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  1. Article ; Online: FLASH Radiotherapy in a Value-Based Health Care Environment-Reply.

    Mascia, Anthony E / Daugherty, Emily C / Breneman, John C

    JAMA oncology

    2023  Volume 9, Issue 5, Page(s) 727

    MeSH term(s) Humans ; Value-Based Health Care ; Radiotherapy Dosage ; Radiotherapy/adverse effects
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2023.0134
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  2. Article: Radiation Therapy in the Treatment of Head and Neck Rhabdomyosarcoma.

    Frankart, Andrew J / Breneman, John C / Pater, Luke E

    Cancers

    2021  Volume 13, Issue 14

    Abstract: The use of radiation therapy is an important part of multimodality treatment for rhabdomyosarcoma. The specific doses, treatment volumes, and techniques used in radiation therapy can vary dramatically based upon a number of factors including location, ... ...

    Abstract The use of radiation therapy is an important part of multimodality treatment for rhabdomyosarcoma. The specific doses, treatment volumes, and techniques used in radiation therapy can vary dramatically based upon a number of factors including location, tumor size, and molecular characteristics, resulting in complex decisions in treatment planning. This article reviews the principles of evaluation and management for head and neck rhabdomyosarcoma including a summary of the historical studies upon which current management is based.
    Language English
    Publishing date 2021-07-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13143567
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  3. Article ; Online: Long-term effects of total skin electron beam therapy for mycosis fungoides on hair and nail loss and regrowth.

    Breneman, Debra L / Breneman, Alyssa / Ballman, Elaine / Breneman, John C

    The Journal of dermatological treatment

    2021  Volume 33, Issue 4, Page(s) 1975–1978

    Abstract: Objective: To better document the risk of permanent hair and nail loss after total skin electron beam therapy (TSEBT) for mycosis fungoides (MF).: Methods: Interviews and evaluations were conducted in 13 patients with MF treated with TSEBT alone and ... ...

    Abstract Objective: To better document the risk of permanent hair and nail loss after total skin electron beam therapy (TSEBT) for mycosis fungoides (MF).
    Methods: Interviews and evaluations were conducted in 13 patients with MF treated with TSEBT alone and two patients treated with concomitant TSEBT and chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). Evaluated parameters included time to hair and nail loss and regrowth, the density of hair regrowth, and quality of hair and nail regrowth.
    Results: Most patients had complete loss of scalp hair during treatment, and new growth appeared about 2 months following treatment completion. After 18 months, most patients felt their hair had regrown to about 70% of baseline thickness without cosmetically obvious alopecia. The patients treated with TSEBT and concomitant chemotherapy had substantially less scalp hair regrowth with persistent cosmetically obvious alopecia. Some lost eyebrows and eyelashes, but complete or near-complete regrowth generally occurred. Most patients lost their nails following TSEBT, with complete regrowth noted by most patients 5 months after treatment. New nails were most often normal, but a few patients developed post-therapy nail dystrophies.
    Conclusion: This data can be used to better inform patients of likely long-term changes of hair and nails following TSEBT.
    MeSH term(s) Alopecia/etiology ; Electrons ; Hair ; Humans ; Mycosis Fungoides/drug therapy ; Mycosis Fungoides/radiotherapy ; Nail Diseases/drug therapy ; Nail Diseases/etiology ; Nail Diseases/radiotherapy ; Skin Neoplasms/drug therapy ; Skin Neoplasms/radiotherapy
    Language English
    Publishing date 2021-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2021.1906398
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    Zs.A 2627: Show issues Location:
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  4. Article ; Online: Introduction to the COG/SIOP/PROS supplement on radiation oncology.

    Kalapurakal, John A / Breneman, John C / Janssens, Geert O / Marcus, Karen

    Pediatric blood & cancer

    2020  Volume 68 Suppl 2, Page(s) e28768

    MeSH term(s) Child ; Humans ; Neoplasms/radiotherapy ; Periodicals as Topic ; Radiation Oncology/standards
    Language English
    Publishing date 2020-10-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.28768
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    Zs.A 1131: Show issues Location:
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  5. Article ; Online: Extraneural Metastases of Diffuse Midline Glioma, H3 K27M-Mutant at Diagnosis: Case Report, Review of the Literature, and Identifying Targetable Alterations.

