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  1. Book ; Online ; Thesis: Die Bedeutung der Glykokalix für die Rekrutierung von Leukozyten und Thrombozyten sowie die mikrovaskuläre Permeabilität und Angiogenese im Tiermodell des Mammakarzinoms

    Braun, Constanze Isabel [Verfasser] / Göbel, Thomas [Akademischer Betreuer]

    2021  

    Author's details Constanze Isabel Braun ; Betreuer: Thomas Göbel
    Keywords Tiere (Zoologie) ; Animals (Zoology)
    Subject code sg590
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Conference proceedings: A novel experimental approach for In Vivo analyses of the salivary gland microvasculature and saliva production upon gamma radiotherapy

    Uhl, Bernd / Luft, Joshua / Dominik, Julian / Braun, Constanze / Steiger, Katja / Weichert, Wilko / Canis, Martin / Lauber, Kirsten / Reichel, Christoph

    Laryngo-Rhino-Otologie

    2024  Volume 103, Issue S 02

    Event/congress 95th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e. V., Bonn, Messe Essen, 2024-05-08
    Language English
    Publishing date 2024-04-19
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0044-1785154
    Database Thieme publisher's database

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  3. Article ; Conference proceedings: Ein neues In-vivo-Modell zur Analyse der Speichelproduktion und Mikrozirkulation in Kopfspeicheldrüsen nach Gammastrahlentherapie

    Uhl, Bernd / Luft, Joshua / Dominik, Julian / Braun, Constanze / Steiger, Katja / Weichert, Wilko / Canis, Martin / Lauber, Kirsten / Reichel, Christoph

    Laryngo-Rhino-Otologie

    2024  Volume 103, Issue S 02

    Event/congress 95. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V., Bonn, Messe Essen, 2024-05-08
    Language German
    Publishing date 2024-04-19
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0044-1784440
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  4. Article ; Online: A Novel Experimental Approach for

    Uhl, Bernd / Braun, Constanze / Dominik, Julian / Luft, Joshua / Canis, Martin / Reichel, Christoph A

    Frontiers in immunology

    2021  Volume 11, Page(s) 604470

    Abstract: Microvascular dysfunction plays a fundamental role in the pathogenesis of salivary gland disorders. Restoring and preserving microvascular integrity might therefore represent a promising strategy for the treatment of these pathologies. The mechanisms ... ...

    Abstract Microvascular dysfunction plays a fundamental role in the pathogenesis of salivary gland disorders. Restoring and preserving microvascular integrity might therefore represent a promising strategy for the treatment of these pathologies. The mechanisms underlying microvascular dysfunction in salivary glands, however, are still obscure, partly due to the unavailability of adequate
    MeSH term(s) Animals ; Antibodies/pharmacology ; Capillary Permeability/drug effects ; Cell Adhesion Molecules/metabolism ; Chemotaxis, Leukocyte/drug effects ; Flow Cytometry ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Leukocyte Rolling/drug effects ; Leukocytes/drug effects ; Leukocytes/immunology ; Leukocytes/metabolism ; Male ; Mice, Inbred C57BL ; Microscopy, Confocal ; Microscopy, Fluorescence, Multiphoton ; Microvessels/drug effects ; Microvessels/immunology ; Microvessels/metabolism ; Microvessels/pathology ; Phenotype ; Signal Transduction ; Submandibular Gland/blood supply ; Tumor Necrosis Factor-alpha/pharmacology ; Mice
    Chemical Substances Antibodies ; Cell Adhesion Molecules ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2021-02-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.604470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Conference proceedings: Ein neues In-vivo-Modell zur Analyse der Mikrozirkulation in Kopfspeicheldrüsen

    Uhl, Bernd / Braun, Constanze / Dominik, Julian / Luft, Joshua / Canis, Martin / Reichel, Christoph Andreas

    Laryngo-Rhino-Otologie

    (Abstract- und Posterband)

    2022  Volume 101, Issue S 02

    Event/congress Abstract- und Posterband - 93. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn Interface - Fokus Mensch im Zeitalter der technisierten Medizin, Deutsche Messe Hannover, 2022-05-25
    Series title Abstract- und Posterband
    Language German
    Publishing date 2022-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0042-1747137
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  6. Article ; Conference proceedings: A Novel Experimental Approach for  In Vivo  Analyses of the Salivary Gland Microvasculature

    Uhl, Bernd / Braun, Constanze / Dominik, Julian / Luft, Joshua / Canis, Martin / Reichel, Christoph Andreas

    Laryngo-Rhino-Otologie

    (Abstract- und Posterband)

    2022  Volume 101, Issue S 02

    Event/congress Abstract- und Posterband - 93. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn Interface - Fokus Mensch im Zeitalter der technisierten Medizin, Deutsche Messe Hannover, 2022-05-25
    Series title Abstract- und Posterband
    Language English
    Publishing date 2022-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0042-1746493
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  7. Article ; Online: Procoagulant platelets promote immune evasion in triple negative breast cancer.

    Schaubaecher, Johanna / Smiljanov, Bojan / Haring, Florian / Steiger, Katja / Wu, Zhengquan / Ugurluoglu, Anais / Luft, Joshua / Ballke, Simone / Mahameed, Shaan / Schneewind, Vera / Hildinger, Jonas / Canis, Martin / Mittmann, Laura / Braun, Constanze / Zuchtriegel, Gabriele / Kaiser, Rainer / Nicolai, Leo / Mack, Matthias / Weichert, Wilko /
    Lauber, Kirsten / Uhl, Bernd / Reichel, Christoph A

    Blood

    2024  

    Abstract: Triple-negative breast cancer (TNBC) is an aggressive tumor entity, in which immune checkpoint (IC) molecules are primarily synthesized in the tumor environment. Here, we report that procoagulant platelets bear large amounts of such immunomodulatory ... ...

