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Artikel: Removing Craniofacial Titanium Screws: Technical Note.

Lim, Jaims / Bregy, Amade / Gibbons, Kevin

2021 Band 13, Heft 11, Seite(n) e19891

Abstract: Craniotomy, cranioplasty, and craniofacial procedures may involve reoperation for additional treatment of the primary pathological condition or treatment of complications, requiring removal of previously placed hardware. During removal of the titanium ... ...

Abstract	Craniotomy, cranioplasty, and craniofacial procedures may involve reoperation for additional treatment of the primary pathological condition or treatment of complications, requiring removal of previously placed hardware. During removal of the titanium hardware, there is a risk of losing, dropping, or misplacing the titanium screws because of their small size. There are also instances of difficulty disengaging the screw from the screwdriver. We describe the use of a plastic specimen cup in retrieving titanium screws after detaching them from the screwdriver by screwing the screw into the cup, thus rapidly and safely securing and storing screws for collection/discarding or possible reuse. When the empty screwdriver is used to retrieve and unscrew the titanium screw from the cranial flap or the skull bone, a plastic specimen cup should be placed adjacent to the site of screw removal. Once the screw is removed, while it is still fastened to the screwdriver, it is immediately re-screwed and secured onto the base of the plastic specimen cup, which is then placed into a second plastic specimen cup. This method prevents misplacement or dropping of the screw that may otherwise occur when manipulating the screw on or off the screwdriver and avoids perforating the surgeon's glove during handling. We describe the adjunctive use of a plastic specimen cup when removing cranial screws and hardware to rapidly and safely detach the screw and prevent the misplacement, dropping, or loss of screws intraoperatively that results in additional operative time and personnel assistance.
Sprache	Englisch
Erscheinungsdatum	2021-11-25
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.19891
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Cerebral Proliferative Angiopathy Presenting as Subdural Hematoma: A Case Report and Systematic Literature Review.

Hess, Ryan M / Zhang, Jeff F / Cappuzzo, Justin M / Bregy, Amade / Levy, Elad I

World neurosurgery

2022 Band 164, Seite(n) 281–289

Abstract: Cerebral proliferative angiopathy (CPA) is a rare cerebrovascular pathology that presents with unique clinical features due to distinct histologic, angiographic, and pathophysiologic characteristics that separate it from classical arteriovenous ... ...

Abstract	Cerebral proliferative angiopathy (CPA) is a rare cerebrovascular pathology that presents with unique clinical features due to distinct histologic, angiographic, and pathophysiologic characteristics that separate it from classical arteriovenous malformation. The disorder is characterized by uncontrolled angiogenesis in which functional brain parenchyma is interspersed with abnormal vascular channels without a distinct nidus. Common presenting symptoms include headache, seizures, and stroke-like symptoms. Hemorrhagic presentations are rare in contrast to the typical presentations of classical arteriovenous malformation. Here, we report a young woman with a history of a suspected connective tissue disorder who presented to the emergency department with worsening headaches in a delayed fashion after experiencing minor head trauma and was found to have a left-sided subdural hematoma. Angiography confirmed a diagnosis of CPA after abnormal cortical vasculature was noted during the patient's craniotomy. A systematic review of CPA cases described in the literature was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, with the findings discussed.
Mesh-Begriff(e)	Cerebral Angiography ; Cerebrovascular Disorders ; Female ; Headache ; Hematoma, Subdural/diagnostic imaging ; Hematoma, Subdural/etiology ; Hematoma, Subdural/surgery ; Humans ; Intracranial Arteriovenous Malformations/complications ; Intracranial Arteriovenous Malformations/diagnostic imaging ; Intracranial Arteriovenous Malformations/surgery
Sprache	Englisch
Erscheinungsdatum	2022-05-27
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article ; Review ; Systematic Review
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2022.05.096
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Histopathological correlation of brain tumor recurrence vs. radiation effect post-radiosurgery as detected by MRI contrast clearance analysis: a validation study.

Goulenko, Victor / Madhugiri, Venkatesh Shankar / Bregy, Amade / Recker, Matthew / Lipinski, Lindsay / Fabiano, Andrew / Fenstermaker, Robert / Plunkett, Robert / Abad, Ajay / Belal, Ahmed / Alberico, Ronald / Qiu, Jingxin / Prasad, Dheerendra

Journal of neuro-oncology

2024

Abstract: Purpose: The differentiation between adverse radiation effects (ARE) and tumor recurrence or progression (TRP) is a major decision-making point in the follow-up of patients with brain tumors. The advent of immunotherapy, targeted therapy and ... ...

