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  1. Article ; Online: Case Series: Hypercalcemia From Granulomatous Silicosis Developing After COVID-19 Infection.

    Bray, Ashley / Reyes, Jonathan Vincent M / Tarlin, Nancy / Stern, Aaron

    Journal of investigative medicine high impact case reports

    2021  Volume 9, Page(s) 23247096211051206

    Abstract: Hypercalcemia is one of the most commonly encountered laboratory abnormalities in clinical medicine. Various causes have been well established. However, it is likely that the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ...

    Abstract Hypercalcemia is one of the most commonly encountered laboratory abnormalities in clinical medicine. Various causes have been well established. However, it is likely that the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may be a newly found cause of this frequent finding, especially amongst those with a history of cosmetic surgery, specifically by means of silicone injection. In this case series, we describe 2 patients presenting with symptomatic hypercalcemia likely from their prior silicone injections. Interestingly, each patient only developed symptoms of hypercalcemia following infection with SARS-CoV-2.
    MeSH term(s) COVID-19 ; Humans ; Hypercalcemia/etiology ; SARS-CoV-2 ; Silicosis/complications ; Silicosis/diagnosis
    Language English
    Publishing date 2021-10-14
    Publishing country United States
    Document type Journal Article ; Case Reports
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/23247096211051206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Undecaprenol kinase: Function, mechanism and substrate specificity of a potential antibiotic target.

    Baker, Brad R / Ives, Callum M / Bray, Ashley / Caffrey, Martin / Cochrane, Stephen A

    European journal of medicinal chemistry

    2020  Volume 210, Page(s) 113062

    Abstract: The bifunctional undecaprenol kinase/phosphatase (UdpK) is a small, prokaryotic, integral membrane kinase, homologous with Escherichia coli diacylglycerol kinase and expressed by the dgkA gene. In Gram-positive bacteria, UdpK is involved in the ... ...

    Abstract The bifunctional undecaprenol kinase/phosphatase (UdpK) is a small, prokaryotic, integral membrane kinase, homologous with Escherichia coli diacylglycerol kinase and expressed by the dgkA gene. In Gram-positive bacteria, UdpK is involved in the homeostasis of the bacterial undecaprenoid pool, where it converts undecaprenol to undecaprenyl phosphate (C
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Gram-Positive Bacteria/drug effects ; Gram-Positive Bacteria/enzymology ; Microbial Sensitivity Tests ; Molecular Structure ; Phosphotransferases (Alcohol Group Acceptor)/biosynthesis ; Phosphotransferases (Alcohol Group Acceptor)/metabolism
    Chemical Substances Anti-Bacterial Agents ; Enzyme Inhibitors ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; undecaprenol kinase (EC 2.7.1.66)
    Language English
    Publishing date 2020-12-02
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2020.113062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A case of isolated sinus bradycardia as an unusual presentation of adrenal insufficiency.

    Reyes, Jonathan Vincent M / Majeed, Hafsa / Song, David / Ahmad, Saad / Bray, Ashley / Almas, Talal / Alshamlan, Abdulaziz / Lieber, Joseph J

    Annals of medicine and surgery (2012)

    2021  Volume 69, Page(s) 102727

    Abstract: Introduction: Sinus bradycardia is a common entity encountered in clinical practice. The differential diagnosis is quite broad; it can be an incidental finding in otherwise healthy adults or the first clue to a lethal pathology.: Case presentation: ... ...

    Abstract Introduction: Sinus bradycardia is a common entity encountered in clinical practice. The differential diagnosis is quite broad; it can be an incidental finding in otherwise healthy adults or the first clue to a lethal pathology.
    Case presentation: This case highlights a patient who presented with symptomatic sinus bradycardia, which resulted in syncope requiring admission for permanent pacemaker implantation and later found to have an underlying adrenal insufficiency (AI). Patient's underlying hyponatremia was corrected but bradycardia persisted and after the initiation of steroids, bradycardia resolved. Therefore, the likely culprit for bradycardia was AI.
    Discussion: Multiple disease processes that manifest with sinus bradycardia are commonly due to the increased vagal tone or the presence of intrinsic conduction disorders. Sinus bradycardia is a common clinical finding with a broad differential including intrinsic and extrinsic causes of sinus node dysfunction or AV block.
    Conclusion: It is imperative for clinicians to be aware of rare etiologies for underlying symptomatic bradycardia. While extremely effective at preventing symptomatic bradycardia, avoiding a pacemaker by correcting the underlying etiology of symptomatic bradycardia may improve quality of life and avoid an unnecessary procedure.
    Language English
    Publishing date 2021-08-16
    Publishing country England
    Document type Case Reports
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2021.102727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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