foot Injuries/diagnostic imaging ; Fractures, Bone/diagnostic imaging ; Humans ; Prospective Studies ; Sensitivity and Specificity
Language	English
Publishing date	2021-01-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2021.01.006
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Article ; Online: Quality assurance of radiotherapy in the ongoing EORTC 1420 "Best of" trial for early stage oropharyngeal, supraglottic and hypopharyngeal carcinoma: results of the benchmark case procedure.

Stelmes, J-J / Vu, E / Grégoire, V / Simon, C / Clementel, E / Kazmierska, J / Grant, W / Ozsahin, M / Tomsej, M / Vieillevigne, L / Fortpied, C / Hurkmans, E C / Branquinho, A / Andratschke, N / Zimmermann, F / Weber, D-C

Radiation oncology (London, England)

2021 Volume 16, Issue 1, Page(s) 81

Abstract: Introduction: The current phase III EORTC 1420 Best-of trial (NCT02984410) compares the swallowing function after transoral surgery versus intensity modulated radiotherapy (RT) in patients with early-stage carcinoma of the oropharynx, supraglottis and ... ...

Abstract	Introduction: The current phase III EORTC 1420 Best-of trial (NCT02984410) compares the swallowing function after transoral surgery versus intensity modulated radiotherapy (RT) in patients with early-stage carcinoma of the oropharynx, supraglottis and hypopharynx. We report the analysis of the Benchmark Case (BC) procedures before patient recruitment with special attention to dysphagia/aspiration related structures (DARS). Materials and methods: Submitted RT volumes and plans from participating centers were analyzed and compared against the gold-standard expert delineations and dose distributions. Descriptive analysis of protocol deviations was conducted. Mean Sorensen-Dice similarity index (mDSI) and Hausdorff distance (mHD) were applied to evaluate the inter-observer variability (IOV). Results: 65% (23/35) of the institutions needed more than one submission to achieve Quality assurance (RTQA) clearance. OAR volume delineations were the cause for rejection in 53% (40/76) of cases. IOV could be improved in 5 out of 12 OARs by more than 10 mm after resubmission (mHD). Despite this, final IOV for critical OARs in delineation remained significant among DARS by choosing an aleatory threshold of 0.7 (mDSI) and 15 mm (mHD). Conclusions: This is to our knowledge the largest BC analysis among Head and neck RTQA programs performed in the framework of a prospective trial. Benchmarking identified non-common OARs and target delineations errors as the main source of deviations and IOV could be reduced in a significant number of cases after this process. Due to the substantial resources involved with benchmarking, future benchmark analyses should assess fully the impact on patients' clinical outcome.
MeSH term(s)	Benchmarking/methods ; Clinical Trials, Phase III as Topic ; Humans ; Hypopharyngeal Neoplasms/pathology ; Hypopharyngeal Neoplasms/radiotherapy ; Observer Variation ; Organs at Risk/radiation effects ; Oropharyngeal Neoplasms/pathology ; Oropharyngeal Neoplasms/radiotherapy ; Prognosis ; Quality Assurance, Health Care/standards ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Intensity-Modulated/methods ; Retrospective Studies ; Supraglottitis/pathology ; Supraglottitis/radiotherapy
Language	English
Publishing date	2021-05-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2224965-5
ISSN	1748-717X ; 1748-717X
ISSN (online)	1748-717X
ISSN	1748-717X
DOI	10.1186/s13014-021-01809-2
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Article: Management of Unresectable Localized Pelvic Bone Sarcomas: Current Practice and Future Perspectives.

Soares do Brito, Joaquim / Esperança-Martins, Miguel / Abrunhosa-Branquinho, André / Melo-Alvim, Cecilia / Lopes-Brás, Raquel / Janeiro, João / Lopez-Presa, Dolores / Fernandes, Isabel / Portela, José / Costa, Luis

Cancers

2022 Volume 14, Issue 10

Abstract: Bone sarcomas (BS) are rare mesenchymal tumors usually located in the extremities and pelvis. While surgical resection is the cornerstone of curative treatment, some locally advanced tumors are deemed unresectable and hence not suitable for curative ... ...