Abstract	Purpose: The differentiation between adverse radiation effects (ARE) and tumor recurrence or progression (TRP) is a major decision-making point in the follow-up of patients with brain tumors. The advent of immunotherapy, targeted therapy and radiosurgery has made this distinction difficult to achieve in several clinical situations. Contrast clearance analysis (CCA) is a useful technique that can inform clinical decisions but has so far only been histologically validated in the context of high-grade gliomas. Methods: This is a series of 7 patients, treated between 2018 and 2023, for various brain pathologies including brain metastasis, atypical meningioma, and high-grade glioma. MRI with contrast clearance analysis was used to inform clinical decisions and patients underwent surgical resection as indicated. The histopathology findings were compared with the CCA findings in all cases. Results: All seven patients had been treated with gamma knife radiosurgery and were followed up with periodic MR imaging. All patients underwent CCA when the necessity to distinguish tumor recurrence from radiation necrosis arose, and subsequently underwent surgery as indicated. Concordance of CCA findings with histological findings was found in all cases (100%). Conclusions: Based on prior studies on GBM and the surgical findings in our series, delayed contrast extravasation MRI findings correlate well with histopathology across a wide spectrum of brain tumor pathologies. CCA can provide a quick diagnosis and have a direct impact on patients' treatment and outcomes.
Sprache	Englisch
Erscheinungsdatum	2024-05-15
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	604875-4
ISSN	1573-7373 ; 0167-594X
ISSN (online)	1573-7373
ISSN	0167-594X
DOI	10.1007/s11060-024-04697-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Use of Novel Automated Active Irrigation With Drainage Versus Passive Drainage Alone for Chronic Subdural Hematoma-A Propensity Score-Matched Comparative Study With Volumetric Analysis.

Baig, Ammad A / Hess, Ryan M / Khan, Asham / Cappuzzo, Justin M / Turner, Ryan C / Hashmi, Eisa / Bregy, Amade / Kuo, Cathleen C / Nyabuto, Elizabeth / Goyal, Aditya D / Davies, Jason M / Levy, Elad I / Siddiqui, Adnan H

Operative neurosurgery (Hagerstown, Md.)

2023 Band 24, Heft 6, Seite(n) 630–640

Abstract: Background: Passive drainage post-surgical evacuation of symptomatic chronic subdural hematoma (cSDH) is currently standard of care. High rates of infection, drain occlusion, and recurrence are associated complications.: Objective: To explore the use ...

Abstract	Background: Passive drainage post-surgical evacuation of symptomatic chronic subdural hematoma (cSDH) is currently standard of care. High rates of infection, drain occlusion, and recurrence are associated complications. Objective: To explore the use of a novel double-lumen active automated irrigation and aspiration system, IRRAflow (IRRAS), for patients with cSDH and compared procedural and clinical outcomes against passive drainage alone with propensity score matching (PSM) and volumetric analysis. Methods: A prospectively maintained database was retrospectively searched for consecutive patients presenting with cSDH. One-to-one PSM of covariates (including baseline comorbidities and presentation hematoma volume) in active and passive irrigation groups was performed to adjust for treatment selection bias. Rates of hematoma clearance, catheter-related occlusion, and infection; number of revisions; and length of hospital stay were recorded. Results: This study included 55 patients: active continuous irrigation-drainage-21 (21 post-PSM) and passive drainage-34 (21 post-PSM). For PSM groups, a significantly higher rate of hematoma clearance was obtained in the active irrigation-drainage group (0.5 ± 0.4 vs 0.4 ± 0.5 mL/day) and in the passive drainage group; odds ratio (OR) = 1.291 (CI: 1.062-1.570, P = .002) and a significantly lower rate of catheter-related infections (OR = 0.051; CI: 0.004-0.697, P = .039). A nonsignificantly lower hematoma expansion rate at discharge was noted in the active irrigation-drainage group (4.8% vs 23.8%; OR = 0.127; P = .186). No statistical difference in all-cause in-hospital mortality or discharge Glasgow Coma Scale score was observed between groups. Conclusion: Active and automated continuous irrigation plus drainage after cSDH surgical evacuation resulted in faster hematoma clearance and led to favorable clinical outcomes and low complication and revision rates compared with passive irrigation.
Mesh-Begriff(e)	Humans ; Retrospective Studies ; Hematoma, Subdural, Chronic/surgery ; Propensity Score ; Trephining/methods ; Drainage/methods
Sprache	Englisch
Erscheinungsdatum	2023-02-01
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2767575-0
ISSN	2332-4260 ; 2332-4252
ISSN (online)	2332-4260
ISSN	2332-4252
DOI	10.1227/ons.0000000000000630
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Primary Leiomyosarcoma of the Calvarium with Intracranial Extension: a Case Report.

