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  1. Article: JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation

    Braun-Dullaeus, Rüdiger / Mohr, Juliane / Amthauer, Holger / Heidel, Florian / Müller, Andreas

    The journal of clinical investigation, 128(10):4359-4371

    2018  

    Abstract: JAK2-V617F–positive chronic myeloproliferative neoplasia (CMN) commonly displays dysfunction of integrins and adhesion molecules expressed on platelets, erythrocytes, and leukocytes. However, the mechanism by which the 2 major leukocyte integrin chains, ... ...

    Institution Leibniz-Institut für Alternsforschung
    Leibniz-Institut für Neurobiologie
    Abstract JAK2-V617F–positive chronic myeloproliferative neoplasia (CMN) commonly displays dysfunction of integrins and adhesion molecules expressed on platelets, erythrocytes, and leukocytes. However, the mechanism by which the 2 major leukocyte integrin chains, β1 and β2, may contribute to CMN pathophysiology remained unclear. β1 (α4β1; VLA-4) and β2 (αLβ2; LFA-1) integrins are essential regulators for attachment of leukocytes to endothelial cells. We here showed enhanced adhesion of granulocytes from mice with JAK2-V617F knockin (JAK2+/VF mice) to vascular cell adhesion molecule 1– (VCAM1-) and intercellular adhesion molecule 1–coated (ICAM1-coated) surfaces. Soluble VCAM1 and ICAM1 ligand binding assays revealed increased affinity of β1 and β2 integrins for their respective ligands. For β1 integrins, this correlated with a structural change from the low- to the high-affinity conformation induced by JAK2-V617F. JAK2-V617F triggered constitutive activation of the integrin inside-out signaling molecule Rap1, resulting in translocation toward the cell membrane. Employing a venous thrombosis model, we demonstrated that neutralizing anti–VLA-4 and anti–β2 integrin antibodies suppress pathologic thrombosis as observed in JAK2+/VF mice. In addition, aberrant homing of JAK2+/VF leukocytes to the spleen was inhibited by neutralizing anti-β2 antibodies and by pharmacologic inhibition of Rap1. Thus, our findings identified cross-talk between JAK2-V617F and integrin activation promoting pathologic thrombosis and abnormal trafficking of leukocytes to the spleen.
    Keywords Hematology ; Integrins ; Thrombosis
    Language English
    Document type Article
    Database Repository for Life Sciences

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  2. Article ; Online: Confusion in connection with pulmonary hypertension due to premature ventricular complexes requires diagnostic work-up.

    Luani, Blerim / Wiemer, Marcus / Braun-Dullaeus, Rüdiger C

    European heart journal. Case reports

    2023  Volume 7, Issue 7, Page(s) ytad321

    Language English
    Publishing date 2023-07-16
    Publishing country England
    Document type Journal Article
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Der Zellzyklus in der vaskulären Medizin

    Braun-Dullaeus, Rüdiger

    2002  

    Author's details vorgelegt von Rüdiger Christian Braun-Dullaeus
    Language German ; English
    Size 62, [162] Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Gießen, Univ., Habil.-Schr., 2002
    HBZ-ID HT015026007
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 E 767 order to use in reading room Magazin

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  4. Article ; Online: Confusion in a patient with premature ventricular complexes originating in the left ventricular summit.

    Luani, Blerim / Schmeisser, Alexander / Wiemer, Marcus / Braun-Dullaeus, Rüdiger C

    European heart journal. Case reports

    2023  Volume 7, Issue 4, Page(s) ytad142

    Abstract: Background: Premature ventricular complexes (PVCs) originating in the ventricular outflow tracts are mostly of benign character.: Case summary: We describe a rare case of pulmonary hypertension with severe hypoxaemia and confusion caused by a ... ...

    Abstract Background: Premature ventricular complexes (PVCs) originating in the ventricular outflow tracts are mostly of benign character.
    Case summary: We describe a rare case of pulmonary hypertension with severe hypoxaemia and confusion caused by a significant mitral regurgitation (MR) during PVC originating in the left ventricle summit. After successful PVC ablation, all above-mentioned clinical parameters had normalized.
    Discussion: Premature ventricular complexes originating in the outflow tracts should be considered as a potential though rare cause of severe MR and pulmonary hypertension.
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad142
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  5. Article ; Online: In Reply.

