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Article ; Online: Rezeptor-Tyrosinkinase-Fusionen in spindelzelligen Tumoren des Kindesalters.

Brenner, Christiane / Sanders, Christine / Vokuhl, Christian

Pathologie (Heidelberg, Germany)

2023 Volume 44, Issue 6, Page(s) 357–365

Abstract: Pediatric spindle cell tumors are rare and often difficult to diagnose due to a similar morphology and a non-specific immunohistochemical profile. Genetic characterization of these lesions has been constantly improving, which has led to the ... ...

Title translation	Receptor tyrosine kinase- fusions in paediatric spindle cell tumors.
Abstract	Pediatric spindle cell tumors are rare and often difficult to diagnose due to a similar morphology and a non-specific immunohistochemical profile. Genetic characterization of these lesions has been constantly improving, which has led to the identification of new subgroups that were partly included in the WHO classification. Receptor tyrosine kinase fusions play a special role in these tumors and their verification has diagnostic relevance and can be an option for target-oriented therapies. In the case of pediatric spindle cell tumors, genetic fusions form especially with NTRK1‑3, ALK, RET, and ROS1. Overall, pediatric tumors with receptor tyrosine kinase fusions are predominantly low-grade tumors, which are often subdivided into the group of intermediate-malign tumors.
MeSH term(s)	Humans ; Child ; Protein-Tyrosine Kinases/genetics ; Anaplastic Lymphoma Kinase/genetics ; Proto-Oncogene Proteins/genetics ; Receptor Protein-Tyrosine Kinases/genetics ; Lung Neoplasms/genetics
Chemical Substances	Protein-Tyrosine Kinases (EC 2.7.10.1) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; Proto-Oncogene Proteins ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
Language	German
Publishing date	2023-10-11
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ISSN	2731-7196
ISSN (online)	2731-7196
DOI	10.1007/s00292-023-01228-y
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Book ; Conference proceedings: Geschichtsschreibung zu den böhmischen Ländern im 20. Jahrhundert

Brenner, Christiane

Wissenschaftstraditionen, Institutionen, Diskurse ; Vorträge der Tagungen des Collegium Carolinum in Bad Wiessee vom 21. bis 23. November 2003 und vom 12. bis 14 November 2004 ; [Bad Wiesseer Tagungen des Collegium Carolinum, Band 28]

2006

Institution	Collegium Carolinum
Event/congress	Tagung des Collegium Carolinum (2003.11.21-23, BadWiessee) ; Tagung des Collegium Carolinum (2004.11.12-14, BadWiessee)
Author's details	hrsg. von Christiane Brenner
Keywords	Geschichtsschreibung ; Böhmische Länder
Language	German
Size	VI, 485 S., Ill., 24 cm
Publisher	Oldenbourg
Publishing place	München
Document type	Book ; Conference proceedings
ISBN	3486579908 ; 9783486579901
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Conference proceedings: Sozialgeschichtliche Kommunismusforschung

Brenner, Christiane

Tschechoslowakei, Polen, Ungarn und DDR, 1948 - 1968 ; Vorträge der Tagung des Collegium Carolinum in Bad Wiessee vom 22. bis 24. November 2002 ; [Bad Wiesseer Tagungen des Collegium Carolinum, Band 27]

(Bad Wiesseer Tagungen des Collegium Carolinum ; 27)

2005

Institution	Collegium Carolinum
Event/congress	Tagung des Collegium Carolinum (2002.11.22-24, BadWiessee)
Author's details	hrsg. von Christiane Brenner
Series title	Bad Wiesseer Tagungen des Collegium Carolinum ; 27
Keywords	Unterdrückung ; Internationaler Vergleich ; Arbeitswelt ; Staatssozialismus ; Soziale Klasse ; Tschechoslowakei
Language	German ; English
Size	558 S, Ill., Kt
Publisher	Oldenbourg
Publishing place	München
Document type	Book ; Conference proceedings
Note	Beitr. überw. in dt., teilw. in engl.
ISBN	3486576968 ; 9783486576962
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Conference proceedings: Sozialgeschichtliche Kommunismusforschung

Brenner, Christiane

(Bad Wiesseer Tagungen des Collegium Carolinum ; 27)

2005

Institution	Collegium Carolinum
Event/congress	Tagung des Collegium Carolinum (2002.11.22-24, BadWiessee)
Author's details	hrsg. von Christiane Brenner
Series title	Bad Wiesseer Tagungen des Collegium Carolinum ; 27
Keywords	Unterdrückung ; Internationaler Vergleich ; Arbeitswelt ; Staatssozialismus ; Soziale Klasse ; Tschechoslowakei
Language	German ; English
Size	558 S, Ill., Kt
Publisher	Oldenbourg
Publishing place	München
Document type	Book ; Conference proceedings
Note	Beitr. überw. in dt., teilw. in engl.
ISBN	3486576968 ; 9783486576962
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Impact of high-fat diet on the intestinal microbiota and small intestinal physiology before and after the onset of obesity.