Bregy, Amade / Lim, Jaims / Lohman, Robert / Kane, John / Prasad, Dheerendra / Qiu, Jingxin / Fenstermaker, Robert A

Indian journal of surgical oncology

2020 Band 11, Heft Suppl 2, Seite(n) 165–169

Sprache	Englisch
Erscheinungsdatum	2020-07-01
Erscheinungsland	India
Dokumenttyp	Case Reports
ZDB-ID	2568289-1
ISSN	0976-6952 ; 0975-7651
ISSN (online)	0976-6952
ISSN	0975-7651
DOI	10.1007/s13193-020-01129-z
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: In reply.

Shah, Ashish H / Bregy, Amade / Komotar, Ricardo J

World neurosurgery

2014 Band 82, Heft 1-2, Seite(n) e387

Mesh-Begriff(e)	Animals ; Hydrocephalus/etiology ; Hydrocephalus/pathology ; Subarachnoid Hemorrhage/complications
Sprache	Englisch
Erscheinungsdatum	2014-07
Erscheinungsland	United States
Dokumenttyp	Comment ; Letter
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2013.08.006
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Evaluation of a ring enhancing lesion.

Scoma, Christopher B / Shah, Ashish H / Bregy, Amade / Komotar, Ricardo J

BMJ (Clinical research ed.)

2015 Band 351, Seite(n) h5033

Mesh-Begriff(e)	Brain/pathology ; Brain Neoplasms/complications ; Brain Neoplasms/diagnosis ; Brain Neoplasms/pathology ; Female ; Headache/etiology ; Humans ; Magnetic Resonance Imaging ; Memory Disorders/etiology ; Middle Aged ; Vision, Low/etiology
Sprache	Englisch
Erscheinungsdatum	2015-10-05
Erscheinungsland	England
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.h5033
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Increased Expression of Epileptiform Spike/Wave Discharges One Year after Mild, Moderate, or Severe Fluid Percussion Brain Injury in Rats.

Sick, Thomas / Wasserman, Joseph / Bregy, Amade / Sick, Justin / Dietrich, W Dalton / Bramlett, Helen M

Journal of neurotrauma

2017 Band 34, Heft 16, Seite(n) 2467–2474

Abstract: In this study, we describe increased expression of cortical epileptiform spike/wave discharges (SWD) in rats one year after mild, moderate, or severe fluid percussion traumatic brain injury (fpTBI). Groups of rats consisted of animals that had received ... ...

Abstract	In this study, we describe increased expression of cortical epileptiform spike/wave discharges (SWD) in rats one year after mild, moderate, or severe fluid percussion traumatic brain injury (fpTBI). Groups of rats consisted of animals that had received mild, moderate, or severe fpTBI, or sham operation one year earlier than electrocorticography (ECoG) recordings. In addition, we included a group of age-matched naïve animals. ECoG was recorded from awake animals using epidural electrodes implanted on the injured hemisphere (right), sham-operated hemisphere (right), or right hemisphere in naïve animals. The SWDs were detected automatically using Fast Fourier Transformation and a novel algorithm for comparing changes in spectral power to control (nonepileptical) ECoG. The fpTBI resulted in increased expression of SWDs one year after injury compared with sham-operated or naïve animals. The number of SWD-containing ECoG epochs recorded in a 1 h recording session were: naïve 12.9 ± 10.3, n = 8, sham 23.6 ± 8.2, n = 10, mild TBI 78.9 ± 23.9, n = 10, moderate TBI 61.3 ± 32.5, n = 12, severe TBI 72.5 ± 28.3, n = 11 (mean ± standard error of the mean). Increased expression of SWDs was not related to injury severity. SWDs were observed to a lesser extent even in sham-operated and naïve animals. The data indicate that fpTBI exacerbates expression of SWDs in the rat and that this increase may be observed at least one year after injury. As others have discussed, the spontaneous occurrence of these epileptiform events in rodents limits the use of this model for investigations of acquired epilepsy, at least of the nonconvulsive type, after TBI.
Mesh-Begriff(e)	Animals ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/physiopathology ; Electrocorticography ; Epilepsy/etiology ; Epilepsy/physiopathology ; Rats ; Rats, Sprague-Dawley
Sprache	Englisch
Erscheinungsdatum	2017-06-14
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2016.4826
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Therapeutic Targeting of the Notch Pathway in Glioblastoma Multiforme.

