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  1. Article ; Online: An unexpected partnership targeting FLT3wt AML.

    Braun, Thorsten

    Blood

    2022  Volume 140, Issue 24, Page(s) 2529–2530

    MeSH term(s) Humans ; Myeloid Cell Leukemia Sequence 1 Protein ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Bridged Bicyclo Compounds, Heterocyclic ; fms-Like Tyrosine Kinase 3/genetics
    Chemical Substances venetoclax (N54AIC43PW) ; gilteritinib ; Myeloid Cell Leukemia Sequence 1 Protein ; Bridged Bicyclo Compounds, Heterocyclic ; FLT3 protein, human (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022017344
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  2. Article: Venetoclax Combined with Intensive Chemotherapy: A New Hope for Refractory and/or Relapsed Acute Myeloid Leukemia?

    Rahmé, Ramy / Braun, Thorsten

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020549
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  3. Article ; Online: Trends in antenatal corticosteroid administration: did our timing improve?

    Rostin, Paul / Verlohren, Stefan / Henrich, Wolfgang / Braun, Thorsten

    Journal of perinatal medicine

    2024  

    Abstract: Objectives: We aimed to analyze trends in the rate of effective antenatal corticosteroid prophylaxis (ACS) administrations across a spectrum of typical diagnoses associated with preterm birth.: Methods: In this retrospective study we utilized ... ...

    Abstract Objectives: We aimed to analyze trends in the rate of effective antenatal corticosteroid prophylaxis (ACS) administrations across a spectrum of typical diagnoses associated with preterm birth.
    Methods: In this retrospective study we utilized delivery data after ACS from 2014 to 2020 at Charité Berlin, Germany. We evaluated the rate of effective ACS administrations defined as ≤10 days between last dose of ACS and delivery as well as the rate of post-ACS births on/after 37 + 0 weeks. We explored conditions associated with high rates of ineffective ACS administrations (>10 days before delivery). We analyzed the trend of ACS-effectiveness during the study period in the overall cohort and in placental dysfunction and cervical insufficiency diagnoses.
    Results: The overall rate of effective ACS administrations was 42 % (709/1,672). The overall percentage of deliveries after/at 37 + 0 weeks following ACS administration was 19 % (343). Placenta previa, twin pregnancy and isthmocervical insufficiency were associated with ineffective ACS (19-34 % effective i.e. ≤10 days before delivery). The overall ratio of effective ACS applications rose over time (p=0.002). Over the course of this study ACS effectiveness increased in placental dysfunction and isthmocervical insufficiency diagnoses (p=0.028; p=0.001).
    Conclusions: Compared to a previous publication we found a decrease of post-ACS deliveries after/at 37 + 0 weeks (19 vs. 27 %). Ineffective ACS administrations are still frequent in patients with placenta previa, twin pregnancy and isthmocervical insufficiency. It remains to be investigated in future trials if the introduction of new diagnostic tools such as soluble Fms-like tyrosinkinase-1/placental growth factor (sFlt-1/PlGF) testing and placental alpha-microglobulin-1 (PAMG-1) testing directly led to an increased ACS effectiveness.
    Language English
    Publishing date 2024-04-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123512-6
    ISSN 1619-3997 ; 0300-5577 ; 0936-174X
    ISSN (online) 1619-3997
    ISSN 0300-5577 ; 0936-174X
    DOI 10.1515/jpm-2023-0353
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  4. Book ; Thesis: Peptid-abhängige Modulation des [Ca1̱hn21̱hn+]1̱tni-Signals und der Proliferation von CD41̱hn+- und CD81̱hn+-T-Lymphozyten durch Interaktion mit aktivierten dendritischen Zellen

    Braun, Thorsten

    2001  

    Author's details vorgelegt von Thorsten Braun
    Language German
    Size V, 73 Bl., Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 2002 (Nur beschränkt für den Austausch)
    HBZ-ID HT013408240
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 MB 3897 order for loan Magazin

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  5. Article ; Online: Uterine packing with chitosan-covered tamponade to treat postpartum hemorrhage.

    Henrich, Wolfgang / Dückelmann, Anna / Braun, Thorsten / Hinkson, Larry

    American journal of obstetrics and gynecology

    2023  Volume 230, Issue 3S, Page(s) S1061–S1065

    Abstract: Postpartum hemorrhage remains a major cause of maternal mortality and morbidity worldwide with higher rates found in resource-challenged countries. Conventional use of uterotonics such as oxytocin, prostaglandins, and medications to support coagulation, ... ...

