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  1. Article ; Online: The first plant allergen to be cloned-the story of the major birch pollen allergen Bet v 1.

    Breiteneder, Heimo

    Allergy

    2024  Volume 79, Issue 4, Page(s) 1071–1072

    MeSH term(s) Humans ; Allergens ; Betula ; Pollen ; Plant Proteins ; Antigens, Plant
    Chemical Substances Allergens ; Plant Proteins ; Antigens, Plant
    Language English
    Publishing date 2024-02-21
    Publishing country Denmark
    Document type News
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.16066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The History and Science of the Major Birch Pollen Allergen Bet v 1.

    Breiteneder, Heimo / Kraft, Dietrich

    Biomolecules

    2023  Volume 13, Issue 7

    Abstract: The term allergy was coined in 1906 by the Austrian scientist and pediatrician Clemens Freiherr von Pirquet. In 1976, Dietrich Kraft became the head of the Allergy and Immunology Research Group at the Department of General and Experimental Pathology of ... ...

    Abstract The term allergy was coined in 1906 by the Austrian scientist and pediatrician Clemens Freiherr von Pirquet. In 1976, Dietrich Kraft became the head of the Allergy and Immunology Research Group at the Department of General and Experimental Pathology of the University of Vienna. In 1983, Kraft proposed to replace natural extracts used in allergy diagnostic tests and vaccines with recombinant allergen molecules and persuaded Michael Breitenbach to contribute his expertise in molecular cloning as one of the mentors of this project. Thus, the foundation for the Vienna School of Molecular Allergology was laid. With the recruitment of Heimo Breiteneder as a young molecular biology researcher, the work began in earnest, resulting in the publication of the cloning of the first plant allergen Bet v 1 in 1989. Bet v 1 has become the subject of a very large number of basic scientific as well as clinical studies. Bet v 1 is also the founding member of the large Bet v 1-like superfamily of proteins with members-based on the ancient conserved Bet v 1 fold-being present in all three domains of life, i.e., archaea, bacteria and eukaryotes. This suggests that the Bet v 1 fold most likely already existed in the last universal common ancestor. The biological function of this protein was probably related to lipid binding. However, during evolution, a functional diversity within the Bet v 1-like superfamily was established. The superfamily comprises 25 families, one of which is the Bet v 1 family, which in turn is composed of 11 subfamilies. One of these, the PR-10-like subfamily of proteins, contains almost all of the Bet v 1 homologous allergens from pollen and plant foods. Structural and functional comparisons of Bet v 1 and its non-allergenic homologs of the superfamily will pave the way for a deeper understanding of the allergic sensitization process.
    MeSH term(s) Humans ; Allergens ; Betula ; Plant Proteins/chemistry ; Antigens, Plant/genetics ; Pollen/genetics ; Hypersensitivity
    Chemical Substances Allergens ; Plant Proteins ; Antigens, Plant
    Language English
    Publishing date 2023-07-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13071151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Legends of allergy/immunology: Dietrich Kraft.

    Breiteneder, Heimo

    Allergy

    2019  Volume 74, Issue 8, Page(s) 1591–1593

    MeSH term(s) Austria ; Famous Persons ; History, 20th Century ; History, 21st Century ; Humans ; Hypersensitivity/etiology ; Hypersensitivity/history
    Language English
    Publishing date 2019-05-20
    Publishing country Denmark
    Document type Biography ; Historical Article ; News ; Portrait
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.13816
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  4. Book: Das allergene Potential gentechnisch veränderter Pflanzen

    Breiteneder, Heimo

    (Beiträge Lebensmittelangelegenheiten, Veterinärverwaltung, Strahlenschutz, Toxikologie, Gentechnik ; 99,3)

    1999  

    Author's details Heimo Breiteneder
    Series title Beiträge Lebensmittelangelegenheiten, Veterinärverwaltung, Strahlenschutz, Toxikologie, Gentechnik ; 99,3
    Collection
    Language German
    Size 39 S.
    Publisher Bundeskanzleramt, Sekt. VI
    Publishing place Wien
    Publishing country Austria
    Document type Book
    HBZ-ID HT010186262
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    994/2344 available for loan (reading room) Freihandmagazin (U1)

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  5. Book: Das allergene Potential gentechnisch veränderter Pflanzen

    Breiteneder, Heimo

    (Beiträge Lebensmittelangelegenheiten, Veterinärverwaltung, Strahlenschutz, Toxikologie, Gentechnik ; 99,3)

    1999  

    Author's details Heimo Breiteneder
    Series title Beiträge Lebensmittelangelegenheiten, Veterinärverwaltung, Strahlenschutz, Toxikologie, Gentechnik ; 99,3
    Collection
    Language German
    Size 39 S.
    Publisher Bundeskanzleramt, Sekt. VI
    Publishing place Wien
    Publishing country Austria
    Document type Book
    HBZ-ID HT010186262
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 2481 order for loan Magazin

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  6. Article ; Online: Mapping of conformational IgE epitopes of food allergens.

    Breiteneder, Heimo

    Allergy

    2018  Volume 73, Issue 11, Page(s) 2107–2109

    MeSH term(s) Allergens/chemistry ; Allergens/immunology ; Epitope Mapping/methods ; Epitopes/chemistry ; Epitopes/immunology ; Food/adverse effects ; Food Hypersensitivity/immunology ; Humans ; Immunoglobulin E/immunology ; Models, Molecular ; Molecular Conformation ; Software
    Chemical Substances Allergens ; Epitopes ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2018-08-24
    Publishing country Denmark
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.13592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Glycotopes as players in the allergic immune response.

