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  1. Article ; Online: Rehabilitation following total laryngectomy: Oncologic, functional, socio-occupational and psychological aspects.

    Antin, F / Breheret, R / Goineau, A / Capitain, O / Laccourreye, L

    European annals of otorhinolaryngology, head and neck diseases

    2020  Volume 138, Issue 1, Page(s) 19–22

    Abstract: Goal: To review rehabilitation following total laryngectomy by an analysis of epidemiological, oncologic and functional data.: Materials and methods: This retrospective observational study focused on patients having undergone total laryngectomy or ... ...

    Abstract Goal: To review rehabilitation following total laryngectomy by an analysis of epidemiological, oncologic and functional data.
    Materials and methods: This retrospective observational study focused on patients having undergone total laryngectomy or pharyngolaryngectomy between January 1, 2005 and December 31, 2016. Oncologic data notably comprised survival and relapse and predictive factors. The impact of the procedure on quality of life and the voice was analyzed by self-administered questionnaires (EORTC QLQ-C30 and H&N35, VHI 30). A satisfaction questionnaire was also sent to patients.
    Results: One hundred and thirty three patients were included. Overall specific 5-year survival was 65%. The relapse rate was 32%. Factors influencing survival were WHO performance status ≥2 (P<0.05), tumor location (P=0.07), metastatic lymphadenopathy (P=0.017) and positive resection margins (P=0.01). Quality of life was moderately degraded (global EORTC QLQ-C30 status: 61.4±23.9). Type of rehabilitation (P=0.03), tube feeding (P=0.03) and relapse (P<0.01) influenced quality of life. There were no differences in voice quality according to rehabilitation method, and no predictive factors for failure of voice rehabilitation. More than 90% of patients were satisfied with their hospital stay; 43%, however, were not satisfied with community caregiver training for laryngectomy patients.
    Conclusion: Rehabilitation of laryngectomized patients is a current therapeutic challenge. A therapeutic education tool was designed to better meet patient expectations.
    MeSH term(s) Humans ; Laryngeal Neoplasms/surgery ; Laryngectomy ; Quality of Life ; Surveys and Questionnaires ; Voice ; Voice Quality
    Language English
    Publishing date 2020-06-22
    Publishing country France
    Document type Journal Article ; Observational Study
    ZDB-ID 2558008-5
    ISSN 1879-730X ; 1879-7296
    ISSN (online) 1879-730X
    ISSN 1879-7296
    DOI 10.1016/j.anorl.2020.06.006
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  2. Article ; Online: Anatomical and functional rehabilitation after total bilateral maxillectomy using a custom-made bone-anchored titanium prosthesis.

    Gueutier, A / Kün-Darbois, J-D / Laccourreye, L / Breheret, R

    International journal of oral and maxillofacial surgery

    2019  Volume 49, Issue 3, Page(s) 392–396

    Abstract: Surgical reconstruction after a total maxillectomy remains challenging. The standard treatment is the microvascular free flap. In cases of surgical contraindication, oral rehabilitation is usually performed with a palatal obturator prosthesis (PAP). ... ...

    Abstract Surgical reconstruction after a total maxillectomy remains challenging. The standard treatment is the microvascular free flap. In cases of surgical contraindication, oral rehabilitation is usually performed with a palatal obturator prosthesis (PAP). Acceptable anatomical and functional outcomes in terms of speech, mastication, aesthetic appearance, stability, and comfort are not often achieved with a PAP. This technical note describes a technique for reconstruction after total bilateral maxillectomy involving the implantation of a custom-made bone-anchored titanium prosthesis obtained by 3D printing. Good functional and anatomical outcomes were achieved with this technique. It combines the advantages of the obturator prosthesis (short duration of surgery and hospitalization, low morbidity) and free flap (aesthetic/anatomical reconstruction and irremovable comfortable functional rehabilitation). This technique constitutes a new therapeutic alternative for the restoration of large defects after total maxillectomy when free flaps are contraindicated.
    MeSH term(s) Esthetics, Dental ; Humans ; Maxilla ; Maxillary Neoplasms ; Palatal Obturators ; Reconstructive Surgical Procedures ; Titanium
    Chemical Substances Titanium (D1JT611TNE)
    Language English
    Publishing date 2019-09-09
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 353721-3
    ISSN 1399-0020 ; 0901-5027
    ISSN (online) 1399-0020
    ISSN 0901-5027
    DOI 10.1016/j.ijom.2019.08.014
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    Zs.A 931: Show issues Location:
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  3. Article ; Online: Clear cell sarcoma of the soft palate mimicking unclassified melanoma.