    Abstract Postpartum hemorrhage remains a major cause of maternal mortality and morbidity worldwide with higher rates found in resource-challenged countries. Conventional use of uterotonics such as oxytocin, prostaglandins, and medications to support coagulation, such as fibrinogen and tranexamic acid, are helpful but may not be sufficient to arrest life-threatening postpartum hemorrhage. Severe postpartum hemorrhage leads to an increased need for blood transfusions and the use of invasive techniques, such as intrauterine balloon tamponade, compression sutures, and arterial ligation, as advanced steps in the management cascade. In extreme cases where hemorrhage is resistant to these therapies, a hysterectomy may be necessary to avoid possible maternal death. Uterine packing with a chitosan-covered tamponade is an emerging tool in the armamentarium of the obstetrical team, especially when resources for advance surgical and other invasive options may be limited. Modified chitosan-impregnated gauze was originally described in the management of acute hemorrhage in the field of military medicine, combining the physiological antihemorrhaging effect of modified chitosan with a compression tamponade for the acute treatment of wound bleeding. The first described use in obstetrics was in 2012, showing that the chitosan-covered tamponade is an effective intervention to arrest ongoing therapy-resistant postpartum hemorrhage. Further studies showed a reduction in hysterectomies and blood transfusions. The method is, however, underreported and is not yet an established method used worldwide. To demonstrate the step-by-step application of the intrauterine chitosan-covered tamponade in the management of therapy-resistant postpartum hemorrhage, we have produced a teaching video to illustrate the important steps and techniques to optimize the effectiveness and safety of this novel intervention.
    MeSH term(s) Pregnancy ; Female ; Humans ; Chitosan/therapeutic use ; Postpartum Hemorrhage/therapy ; Postpartum Hemorrhage/etiology ; Uterine Balloon Tamponade/adverse effects ; Obstetrics ; Ligation
    Chemical Substances Chitosan (9012-76-4)
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2022.11.1297
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  6. Article: TP53 Alterations in Myelodysplastic Syndromes and Acute Myeloid Leukemia.

    Rahmé, Ramy / Braun, Thorsten / Manfredi, James J / Fenaux, Pierre

    Biomedicines

    2023  Volume 11, Issue 4

    Abstract: TP53 mutations are less frequent in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) than in solid tumors, except in secondary and therapy-related MDS/AMLs, and in cases with complex monosomal karyotype. As in solid tumors, missense ... ...

    Abstract TP53 mutations are less frequent in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) than in solid tumors, except in secondary and therapy-related MDS/AMLs, and in cases with complex monosomal karyotype. As in solid tumors, missense mutations predominate, with the same hotspot mutated codons (particularly codons 175, 248, 273). As TP53-mutated MDS/AMLs are generally associated with complex chromosomal abnormalities, it is not always clear when TP53 mutations occur in the pathophysiological process. It is also uncertain in these MDS/AML cases, which often have inactivation of both TP53 alleles, if the missense mutation is only deleterious through the absence of a functional p53 protein, or through a potential dominant-negative effect, or finally a gain-of-function effect of mutant p53, as demonstrated in some solid tumors. Understanding when TP53 mutations occur in the disease course and how they are deleterious would help to design new treatments for those patients who generally show poor response to all therapeutic approaches.
    Language English
    Publishing date 2023-04-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11041152
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  7. Article ; Online: Apoptosis Inhibitor 5: A Multifaceted Regulator of Cell Fate.

    Abbas, Hafsia / Derkaoui, Dalia Kheira / Jeammet, Louise / Adicéam, Emilie / Tiollier, Jérôme / Sicard, Hélène / Braun, Thorsten / Poyet, Jean-Luc

    Biomolecules

    2024  Volume 14, Issue 1

    Abstract: Apoptosis, or programmed cell death, is a fundamental process that maintains tissue homeostasis, eliminates damaged or infected cells, and plays a crucial role in various biological phenomena. The deregulation of apoptosis is involved in many human ... ...

