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Article ; Online: Progenitor cell-derived extracellular vesicles: an emerging diagnostic and therapeutic tool for renal disease.

Braun, Gerald S / Moeller, Marcus J

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2015 Volume 30, Issue 3, Page(s) 339–341

Language	English
Publishing date	2015-03
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfv027
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Article ; Online: Time on previous renal replacement therapy is associated with worse outcomes of COVID-19 in a regional cohort of kidney transplant and dialysis patients.

Villa, Luigi / Krüger, Thilo / Seikrit, Claudia / Mühlfeld, Anja S / Kunter, Uta / Werner, Cornelius / Kleines, Michael / Schulze-Hagen, Maximilian / Dreher, Michael / Kersten, Alexander / Marx, Nikolaus / Floege, Jürgen / Rauen, Thomas / Braun, Gerald S

Medicine

2021 Volume 100, Issue 10, Page(s) e24893

Abstract: Abstract: Chronic renal replacement therapy by either a kidney transplant (KTX) or hemodialysis (HD) predisposes patients to an increased risk for adverse outcomes of COVID-19. However, details on this interaction remain incomplete. To provide further ... ...

Abstract	Abstract: Chronic renal replacement therapy by either a kidney transplant (KTX) or hemodialysis (HD) predisposes patients to an increased risk for adverse outcomes of COVID-19. However, details on this interaction remain incomplete. To provide further characterization, we undertook a retrospective observational cohort analysis of the majority of the hemodialysis and renal transplant population affected by the first regional outbreak of severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) in Germany. In a region of 250,000 inhabitants we identified a total of 21 cases with SARS-CoV-2 among 100 KTX and 260 HD patients, that is, 7 KTX with COVID-19, 14 HD with COVID-19, and 3 HD with asymptomatic carrier status. As a first observation, KTX recipients exhibited trends for a higher mortality (43 vs 18%) and a higher proportion of acute respiratory distress syndrome (ARDS) (57 vs 27%) when compared to their HD counterparts. As a novel finding, development of ARDS was significantly associated with the time spent on previous renal replacement therapy (RRT), defined as the composite of dialysis time and time on the transplant (non-ARDS 4.3 vs ARDS 10.6 years, P = .016). Multivariate logistic regression analysis showed an OR of 1.7 per year of RRT. The association remained robust when analysis was confined to KTX patients (5.1 vs 13.2 years, P = .002) or when correlating the time spent on a renal transplant alone (P = .038). Similarly, longer RRT correlated with death vs survival (P = .0002). In conclusion our data suggest renal replacement vintage as a novel risk factor for COVID-19-associated ARDS and death. The findings should be validated by larger cohorts.
MeSH term(s)	Aged ; Aged, 80 and over ; COVID-19/epidemiology ; COVID-19/mortality ; Female ; Germany/epidemiology ; Humans ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Kidney Transplantation/mortality ; Logistic Models ; Male ; Middle Aged ; Renal Dialysis/statistics & numerical data ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
Language	English
Publishing date	2021-03-16
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000024893
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Book ; Online ; Thesis: Beobachtungsstudie zur Bedeutung des ionisierten Magnesiums bei chronischer Niereninsuffizienz

Basten, Magdalena Isabel [Verfasser] / Brandenburg, Vincent Matthias [Akademischer Betreuer] / Braun, Gerald S. [Akademischer Betreuer]

2018

Author's details	Magdalena Isabel Basten ; Vincent Matthias Brandenburg, Gerald S. Braun
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek der RWTH Aachen
Publishing place	Aachen
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Book ; Online ; Thesis: Ionenkanäle während der Nephrogenese

Braun, Gerald S

Expressionsmuster und funktionelle Bedeutung

2003

Author's details	vorgelegt von Gerald S. Braun
Language	German
Size	Online-Ressource
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Univ., Diss--München, 2003
Database	Former special subject collection: coastal and deep sea fishing

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Article: Interaction of atypical cadherin Fat1 with SoHo adaptor proteins CAP/ponsin and ArgBP2

Braun, Gerald S / Andrzej Kuszka / CÃ©cile Dau / Wilhelm Kriz / Marcus J. Moeller

Biochemical and biophysical research communications. 2016 Mar. 25, v. 472

2016

Abstract: Mammalian Fat1 is a giant atypical cadherin/tumor suppressor involved in the regulation of cellular orientation, migration, and growth. Fat1 is implicated in the development of the brain, eye, and kidney. Altered expression or mutations of FAT1 are also ... ...

