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  1. Article: Effects of unilateral superimposed high-frequency jet ventilation on porcine hemodynamics and gas exchange during one-lung flooding.

    Lesser, Thomas / Wolfram, Frank / Braun, Conny / Gottschall, Reiner

    World journal of experimental medicine

    2024  Volume 14, Issue 1, Page(s) 87256

    Abstract: Background: Superimposed high-frequency jet ventilation (SHFJV) is suitable for respiratory motion reduction and essential for effective lung tumor ablation. Fluid filling of the target lung wing one-lung flooding (OLF) is necessary for therapeutic ... ...

    Abstract Background: Superimposed high-frequency jet ventilation (SHFJV) is suitable for respiratory motion reduction and essential for effective lung tumor ablation. Fluid filling of the target lung wing one-lung flooding (OLF) is necessary for therapeutic ultrasound applications. However, whether unilateral SHFJV allows adequate hemodynamics and gas exchange is unclear.
    Aim: To compared SHFJV with pressure-controlled ventilation (PCV) during OLF by assessing hemodynamics and gas exchange in different animal positions.
    Methods: SHFJV or PCV was used alternatingly to ventilate the non-flooded lungs of the 12 anesthetized pigs during OLF. The animal positions were changed from left lateral position to supine position (SP) to right lateral position (RLP) every 30 min. In each position, ventilation was maintained for 15 min in both modalities. Hemodynamic variables and arterial blood gas levels were repeatedly measured.
    Results: Unilateral SHFJV led to lower carbon dioxide removal than PCV without abnormally elevated carbon dioxide levels. SHFJV slightly decreased oxygenation in SP and RLP compared with PCV; the lowest values of PaO
    Conclusion: In porcine model, unilateral SHFJV may provide adequate ventilation in different animal positions during OLF. Lower oxygenation and CO
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2764849-7
    ISSN 2220-315X
    ISSN 2220-315X
    DOI 10.5493/wjem.v14.i1.87256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A special double lumen tube for use in pigs is suitable for different lung ventilation conditions.

    Lesser, Thomas / Braun, Conny / Wolfram, Frank / Gottschall, Reiner

    Research in veterinary science

    2020  Volume 133, Page(s) 111–116

    Abstract: Previous studies of haemodynamic and blood gas variables during one-lung ventilation in pigs have used a double lumen tube designed for use in humans. However, because of interspecies differences in bronchial anatomy, a special design for pigs is ... ...

    Abstract Previous studies of haemodynamic and blood gas variables during one-lung ventilation in pigs have used a double lumen tube designed for use in humans. However, because of interspecies differences in bronchial anatomy, a special design for pigs is required. In this study, we evaluated a new left-sided double lumen endobronchial tube designed for use in pigs under different lung ventilation conditions. Ten female pigs (weighing 35-40 kg) were transorally intubated, first with a single lumen tube and then with the left-sided double lumen tube for pigs, and mechanically ventilated. Haemodynamic and blood gas variables were recorded before and after intubation with the double lumen tube and before and after one-lung flooding of the left lung with saline solution. Each pig was repositioned (left lateral, to dorsal, to right lateral) every 30 min during one-lung flooding. Bronchoscopy and thoracic radiography were performed at fixed intervals. Blood gas variables during two-lung ventilation were not impaired by intubation with the double lumen endobronchial tube for pigs, compared with intubation with the single lumen tube. Haemodynamic and blood gas variables were not impaired by one-lung flooding. Complete flooding of the left lung was achieved for all pigs. Two-lung ventilation to reventilate the previously flooded lung provided complete air filling for all pigs. Use of this tube resulted in lung separation without obstruction of bronchi or resultant atelectasis. In this study, the new double lumen tube for pigs was safe for one-lung flooding and prevented fluid entry into the non-flooded lung.
    MeSH term(s) Animals ; Bronchoscopy/veterinary ; Female ; Hemodynamics ; Intubation, Intratracheal/instrumentation ; Intubation, Intratracheal/veterinary ; One-Lung Ventilation/instrumentation ; One-Lung Ventilation/veterinary ; Radiography ; Swine/anatomy & histology
    Language English
    Publishing date 2020-09-12
    Publishing country England
    Document type Evaluation Study ; Journal Article
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2020.09.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 673: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Effects of one-lung flooding on porcine haemodynamics and gas exchange.