Araújo, João Ricardo / Tomas, Julie / Brenner, Christiane / Sansonetti, Philippe J

Biochimie

2017 Volume 141, Page(s) 97–106

Abstract: The modulation of the intestinal microbiota by high-fat diet (HFD) has a major impact on both immunological and metabolic functions of the host. Taking this into consideration, the aim of this contribution is to review the impact of HFD on microbiota ... ...

Abstract	The modulation of the intestinal microbiota by high-fat diet (HFD) has a major impact on both immunological and metabolic functions of the host. Taking this into consideration, the aim of this contribution is to review the impact of HFD on microbiota profile and small intestinal physiology before and after the onset of obesity and its metabolic complications. Evidence from animal studies suggest that before the onset of obesity and its metabolic complications, HFD induces intestinal dysbiosis - encompassing changes in composition balance and massive redistribution with bacteria occupying intervillous spaces and crypts - associated with early physiopathological changes, predominantly in the ileum, such as low-grade inflammation, decreased antimicrobial peptides expression, impaired mucus production, secretion and layer's thickness, and decreased expression of tight junction proteins. With time, major inflammatory signals (e.g. toll-like receptor-4 dependent) become activated, thereby stimulating proinflammatory cytokines secretion in the small intestine. This inflammatory state might subsequently exacerbate disruption of the mucus layer barrier and increase epithelial permeability of the small intestine, thereby creating an environment that facilitates the passage of bacterial components (e.g. lipopolysaccharide, peptidoglycan and flagellin) and metabolites from the intestinal lumen (e.g. secondary bile acids) to the circulation and peripheral tissues (i.e. leaky gut), eventually promoting the development of systemic inflammation, obesity, adiposity, insulin resistance and glucose intolerance preceding hyperglycemia. Although the mechanisms are still not completely understood, prebiotics, probiotics, polyphenols, peroxisome proliferator-activated receptor-γ agonists (such as rosiglitazone) and exercise have been shown to reverse HFD-induced intestinal phenotype and to attenuate the severity of obesity and its associated metabolic complications.
Language	English
Publishing date	2017-10
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120345-9
ISSN	1638-6183 ; 0300-9084
ISSN (online)	1638-6183
ISSN	0300-9084
DOI	10.1016/j.biochi.2017.05.019
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Article ; Online: Bioactive reagents used in mesotherapy for skin rejuvenation in vivo induce diverse physiological processes in human skin fibroblasts in vitro- a pilot study.

Jäger, Claudia / Brenner, Christiane / Habicht, Jüri / Wallich, Reinhard

Experimental dermatology

2012 Volume 21, Issue 1, Page(s) 72–75

Abstract: The promise of mesotherapy is maintenance and/or recovery of a youthful skin with a firm, bright and moisturized texture. Currently applied medications employ microinjections of hyaluronic acid, vitamins, minerals and amino acids into the superficial ... ...

Abstract	The promise of mesotherapy is maintenance and/or recovery of a youthful skin with a firm, bright and moisturized texture. Currently applied medications employ microinjections of hyaluronic acid, vitamins, minerals and amino acids into the superficial layer of the skin. However, the molecular and cellular processes underlying mesotherapy are still elusive. Here we analysed the effect of five distinct medication formulas on pivotal parameters involved in skin ageing, that is collagen expression, cell proliferation and morphological changes using normal human skin fibroblast cultures in vitro. Whereas in the presence of hyaluronic acid, NCTF135(®) and NCTF135HA(®) , cell proliferation was comparable to control cultures; however, with higher expression of collagen type-1, matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1, addition of Soluvit(®) N and Meso-BK led to apoptosis and/or necrosis of human fibroblasts. The data indicate that bioactive reagents currently applied for skin rejuvenation elicit strikingly divergent physiological processes in human skin fibroblast in vitro.
MeSH term(s)	Cell Proliferation/drug effects ; Cells, Cultured ; Collagen Type I/metabolism ; Fibroblasts/drug effects ; Humans ; Hyaluronic Acid/pharmacology ; Matrix Metalloproteinase 1/metabolism ; Mesotherapy ; Pilot Projects ; Skin Aging/drug effects ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Vitamins/pharmacology
Chemical Substances	Collagen Type I ; TIMP1 protein, human ; Tissue Inhibitor of Metalloproteinase-1 ; Vitamins ; Hyaluronic Acid (9004-61-9) ; MMP1 protein, human (EC 3.4.24.7) ; Matrix Metalloproteinase 1 (EC 3.4.24.7)
Language	English
Publishing date	2012-01
Publishing country	Denmark
Document type	Comparative Study ; Letter
ZDB-ID	1130936-2
ISSN	1600-0625 ; 0906-6705
ISSN (online)	1600-0625
ISSN	0906-6705
DOI	10.1111/j.1600-0625.2011.01400.x
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Zs.A 3508: Show issues