Abstract	Mammalian Fat1 is a giant atypical cadherin/tumor suppressor involved in the regulation of cellular orientation, migration, and growth. Fat1 is implicated in the development of the brain, eye, and kidney. Altered expression or mutations of FAT1 are also associated with cancer and facioscapulohumeral muscular dystrophy (FSHD). Yet, the mechanistic functions of this pathway remain incompletely understood. Here, we report the identification of Sorbin-homology (SoHo) proteins as novel interaction partners of Fat1 by virtue of a yeast-two-hybrid screen. SoHo proteins play diverse roles as adaptor proteins in cell signaling, cell adhesion and sarcomere architecture, including altered expression in cancer and FSHD. Specifically, we found SoHo proteins CAP/ponsin-1 and -2 (Sorbs1) and ArgBP2 (Sorbs2) to interact with the cytoplasmic domain of Fat1. We mapped the interaction to a prolin-rich classic type II PXXP motif within Fat1 and to the three Src-homology (SH3) domains within SoHo proteins using mutant expression in yeast, pulldown assays, and cell culture. Functionally, endogenous ponsin-2 expression of NRK-52E cells at cellular leading edges was lost upon knockdown of Fat1. In summary, our data point to an interaction of Fat1 with SoHo proteins that is able to recruit SoHo proteins to sites of Fat1 expression.
Keywords	brain ; cadherins ; cell adhesion ; cell culture ; eyes ; kidneys ; mammals ; muscular dystrophy ; mutants ; mutation ; neoplasms ; sarcomeres ; yeasts ; Cell junction ; Leading edge ; PXXP ; Yeast-two-hybrid ; Pulldown ; Knockdown
Language	English
Dates of publication	2016-0325
Size	p. 88-94.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2016.02.069
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Interaction of atypical cadherin Fat1 with SoHo adaptor proteins CAP/ponsin and ArgBP2.

Braun, Gerald S / Kuszka, Andrzej / Dau, Cécile / Kriz, Wilhelm / Moeller, Marcus J

Biochemical and biophysical research communications

2016 Volume 472, Issue 1, Page(s) 88–94

Abstract	Mammalian Fat1 is a giant atypical cadherin/tumor suppressor involved in the regulation of cellular orientation, migration, and growth. Fat1 is implicated in the development of the brain, eye, and kidney. Altered expression or mutations of FAT1 are also associated with cancer and facioscapulohumeral muscular dystrophy (FSHD). Yet, the mechanistic functions of this pathway remain incompletely understood. Here, we report the identification of Sorbin-homology (SoHo) proteins as novel interaction partners of Fat1 by virtue of a yeast-two-hybrid screen. SoHo proteins play diverse roles as adaptor proteins in cell signaling, cell adhesion and sarcomere architecture, including altered expression in cancer and FSHD. Specifically, we found SoHo proteins CAP/ponsin-1 and -2 (Sorbs1) and ArgBP2 (Sorbs2) to interact with the cytoplasmic domain of Fat1. We mapped the interaction to a prolin-rich classic type II PXXP motif within Fat1 and to the three Src-homology (SH3) domains within SoHo proteins using mutant expression in yeast, pulldown assays, and cell culture. Functionally, endogenous ponsin-2 expression of NRK-52E cells at cellular leading edges was lost upon knockdown of Fat1. In summary, our data point to an interaction of Fat1 with SoHo proteins that is able to recruit SoHo proteins to sites of Fat1 expression.
MeSH term(s)	Amino Acid Sequence ; Animals ; COS Cells ; Cadherins/chemistry ; Cadherins/genetics ; Cadherins/metabolism ; Cell Line ; Cercopithecus aethiops ; Gene Knockdown Techniques ; Mice ; Microfilament Proteins/chemistry ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Mutagenesis, Site-Directed ; Protein Interaction Domains and Motifs ; Rats ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Two-Hybrid System Techniques ; src Homology Domains
Chemical Substances	Cadherins ; Fath protein, mouse ; Microfilament Proteins ; Recombinant Fusion Proteins ; Sorbs2 protein, mouse ; ponsin
Language	English
Publishing date	2016-03-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2016.02.069
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Article ; Online: Occurrence of HSV-1-induced pneumonitis in patients under standard immunosuppressive therapy for rheumatic, vasculitic, and connective tissue disease