    Lesser, Thomas / Wolfram, Frank / Braun, Conny / Gottschall, Reiner

    International journal of medical sciences

    2020  Volume 17, Issue 18, Page(s) 3165–3173

    Abstract: Background and aim: ...

    Abstract Background and aim:
    MeSH term(s) Animals ; Biopsy, Needle/methods ; Disease Models, Animal ; Female ; Hemodynamics/physiology ; Humans ; Image-Guided Biopsy/methods ; Lung/diagnostic imaging ; Lung/pathology ; Lung/physiology ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Pulmonary Gas Exchange/physiology ; Sus scrofa ; Ultrasonography, Interventional/methods
    Language English
    Publishing date 2020-10-23
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.50852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A special double lumen tube for use in pigs is suitable for different lung ventilation conditions

    Lesser, Thomas / Braun, Conny / Wolfram, Frank / Gottschall, Reiner

    Research in veterinary science. 2020 Dec., v. 133

    2020  

    Abstract: Previous studies of haemodynamic and blood gas variables during one-lung ventilation in pigs have used a double lumen tube designed for use in humans. However, because of interspecies differences in bronchial anatomy, a special design for pigs is ... ...

    Abstract Previous studies of haemodynamic and blood gas variables during one-lung ventilation in pigs have used a double lumen tube designed for use in humans. However, because of interspecies differences in bronchial anatomy, a special design for pigs is required. In this study, we evaluated a new left-sided double lumen endobronchial tube designed for use in pigs under different lung ventilation conditions.Ten female pigs (weighing 35–40 kg) were transorally intubated, first with a single lumen tube and then with the left-sided double lumen tube for pigs, and mechanically ventilated. Haemodynamic and blood gas variables were recorded before and after intubation with the double lumen tube and before and after one-lung flooding of the left lung with saline solution. Each pig was repositioned (left lateral, to dorsal, to right lateral) every 30 min during one-lung flooding. Bronchoscopy and thoracic radiography were performed at fixed intervals.Blood gas variables during two-lung ventilation were not impaired by intubation with the double lumen endobronchial tube for pigs, compared with intubation with the single lumen tube. Haemodynamic and blood gas variables were not impaired by one-lung flooding. Complete flooding of the left lung was achieved for all pigs. Two-lung ventilation to reventilate the previously flooded lung provided complete air filling for all pigs. Use of this tube resulted in lung separation without obstruction of bronchi or resultant atelectasis. In this study, the new double lumen tube for pigs was safe for one-lung flooding and prevented fluid entry into the non-flooded lung.
    Keywords air ; blood gases ; breathing ; bronchoscopy ; females ; hemodynamics ; radiography ; research ; sodium chloride ; swine ; veterinary medicine
    Language English
    Dates of publication 2020-12
    Size p. 111-116.
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2020.09.007
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2292: Show issues

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  5. Article ; Online: In Vivo Assessment of Lung Ultrasound Features Mimicking Viral Pneumonia Using a Large Animal Model.

    Wolfram, Frank / Braun, Conny / Gutsche, Holger / Lesser, Thomas Guenther

    IEEE transactions on ultrasonics, ferroelectrics, and frequency control

    2020  Volume 67, Issue 11, Page(s) 2258–2264

    Abstract: Lung ultrasound (LUS) is a practical tool for lung diagnosis when computer tomography (CT) is not available. Recent findings suggest that LUS diagnosis is highly advantageous because of its mobility and correlation with radiological findings for viral ... ...