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Book: Arbeiten & Feminismus

Brandl, Monika / Brenner, Christiane / Buntenbach, Annelie / Ferner, Elke / Fried, Barbara / Glänzer, Edeltraud / Gündner-Ede, Elke / Kipping, Katja / Klenner, Christina / Laux, Ulrike / Meyer, Jörg / Rosenberger, Michaela / Tepe, Marlis

Jörg Meyer (Hrsg.) ; Gespräche mit Christiane Benner, Monika Brandl, Annelie Buntenbach, Elke Ferner, Barbara Fried, Edeltraud Glänzer, Elke Gündner-Ede, Katja Kipping, Ulrike Laux, Michaela Rosenberger und Marlies Tepe ; Nachwort von Christina Klenner

2017

Title variant	Eine Flugschrift ; Arbeiten und Feminismus
Institution	VSA-Verlag für das Studium der Arbeiterbewegung
Keywords	Chancengleichheit ; Geschlechtsunterschied ; Arbeitswelt ; Arbeitnehmerin ; Lohngleichheit
Language	German
Size	117 Seiten, Illustrationen, Diagramme
Publisher	VSA: Verlag
Publishing place	Hamburg
Document type	Book
ISBN	3899657489 ; 9783899657487
Database	Federal Institute for Risk Assessment

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Article ; Online: Mapping the ligand-binding region of Borrelia hermsii fibronectin-binding protein.

Brenner, Christiane / Bomans, Katharina / Habicht, Jüri / Simon, Markus M / Wallich, Reinhard

PloS one

2013 Volume 8, Issue 5, Page(s) e63437

Abstract: Many pathogenic microorganisms express fibronectin-binding molecules that facilitate their adherence to the extracellular matrix and/or entry into mammalian cells. We have previously described a Borrelia recurrentis gene, cihC that encodes a 40-kDa ... ...

Abstract	Many pathogenic microorganisms express fibronectin-binding molecules that facilitate their adherence to the extracellular matrix and/or entry into mammalian cells. We have previously described a Borrelia recurrentis gene, cihC that encodes a 40-kDa surface receptor for both, fibronectin and the complement inhibitors C4bp and C1-Inh. We now provide evidence for the expression of a group of highly homologues surface proteins, termed FbpA, in three B. hermsii isolates and two tick-borne relapsing fever spirochetes, B. parkeri and B. turicatae. When expressed in Escherichia coli or B. burgdorferi, four out of five proteins were shown to selectively bind fibronectin, whereas none of five proteins were able to bind the human complement regulators, C4bp and C1-Inh. By applying deletion mutants of the B. hermsii fibronectin-binding proteins a putative high-affinity binding site for fibronectin was mapped to its central region. In addition, the fibronectin-binding proteins of B. hermsii were found to share sequence homology with BBK32 of the Lyme disease spirochete B. burgdorferi with similar function suggesting its involvement in persistence and/or virulence of relapsing fever spirochetes.
MeSH term(s)	Adhesins, Bacterial/chemistry ; Adhesins, Bacterial/genetics ; Adhesins, Bacterial/metabolism ; Amino Acid Sequence ; Borrelia/genetics ; Borrelia/metabolism ; Cloning, Molecular ; Fibronectins/metabolism ; Humans ; Ligands ; Molecular Sequence Data ; Peptide Hydrolases/metabolism ; Protein Structure, Tertiary ; Sequence Homology, Nucleic Acid
Chemical Substances	Adhesins, Bacterial ; Fibronectins ; Ligands ; fibronectin-binding proteins, bacterial ; Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2013-05-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0063437
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Molecular characterization of the interaction of Borrelia parkeri and Borrelia turicatae with human complement regulators.