Ihrler Stephan / Braun Gerald S / Witt Matthias N / Schmid Holger

BMC Pulmonary Medicine, Vol 9, Iss 1, p

2009 Volume 22

Abstract: Abstract Background Herpes simplex virus type-1 (HSV-1) has been described to cause respiratory tract infections in critically ill patients or in individuals that are immunocompromised. It is a continuing matter of debate under which circumstances HSV-1 ... ...

Abstract	Abstract Background Herpes simplex virus type-1 (HSV-1) has been described to cause respiratory tract infections in critically ill patients or in individuals that are immunocompromised. It is a continuing matter of debate under which circumstances HSV-1 is a relevant pathogen for pneumonitis. While its role during critical illness has been investigated by prospective interventional studies, comparatively little systematic data is available on the role of HSV-1 for pneumonitis in outpatients with autoimmune disease under a maintenance regimen of immunosuppression. Methods We retrospectively reviewed the charts of ~1400 patients with rheumatoid arthritis, vasculitis, and systemic lupus erythematosus (SLE) that were followed at the outpatient clinic of a German University hospital during the years 2000–2007. Episodes of admission to a ward resulting in the diagnosis of pneumonia/pneumonitis were identified, and the type of pneumonia and clinical features retrospectively studied. Results 63 patients with rheumatoid arthritis, vasculitis, or SLE were admitted to a ward and diagnosed to have pneumonia/pneumonitis. Using bronchoscopy a total of 6 cases of pulmonary infection associated with HSV-1 in the lower respiratory tract were identified. Among those, 2 cases suggested a causative role of HSV-1 as the sole agent causing pneumonitis that proved clinically responsive to antiviral treatment. In the remaining 4 cases HSV-1 appeared as a bystander of bacterial infection. Maintenance therapy with leflunomide, which inhibits HSV-1 assembly in vitro , was associated with a milder course of pneumonitis in one patient. Detection of HSV-1 was associated with stronger immunosuppressive regimens and vasculitic disease. Conclusion The present study analyzed the frequency and hallmarks of cases of HSV-1 associated pneumonitis that occurred in a comparatively large cohort of patients with rheumatologic autoimmune diseases. In an area of controversy, this study provides further evidence that HSV-1 causes isolated pneumonitis in the immunocompromised. The study may provide an estimate on the frequency of relevant HSV-1 infection and bacterial agents in outpatients with autoimmune disease.
Keywords	Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2009-05-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Validation of a Prospective Urinalysis-Based Prediction Model for ICU Resources and Outcome of COVID-19 Disease: A Multicenter Cohort Study.

Journal of clinical medicine

2021 Volume 10, Issue 14

Abstract: In COVID-19, guidelines recommend a urinalysis on hospital admission as SARS-CoV-2 renal tropism, post-mortem, was associated with disease severity and mortality. Following the hypothesis from our pilot study, we now validate an algorithm harnessing ... ...

Abstract	In COVID-19, guidelines recommend a urinalysis on hospital admission as SARS-CoV-2 renal tropism, post-mortem, was associated with disease severity and mortality. Following the hypothesis from our pilot study, we now validate an algorithm harnessing urinalysis to predict the outcome and the need for ICU resources on admission to hospital. Patients were screened for urinalysis, serum albumin (SA) and antithrombin III activity (AT-III) obtained prospectively on admission. The risk for an unfavorable course was categorized as (1) "low", (2) "intermediate" or (3) "high", depending on (1) normal urinalysis, (2) abnormal urinalysis with SA ≥ 2 g/dL and AT-III ≥ 70%, or (3) abnormal urinalysis with SA or AT-III abnormality. Time to ICU admission or death served as the primary endpoint. Among 223 screened patients, 145 were eligible for enrollment, 43 falling into the low, 84 intermediate, and 18 into high-risk categories. An abnormal urinalysis significantly elevated the risk for ICU admission or death (63.7% vs. 27.9%; HR 2.6; 95%-CI 1.4 to 4.9;
Language	English
Publishing date	2021-07-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10143049
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Development of renal function.