    Genz, Conrad / Braun-Dullaeus, Ruediger C

    Deutsches Arzteblatt international

    2022  Volume 118, Issue 43, Page(s) 739–740

    Language English
    Publishing date 2022-01-27
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2021.0302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Analysis of a nurse-provided on-call peritoneal dialysis support in an outpatient reference care centre.

    Albert, Annemarie / Richter, Stefan / Kalk, Philipp / Stieger, Philipp / Woitas, Rainer Peter / Braun-Dullaeus, Rüdiger C / Albert, Christian

    BMC nursing

    2024  Volume 23, Issue 1, Page(s) 144

    Abstract: Background: To analyse the nature of medical or technical emergency issues of ambulatory peritoneal dialysis (PD) patients calling a nurse-provided emergency PD support service of a reference centre that is provided all year in the after-hours.: ... ...

    Abstract Background: To analyse the nature of medical or technical emergency issues of ambulatory peritoneal dialysis (PD) patients calling a nurse-provided emergency PD support service of a reference centre that is provided all year in the after-hours.
    Methods: We retrospectively analysed patients' chief complaint, urgency, resolution of and association to current PD treatment and modality directed to an on-call nurse-provided PD support service from 2015-2021 based on routinely collected health data. Calls were systematically categorized being technical/procedural-, medical-, material-related or type of correspondence. Call urgency was categorized to have "immediate consequence", inquiry was eligible for "processing next working day" or whether there was "no need for further action". Call outcomes were classified according to whether patients were able to initiate, resume or finalize their treatments or whether additional interventions were required. Unexpected adverse events such as patients' acute hospitalization or need for nurses' home visits were evaluated and quantified.
    Results: In total 753 calls were documented. Most calls were made around 7:30 a.m. (5:00-9:00; median, 25-75
    Conclusion: The on-call PD-nurse provides patient support for acute and imminent issues enabling them to successfully initiate, resume or finalize their prescribed treatment. Nurses triage of acute conditions facilitated rapid diagnostics and therapy. Maintaining quality PD homecare, the provision of trained personnel is indispensable. The information gathered in this study may therefore be used as a foundation to tailor educational programs for nephrology nurses and doctors to further develop their competencies in PD.
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091496-9
    ISSN 1472-6955
    ISSN 1472-6955
    DOI 10.1186/s12912-024-01812-4
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  7. Article ; Online: Inhibition of Platelet Aggregation After Coronary Stenting in Patients Receiving Oral Anticoagulation.

    Genz, Conrad / Braun-Dullaeus, Ruediger C

    Deutsches Arzteblatt international

    2021  Volume 118, Issue Forthcoming

    Abstract: Background: Approximately 18% of patients with atrial fibrillation undergo a percutaneous coronary intervention (PCI) to treat coronary heart disease. Pharmacological anticoagulation in patients with atrial fibrillation and PCI involves a trade-off of ... ...

    Abstract Background: Approximately 18% of patients with atrial fibrillation undergo a percutaneous coronary intervention (PCI) to treat coronary heart disease. Pharmacological anticoagulation in patients with atrial fibrillation and PCI involves a trade-off of potential ischemic and hemorrhagic complications.
    Methods: This review is based on pertinent publications that were retrieved by a selective literature search, including current guidelines and recommendations.
    Results: Dual antiplatelet therapy (DAPT) with acetylsalicylic acid (ASA) and a P2Y12 inhibitor protects against stent thrombosis, but not against thromboembolic stroke. In contrast, oral anticoagulation does provide effective prevention against stroke during atrial fibrillation. Combining DAPT with oral anticoagulation (triple therapy) over the long term, as has been recommended to date, carries an elevated risk of hemorrhage. In a randomized controlled trial, 44% of patients with atrial fibrillation receiving triple therapy sustained a hemorrhagic event, compared to 19.4% of patients receiving dual therapy. A meta-analysis has shown that clinically relevant hemorrhage is less common under combined treatment with one of the new oral anticoagulants (NOAC) and a single antiplatelet drug than under triple therapy including a vitamin K antagonist (hazard ratio, 0.56; 95% confidence interval 0.39; 0.80]), but no significant difference was found with respect to stent thrombosis, myocardial infarction, or overall mortality.
    Conclusion: After coronary stent implantation, dual therapy with a NOAC and a P2Y12 inhibitor is recommended, subsequent to triple therapy given only during the peri-interventional period.
    Language English
    Publishing date 2021-06-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2021.0150
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  8. Article: Baxter Physioneal, Extraneal, Nutrineal (PEN) and Dianeal solution bags can be accidentally connected to Fresenius peritoneal dialysis catheter extensions in a non-sterile manner.