    Donzel, M / Zidane-Marinnes, M / Paindavoine, S / Breheret, R / de la Fouchardière, A

    Pathology

    2019  Volume 51, Issue 3, Page(s) 331–334

    MeSH term(s) Adult ; Diagnosis, Differential ; Humans ; Male ; Melanoma/diagnosis ; Melanoma/pathology ; Palatal Neoplasms/diagnosis ; Palatal Neoplasms/pathology ; Palate, Soft/pathology ; Sarcoma, Clear Cell/diagnosis ; Sarcoma, Clear Cell/pathology
    Language English
    Publishing date 2019-03-02
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2018.10.019
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    Zs.A 723: Show issues Location:
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  4. Article ; Online: Paralysie vélaire aiguë réversible de l'enfant : à propos d'un cas.

    Brecheteau, C / Laccourreye, L / Gueden, S / Breheret, R

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

    2015  Volume 22, Issue 5, Page(s) 544–546

    Abstract: Introduction: Approximately 40 cases of acute idiopathic velopharyngeal reversible paralysis in the pediatric population have been reported in the literature.: Observation: We present the case of a 12-year-old boy who had consulted in pediatric ... ...

    Title translation Pediatric reversible acute velar palsy: A case report.
    Abstract Introduction: Approximately 40 cases of acute idiopathic velopharyngeal reversible paralysis in the pediatric population have been reported in the literature.
    Observation: We present the case of a 12-year-old boy who had consulted in pediatric emergency departments for symptomatology including rhinolalia, nasal regurgitation, and deviation of the labial commissure. Paraclinical explorations helped diagnose rhombencephalitis with enterovirus. The introduction of oral corticosteroids was followed by rapid clinical improvement in 3 days. Monitoring 1 month later showed complete regression of symptoms.
    Discussion: Similar cases in the literature describe the occurrence of nasal regurgitation and rhinolalia, sometimes associated with other cranial nerve impairment. The pathogenesis is rarely highlighted and the imaging results are always normal. Ad integrum recovery with or without corticosteroids is the rule. In light of this literature review, it is possible to conclude that the occurrence of such a suggestive clinical picture should limit the often costly and unnecessary additional tests.
    MeSH term(s) Administration, Oral ; Adrenal Cortex Hormones/therapeutic use ; Child ; Cranial Nerve Diseases/diagnosis ; Cranial Nerve Diseases/drug therapy ; Encephalitis, Viral/diagnosis ; Encephalitis, Viral/drug therapy ; Enterovirus Infections/diagnosis ; Enterovirus Infections/drug therapy ; Facial Nerve Diseases/diagnosis ; Facial Nerve Diseases/drug therapy ; Glossopharyngeal Nerve Diseases/diagnosis ; Glossopharyngeal Nerve Diseases/drug therapy ; Humans ; Male ; Paralysis/diagnosis ; Paralysis/drug therapy ; Rhombencephalon ; Treatment Outcome ; Vagus Nerve Diseases/diagnosis ; Vagus Nerve Diseases/drug therapy ; Velopharyngeal Insufficiency/diagnosis ; Velopharyngeal Insufficiency/drug therapy
    Chemical Substances Adrenal Cortex Hormones
    Language French
    Publishing date 2015-05
    Publishing country France
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 1181947-9
    ISSN 1769-664X ; 0929-693X
    ISSN (online) 1769-664X
    ISSN 0929-693X
    DOI 10.1016/j.arcped.2015.02.002
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    Zs.A 3942: Show issues Location:
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  5. Article ; Online: Importance of malnutrition and associated diseases in the management of Zenker's diverticulum.