Braun, Gerald S / Huber, Stephan M

Zoology (Jena, Germany)

2002 Volume 105, Issue 4, Page(s) 341–354

Abstract: The mammalian metanephric kidney develops following a general principle of organogenesis of epithelial organs, i.e., along the tree-like structure of an arborizing ductal system (the ureteric bud and cortical collecting duct). In parallel, the proximal ... ...

Abstract	The mammalian metanephric kidney develops following a general principle of organogenesis of epithelial organs, i.e., along the tree-like structure of an arborizing ductal system (the ureteric bud and cortical collecting duct). In parallel, the proximal portions of the uriniferous tubule develop by mesenchymal-to-epithelial transition of the neighbouring mesenchyme. On one hand, vectorial transport systems in nephrogenesis should be functional at the onset of glomerular filtration in any of the newly formed nephron generations to prevent loss of salt, water and metabolites. On the other hand, developing nephron epithelia must serve the needs of organ-formation such as cell proliferation and fluid-secretion for morphogenic purposes. This review intends to summarize current data and concepts on the development of renal epithelial functions with an emphasis on ion channels. Current model systems are introduced, such as ureteric bud cell monolayer culture, in vitro nephron culture, HEK293 cell culture, and the dissection of tubular cells for direct analysis. The current data on the developmental expression and functions of ENaC Na(+) channels, the CFTR, ClC-2 Cl(ndash;) channels, L-type Ca(2+) channels, P2 purinoceptors, and the Kir6.1/SUR2, ROMK (Kir1.1), and Kv K(+) channels are presented.
Language	English
Publishing date	2002
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1191401-4
ISSN	1873-2720 ; 0944-2006
ISSN (online)	1873-2720
ISSN	0944-2006
DOI	10.1078/0944-2006-00073
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: YB-1 increases glomerular, but decreases interstitial fibrosis in CNI-induced nephropathy.

Gibbert, Lydia / Hermert, Daniela / Wang, Jialin / M Breitkopf, Daniel / Alidousty, Christina / Neusser, Matthias / Cohen, Clemens D / Gröne, Elisabeth / Macheleidt, Iris / Rauen, Thomas / Braun, Gerald S / Floege, Jürgen / Ostendorf, Tammo / Raffetseder, Ute

Clinical immunology (Orlando, Fla.)

2018 Volume 194, Page(s) 67–74

Abstract: Calcineurin inhibitors (CNIs) are a cornerstone of the current treatment in solid organ transplantation and autoimmune disease. However, CNIs also bear deleterious effects as they cause glomerular and tubulointerstitial fibrosis in the kidney. We ... ...

Abstract	Calcineurin inhibitors (CNIs) are a cornerstone of the current treatment in solid organ transplantation and autoimmune disease. However, CNIs also bear deleterious effects as they cause glomerular and tubulointerstitial fibrosis in the kidney. We recently identified Y-box protein-1 (YB-1) as a novel downstream effector of CNI-signaling in the cytoplasm of glomerular cells. In the present study, we corroborate the pro-fibrotic role of YB-1 in glomeruli of patients under CNI-treatment. Such effects in glomeruli are significantly mitigated in CNI-treated mice with half-normal YB-1 expression (Yb1
MeSH term(s)	Animals ; Calcineurin Inhibitors/adverse effects ; Extracellular Matrix/genetics ; Extracellular Matrix/metabolism ; Female ; Fibrosis/genetics ; Fibrosis/metabolism ; Kidney/drug effects ; Kidney/metabolism ; Kidney Diseases/chemically induced ; Kidney Diseases/genetics ; Kidney Diseases/metabolism ; Kidney Glomerulus/metabolism ; Kidney Transplantation/methods ; Mice ; Transcription Factors/metabolism ; Transcription, Genetic/drug effects ; Transcription, Genetic/genetics
Chemical Substances	Calcineurin Inhibitors ; Transcription Factors ; YB-1 protein, mouse
Language	English
Publishing date	2018-07-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2018.07.002
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