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  1. Article: A syndrome characterized by generalized cutaneous eruption, chorioretinitis and eosinophilia, probably due to chronic toxoplasma infection.

    BRENNAN, A J / BROWN, T M

    The American journal of medicine

    2007  Volume 7, Issue 3, Page(s) 431–436

    MeSH term(s) Chorioretinitis ; Eosinophilia ; Eosinophils ; Humans ; Leukocyte Count ; Skin Diseases ; Syndrome ; Toxoplasma ; Toxoplasmosis
    Language English
    Publishing date 2007-05-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/0002-9343(49)90476-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.289: Show issues Location:
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  2. Article: Streptomycin-resistant tubercle bacilli; isolation of resistant organisms from pleural fluid prior to institution of streptomycin therapy.

    BRENNAN, A J / WICHELHAUSEN, R H

    Journal of the American Medical Association

    2006  Volume 140, Issue 16, Page(s) 1275

    MeSH term(s) Bacillus ; Exudates and Transudates ; Health Facilities ; Lactobacillus casei ; Microbial Viability ; Mycobacterium tuberculosis ; Streptomycin
    Chemical Substances Streptomycin (Y45QSO73OB)
    Language English
    Publishing date 2006-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0002-9955 ; 0254-9077 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0002-9955 ; 0254-9077 ; 0098-7484
    DOI 10.1001/jama.1949.82900510005006c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Use of antihistamine drugs in the treatment for trigeminal neuralgia.

    HORTON, C E / BRENNAN, A J

    Journal of the American Medical Association

    2006  Volume 136, Issue 13, Page(s) 870–872

    MeSH term(s) Anti-Allergic Agents ; Histamine Antagonists ; Humans ; Neuralgia ; Trigeminal Neuralgia
    Chemical Substances Anti-Allergic Agents ; Histamine Antagonists
    Language English
    Publishing date 2006-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0002-9955 ; 0254-9077 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0002-9955 ; 0254-9077 ; 0098-7484
    DOI 10.1001/jama.1948.72890300001006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Reconsolidation of liquefield sand

    Brennan, A. J / Madabhushi, S. P. G

    (CUED/D-SOILS/TR ; 347)

    2009  

    Author's details A. J. Brennan and S. P. G. Madabhushi
    Series title CUED/D-SOILS/TR ; 347
    Language English
    Size 18 S., graph. Darst.
    Publisher Univ., Dep. of Engineering
    Publishing place Cambridge
    Document type Book
    Note Literaturverz. S. 17 - 18
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article ; Online: Intradermal delivery of DNA encoding HCV NS3 and perforin elicits robust cell-mediated immunity in mice and pigs.

    Grubor-Bauk, B / Yu, W / Wijesundara, D / Gummow, J / Garrod, T / Brennan, A J / Voskoboinik, I / Gowans, E J

    Gene therapy

    2016  Volume 23, Issue 1, Page(s) 26–37

    Abstract: Currently, no vaccine is available against hepatitis C virus (HCV), and although DNA vaccines have considerable potential, this has not been realised. Previously, the efficacy of DNA vaccines for human immunodeficiency virus (HIV) and HCV was shown to be ...

    Abstract Currently, no vaccine is available against hepatitis C virus (HCV), and although DNA vaccines have considerable potential, this has not been realised. Previously, the efficacy of DNA vaccines for human immunodeficiency virus (HIV) and HCV was shown to be enhanced by including the gene for a cytolytic protein, viz. perforin. In this study, we examined the mechanism of cell death by this bicistronic DNA vaccine, which encoded the HCV non-structural protein 3 (NS3) under the control of the CMV promoter and perforin is controlled by the SV40 promoter. Compared with a canonical DNA vaccine and a bicistronic DNA vaccine encoding NS3 and the proapoptotic gene NSP4, the perforin-containing vaccine elicited enhanced cell-mediated immune responses against the NS3 protein in vaccinated mice and pigs, as determined by ELISpot and intracellular cytokine staining, whereas a mouse challenge model suggested that the immunity was CD8(+) T-cell-dependent. The results of the study showed that the inclusion of perforin in the DNA vaccine altered the fate of NS3-positive cells from apoptosis to necrosis, and this resulted in more robust immune responses in mice and pigs, the latter of which represents an accepted large animal model in which to test vaccine efficacy.
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Line, Tumor ; DNA, Viral/genetics ; DNA, Viral/isolation & purification ; Disease Models, Animal ; Enzyme-Linked Immunospot Assay ; Glycoproteins/genetics ; Glycoproteins/immunology ; HEK293 Cells ; Hepacivirus ; Humans ; Immunity, Cellular ; Immunization ; Male ; Mice ; Perforin/genetics ; Perforin/immunology ; Promoter Regions, Genetic ; Swine ; Toxins, Biological/genetics ; Toxins, Biological/immunology ; Vaccines, DNA/genetics ; Vaccines, DNA/immunology ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/immunology
    Chemical Substances DNA, Viral ; Glycoproteins ; NS28 protein, rotavirus ; NS3 protein, hepatitis C virus ; Toxins, Biological ; Vaccines, DNA ; Viral Nonstructural Proteins ; Perforin (126465-35-8)
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1191036-7
    ISSN 1476-5462 ; 0969-7128
    ISSN (online) 1476-5462
    ISSN 0969-7128
    DOI 10.1038/gt.2015.86
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3991: Show issues Location:
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  6. Article ; Online: Perforin deficiency and susceptibility to cancer.