Gersey, Zachary / Osiason, Adam D / Bloom, Laura / Shah, Sumedh / Thompson, John W / Bregy, Amade / Agarwal, Nitin / Komotar, Ricardo J

World neurosurgery

2019 Band 131, Seite(n) 252–263.e2

Abstract: Background: Glioblastoma (GBM) is the most common and deadly form of brain tumor. After standard treatment of resection, radiotherapy, and chemotherapy, the 5-year survival is <5%. In recent years, research has uncovered several potential targets within ...

Abstract	Background: Glioblastoma (GBM) is the most common and deadly form of brain tumor. After standard treatment of resection, radiotherapy, and chemotherapy, the 5-year survival is <5%. In recent years, research has uncovered several potential targets within the Notch signaling pathway, which may lead to improved patient outcomes. Methods: A literature search was performed for articles containing the terms "Glioblastoma" and "Receptors, Notch" between 2003 and July 2015. Of the 62 articles retrieved, 46 met our criteria and were included in our review. Nine articles were identified from other sources and were subsequently included, leaving 55 articles reviewed. Results: Of the 55 articles reviewed, 47 used established human GBM cell lines. Seventeen articles used human GBM surgical samples. Forty-five of 48 articles that assessed Notch activity showed increased expression in GBM cell lines. Targeting the Notch pathway was carried out through Notch knockdown and overexpression and targeting δ-like ligand, Jagged, γ-secretase, ADAM10, ADAM17, and Mastermindlike protein 1. Arsenic trioxide, microRNAs, and several other compounds were shown to have an effect on the Notch pathway in GBM. Notch activity in GBM was also shown to be associated with hypoxia and certain cancer-related molecular pathways such as PI3K/AKT/mTOR and ERK/MAPK. Most articles concluded that Notch activity amplifies malignant characteristics in GBM and targeting this pathway can bring about amelioration of these effects. Conclusions: Recent literature suggests targeting the Notch pathway has great potential for future therapies for GBM.
Mesh-Begriff(e)	ADAM Proteins/antagonists & inhibitors ; Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Antineoplastic Agents/pharmacology ; Arsenic Trioxide/pharmacology ; Brain Neoplasms/blood supply ; Brain Neoplasms/therapy ; Cell Hypoxia ; Cell Line, Tumor ; Gene Knockdown Techniques ; Glioblastoma/blood supply ; Glioblastoma/therapy ; Humans ; Inhibitor of Differentiation Proteins/antagonists & inhibitors ; Kruppel-Like Transcription Factors/antagonists & inhibitors ; MicroRNAs/pharmacology ; Microvessels ; Molecular Targeted Therapy/methods ; Neoplasm Proteins/antagonists & inhibitors ; Netrin-1/antagonists & inhibitors ; Niclosamide/pharmacology ; Receptors, Notch/antagonists & inhibitors ; Receptors, Notch/genetics ; Receptors, Urokinase Plasminogen Activator/antagonists & inhibitors ; Resveratrol/pharmacology ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Tretinoin/pharmacology
Chemische Substanzen	Antineoplastic Agents ; Inhibitor of Differentiation Proteins ; Kruppel-Like Transcription Factors ; MicroRNAs ; Neoplasm Proteins ; Receptors, Notch ; Receptors, Urokinase Plasminogen Activator ; Netrin-1 (158651-98-0) ; Tretinoin (5688UTC01R) ; Niclosamide (8KK8CQ2K8G) ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; ADAM Proteins (EC 3.4.24.-) ; Resveratrol (Q369O8926L) ; Arsenic Trioxide (S7V92P67HO)
Sprache	Englisch
Erscheinungsdatum	2019-07-31
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2019.07.180
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: No association between serum ferritin levels >10 microg/l and hair loss activity in women.

Bregy, Amadé / Trueb, Ralph M

Dermatology (Basel, Switzerland)

2008 Band 217, Heft 1, Seite(n) 1–6

Mesh-Begriff(e)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Alopecia/blood ; Alopecia/etiology ; Anemia, Iron-Deficiency/complications ; Anemia, Iron-Deficiency/diagnosis ; Female ; Ferritins/blood ; Ferritins/deficiency ; Hair/growth & development ; Hair/pathology ; Humans ; Middle Aged ; Scalp/pathology ; Sensitivity and Specificity ; Severity of Illness Index ; Statistics as Topic
Chemische Substanzen	Ferritins (9007-73-2)
Sprache	Englisch
Erscheinungsdatum	2008
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	1099692-8
ISSN	1421-9832 ; 1018-8665
ISSN (online)	1421-9832
ISSN	1018-8665
DOI	10.1159/000118505
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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