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  1. Article ; Online: Identification of a novel CG307 sub-clade in third-generation-cephalosporin-resistant

    Selvaraj Anand, Selvalakshmi / Wu, Chin-Ting / Bremer, Jordan / Bhatti, Micah / Treangen, Todd J / Kalia, Awdhesh / Shelburne, Samuel A / Shropshire, William C

    Microbial genomics

    2024  Volume 10, Issue 2

    Abstract: Despite the notable clinical impact, recent molecular epidemiology regarding third-generation-cephalosporin-resistant (3GC-R) ...

    Abstract Despite the notable clinical impact, recent molecular epidemiology regarding third-generation-cephalosporin-resistant (3GC-R)
    MeSH term(s) Humans ; United States/epidemiology ; Klebsiella pneumoniae/genetics ; Bacteremia/epidemiology ; Comparative Genomic Hybridization ; Databases, Factual ; Cephalosporins
    Chemical Substances Cephalosporins
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.001201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Temporal Dynamics of Genetically Heterogeneous Extended-Spectrum Cephalosporin Resistant

    Shropshire, William C / Strope, Benjamin / Anand, Selvalakshmi Selvaraj / Bremer, Jordan / McDaneld, Patrick / Bhatti, Micah M / Flores, Anthony R / Kalia, Awdhesh / Shelburne, Samuel A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Extended-spectrum cephalosporin resistant : Importance: Given ... ...

    Abstract Extended-spectrum cephalosporin resistant
    Importance: Given that
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.07.527510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genetic determinants underlying the progressive phenotype of β-lactam/β-lactamase inhibitor resistance in

    Shropshire, William C / Amiji, Hatim / Bremer, Jordan / Selvaraj Anand, Selvalakshmi / Strope, Benjamin / Sahasrabhojane, Pranoti / Gohel, Marc / Aitken, Samuel / Spitznogle, Sarah / Zhan, Xiaowei / Kim, Jiwoong / Greenberg, David E / Shelburne, Samuel A

    Microbiology spectrum

    2023  Volume 11, Issue 6, Page(s) e0222123

    Abstract: Importance: The increased feasibility of whole-genome sequencing has generated significant interest in using such molecular diagnostic approaches to characterize difficult-to-treat, antimicrobial-resistant (AMR) infections. Nevertheless, there are ... ...

    Abstract Importance: The increased feasibility of whole-genome sequencing has generated significant interest in using such molecular diagnostic approaches to characterize difficult-to-treat, antimicrobial-resistant (AMR) infections. Nevertheless, there are current limitations in the accurate prediction of AMR phenotypes based on existing AMR gene database approaches, which primarily correlate a phenotype with the presence/absence of a single AMR gene. Our study utilized a large cohort of cephalosporin-susceptible
    MeSH term(s) Humans ; beta-Lactamase Inhibitors/pharmacology ; Escherichia coli/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Lactams ; Escherichia coli Infections/drug therapy ; Phenotype ; beta-Lactams/pharmacology ; Monobactams ; beta-Lactamases/genetics ; Microbial Sensitivity Tests
    Chemical Substances beta-Lactamase Inhibitors ; Anti-Bacterial Agents ; Lactams ; beta-Lactams ; Monobactams ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02221-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Temporal dynamics of genetically heterogeneous extended-spectrum cephalosporin-resistant

    Shropshire, William C / Strope, Benjamin / Selvaraj Anand, Selvalakshmi / Bremer, Jordan / McDaneld, Patrick / Bhatti, Micah M / Flores, Anthony R / Kalia, Awdhesh / Shelburne, Samuel A

    mSphere

    2023  Volume 8, Issue 4, Page(s) e0018323

    Abstract: Extended-spectrum cephalosporin- ... ...

    Abstract Extended-spectrum cephalosporin-resistant
    MeSH term(s) Humans ; Cephalosporins/pharmacology ; Escherichia coli/genetics ; Anti-Bacterial Agents ; Escherichia coli Infections/epidemiology ; Monobactams ; beta-Lactamases/genetics ; Sepsis
    Chemical Substances Cephalosporins ; Anti-Bacterial Agents ; Monobactams ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00183-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Identification of distinct impacts of CovS inactivation on the transcriptome of acapsular group A streptococci.

    DebRoy, Sruti / Shropshire, William C / Vega, Luis / Tran, Chau / Horstmann, Nicola / Mukherjee, Piyali / Selvaraj-Anand, Selvalakshmi / Tran, Truc T / Bremer, Jordan / Gohel, Marc / Arias, Cesar A / Flores, Anthony R / Shelburne, Samuel A

    mSystems

    2023  Volume 8, Issue 4, Page(s) e0022723

    Abstract: Group A streptococcal (GAS) strains causing severe, invasive infections often have mutations in the control of virulence two-component regulatory system (CovRS) which represses capsule production, and high-level capsule production is considered critical ... ...

    Abstract Group A streptococcal (GAS) strains causing severe, invasive infections often have mutations in the control of virulence two-component regulatory system (CovRS) which represses capsule production, and high-level capsule production is considered critical to the GAS hypervirulent phenotype. Additionally, based on studies in
    MeSH term(s) Humans ; Transcriptome/genetics ; Bacterial Proteins/genetics ; Virulence/genetics ; Mutation/genetics ; Phenotype ; Streptococcus pyogenes/genetics
    Chemical Substances Bacterial Proteins
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2379-5077
    ISSN (online) 2379-5077
    DOI 10.1128/msystems.00227-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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