Schott, Melanie / Grosskinsky, Sonja / Brenner, Christiane / Kraiczy, Peter / Wallich, Reinhard

Infection and immunity

2010 Volume 78, Issue 5, Page(s) 2199–2208

Abstract: In North America, tick-borne relapsing fever is caused by the species Borrelia hermsii, B. parkeri, and B. turicatae, which are transmitted to humans through the bite of the respective infected tick vectors. Here we describe the identification and ... ...

Abstract	In North America, tick-borne relapsing fever is caused by the species Borrelia hermsii, B. parkeri, and B. turicatae, which are transmitted to humans through the bite of the respective infected tick vectors. Here we describe the identification and functional characterization of a surface lipoprotein of B. parkeri, designated BpcA, that binds the human complement regulators factor H and factor H-related protein 1 and, simultaneously, the host protease plasminogen. In contrast, the homologous B. turicatae protein failed to bind human factor H and factor H-related protein 1 but retained its plasminogen binding capacity. Factor H bound to BpcA maintains its regulatory capacity to control C3b deposition and C3 convertase activity. Ectopic expression of BpcA in a serum-sensitive B. burgdorferi strain protects transformed cells from complement-mediated killing. Furthermore, bound plasminogen/plasmin endows B. parkeri and B. turicatae with the potential to degrade extracellular matrix components. These findings expand our understanding of the putative recent evolutionary separation of Borrelia parkeri and Borrelia turicatae, provide evidence that B. parkeri differs from B. turicatae in its ability to resist complement attack, and may help in understanding the pathological processes underlying tick-borne relapsing fever.
MeSH term(s)	Amino Acid Sequence ; Bacterial Proteins/genetics ; Bacterial Proteins/immunology ; Blood Bactericidal Activity ; Blood Proteins/immunology ; Blood Proteins/metabolism ; Borrelia/genetics ; Borrelia/immunology ; Complement Factor H/immunology ; Complement Factor H/metabolism ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Humans ; Molecular Sequence Data ; North America ; Plasminogen/metabolism ; Protein Binding ; Sequence Alignment ; Sequence Analysis, DNA
Chemical Substances	Bacterial Proteins ; Blood Proteins ; DNA, Bacterial ; factor H-related protein 1 ; Complement Factor H (80295-65-4) ; Plasminogen (9001-91-6)
Language	English
Publishing date	2010-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/IAI.00089-10
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Article: Molecular Characterization of the Interaction of Borrelia parkeri and Borrelia turicatae with Human Complement Regulators

Schott, Melanie / Grosskinsky, Sonja / Brenner, Christiane / Kraiczy, Peter / Wallich, Reinhard

Infection and immunity. 2010 May, v. 78, no. 5

2010

Abstract	In North America, tick-borne relapsing fever is caused by the species Borrelia hermsii, B. parkeri, and B. turicatae, which are transmitted to humans through the bite of the respective infected tick vectors. Here we describe the identification and functional characterization of a surface lipoprotein of B. parkeri, designated BpcA, that binds the human complement regulators factor H and factor H-related protein 1 and, simultaneously, the host protease plasminogen. In contrast, the homologous B. turicatae protein failed to bind human factor H and factor H-related protein 1 but retained its plasminogen binding capacity. Factor H bound to BpcA maintains its regulatory capacity to control C3b deposition and C3 convertase activity. Ectopic expression of BpcA in a serum-sensitive B. burgdorferi strain protects transformed cells from complement-mediated killing. Furthermore, bound plasminogen/plasmin endows B. parkeri and B. turicatae with the potential to degrade extracellular matrix components. These findings expand our understanding of the putative recent evolutionary separation of Borrelia parkeri and Borrelia turicatae, provide evidence that B. parkeri differs from B. turicatae in its ability to resist complement attack, and may help in understanding the pathological processes underlying tick-borne relapsing fever.
Keywords	Borrelia hermsii ; Borrelia parkeri ; Borrelia turicatae ; binding capacity ; complement ; extracellular matrix ; fever ; humans ; lipoproteins ; plasmin ; plasminogen ; ticks ; North America
Language	English
Size	p. 2199-2208.
Publishing place	American Society for Microbiology
Document type	Article
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
Database	NAL-Catalogue (AGRICOLA)

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