    Abstract Lung ultrasound (LUS) is a practical tool for lung diagnosis when computer tomography (CT) is not available. Recent findings suggest that LUS diagnosis is highly advantageous because of its mobility and correlation with radiological findings for viral pneumonia. Simple models for both educational evaluation and technical evaluation are needed. Therefore, this work investigates the usability of a large animal model under aspects of LUS features of viral pneumonia using saline one lung flooding. Six pigs were intubated with a double-lumen tube, and the left lung was instilled with saline. During the instillation of up to 12.5 ml/kg, the sonographic features were assessed. All features present during viral pneumonia were found, such as B-lines, white lung syndrome, pleural thickening, and the formation of pleural consolidations. Sonographic findings correlate well with current LUS scores for COVID19. The scores of 1, 2, and 3 were dominantly present at 1-4-, 4-8-, and 8-12-ml/kg saline instillation, respectively. The noninfective animal model can be used for further investigation of the LUS features and can serve in education, by helping with the appropriate handling of LUS in clinical practice during management of viral pneumonia.
    MeSH term(s) Animals ; COVID-19 ; Female ; Image Interpretation, Computer-Assisted/methods ; Lung/diagnostic imaging ; Lung/pathology ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/pathology ; Swine ; Ultrasonography/methods
    Keywords covid19
    Language English
    Publishing date 2020-07-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1525-8955
    ISSN (online) 1525-8955
    DOI 10.1109/TUFFC.2020.3010299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Ernährungsphysiologische Beurteilung kommerzieller Feucht-Alleinfuttermittel für Katzen.

    Rückert, Cornelia / Braun, Conny / Vervuert, Ingrid

    Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere

    2017  Volume 45, Issue 4, Page(s) 219–225

    Abstract: Objective: To evaluate commercial complete canned cat foods according to their composition, labeling and nutritional characteristics.: Materials and methods: A total of 21 commercial complete canned compound feeds for adult cats were analyzed for ... ...

    Title translation Evaluation of nutritional characteristics of commercial canned cat diets.
    Abstract Objective: To evaluate commercial complete canned cat foods according to their composition, labeling and nutritional characteristics.
    Materials and methods: A total of 21 commercial complete canned compound feeds for adult cats were analyzed for crude nutrients, minerals, vitamins, selected amino acids and taurine. The analyzed parameters were compared to the internal set of standards of the European Pet Food Industry Federation (FEDIAF). The energy content was calculated and compared with the labeled recommendations regarding the amounts of diet that should be fed. Analyzed nutrients were compared with the labeled nutrients according to the regulations of the EU food and feed law (directive EU regulation 767/2009).
    Results: In many cases, the labeled feeding protocols did not match the calculated daily energy requirements. In eight complete foods, the recommended daily feed amounts were underestimated and four recommendations exceeded energy requirements of adult cats. In 12 complete foods, the calcium and phosphorus contents were threefold higher than the respective requirement. In 16 of 21 complete foods, substantial discrepancies were observed between the recommendations and the analyzed trace elements. In particular, selenium contents exceeded the selenium requirement more than threefold. The vitamin, arginine and taurine contents showed no significant discrepancies to the recommendations. With respect to the labeled nutrients, there were only minor deviations from the regulations of the European law.
    Conclusion and clinical relevance: In general, healthy adult cats are adequately supplied with energy and nutrients when feeding commercial canned complete diets for cats. In cases of body weight loss or gain, the labelled feed amounts should be questioned. The high phosphorus contents are an issue of concern, because a high phosphorus intake can potentially increase the risk for urinary stones and particularly for older cats the risk for renal insufficiency. Furthermore, it is recommended to decrease the high selenium levels by the reduction of selenium-rich feed materials such as offal.
    Language German
    Publishing date 2017-08-10
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ISSN 1434-1239
    ISSN 1434-1239
    DOI 10.15654/TPK-170029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: In Vivo Assessment of Lung Ultrasound Features Mimicking Viral Pneumonia Using a Large Animal Model

    Wolfram, Frank / Braun, Conny / Gutsche, Holger / Lesser, Thomas Guenther

    IEEE Trans Ultrason Ferroelectr Freq Control

    Abstract: Lung ultrasound (LUS) is a practical tool for lung diagnosis when computer tomography (CT) is not available. Recent findings suggest that LUS diagnosis is highly advantageous because of its mobility and correlation with radiological findings for viral ... ...

