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  1. Book ; Thesis: Verlaufskontrollen an Implantaten bei Vorliegen von mit Verbundbrücken versorgter Freiendsituation

    Breitschwerdt, Stefan

    1993  

    Author's details vorgelegt von Stefan Breitschwerdt
    Language German
    Size 72 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tübingen, Univ., Diss., 1993
    HBZ-ID HT006155508
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    94 D 267 order for loan Magazin

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  2. Article: Impaired immunogenicity after vaccination for SARS-CoV-2 in patients with gastrointestinal cancer: does tumor entity matter?

    Monin, Malte Benedikt / Gorny, Jens Gabriel / Berger, Moritz / Baier, Leona I / Zhou, Taotao / Mahn, Robert / Sadeghlar, Farsaneh / Möhring, Christian / Boesecke, Christoph / van Bremen, Kahtrin / Rieke, Gereon J / Schlabe, Stefan / Breitschwerdt, Stefan / Marinova, Milka / Schmidt-Wolf, Ingo G H / Strassburg, Christian P / Eis-Hübinger, Anna-Maria / Gonzalez-Carmona, Maria A

    Journal of gastrointestinal oncology

    2023  Volume 14, Issue 3, Page(s) 1218–1234

    Abstract: Background: SARS-CoV-2 immunogenicity in patients with gastrointestinal cancer (GI cancer) following second and third vaccination was analyzed.: Methods: A total of 125 patients under active anticancer therapy or in follow-up care were included in ... ...

    Abstract Background: SARS-CoV-2 immunogenicity in patients with gastrointestinal cancer (GI cancer) following second and third vaccination was analyzed.
    Methods: A total of 125 patients under active anticancer therapy or in follow-up care were included in this prospective study. Seroprevalence of SARS-CoV-2 anti-spike and surrogate neutralization antibodies (NABs) was measured.
    Results: Four weeks after second vaccination, adequate titers of SARS-CoV-2 anti-spike immunoglobulin G (IgG) [≥282.0 binding antibody units (BAU)/mL] were found in 62.2% of patients under treatment versus 96.3% of patients in follow-up care (P<0.01). Sufficient titers of SARS-CoV-2 surrogate NAB (≥85.0%) were found in 32.7% of patients under treatment versus 70.6% in follow-up care (P<0.01). Titers of SARS-CoV-2 anti-spike IgG were especially low in patients with colorectal cancer (CRC). For SARS-CoV-2 surrogate NAB, patients with hepatocellular carcinoma (HCC) and with pancreaticobiliary cancer showed the lowest titers (P<0.01). SARS-CoV-2 anti-spike IgG and SARS-CoV-2 surrogate NAB were associated with a correlation coefficient of 0.93. Reaching a titer of SARS-CoV-2 anti-spike IgG ≥482.0 BAU/mL, protective levels of SARS-CoV-2 surrogate NAB (≥85.0%) could be assumed. Following booster vaccination, all patients reached effective antibody titers.
    Conclusions: Patients with active GI cancer showed impaired immunogenicity after second SARS-CoV-2 vaccination which was overcome by booster vaccination. Our findings were tumor-related and pronounced in patients with CRC and HCC. Waning immunity over time and antibody escape phenomena by variant of concern Omicron must be considered in these especially vulnerable patients.
    Language English
    Publishing date 2023-06-26
    Publishing country China
    Document type Journal Article
    ZDB-ID 2594644-4
    ISSN 2219-679X ; 2078-6891
    ISSN (online) 2219-679X
    ISSN 2078-6891
    DOI 10.21037/jgo-22-1065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book ; Thesis: Verlaufskontrollen an Implantaten bei Vorliegen von mit Verbundbrücken versorgter Freiendsituation

    Breitschwerdt, Stefan

    1993  

    Author's details Stefan Breitschwerdt
    Language Undetermined
    Size 72 S, Ill., graph. Darst, 21 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @Tübingen, Univ., Diss. : 1993
    Database Former special subject collection: coastal and deep sea fishing

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