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  1. AU="Brennan, Anna"
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  1. Article ; Online: Hats off to 20S proteasome substrate discovery.

    Church, Taylor R / Brennan, Anna / Margolis, Seth S

    Molecular systems biology

    2024  Volume 20, Issue 4, Page(s) 293–295

    MeSH term(s) Proteasome Endopeptidase Complex ; Cytoplasm
    Chemical Substances Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2193510-5
    ISSN 1744-4292 ; 1744-4292
    ISSN (online) 1744-4292
    ISSN 1744-4292
    DOI 10.1038/s44320-024-00028-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neuronal membrane proteasome-derived peptides modulate NMDAR-dependent neuronal signaling to promote changes in gene expression.

    Türker, Fulya / Brennan, Anna / Margolis, Seth S

    Molecular biology of the cell

    2023  Volume 35, Issue 1, Page(s) ar6

    Abstract: The neuronal membrane proteasome (NMP) degrades intracellular proteins into peptides that are released directly into the extracellular space, whereby they stimulate neurons to promote signaling mechanisms that remain unknown. Here, we demonstrate that ... ...

    Abstract The neuronal membrane proteasome (NMP) degrades intracellular proteins into peptides that are released directly into the extracellular space, whereby they stimulate neurons to promote signaling mechanisms that remain unknown. Here, we demonstrate that neuronal stimulation promotes NMP activity and, subsequently, enhanced production of NMP peptides. We show that these neuronal activity-dependent NMP peptides can rapidly promote N-methyl-D-aspartate receptor (NMDAR)-dependent calcium influx in neurons. This leads to sustained phosphorylation of the well-defined stimulus-induced transcription factor, cyclic AMP response element (CRE)-binding protein (CREB). Downstream of these events, we identified changes to neuronal target genes which included increased expression of immediate early genes (e.g.,
    MeSH term(s) Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Neurons/metabolism ; Peptides/metabolism ; Cyclic AMP Response Element-Binding Protein/genetics ; Cyclic AMP Response Element-Binding Protein/metabolism ; Gene Expression ; Calcium/metabolism
    Chemical Substances Receptors, N-Methyl-D-Aspartate ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Peptides ; Cyclic AMP Response Element-Binding Protein ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E23-06-0218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2853: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 410: Show issues

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  3. Article ; Online: Regenerative potential and limitations in a zebrafish model of hyperglycemia-induced nerve degeneration.

    Sargent, Sheridan / Brennan, Anna / Clark, Jessica Kennett

    Developmental dynamics : an official publication of the American Association of Anatomists

    2023  Volume 252, Issue 6, Page(s) 742–760

    Abstract: Background: Previous work from our lab has described a model of motor nerve degeneration in hyperglycemic zebrafish larvae which resembles mammalian models of diabetic peripheral neuropathy (DPN). Here, we optimized the hyperglycemic-induction protocol, ...

    Abstract Background: Previous work from our lab has described a model of motor nerve degeneration in hyperglycemic zebrafish larvae which resembles mammalian models of diabetic peripheral neuropathy (DPN). Here, we optimized the hyperglycemic-induction protocol, characterized deficits in nerve structure and behavioral function, and then examined the regenerative potential following recovery from the hyperglycemic state.
    Results: In agreement with our previous work, hyperglycemia induced motor nerve degeneration and behavioral deficits. However, the optimized protocol initiated disruption of tight junctions within the blood-nerve barrier, a phenotype apparent in mammalian models of DPN. Following a 10-day recovery period, regeneration of motor nerve components was apparent, but behavioral deficits persisted. We next examined the effect of hyperglycemia on the musculoskeletal system and found subtle deficits in muscle that resolved following recovery, and robust deficits in the skeletal system which persisted following recovery.
    Conclusion: Here we optimized our previous model of hyperglycemia-induced motor nerve degeneration to more closely align with that observed in mammalian models and then characterized the regenerative potential following recovery from hyperglycemia. Notably, we observed striking impairments to skeletal development, which underscores the global impact hyperglycemia has across systems, and provides a framework for elucidating molecular mechanisms responsible for regenerative events moving forward.
    MeSH term(s) Animals ; Zebrafish ; Peripheral Nervous System ; Hyperglycemia/chemically induced ; Nerve Degeneration ; Mammals
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1102541-4
    ISSN 1097-0177 ; 1058-8388
    ISSN (online) 1097-0177
    ISSN 1058-8388
    DOI 10.1002/dvdy.583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.60: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 64: Show issues

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  4. Article ; Online: The nociceptive activity of peripheral sensory neurons is modulated by the neuronal membrane proteasome.

    Villalón Landeros, Eric / Kho, Samuel C / Church, Taylor R / Brennan, Anna / Türker, Fulya / Delannoy, Michael / Caterina, Michael J / Margolis, Seth S

    Cell reports

    2024  Volume 43, Issue 4, Page(s) 114058

    Abstract: Proteasomes are critical for peripheral nervous system (PNS) function. Here, we investigate mammalian PNS proteasomes and reveal the presence of the neuronal membrane proteasome (NMP). We show that specific inhibition of the NMP on distal nerve fibers ... ...