    Abstract Lung ultrasound (LUS) is a practical tool for lung diagnosis when computer tomography (CT) is not available. Recent findings suggest that LUS diagnosis is highly advantageous because of its mobility and correlation with radiological findings for viral pneumonia. Simple models for both educational evaluation and technical evaluation are needed. Therefore, this work investigates the usability of a large animal model under aspects of LUS features of viral pneumonia using saline one lung flooding. Six pigs were intubated with a double-lumen tube, and the left lung was instilled with saline. During the instillation of up to 12.5 ml/kg, the sonographic features were assessed. All features present during viral pneumonia were found, such as B-lines, white lung syndrome, pleural thickening, and the formation of pleural consolidations. Sonographic findings correlate well with current LUS scores for COVID19. The scores of 1, 2, and 3 were dominantly present at 1-4-, 4-8-, and 8-12-ml/kg saline instillation, respectively. The noninfective animal model can be used for further investigation of the LUS features and can serve in education, by helping with the appropriate handling of LUS in clinical practice during management of viral pneumonia.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #707579
    Database COVID19

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  8. Article: Ernährungsphysiologische Beurteilung kommerzieller Feucht-Alleinfuttermittel für Katzen

    Rückert, Cornelia / Braun, Conny / Vervuert, Ingrid

    Tierärztliche Praxis K: Kleintiere/Heimtiere

    2017  Volume 45, Issue 04, Page(s) 219–225

    Abstract: Ziel: Beurteilung kommerzieller Alleinfuttermittel (Feuchtfutter) für adulte Katzen in Bezug auf Zusammensetzung und Deklarationstreue sowie ernährungsphysiologische Einschätzung. : Material und Methoden: 21 kommerzielle Feucht-Alleinfuttermittel für ...

    Abstract Ziel: Beurteilung kommerzieller Alleinfuttermittel (Feuchtfutter) für adulte Katzen in Bezug auf Zusammensetzung und Deklarationstreue sowie ernährungsphysiologische Einschätzung.
    Material und Methoden: 21 kommerzielle Feucht-Alleinfuttermittel für adulte Katzen wurden auf die Rohnährstoff-, Mengenelement-, Spurenelement- und Vitamingehalte sowie Gehalte an ausgewählten Aminosäuren und Taurin analysiert. Die Energiegehalte wurden kalkuliert und mit den Fütterungsempfehlungen der Hersteller verglichen. Anhand des gültigen europäischen Futtermittelrechts (basierend auf EG VO 767/2009) erfolgte eine Einschätzung der Deklarationstreue.
    Ergebnisse: Die empfohlenen Futtermengen wichen häufig von den kalkulierten Werten ab. Bei acht Futtermitteln waren sie zu niedrig angesetzt, vier Empfehlungen veranschlagten eine zu hohe Futtermenge. Die Kalzium- und Phosphorgehalte von 12 Futtermitteln überschritten die Versorgungsempfehlung um mehr als das Dreifache. Beim Gehalt an Spurenelementen wiesen 16 von 21 Futtermitteln erhebliche Abweichungen zu den Bedarfsempfehlungen auf. Besonders auffällig waren die Selengehalte, die im Mittel bei über 300% der Bedarfsempfehlung lagen. Die Vitamin- sowie die Arginin- und Tauringehalte deckten sich weitestgehend mit den Bedarfsempfehlungen. Die Deklarationsvorschriften wurden mit wenigen Abweichungen eingehalten.
    Schlussfolgerung und klinische Relevanz: Katzen sind mit einem kommerziellen Feucht-Alleinfuttermittel in weiten Bereichen bedarfsdeckend versorgt. Bei Abweichungen vom gewünschten Ernährungszustand kann es sinnvoll sein, die deklarierte Empfehlung zur täglichen Futtermenge kritisch zu hinterfragen. Zudem wäre es empfehlenswert, dass Futtermittelhersteller die vielfach überhöhten Phosphorgehalte reduzieren. Zum einen lässt sich ein höheres Risiko der Harnsteinbildung bei einer Phosphorüberversorgung nicht ausschließen, zum anderen dient dies einer Schonung der Nieren älterer Tiere (Disposition für eine Niereninsuffizienz). Auch die überhöhten Selengehalte sollten durch anteilmäßige Reduzierung von selenreichen Einzelkomponenten wie bestimmten Innereien in der Rezeptur gesenkt werden.
    Keywords Futtermittel ; Deklaration ; FEDIAF-Empfehlung ; Kalzium ; Phosphor ; Selen ; Pet food ; labeling ; FEDIAF recommendation ; calcium ; phosphorus ; sele nium
    Language German
    Publishing date 2017-07-01
    Publisher Schattauer GmbH
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2567-5842 ; 1434-1239
    ISSN (online) 2567-5842
    ISSN 1434-1239
    DOI 10.15654/TPK-170029
    Database Thieme publisher's database

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