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  1. Book ; Online ; Thesis: Vergleichende morphologische und funktionelle Untersuchungen zur Pathogenese von Influenzavirusinfektionen bei Säugern und Vögeln

    Breithaupt, Angele

    (Edition scientifique)

    2011  

    Author's details eingereicht von Angele Breithaupt
    Series title Edition scientifique
    Keywords Geflügelpestvirus ; Pathomechanismus
    Subject Klassisches Geflügelpestvirus ; Hochpathogenes aviäres Influenzavirus ; HPAIV ; Vogelgrippevirus ; Influenza A-H5N1-Virus
    Language German
    Edition 1. Aufl.
    Publisher VVB Laufersweiler
    Publishing place Giessen
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Giessen, Univ., Diss., 2011
    Note Open Access
    HBZ-ID HT017157176
    ISBN 978-3-8359-5758-9 ; 3-8359-5758-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Was verrät uns die Pathologie über mögliche Verlaufsunterschiede der Afrikanischen Schweinpest bei Haus- und Wildschweinen?

    Breithaupt, Angele

    Studie zur vergleichenden Pathologie bei Haus- und Wildschweinen nach Infektion mit dem moderat-virulenten ASPV-Stamm „Estland 2014“

    2021  

    Keywords Text ; ddc:570 ; Afrikanische Schweinepest -- ASP -- Studie -- ASPV-Stamm „Estland 2014“
    Language German
    Publishing date 2021-01-13
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Audio / Video ; Online: ECVP Examen - soll ich mir das wirklich antun? Und Jobs in der Industrie für Pathologen – mehr als nur Mäuse-Lebern?

    Breithaupt, Angele

    2020  

    Abstract: Der Vortrag ist im Programmheft, Seite 5, ausgewiesen. ...

    Abstract Der Vortrag ist im Programmheft, Seite 5, ausgewiesen.
    Keywords Text ; ddc:630
    Language German
    Publishing date 2020-03-07
    Publishing country de
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Characterization of experimental Shuni virus infection in the mouse.

    Breithaupt, Angele / Sick, Franziska / Golender, Natalia / Beer, Martin / Wernike, Kerstin

    Veterinary pathology

    2023  Volume 60, Issue 3, Page(s) 341–351

    Abstract: Shuni virus (SHUV), an orthobunyavirus of the Simbu serogroup, was initially isolated in Nigeria in the 1960s, further detected in other African countries and in the Middle East, and is now endemic in Israel. Transmitted by blood-sucking insects, SHUV ... ...

    Abstract Shuni virus (SHUV), an orthobunyavirus of the Simbu serogroup, was initially isolated in Nigeria in the 1960s, further detected in other African countries and in the Middle East, and is now endemic in Israel. Transmitted by blood-sucking insects, SHUV infection is associated with neurological disease in cattle and horses, and with abortion, stillbirth, or the birth of malformed offspring in ruminants. Surveillance studies also indicated a zoonotic potential. This study aimed to test the susceptibility of the well-characterized interferon (IFN)-α/β receptor knock-out mouse model (
    MeSH term(s) Cattle ; Animals ; Female ; Mice ; Horses ; Bunyaviridae Infections/diagnosis ; Bunyaviridae Infections/veterinary ; Orthobunyavirus/genetics ; Ruminants ; RNA ; Horse Diseases
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188012-3
    ISSN 1544-2217 ; 0300-9858
    ISSN (online) 1544-2217
    ISSN 0300-9858
    DOI 10.1177/03009858231155402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 629: Show issues Location:
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  5. Article ; Online: Aktuelles zu Rustrelavirus-Infektionen bei Wild- und Zootieren im Nordosten Deutschlands

    Breithaupt, Angele / Rubbenstroth, Dennis

    2022  

    Keywords Text ; ddc:610
    Language German
    Publishing date 2022-11-24
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Characterization of experimental Shuni virus infection in the mouse

    Breithaupt, Angele / Sick, Franziska / Golender, Natalia / Beer, Martin / Wernike, Kerstin

    Veterinary Pathology. 2023 May, v. 60, no. 3 p.341-351

    2023  

    Abstract: Shuni virus (SHUV), an orthobunyavirus of the Simbu serogroup, was initially isolated in Nigeria in the 1960s, further detected in other African countries and in the Middle East, and is now endemic in Israel. Transmitted by blood-sucking insects, SHUV ... ...