    Abstract Triple-negative breast cancer (TNBC) is an aggressive tumor entity, in which immune checkpoint (IC) molecules are primarily synthesized in the tumor environment. Here, we report that procoagulant platelets bear large amounts of such immunomodulatory factors and that the presence of these cellular blood components in TNBC relates to pro-tumorigenic immune cell activity and impaired survival. Mechanistically, tumor-released nucleic acids attract platelets into the aberrant tumor microvasculature where they undergo procoagulant activation, thus delivering specific stimulatory and inhibitory IC molecules. This concomitantly promotes pro-tumorigenic myeloid leukocyte responses and compromises anti-tumorigenic lymphocyte activity, ultimately supporting tumor growth. Interference with platelet-leukocyte interactions prevented immune cell misguidance and suppressed tumor progression, nearly as effective as systemic IC inhibition. Hence, our data uncover a self-sustaining mechanism of TNBC in utilizing platelets to misdirect immune cell responses. Targeting this irregular multicellular interplay might represent a novel immunotherapeutic strategy in TNBC without side effects of systemic IC inhibition.
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023022928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Conference proceedings: Prokoagulante Thrombozyten vermitteln die intratumorale Fehlleitung von Immunzellen

    Reichel, Christoph / Schaubächer, Johanna / Haring, Florian / Smiljanov, Bojan / Steiger, Katja / Wu, Zhengquan / Luft, Joshua / Ballke, Simone / Mahameed, Shaan / Schneewind, Vera / Hildinger, Jonas / Canis, Martin / Mittmann, Laura / Braun, Constanze / Zuchtriegel, Gabriele / Mack, Matthias / Weichert, Wilko / Lauber, Kirsten / Uhl, Bernd

    Laryngo-Rhino-Otologie

    2024  Volume 103, Issue S 02

    Event/congress 95. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V., Bonn, Messe Essen, 2024-05-08
    Language German
    Publishing date 2024-04-19
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0044-1784153
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  9. Article ; Conference proceedings: Pro-coagulant platelets promote immune evasion

    Reichel, Christoph / Schaubächer, Johanna / Haring, Florian / Smiljanov, Bojan / Steiger, Katja / Wu, Zhengquan / Luft, Joshua / Ballke, Simone / Mahameed, Shaan / Schneewind, Vera / Hildinger, Jonas / Canis, Martin / Mittmann, Laura / Braun, Constanze / Zuchtriegel, Gabriele / Mack, Matthias / Weichert, Wilko / Lauber, Kirsten / Uhl, Bernd

    Laryngo-Rhino-Otologie

    2024  Volume 103, Issue S 02

    Event/congress 95th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e. V., Bonn, Messe Essen, 2024-05-08
    Language English
    Publishing date 2024-04-19
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0044-1784768
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  10. Article ; Online: uPA-PAI-1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils.

    Uhl, Bernd / A Mittmann, Laura / Dominik, Julian / Hennel, Roman / Smiljanov, Bojan / Haring, Florian / B Schaubächer, Johanna / Braun, Constanze / Padovan, Lena / Pick, Robert / Canis, Martin / Schulz, Christian / Mack, Matthias / Gutjahr, Ewgenija / Sinn, Peter / Heil, Jörg / Steiger, Katja / Kanse, Sandip M / Weichert, Wilko /
    Sperandio, Markus / Lauber, Kirsten / Krombach, Fritz / Reichel, Christoph A

    EMBO molecular medicine

    2021  Volume 13, Issue 6, Page(s) e13110

    Abstract: High intratumoral levels of urokinase-type plasminogen activator (uPA)-plasminogen activator inhibitor-1 (PAI-1) heteromers predict impaired survival and treatment response in early breast cancer. The pathogenetic role of this protein complex remains ... ...

    Abstract High intratumoral levels of urokinase-type plasminogen activator (uPA)-plasminogen activator inhibitor-1 (PAI-1) heteromers predict impaired survival and treatment response in early breast cancer. The pathogenetic role of this protein complex remains obscure. Here, we demonstrate that heteromerization of uPA and PAI-1 multiplies the potential of the single proteins to attract pro-tumorigenic neutrophils. To this end, tumor-released uPA-PAI-1 utilizes very low-density lipoprotein receptor and mitogen-activated protein kinases to initiate a pro-inflammatory program in perivascular macrophages. This enforces neutrophil trafficking to cancerous lesions and skews these immune cells toward a pro-tumorigenic phenotype, thus supporting tumor growth and metastasis. Blockade of uPA-PAI-1 heteromerization by a novel small-molecule inhibitor interfered with these events and effectively prevented tumor progression. Our findings identify a therapeutically targetable, hitherto unknown interplay between hemostasis and innate immunity that drives breast cancer progression. As a personalized immunotherapeutic strategy, blockade of uPA-PAI-1 heteromerization might be particularly beneficial for patients with highly aggressive uPA-PAI-1
    MeSH term(s) Breast Neoplasms ; Female ; Humans ; Lymphatic Metastasis ; Neutrophils ; Plasminogen Activator Inhibitor 1 ; Urokinase-Type Plasminogen Activator
    Chemical Substances Plasminogen Activator Inhibitor 1 ; Urokinase-Type Plasminogen Activator (EC 3.4.21.73)
    Language English
    Publishing date 2021-05-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2467145-9
    ISSN 1757-4684 ; 1757-4676
    ISSN (online) 1757-4684
    ISSN 1757-4676
    DOI 10.15252/emmm.202013110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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