    Lazow, Margot A / Leach, James L / Trout, Andrew T / Breneman, John C / Fouladi, Maryam / Fuller, Christine

    Journal of pediatric hematology/oncology

    2021  Volume 44, Issue 2, Page(s) e597–e604

    Abstract: Extraneural metastases are rare in pediatric high-grade gliomas and little is known about the genomic profiles of tumors that disseminate beyond the central nervous system. We describe a pediatric patient with H3 K27M-mutant diffuse midline glioma of the ...

    Abstract Extraneural metastases are rare in pediatric high-grade gliomas and little is known about the genomic profiles of tumors that disseminate beyond the central nervous system. We describe a pediatric patient with H3 K27M-mutant diffuse midline glioma of the brain and spine with biopsy-confirmed osseous metastases present at diagnosis and suspected metastatic parenchymal pulmonary disease. Several potentially clinically and/or therapeutically relevant genomic alterations were identified, including H3F3A and TP53 mutations as well as MET, CDK6, EMSY, and PIK3CG amplifications. Sequencing is critical to improve our understanding of the molecular drivers of distant metastases and discover therapeutic targets that penetrate all disease sites.
    MeSH term(s) Astrocytoma/genetics ; Brain Neoplasms/pathology ; Child ; Glioma/pathology ; Histones/genetics ; Humans ; Mutation
    Chemical Substances Histones
    Language English
    Publishing date 2021-05-08
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000002189
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    Zs.A 1537: Show issues Location:
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  6. Article ; Online: Genome-Driven Therapy for Chemotherapy-Resistant Metastatic

    Lazow, Margot A / Johnson, Sheryl L / Johnson, Neil D / Breneman, John C / Dexheimer, Phillip J / Szabo, Sara / Pressey, Joseph G

    JCO precision oncology

    2022  Volume 4, Page(s) 498–504

    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.20.00032
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  7. Article ; Online: Fatal brainstem injury following proton radiation in a patient with medulloblastoma and a germline variant in RNF213.

    Klawinski, Darren M / Cottrell, Catherine E / Schieffer, Kathleen M / Indyk, Justin A / Gandhi, Kajal / Mardis, Elaine R / Rodriguez, Diana P / Breneman, John C / Osorio, Diana S

    Pediatric blood & cancer

    2023  Volume 71, Issue 1, Page(s) e30739

    Abstract: Brainstem injury occurs secondary to radiation to the posterior fossa in up to 2% of pediatric patients. It may occur after months to years after treatment. It has been associated with age less than 5 years and with comorbid conditions such as ... ...

    Abstract Brainstem injury occurs secondary to radiation to the posterior fossa in up to 2% of pediatric patients. It may occur after months to years after treatment. It has been associated with age less than 5 years and with comorbid conditions such as cerebrovascular disease, diabetes mellitus, and hypertension. Radiation necrosis is often symptomatic and can be fatal. A pathogenic variant in RNF213 was found in a patient who suffered fatal radiation necrosis. This mutation has been associated with moyamoya disease and may predispose to radiation necrosis.
    MeSH term(s) Child, Preschool ; Humans ; Adenosine Triphosphatases/genetics ; Brain Stem/pathology ; Cerebellar Neoplasms/genetics ; Cerebellar Neoplasms/radiotherapy ; Cerebellar Neoplasms/complications ; Genetic Predisposition to Disease ; Medulloblastoma/genetics ; Medulloblastoma/radiotherapy ; Medulloblastoma/complications ; Moyamoya Disease/pathology ; Necrosis/complications ; Necrosis/pathology ; Protons ; Radiation Injuries/pathology ; Ubiquitin-Protein Ligases/genetics
    Chemical Substances Adenosine Triphosphatases (EC 3.6.1.-) ; Protons ; RNF213 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.30739
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    Zs.A 1131: Show issues Location:
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  8. Article ; Online: Palliative radiation therapy for children with cancer.

    Tsang, Derek S / Vargo, John Austin / Goddard, Karen / Breneman, John C / Kalapurakal, John A / Marcus, Karen J

    Pediatric blood & cancer

    2021  Volume 68 Suppl 2, Page(s) e28292

    Abstract: Radiation therapy (RT) is often used as a palliative treatment for children with recurrent malignant disease to ameliorate or prevent symptoms. However, no guidelines exist regarding the clinical indications or dose fractionation for palliative RT. The ... ...