    Abstract Shuni virus (SHUV), an orthobunyavirus of the Simbu serogroup, was initially isolated in Nigeria in the 1960s, further detected in other African countries and in the Middle East, and is now endemic in Israel. Transmitted by blood-sucking insects, SHUV infection is associated with neurological disease in cattle and horses, and with abortion, stillbirth, or the birth of malformed offspring in ruminants. Surveillance studies also indicated a zoonotic potential. This study aimed to test the susceptibility of the well-characterized interferon (IFN)-α/β receptor knock-out mouse model (Ifnar⁻/⁻), to identify target cells, and to describe the neuropathological features. Ifnar⁻/⁻mice were subcutaneously infected with two different SHUV strains, including a strain isolated from the brain of a heifer showing neurological signs. The second strain represented a natural deletion mutant exhibiting a loss of function of the S-segment-encoded nonstructural protein NSs, which counteracts the host's IFN response. Here it is shown that Ifnar⁻/⁻mice are susceptible to both SHUV strains and can develop fatal disease. Histological examination confirmed meningoencephalomyelitis in mice as described in cattle with natural and experimental infections. RNA in situ hybridization was applied using RNA Scope™ for SHUV detection. Target cells identified included neurons and astrocytes, as well as macrophages in the spleen and gut-associated lymphoid tissue. Thus, this mouse model is particularly beneficial for the evaluation of virulence determinants in the pathogenesis of SHUV infection in animals.
    Keywords RNA ; Shuni orthobunyavirus ; animal pathology ; astrocytes ; brain ; fetal death ; heifers ; histology ; hybridization ; interferons ; macrophages ; meningoencephalitis ; mice ; models ; monitoring ; mutants ; pathogenesis ; progeny ; serotypes ; spleen ; viral nonstructural proteins ; virulence ; zoonoses ; Israel ; Middle East ; Nigeria ; arbovirus ; animal model ; bunyavirus ; meningoencephalomyelitis ; mouse ; Shuni virus ; zoonotic virus
    Language English
    Dates of publication 2023-05
    Size p. 341-351.
    Publishing place SAGE Publications
    Document type Article ; Online
    ZDB-ID 188012-3
    ISSN 1544-2217 ; 0300-9858
    ISSN (online) 1544-2217
    ISSN 0300-9858
    DOI 10.1177/03009858231155402
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 1959: Show issues

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  7. Article: Pathology of African Swine Fever in Wild Boar Carcasses Naturally Infected with German Virus Variants.

    Sehl-Ewert, Julia / Deutschmann, Paul / Breithaupt, Angele / Blome, Sandra

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 11

    Abstract: In 2020, African swine fever (ASF) was first identified in German wild boar, reaching a case number of about 4400 to date. Upon experimental infection, pathology is well documented; however, data on field infections are scarce in domestic pigs and not ... ...

    Abstract In 2020, African swine fever (ASF) was first identified in German wild boar, reaching a case number of about 4400 to date. Upon experimental infection, pathology is well documented; however, data on field infections are scarce in domestic pigs and not available from wild boar, respectively. Although the ASF viral genome is considered exceptionally stable, a total of five lineages with 10 distinct virus variants of genotype II have emerged in Eastern Germany. To investigate the pathology in naturally infected wild boar and to evaluate virus variants II, III and IV for their virulence, wild boar carcasses were obtained from three different outbreak areas. The carcasses underwent virological and pathomorphological investigation. The animals revealed characteristic ASF lesions of the highest severity accompanied by bacterial infections in several cases. In particular, wild boar infected with variant IV from Spree-Neiße (SN) district showed lower viral genome loads and total viral antigen scores, but simultaneously tended to reveal more chronic lesions. Our findings indicate a protracted course of the disease at least after infection with variant IV, but need confirmation under standardized experimental conditions. There is a strong need to monitor differences in the virulence among variants to identify potential attenuation that might complicate diagnosis. In addition, veterinarians, hunters and farmers need to be made aware of less acute courses of ASF to consider this as an important differential to chronic classical swine fever.
    Language English
    Publishing date 2022-11-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11111386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The role of PB1-F2 in adaptation of high pathogenicity avian influenza virus H7N7 in chickens.