    Swoboda, Ines / Breiteneder, Heimo

    Allergy

    2022  Volume 78, Issue 1, Page(s) 14–16

    MeSH term(s) Humans ; Hypersensitivity ; Immunity
    Language English
    Publishing date 2022-12-05
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15500
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  8. Article ; Online: The Molecular Allergology User's Guide version 2.0 is freely available!

    Hoffmann-Sommergruber, Karin / Santos, Alexandra F / Breiteneder, Heimo

    Allergy

    2023  Volume 78, Issue 5, Page(s) 1139–1141

    MeSH term(s) Humans ; Hypersensitivity/diagnosis ; Immunoglobulin E ; Allergens ; Basophils ; Mast Cells
    Chemical Substances Immunoglobulin E (37341-29-0) ; Allergens
    Language English
    Publishing date 2023-03-30
    Publishing country Denmark
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Identification of probable pectinesterase as a major allergen of pollen of the Asian white birch (Betula platyphylla) in northern China.

    Xu, Yingyang / Gepp, Barbara / Lengger, Nina / Yin, Jia / Breiteneder, Heimo

    Asian Pacific journal of allergy and immunology

    2023  

    Abstract: Background: Pollen of the Asian white birch (Betula platyphylla) is a major source of allergens in spring in northern China, yet little research on its pollen allergens has been done so far.: Objective: To analyze the B. platyphylla pollen allergen ... ...

    Abstract Background: Pollen of the Asian white birch (Betula platyphylla) is a major source of allergens in spring in northern China, yet little research on its pollen allergens has been done so far.
    Objective: To analyze the B. platyphylla pollen allergen profile of patients from northern China and to identify the major pollen allergens in this patient cohort.
    Methods: Sera from 35 Chinese patients with birch pollinosis were collected for this study. The IgE-binding proteins in B. platyphylla pollen extract were analyzed by IgE immunoblots. A novel major allergen was purified by cation exchange chromatography and affinity chromatography. Its IgE reactivity was evaluated by ELISA. The protein was excised from a 2D electrophoresis gel and subjected to ESI-QUAD-TOF.
    Results: In our study cohort, the prevalence of IgE specific for Bet v 1 was 68.8% (n = 22/32) as measured by ImmunoCAP. In immunoblots, two major bands at around 17 kDa and 70 kDa were detected by IgE from 68.5% (24/35) and 65.7% (23/35) of sera, respectively. The 17 kDa band was identified as Bet v 1 by a monoclonal antibody to Bet v 1 and inhibition experiments with recombinant Bet v 1. The 70 kDa band was a polymorphic glycoprotein and 7 isoforms were found. The protein was identified as probably pectinesterase with a molecular weight of 66 kDa and a PI of 5.7.
    Conclusions: A 66 kDa protein, probably belonging to pectinesterase family, was identified as a novel major allergen of B. platyphylla pollen in patients from northern China.
    Language English
    Publishing date 2023-07-16
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 605782-2
    ISSN 2228-8694 ; 0125-877X
    ISSN (online) 2228-8694
    ISSN 0125-877X
    DOI 10.12932/AP-100722-1409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Immunohistochemical detection of the chondroitin sulfate proteoglycan 4 protein in primary and metastatic melanoma.

    Grossauer, Anna / Uranowska, Karolina / Kitzwögerer, Melitta / Mostegel, Margit / Breiteneder, Heimo / Hafner, Christine

    Oncology letters

    2023  Volume 26, Issue 3, Page(s) 382

    Abstract: Treatment of malignant melanoma, the most aggressive form of skin cancer, continues to be a major challenge for clinicians. New targeted therapies with kinase inhibitors or drugs which modify the immune response are often accompanied by the development ... ...

    Abstract Treatment of malignant melanoma, the most aggressive form of skin cancer, continues to be a major challenge for clinicians. New targeted therapies with kinase inhibitors or drugs which modify the immune response are often accompanied by the development of resistance or severe side effects. In this context, chondroitin sulfate proteoglycan 4 (CSPG4), a highly immunogenic melanoma tumor antigen, could be a potential target for alternative therapeutic approaches. The aim of the present study was to identify differences in the levels of CSPG4 protein expression in primary and metastatic melanomas as well as to analyze correlations between CSPG4 expression and histopathological data and patient characteristics. A total of 189 melanoma tissue samples from Lower Austria, including primary melanomas and melanoma metastases, were immunohistochemically stained for the expression of CSPG4 and statistical analyses were performed. A total of 65.6% of melanoma tissue samples stained positive for the expression of CSPG4. Primary nodular and primary superficial spreading melanomas demonstrated a significantly higher number of positively stained tissue samples for CSPG4 compared with primary lentigo maligna melanomas. No significant differences in the expression of CSPG4 were demonstrated between primary melanomas and melanoma metastases. The present study supports the advancement of the understanding of CSPG4 tissue expression patterns in melanoma patients and provides additional information for further investigation of CSPG4 as a potential therapeutic target.
    Language English
    Publishing date 2023-07-20
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2023.13968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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