    Boucher, S / Breheret, R / Laccourreye, L

    European annals of otorhinolaryngology, head and neck diseases

    2015  Volume 132, Issue 3, Page(s) 125–128

    Abstract: Objectives: To study the impact of malnutrition on a population treated for Zenker's diverticulum and to look for the causes of persistence or recurrence of dysphagia after endoscopic surgery.: Material and methods: This retrospective study included ... ...

    Abstract Objectives: To study the impact of malnutrition on a population treated for Zenker's diverticulum and to look for the causes of persistence or recurrence of dysphagia after endoscopic surgery.
    Material and methods: This retrospective study included 30 patients with Zenker's diverticulum treated by endoscopy. All swallowing disorders and manifestations of malnutrition and postoperative improvement in and/or recurrence of symptoms were noted.
    Results: Nutritional status was evaluated for 26 patients. Before surgery, 54% suffered from malnutrition, which was severe in 31%; 28.6% of the cases with malnutrition showed postoperative complications, versus 8.3% of cases without baseline malnutrition. Ninety percent of patients (n=27) declared complete resolution of symptoms. Nine patients presented recurrence of dysphagia, including 6 with recurrence of Zenker's diverticulum and 3 with, respectively, inclusion body myopathy, esophageal hypertonia and central disease.
    Conclusion: Malnutrition should be quantified and treated before and after surgery for Zenker's diverticulum to prevent complications and decrease mortality. Associated pathologies should be systematically screened for, especially in case of recurrence of swallowing disorder without recurrence of Zenker's diverticulum.
    MeSH term(s) Aged ; Aged, 80 and over ; Deglutition Disorders/etiology ; Diverticulitis/complications ; Diverticulitis/diagnosis ; Diverticulitis/surgery ; Esophagoscopy/methods ; Female ; Humans ; Male ; Malnutrition/complications ; Middle Aged ; Recurrence ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; Zenker Diverticulum/surgery
    Language English
    Publishing date 2015-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 2558008-5
    ISSN 1879-730X ; 1879-7296
    ISSN (online) 1879-730X
    ISSN 1879-7296
    DOI 10.1016/j.anorl.2015.01.004
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  6. Article ; Online: Spontaneous Breathing for Panendoscopy? Retrospective Cohort and Results of a French Practice Survey.

    Habrial, Pierre / Léger, Maxime / Costerousse, Fabienne / Debiasi, Julie / Breheret, Renaud / Vacheron, Charles-Hervé / Rineau, Emmanuel / Lasocki, Sigismond

    OTO open

    2022  Volume 6, Issue 1, Page(s) 2473974X211065015

    Abstract: Objective: Avoiding tracheal intubation by using general anesthesia with spontaneous breathing (GASB) is attractive for upper airway panendoscopy. The aim of this study was to estimate the incidence of adverse events during panendoscopy under GASB and ... ...

    Abstract Objective: Avoiding tracheal intubation by using general anesthesia with spontaneous breathing (GASB) is attractive for upper airway panendoscopy. The aim of this study was to estimate the incidence of adverse events during panendoscopy under GASB and to assess the practices of French anesthesiologists.
    Study design: Two-phase study: monocentric retrospective study and national survey.
    Setting: University hospital center.
    Methods: Patients who underwent a panendoscopy under GASB at the University Hospital of Angers between January 1 and December 31, 2014, were reviewed. Failure of GASB was defined as an episode of hypoxemia (SpO
    Results: Among the 95 included patients, 22 (23%) experienced a failure of GASB: 3 tolerated hypoxemia, 15 had face mask ventilation episodes, and 4 were intubated. Three factors were associated with failure: obesity (odds ratio, 11.94; 95% CI, 3.20-44.64), history of difficult intubation defined as a Cormack score ≥3 (odds ratio, 6.20; 95% CI, 1.51-25.41), and laryngeal tumor (odds ratio, 2.81; 95% CI, 1.04-7.56). Among the 3930 members of the French Society of Anaesthesia and Intensive Care in 2018, 662 (16.8%) responded to the survey. The 2 preferred techniques to perform panendoscopy were intubation (62%) and intravenous sedation with spontaneous breathing (37%).
    Conclusion: Although general anesthesia with orotracheal intubation remains the preferred technique for panendoscopy in France, GASB is an attractive alternative with a low failure rate. Risk factors for failure are obesity, history of difficult intubation, and laryngeal tumor.
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Journal Article
    ISSN 2473-974X
    ISSN (online) 2473-974X
    DOI 10.1177/2473974X211065015
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  7. Article ; Online: A chronic supra-orbital swelling.