    Albert, Annemarie / Richter, Stefan / Woitas, Rainer Peter / Hinkel, Ulrich Paul / Stieger, Philipp / Braun-Dullaeus, Rüdiger C / Albert, Christian

    Clinical kidney journal

    2024  Volume 17, Issue 4, Page(s) sfae067

    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfae067
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6587: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Was der (Allgemein- und Viszeral‑)Chirurg über die Thromboseprophylaxe wissen sollte.

    Meißler, Saskia / Braun-Dullaeus, Rüdiger / Hansen, Michael / Meyer, Frank

    Chirurgie (Heidelberg, Germany)

    2022  Volume 93, Issue 7, Page(s) 676–686

    Abstract: A persisting problem in the clinical operative routine is surgery-associated venous thromboembolisms with the possible complications. The competent and reliably realized prophylaxis of thromboembolism is part of the original and elementary tasks of the ... ...

    Title translation What the (general and abdominal) surgeon should know about thrombosis prophylaxis.
    Abstract A persisting problem in the clinical operative routine is surgery-associated venous thromboembolisms with the possible complications. The competent and reliably realized prophylaxis of thromboembolism is part of the original and elementary tasks of the surgeon, both the operator as well as the clinically active physician. Many preventive approaches were developed and established in the daily management but a residual risk for development of thrombosis still remains. Under this aspect a search was carried out particularly with respect to scientific literature with review and guideline character on the topic of risk stratification, prophylactic procedures in general and for specific indications.
    MeSH term(s) Anticoagulants/adverse effects ; Humans ; Surgeons ; Thromboembolism/drug therapy ; Thrombosis/etiology ; Venous Thrombosis/prevention & control
    Chemical Substances Anticoagulants
    Language German
    Publishing date 2022-02-11
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2731-698X
    ISSN (online) 2731-698X
    DOI 10.1007/s00104-021-01568-6
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  10. Article ; Online: Medical education during the Covid-19 pandemic long-term experiences of German clinical medical students.

    Gottschalk, Marc / Milch, Pascal M / Albert, Christian / Werwick, Katrin / Braun-Dullaeus, Ruediger C / Stieger, Philipp

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0286642

    Abstract: Introduction: Due to the Covid-19 pandemic and the accompanying hygiene regulations, medical students in Germany faced multiple educational and personal challenges. The challenges included the cancellation and digitalisation of courses, the closing of ... ...

    Abstract Introduction: Due to the Covid-19 pandemic and the accompanying hygiene regulations, medical students in Germany faced multiple educational and personal challenges. The challenges included the cancellation and digitalisation of courses, the closing of university institutions such as libraries, a decrease in social contacts, and the risk of a Covid-19 infection. The aim of this study was to understand medical students' pandemic experiences as well as the consequences of these experiences for the students' future work as physicians.
    Materials and methods: We performed 15 guided, one-on-one interviews with clinical medical students (third to fifth year) at the Otto-von-Guericke-University Magdeburg. Interviews were recorded, transcribed, and anonymised. We performed a qualitative content analysis in accordance with Mayring and thereby formed an inductive category system. The Consolidated Criteria for Reporting Qualitative Research (COREQ) were applied.
    Results: Five categories were inductively formed: "Changes in the teaching experience", "negative effects on the learning experience", "decrease in personal social contacts", "contact with covid-19", and "pandemic-associated stress increase". The participating students reported higher levels of stress due to isolation and uncertainty regarding their educational future. Furthermore, students welcomed the digitalisation of lectures, developed individual coping strategies, and voluntarily took part in the care of Covid-19 patients. Limitations to social interactions were perceived as the major restrictive factor to their educational structure, their perceived learning success and personal development.
    Conclusion: This study identified social restrictions as well as didactic and academic structural challenges as relevant factors contributing to perceived stress and fear for medical students during the Covid-19 pandemic, especially as regards their learning experience. Students' acceptance of digitalised learning may enable regular interaction with university peers and may facilitate a structured educational life. However, the implementation of digital resources could not provide a sufficient substitute for in-person courses.
    MeSH term(s) Humans ; Students, Medical ; Pandemics ; COVID-19/epidemiology ; Educational Status ; Education, Medical
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0286642
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