    Brennan, A J / Chia, J / Trapani, J A / Voskoboinik, I

    Cell death and differentiation

    2010  Volume 17, Issue 4, Page(s) 607–615

    Abstract: Cytotoxic lymphocytes (CLs) are the killer cells that destroy intracellular pathogen-infected and transformed cells, predominantly through the cytotoxic granule-mediated death pathway. Soluble cytotoxic granule components, including pore-forming perforin ...

    Abstract Cytotoxic lymphocytes (CLs) are the killer cells that destroy intracellular pathogen-infected and transformed cells, predominantly through the cytotoxic granule-mediated death pathway. Soluble cytotoxic granule components, including pore-forming perforin and pro-apoptotic serine proteases, granzymes, synergize to induce unscheduled apoptosis of the target cell. A complete loss of CL function results in an aggressive immunoregulatory disorder, familial hemophagocytic lymphohistiocytosis, whereas a partial loss of function seems to be a factor strongly predisposing to hematological malignancies. This review discusses the pathological manifestations of CL deficiencies due to impaired perforin function and describes novel aspects of perforin biology.
    MeSH term(s) Animals ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Genetic Predisposition to Disease/genetics ; Granzymes/metabolism ; Humans ; Immune System/enzymology ; Immune System/physiopathology ; Immunologic Surveillance/physiology ; Lymphohistiocytosis, Hemophagocytic/enzymology ; Lymphohistiocytosis, Hemophagocytic/genetics ; Lymphohistiocytosis, Hemophagocytic/immunology ; Mice ; Neoplasms/enzymology ; Neoplasms/genetics ; Neoplasms/immunology ; Perforin ; Pore Forming Cytotoxic Proteins/deficiency ; Pore Forming Cytotoxic Proteins/genetics ; T-Lymphocytes, Cytotoxic/enzymology ; T-Lymphocytes, Cytotoxic/immunology
    Chemical Substances Apoptosis Regulatory Proteins ; PRF1 protein, human ; Pore Forming Cytotoxic Proteins ; Perforin (126465-35-8) ; Granzymes (EC 3.4.21.-)
    Language English
    Publishing date 2010-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/cdd.2009.212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4230: Show issues Location:
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    Zs.MG 80: Show issues

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  7. Article: Wellness comes to work.

    Brennan, A J

    Management world

    1985  Volume 14, Issue 2, Page(s) 12–15

    MeSH term(s) Commerce ; Florida ; Health Promotion/economics ; Occupational Health Services/organization & administration
    Language English
    Publishing date 1985-02
    Publishing country United States
    Document type Journal Article
    ISSN 0090-3825
    ISSN 0090-3825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Health and fitness boom moves into corporate America.

    Brennan, A J

    Occupational health & safety (Waco, Tex.)

    1985  Volume 54, Issue 7, Page(s) 38–40, 42–5

    MeSH term(s) Adult ; Back Pain/therapy ; Body Weight ; Breast Neoplasms/diagnosis ; Cholesterol/blood ; Female ; Health Education ; Health Promotion ; Humans ; Hypertension/prevention & control ; Male ; Middle Aged ; Nutritional Physiological Phenomena ; Occupational Health Services ; Physical Fitness ; Pilot Projects ; Smoking ; United States
    Chemical Substances Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 1985-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752994-6
    ISSN 0362-4064
    ISSN 0362-4064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Worksite health promotion can be cost-effective.

    Brennan, A J

    The Personnel administrator

    1983  Volume 28, Issue 4, Page(s) 39–42

    MeSH term(s) Awareness ; Health Promotion/economics ; Humans ; Occupational Health Services/economics ; United States
    Language English
    Publishing date 1983-04
    Publishing country United States
    Document type Journal Article
    ISSN 0031-5729
    ISSN 0031-5729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: How to set up a corporate wellness program.

    Brennan, A J

    Management review

    1983  Volume 72, Issue 5, Page(s) 41–47

    MeSH term(s) Health Promotion/organization & administration ; Occupational Health Services/organization & administration ; United States
    Language English
    Publishing date 1983-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2066714-0
    ISSN 0025-1895
    ISSN 0025-1895
    Database MEDical Literature Analysis and Retrieval System OnLINE

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