    Brecheteau, C / Laccourreye, L / Breheret, R

    European annals of otorhinolaryngology, head and neck diseases

    2013  Volume 130, Issue 3, Page(s) 161–163

    MeSH term(s) Abscess/diagnostic imaging ; Abscess/microbiology ; Abscess/pathology ; Abscess/surgery ; Aspergillosis/complications ; Aspergillosis/diagnostic imaging ; Aspergillosis/pathology ; Aspergillosis/surgery ; Chronic Disease ; Frontal Sinus/diagnostic imaging ; Frontal Sinus/microbiology ; Frontal Sinus/pathology ; Frontal Sinus/surgery ; Humans ; Male ; Middle Aged ; Orbit/diagnostic imaging ; Orbit/surgery ; Radiography ; Treatment Outcome
    Language English
    Publishing date 2013-06
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 2558008-5
    ISSN 1879-730X ; 1879-7296
    ISSN (online) 1879-730X
    ISSN 1879-7296
    DOI 10.1016/j.anorl.2012.10.003
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  8. Article ; Online: Efficacy and safety of early G-CSF administration in patients with head and neck cancer treated by docetaxel-cisplatin and 5-fluorouracil (DCF protocol): a retrospective study.

    Linot, B / Augereau, P / Breheret, R / Laccourreye, L / Capitain, O

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2014  Volume 22, Issue 10, Page(s) 2831–2837

    Abstract: Background: Induction chemotherapy with docetaxel-cisplatin and 5-fluorouracil (DCF) for locally advanced head and neck cancers (HNC) is associated with a high risk of severe neutropenia or febrile neutropenia (FN). We conducted a retrospective study to ...

    Abstract Background: Induction chemotherapy with docetaxel-cisplatin and 5-fluorouracil (DCF) for locally advanced head and neck cancers (HNC) is associated with a high risk of severe neutropenia or febrile neutropenia (FN). We conducted a retrospective study to evaluate the efficacy and safety of administering granulocyte colony-stimulating factor (G-CSF) on day 3 (D3) during chemotherapy (early G-CSF stimulation) versus after the end of chemotherapy, as per current guidelines (i.e., after the end of 5-FU perfusion; D7), and its impact on patient outcomes.
    Patients and methods: Patients ≥19 years old, with advanced HNC who received DCF induction chemotherapy (D and P 75 mg per meter squared (mg/m(2)) on day 1 and 5-FU 750 mg/m(2)/day from D1 to D5), were included in the analysis.
    Results: Data of 70 patients were analyzed from 01 January 2003 to 01 December 2010. Mean age was 56 years (range 45 to 77 years). Thirty-six patients (51.4 %) received pegfilgrastim on D7, and 28 (40 %) started G-CSF prophylaxis during chemotherapy; 12 (17.1 %) had daily filgrastim and 16 (22.9 %) pegfilgrastim on D3. Overall response rate (ORR) was 89.6 % (three early deaths due to infectious complications; 4.3 %). The 3-year overall survival (OS) rate was 72.8 %. FN rate was 14.3 % and chemotherapy delay was 12.9 %. In the D7 G-CSF arm, incidence of grade 3-4 neutropenia (p = 0.023), FN (p = 0.029), and cycle delays (p = 0.006) was statistically higher than the "early" G-CSF arm. A decrease of OS was observed at 2 years (from 85.1 to 63.5 %) of chemotherapy discontinuation or FN (p = 0.0348).
    Discussion: Early administration of G-CSF is safe and seems to be more effective than D7. Future prospective trials are required to confirm our results.
    MeSH term(s) Aged ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/pharmacology ; Antineoplastic Protocols ; Cisplatin/adverse effects ; Cisplatin/pharmacology ; Docetaxel ; Drug Therapy, Combination ; Female ; Fluorouracil/adverse effects ; Fluorouracil/pharmacology ; Granulocyte Colony-Stimulating Factor/adverse effects ; Granulocyte Colony-Stimulating Factor/pharmacology ; Head and Neck Neoplasms/drug therapy ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Taxoids/adverse effects ; Taxoids/pharmacology
    Chemical Substances Antineoplastic Agents ; Taxoids ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Docetaxel (15H5577CQD) ; Cisplatin (Q20Q21Q62J) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2014-05-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-014-2270-8
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    Zs.A 3697: Show issues Location:
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  9. Article ; Online: Juvenile ossifying fibroma of the maxilla.