    Abstract Proteasomes are critical for peripheral nervous system (PNS) function. Here, we investigate mammalian PNS proteasomes and reveal the presence of the neuronal membrane proteasome (NMP). We show that specific inhibition of the NMP on distal nerve fibers innervating the mouse hind paw leads to reduction in mechanical and pain sensitivity. Through investigating PNS NMPs, we demonstrate their presence on the somata and proximal and distal axons of a subset of dorsal root ganglion (DRG) neurons. Single-cell RNA sequencing experiments reveal that the NMP-expressing DRGs are primarily MrgprA3
    MeSH term(s) Animals ; Sensory Receptor Cells/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Ganglia, Spinal/metabolism ; Mice ; Mice, Inbred C57BL ; Nociception ; Male ; Cell Membrane/metabolism ; Calcium Signaling
    Chemical Substances Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.114058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: California Sexually Violent Predator (SVP) Evaluations in the Field: Static-99R and Diagnostic Field Reliability.

    Lockhart, Joseph / DiCiro, Melinda / Rokop, James / Brennan, Anna

    Sexual abuse : a journal of research and treatment

    2021  Volume 34, Issue 4, Page(s) 425–455

    Abstract: Tests and diagnoses used in sexually violent predator (SVP) evaluations must be reliable, as reliability is foundational to validity. The current study contained a stratified sample of evaluations of 395 individuals referred as potential SVPs between ... ...

    Abstract Tests and diagnoses used in sexually violent predator (SVP) evaluations must be reliable, as reliability is foundational to validity. The current study contained a stratified sample of evaluations of 395 individuals referred as potential SVPs between 2012 and 2017. Each individual was initially evaluated by at least two experts. The sample included three groups: individuals not meeting SVP criteria (
    MeSH term(s) California ; Humans ; Paraphilic Disorders/psychology ; Reproducibility of Results ; Risk Assessment ; Sex Offenses/psychology ; Sexual Behavior
    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1283507-9
    ISSN 1573-286X ; 1079-0632
    ISSN (online) 1573-286X
    ISSN 1079-0632
    DOI 10.1177/10790632211042364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3271: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Interpretative characteristics and case features associated with the performances of radiologists in reading mammograms: A study from a non-screening population in Asia.

    Trieu, Phuong Dung Yun / Puslednik, Louise / Colley, Brooke / Brennan, Anna / Rodriguez, Veruska Cediel / Cook, Nicholas / Dean, Kaitlin / Dryburgh, Sarah / Lowe, Hayden / Mahon, Charlotte / McGowan, Saxon / O'Brien, Joshua / Moog, William / Whale, Jorja / Wong, Dennis / Li, Tong / Brennan, Patrick C

    Asia-Pacific journal of clinical oncology

    2020  Volume 17, Issue 1, Page(s) 139–148

    Abstract: Aims: To explore radiologist characteristics and case features associated with diagnostic performances in cancer detection on mammograms in a South East Asian population.: Methods: Fifty-three radiologists reported 60 mammographic examinations which ... ...

    Abstract Aims: To explore radiologist characteristics and case features associated with diagnostic performances in cancer detection on mammograms in a South East Asian population.
    Methods: Fifty-three radiologists reported 60 mammographic examinations which consisted of 40 normal and 20 cancer-containing cases at the BREAST workshops. Radiologists were asked to examine each mammogram using the BIRADS on diagnostic monitors. Differences in reader characteristics and case features between correct and incorrect decisions were assessed separately for cancer and normal cases. Univariate and multivariate logistic regressions were applied to generate odds ratios (OR) for significant factors related to correct decisions.
    Results: Radiologists who spent ≥10 hours/week reporting mammograms had a higher possibility of detecting cancer lesions (OR = 1.6; P = 0.01). A higher rate of accuracy in reporting negative cases was associated with female radiologists (OR = 1.4; P = 0.002), radiologists who read ≤20 mammograms per week (OR = 1.5; P < 0.0001), had completed training course (OR = 1.7; P < 0.0001) or wore eyeglasses (OR = 1.4; P = 0.01). Cancer cases with breast density >50% (OR = 2.1; P < 0.0001), having abnormal lesions ≥9 mm (OR = 1.8; P < 0.0001), or displaying calcifications, a discrete mass or nonspecific density (OR = 1.6; P < 0.0001) were recorded with a higher detection rate by radiologists than other cases. Lesions located on the right breasts (OR = 1.8; P < 0.0001) or found in the lower inner, upper outer or mixed locations (OR = 2.7; P < 0.0001) were also recorded with a better diagnostic possibility compared with other lesions.
    Conclusion: This work identified key features related to diagnostic accuracy of breast cancer on mammograms in a nonscreening population, which is helpful for developing appropriate strategies to improve breast cancer detectability of radiologists.
    MeSH term(s) Adult ; Asia ; Breast/diagnostic imaging ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Clinical Competence ; Female ; Humans ; Logistic Models ; Male ; Mammography ; Odds Ratio ; Radiologists
    Language English
    Publishing date 2020-09-07
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2187409-8
    ISSN 1743-7563 ; 1743-7555
    ISSN (online) 1743-7563
    ISSN 1743-7555
    DOI 10.1111/ajco.13429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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