    Hohensee, Luise / Scheibner, David / Schäfer, Alexander / Shelton, Holly / Mettenleiter, Thomas C / Breithaupt, Angele / Dorhoi, Anca / Abdelwhab, Elsayed M / Blohm, Ulrike

    Veterinary research

    2024  Volume 55, Issue 1, Page(s) 5

    Abstract: Avian influenza viruses (AIV) of the H7N7 subtype are enzootic in the wild bird reservoir in Europe, cause infections in poultry, and have sporadically infected humans. The non-structural protein PB1-F2 is encoded in a second open frame in the polymerase ...

    Abstract Avian influenza viruses (AIV) of the H7N7 subtype are enzootic in the wild bird reservoir in Europe, cause infections in poultry, and have sporadically infected humans. The non-structural protein PB1-F2 is encoded in a second open frame in the polymerase segment PB1 and its sequence varies with the host of origin. While mammalian isolates predominantly carry truncated forms, avian isolates typically express full-length PB1-F2. PB1-F2 is a virulence factor of influenza viruses in mammals. It modulates the host immune response, causing immunopathology and increases pro-inflammatory responses. The role of full-length PB1-F2 in IAV pathogenesis as well as its impact on virus adaptation and virulence in poultry remains enigmatic. Here, we characterised recombinant high pathogenicity AIV (HPAIV) H7N7 expressing or lacking PB1-F2 in vitro and in vivo in chickens. In vitro, full-length PB1-F2 modulated viability of infected chicken fibroblasts by limiting apoptosis. In chickens, PB1-F2 promoted gastrointestinal tropism, as demonstrated by enhanced viral replication in the gut and increased cloacal shedding. PB1-F2's effects on cellular immunity however were marginal. Overall, chickens infected with full-length PB1-F2 virus survived for shorter periods, indicating that PB1-F2 is also a virulence factor in bird-adapted viruses.
    MeSH term(s) Humans ; Animals ; Chickens/metabolism ; Influenza in Birds ; Virulence ; Influenza A Virus, H7N7 Subtype ; Viral Proteins/metabolism ; Influenza A virus/metabolism ; Virulence Factors/genetics ; Mammals
    Chemical Substances Viral Proteins ; Virulence Factors
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1146298-x
    ISSN 1297-9716 ; 0928-4249
    ISSN (online) 1297-9716
    ISSN 0928-4249
    DOI 10.1186/s13567-023-01257-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1313: Show issues Location:
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  9. Article ; Online: Leaderless foot-and-mouth disease virus serotype O did not cause clinical disease and failed to establish a persistent infection in cattle.

    Litz, Benedikt / Sehl-Ewert, Julia / Breithaupt, Angele / Landmesser, Anja / Pfaff, Florian / Romey, Aurore / Blaise-Boisseau, Sandra / Beer, Martin / Eschbaumer, Michael

    Emerging microbes & infections

    2024  , Page(s) 2348526

    Abstract: The foot-and-mouth disease virus (FMDV) Leader proteinase ... ...

    Abstract The foot-and-mouth disease virus (FMDV) Leader proteinase L
    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2024.2348526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: In vivo models for rustrela virus (RusV) infection in potential reservoir and spill-over hosts

    Klein, Antonia / Breithaupt, Angele / Wylezich, Claudia / Weinert, Sophie / Beer, Martin / Schlottau, Kore / Rubbenstroth, Dennis*

    [Poster]

    2024  

    Keywords Text ; abstract_or_summary ; ddc:610
    Language English
    Publishing date 2024-03-25
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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