    Breheret, R / Jeufroy, C / Cassagnau, E / Malard, O

    European annals of otorhinolaryngology, head and neck diseases

    2011  Volume 128, Issue 6, Page(s) 317–320

    Abstract: Introduction: Juvenile ossifying fibroma is a rare, benign fibro-osseous tumour. In the light of a clinical case, the authors review the diagnosis, treatment and histological classification of these tumours.: Case report: A seven-year-old child ... ...

    Abstract Introduction: Juvenile ossifying fibroma is a rare, benign fibro-osseous tumour. In the light of a clinical case, the authors review the diagnosis, treatment and histological classification of these tumours.
    Case report: A seven-year-old child presented with a naso-orbito-ethmoidal trabecular juvenile ossifying fibroma. Complete surgical resection via a transfacial approach was performed after a preoperative work-up comprising head and neck CT and MRI.
    Discussion: A review of the literature reveals that treatment of this aggressive tumour must comprise complete surgical resection via an incision determined by local tumour extension.
    Conclusion: Patients with juvenile ossifying fibroma tumour require long-term follow-up due to the high recurrence rate.
    MeSH term(s) Child ; Female ; Fibroma, Ossifying/diagnosis ; Fibroma, Ossifying/surgery ; Humans ; Maxillary Neoplasms/diagnosis ; Maxillary Neoplasms/surgery
    Language English
    Publishing date 2011-12
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 2558008-5
    ISSN 1879-730X ; 1879-7296
    ISSN (online) 1879-730X
    ISSN 1879-7296
    DOI 10.1016/j.anorl.2011.02.007
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  10. Article ; Online: Ultrasound-guided botulinum toxin injections for treatment of drooling.

    Breheret, R / Bizon, A / Jeufroy, C / Laccourreye, L

    European annals of otorhinolaryngology, head and neck diseases

    2011  Volume 128, Issue 5, Page(s) 224–229

    Abstract: Objectives: To evaluate the efficacy of treatment of drooling by ultrasound-guided botulinum toxin injection of the salivary glands and to determine the optimal modalities of this procedure.: Patients and methods: This study is a retrospective review ...

    Abstract Objectives: To evaluate the efficacy of treatment of drooling by ultrasound-guided botulinum toxin injection of the salivary glands and to determine the optimal modalities of this procedure.
    Patients and methods: This study is a retrospective review of patients treated for drooling by injection of 100 units of Botox(®) into the parotid and submaxillary glands between 2002 and 2008. Efficacy was evaluated by a quality of life questionnaire six weeks after the injections.
    Results: One hundred and eleven injection sessions were performed in 70 patients aged one to 84 years with a beneficial effect in 66% of cases. The most effective protocol was injection of 20 units of botulinum toxin into each submaxillary gland and 30 units of toxin into each parotid gland.
    Conclusion: The treatment of drooling by Botox(®) injections into salivary glands is effective. The authors propose ultrasound-guided injection of both submaxillary glands and both parotid glands. These injections can be repeated in the case of recurrence of drooling.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Botulinum Toxins, Type A/administration & dosage ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Injections ; Male ; Middle Aged ; Neurotoxins/administration & dosage ; Parotid Gland ; Retrospective Studies ; Sialorrhea/drug therapy ; Submandibular Gland ; Ultrasonography, Interventional ; Young Adult
    Chemical Substances Neurotoxins ; onabotulinumtoxinA (E211KPY694) ; Botulinum Toxins, Type A (EC 3.4.24.69)
    Language English
    Publishing date 2011-11
    Publishing country France
    Document type Journal Article
    ZDB-ID 2558008-5
    ISSN 1879-730X ; 1879-7296
    ISSN (online) 1879-730X
    ISSN 1879-7296
    DOI 10.1016/j.anorl.2010.12.010
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