Abstract	Bone sarcomas (BS) are rare mesenchymal tumors usually located in the extremities and pelvis. While surgical resection is the cornerstone of curative treatment, some locally advanced tumors are deemed unresectable and hence not suitable for curative intent. This is often true for pelvic sarcoma due to anatomic complexity and proximity to vital structures, making treatment options for these tumors generally limited and not unanimous, with decisions being made on an individual basis after multidisciplinary discussion. Several studies have been published in recent years focusing on innovative treatment options for patients with locally advanced sarcoma not amenable to local surgery. The present article reviews the evidence regarding the treatment of patients with locally advanced and unresectable pelvic BS, with the goal of providing an overview of treatment options for the main BS histologic subtypes involving this anatomic area and exploring future therapeutic perspectives. The management of unresectable localized pelvic BS represents a major challenge and is hampered by the lack of comprehensive and standardized guidelines. As such, the optimal treatment needs to be individually tailored, weighing a panoply of patient- and tumor-related factors. Despite the bright prospects raised by novel therapeutic approaches, the role of each treatment option in the therapeutic armamentarium of these patients requires solid clinical evidence before becoming fully established.
Language	English
Publishing date	2022-05-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14102546
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Article: A case of post-radiotherapy gastritis: radiation does not explain everything.

Abrunhosa-Branquinho, André / Barata, Pedro / Vitorino, Emília / Oliveira, Emília / Bujor, Laurentiu / Jorge, Marília

Case reports in oncology

2015 Volume 8, Issue 1, Page(s) 9–14

Abstract: Hemorrhagic gastritis is a possible late toxicity outcome after radical radiotherapy but it is nowadays a very rare condition and most likely depends on other clinical factors. We report the case of a 77-year-old woman with a symptomatic solitary ... ...

Abstract	Hemorrhagic gastritis is a possible late toxicity outcome after radical radiotherapy but it is nowadays a very rare condition and most likely depends on other clinical factors. We report the case of a 77-year-old woman with a symptomatic solitary extramedullary intra-abdominal plasmacytoma and multiple gastric comorbidities, treated with external beam radiotherapy. Despite the good response to radiotherapy, the patient experienced multiple gastric bleeding a few months later, with the need of multiple treatments for its control. In this paper we will discuss in detail all aspects related to the different causes of hemorrhagic gastritis.
Language	English
Publishing date	2015-01-14
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2458961-5
ISSN	1662-6575
ISSN	1662-6575
DOI	10.1159/000371653
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Article ; Online: Profile of European proton and carbon ion therapy centers assessed by the EORTC facility questionnaire

Weber, D.C. / Abrunhosa Branquinho, A. / Bolsi, A. / Kacperek, A. / Dendale, R. / Geismar, D. / Bachtiary, B. / Hall, A. / Heufelder, J. / Herfarth, K. / Debus, J. / Amichetti, M. / Krause, M. / Orecchia, R. / Vondracek, V. / Thariat, J. / Kajdrowicz, T. / Nilsson, K. / Grau, C.

2017

Abstract: Background We performed a survey using the modified EORTC Facility questionnaire pFQ to evaluate the human, technical and organizational resources of particle centers in Europe. Material and methods The modified pFQ consisted of 235 questions distributed ...

Abstract	Background We performed a survey using the modified EORTC Facility questionnaire pFQ to evaluate the human, technical and organizational resources of particle centers in Europe. Material and methods The modified pFQ consisted of 235 questions distributed in 11 sections accessible on line on an EORTC server. Fifteen centers from 8 countries completed the pFQ between May 2015 and December 2015. Results The average number of patients treated per year and per particle center was 221 range, 40 557 . The majority 66.7 of centers had pencil beam or raster scanning capability. Four 27 centers were dedicated to eye treatment only. An increase in the patients health professional FTE ratio was observed for eye tumor only centers when compared to other centers. All centers treated routinely chordomas chondrosarcomas, brain tumors and sarcomas but rarely breast cancer. The majority of centers treated pediatric cases with particles. Only a minority of the queried institutions treated non static targets. Conclusions As the number of particle centers coming online will increase, the experience with this treatment modality will rise in Europe. Children can currently be treated in these facilities in a majority of cases. The majority of these centers provide state of the art particle beam therapy. 2017 Elsevier B.V. All rights reserved. Radiotherapy and Oncology 124 2017 185 189
Keywords	Accelerator research and development
Subject code	616
Language	Undetermined
Publishing date	2017-01-01
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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