    Abstract Radiation therapy (RT) is often used as a palliative treatment for children with recurrent malignant disease to ameliorate or prevent symptoms. However, no guidelines exist regarding the clinical indications or dose fractionation for palliative RT. The goal of this report is to provide guidelines for the use of palliative RT in children with cancer. In this guideline, appropriate indications for palliative RT, recommended dose-fractionation schedules, relevant toxicities, and avenues for future research are explored. RT is an effective palliative treatment for bone, brain, liver, lung, abdominopelvic and head-and-neck metastases, spinal cord compression, superior vena cava syndrome, and bleeding. Single-fraction regimens (8 Gy in one fraction) for children with short life expectancy are recommended for simple, uncomplicated bone metastases and can be considered for some patients with lung or liver metastases. A short, hypofractionated regimen (20 Gy in five fractions) may be used for other indications to minimize overall burden of therapy. There are little data supporting use of more prolonged fractionation regimens, though they may be considered for patients with very good performance status. Future research should focus on response and outcomes data collection, and to rigorously evaluate the role of stereotactic body RT in well-designed, prospective studies.
    MeSH term(s) Child ; Humans ; Neoplasm Recurrence, Local/prevention & control ; Neoplasms/pathology ; Neoplasms/radiotherapy ; Palliative Care/methods ; Prognosis ; Radiotherapy/methods ; Survival Rate
    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.28292
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  9. Article ; Online: Linac-based fractionated stereotactic radiosurgery for high-risk meningioma.

    Prasad, Rahul N / Breneman, John C / Struve, Timothy / Warnick, Ronald E / Pater, Luke E

    Journal of radiosurgery and SBRT

    2018  Volume 5, Issue 4, Page(s) 269–276

    Abstract: Purpose: Single-fraction stereotactic radiosurgery(SRS) for meningioma has high rates of symptomatic perilesional edema in some settings. Fractionated stereotactic radiosurgery(fSRS) could decrease edema rates while maintaining tumor control.: Methods ...

    Abstract Purpose: Single-fraction stereotactic radiosurgery(SRS) for meningioma has high rates of symptomatic perilesional edema in some settings. Fractionated stereotactic radiosurgery(fSRS) could decrease edema rates while maintaining tumor control.
    Methods and materials: Patients at an institution were retrospectively reviewed(2013-2017). Adults receiving definitive, linear accelerator(linac)-based fSRS (25-30Gy/5 fractions) were included. fSRS was recommended for tumors at high risk for perilesional edema with SRS due to large size, prior irradiation, or proximity to organs at risk. Endpoints included rates of symptomatic, radiographically-defined perilesional edema and local control(LC).
    Results: 12 Patients with 13 meningiomas met criteria. 24-month actuarial LC and overall survival were 87% and 100%. Symptomatic, post-treatment edema was identified on follow-up MRI in 31% of cases. No variables predicted edema, but affected lesions were larger(6.82 v. 2.46cc).
    Conclusion: Linac-based fSRS for meningioma has high local control and modest toxicity rates similar to SRS in the literature. Prospective studies comparing fSRS/SRS are warranted.
    Language English
    Publishing date 2018-11-14
    Publishing country United States
    Document type Journal Article
    ISSN 2156-4647
    ISSN (online) 2156-4647
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  10. Article ; Online: Iodine-125 seed migration within brain parenchyma after brachytherapy for brain metastasis: case report.

    Brahimaj, Bledi / Lamba, Michael / Breneman, John C / Warnick, Ronald E

    Journal of neurosurgery

    2016  Volume 125, Issue 5, Page(s) 1167–1170

    Abstract: This case report documents the migration of 3 iodine-125 ( ...

    Abstract This case report documents the migration of 3 iodine-125 (
    MeSH term(s) Aged ; Brachytherapy/adverse effects ; Brain ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/secondary ; Female ; Foreign-Body Migration/etiology ; Humans ; Iodine Radioisotopes/therapeutic use ; Ovarian Neoplasms/pathology ; Parenchymal Tissue
    Chemical Substances Iodine Radioisotopes
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2015.11.JNS151464
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