    Abstract Apoptosis, or programmed cell death, is a fundamental process that maintains tissue homeostasis, eliminates damaged or infected cells, and plays a crucial role in various biological phenomena. The deregulation of apoptosis is involved in many human diseases, including cancer. One of the emerging players in the intricate regulatory network of apoptosis is apoptosis inhibitor 5 (API5), also called AAC-11 (anti-apoptosis clone 11) or FIF (fibroblast growth factor-2 interacting factor). While it may not have yet the same level of notoriety as some other cancer-associated proteins, API5 has garnered increasing attention in the cancer field in recent years, as elevated API5 levels are often associated with aggressive tumor behavior, resistance to therapy, and poor patient prognosis. This review aims to shed light on the multifaceted functions and regulatory mechanisms of API5 in cell fate decisions as well as its interest as therapeutic target in cancer.
    MeSH term(s) Humans ; Apoptosis Regulatory Proteins/metabolism ; Nuclear Proteins/metabolism ; Apoptosis ; Neoplasms/genetics ; Cell Differentiation
    Chemical Substances Apoptosis Regulatory Proteins ; Nuclear Proteins
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14010136
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  8. Article ; Online: Alterations of materno-placento-fetal glucose homeostasis after a single course of antenatal betamethasone.

    Hardt, Anne-Katrin / Braun Tavares, Franziska / Ehrlich, Loreen / Henrich, Wolfgang / Plagemann, Andreas / Braun, Thorsten

    Placenta

    2023  Volume 142, Page(s) 64–74

    Abstract: Introduction: Intrauterine growth impairment is associated with long-term metabolic changes (perinatal programming). We recently demonstrated that antenatal betamethasone (BET) decreased head circumference in term born females. Since glucose is the main ...

    Abstract Introduction: Intrauterine growth impairment is associated with long-term metabolic changes (perinatal programming). We recently demonstrated that antenatal betamethasone (BET) decreased head circumference in term born females. Since glucose is the main energy source for fetal growth, BET-induced changes in maternal glucose homeostasis, a reduced transplacental glucose transfer or an altered fetal glucose utilization may be linked with the observed growth impairment.
    Methods: 86 pregnant women exposed to BET (single course, <34 + 0 weeks of gestation (wks)) were compared to 92 gestational-age/sex-matched controls. Glucose, insulin, leptin, insulin-like growth factors (IGF-1, IGF-2) and their binding proteins (IGFBP-1, IGFBP-3) were measured in maternal and umbilical cord blood samples. Homeostasis Model Assessment (HOMA-IR) was calculated. Placental glucose transporter 1 and 3 (GLUT1, GLUT3) protein levels were determined. Statistics were performed for overall and subgroup analysis (gestational age, sex).
    Results: After BET maternal HOMA-IR was elevated, IGFBP-1 reduced. In female pregnancies, glucose levels ≥37 + 0 wks and IGF-1 levels <37 + 0 wks were tendentially increased. Placental GLUT1 and GLUT3 protein levels were not significantly altered. Fetal umbilical venous glucose levels ≥37 + 0 wks were increased. HOMA-IR tended to be elevated in females.
    Discussion: Growth impairment after BET appears neither caused by maternal nor fetal hypoglycemia nor changes of GLUT1 and GLUT3 total protein levels. Nonetheless, glucose homeostasis of mothers and daughters was altered even beyond the BET time frame (hyperglycemia, enhanced insulin resistance). Despite glucose supply was sufficient, an anabolic effect was apparently absent. Overall, our results highlight the relevance of adequate glucose management after BET and peripartum.
    Language English
    Publishing date 2023-07-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 603951-0
    ISSN 1532-3102 ; 0143-4004
    ISSN (online) 1532-3102
    ISSN 0143-4004
    DOI 10.1016/j.placenta.2023.07.295
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  9. Article: Pränataldiagnostik und Geburtsmedizin. Antenatale RDS-Prophylaxe

    Braun, Thorsten

    CME Praktische Fortbildung : Gynäkologie, Geburtsmedizin und Gynäkologische Endokrinologie

    2016  Volume -, Issue 1, Page(s) 36

    Language German
    Document type Article
    ZDB-ID 2241422-8
    ISSN 1614-8533
    Database Current Contents Medicine

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  10. Book ; Online ; Thesis: Antenatale Glukokortikoid-Therapie, fetale Programmierung und die Rolle der Plazenta

    Braun, Thorsten [Verfasser]

    2017  

    Author's details Thorsten Braun
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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