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Article: Réactivations virales en réanimation : biomarqueurs de dysfonctionnement immunitaire ou véritables pathogènes ?

Castain, Louise / Bressollette-Bodin, Céline

2021 Volume 25, Issue 3, Page(s) 168–182

Abstract: Studies performed in patients considered as immunocompetent and hospitalized in intensive care unit (ICU) have revealed profound immune alterations leading to an increased risk of viral reactivations. In particular, Herpesviridae reactivations (HSV and ... ...

Title translation	Viral reactivations in intensive care unit: biomarkers of immune dysfunction or true pathogens?
Abstract	Studies performed in patients considered as immunocompetent and hospitalized in intensive care unit (ICU) have revealed profound immune alterations leading to an increased risk of viral reactivations. In particular, Herpesviridae reactivations (HSV and CMV) have been associated with an increased morbidity and mortality in ICU patients. Early diagnosis of these reactivations is now recommended in ICU patients, but the indications of an antiviral therapy remain to be better defined. Advances in molecular biology now allow us to study the human virome in different biological compartments. Among the more frequent viruses detected in the virome, Torque Teno Virus (TTV) has been shown to be associated to the immunocompetence level of immunocompromised patients at risk of opportunistic viral infections. In organ transplant patients, the TTV proportion in blood increases with the degree of immunosuppression and the risk of secondary infections. It remains to be evaluated in other immune dysfunction settings, such as ICU patients. Human virome modulation, as measured by metagenomics, is a promising tool to investigate immune status in various clinical settings. It could be an innovative marker for personalized care, including the evaluation of immunomodulatory molecules use for the prevention and treatment of infectious complications in ICU patients.
Language	French
Publishing date	2021-07-16
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	2118387-9
ISSN	1950-6961 ; 1267-8694
ISSN (online)	1950-6961
ISSN	1267-8694
DOI	10.1684/vir.2021.0905
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Les 14es Journées scientifiques de l’Afipp.

Bressollette-Bodin, Céline / Touzé, Antoine / Jung, Alain / Herfs, Michael / Lepiller, Quentin / Bravo, Ignacio / Péré, Hélène / Clavel, Christine

Virologie (Montrouge, France)

2024 Volume 28, Issue 1, Page(s) 44–54

Title translation	The 14th Afipp scientific days.
Language	French
Publishing date	2024-02-21
Publishing country	France
Document type	Journal Article
ZDB-ID	2118387-9
ISSN	1950-6961 ; 1267-8694
ISSN (online)	1950-6961
ISSN	1267-8694
DOI	10.1684/vir.2024.1037
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Article: BK polyomavirus: virus-cell interactions, host immune response, and viral pathogenesis.

Mazalrey, Simon / Mc Ilroy, Dorian / Bressollette-Bodin, Céline

Virologie (Montrouge, France)

2020 Volume 19, Issue 5, Page(s) 207–224

Abstract: The BK polyomavirus (BKPyV) is one of the main human polyomaviruses. After primary infection, it establishes a persistent infection, and acts as an opportunistic pathogen, innocuous in immunocompetent hosts, but causing potentially serious pathology in ... ...

Title translation	Le polyomavirus BK. Interactions virus-cellule, réponse immunitaire antivirale, pathogenèse virale.
Abstract	The BK polyomavirus (BKPyV) is one of the main human polyomaviruses. After primary infection, it establishes a persistent infection, and acts as an opportunistic pathogen, innocuous in immunocompetent hosts, but causing potentially serious pathology in the context of immunosuppression, in particular in kidney and hematopoietic stem cell graft recipients. Much progress has been made in recent years in the description of virus-cell interactions, but many aspects of viral physiopathology remain mysterious, principally due to the asymptomatic nature of infection in immunocompetent individuals and the lack of an animal model. The characteristics of the antiviral immune response are beginning to become more clearly understood, particularly in kidney transplant patients. Work in these areas is important in order to identify patients at high risk of developing a severe infection. Indeed, in the absence of an effective antiviral therapy few therapeutic options are available, and patient management remains based on modulation of immunosuppressive therapy.
Language	English
Publishing date	2020-04-10
Publishing country	France
Document type	Journal Article
ISSN	1267-8694
ISSN	1267-8694
DOI	10.1684/vir.2015.0623
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Article ; Online: Virus-Associated Nephropathies: A Narrative Review.

Masset, Christophe / Le Turnier, Paul / Bressollette-Bodin, Céline / Renaudin, Karine / Raffi, François / Dantal, Jacques

International journal of molecular sciences

2022 Volume 23, Issue 19

Abstract: While most viral infections cause mild symptoms and a spontaneous favorable resolution, some can lead to severe or protracted manifestations, specifically in immunocompromised hosts. Kidney injuries related to viral infections may have multiple causes ... ...

Abstract	While most viral infections cause mild symptoms and a spontaneous favorable resolution, some can lead to severe or protracted manifestations, specifically in immunocompromised hosts. Kidney injuries related to viral infections may have multiple causes related to the infection severity, drug toxicity or direct or indirect viral-associated nephropathy. We review here the described virus-associated nephropathies in order to guide diagnosis strategies and treatments in cases of acute kidney injury (AKI) occurring concomitantly with a viral infection. The occurrence of virus-associated nephropathy depends on multiple factors: the local epidemiology of the virus, its ability to infect renal cells and the patient's underlying immune response, which varies with the state of immunosuppression. Clear comprehension of pathophysiological mechanisms associated with a summary of described direct and indirect injuries should help physicians to diagnose and treat viral associated nephropathies.
MeSH term(s)	Acute Kidney Injury/etiology ; Humans ; Immunosuppression Therapy ; Kidney ; Kidney Transplantation ; Virus Diseases/complications
Language	English
Publishing date	2022-10-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231912014
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Article ; Online: Intra-patient viral evolution in polyomavirus-related diseases.

McIlroy, Dorian / Halary, Franck / Bressollette-Bodin, Céline

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2019 Volume 374, Issue 1773, Page(s) 20180301

Abstract: Human polyomaviruses show relatively little genetic polymorphism between isolates, indicating that these viruses are genetically stable between hosts. However, it has become increasingly clear that intra-host molecular evolution is a feature of some ... ...

Abstract	Human polyomaviruses show relatively little genetic polymorphism between isolates, indicating that these viruses are genetically stable between hosts. However, it has become increasingly clear that intra-host molecular evolution is a feature of some polyomavirus (PyV) infections in humans. Mutations inducing premature stop codons in the early region of the integrated Merkel cell PyV genome lead to the expression of a truncated form of the large tumour (LT) antigen that is critical for the transformation of Merkel cell carcinoma (MCC) cells. Non-coding control region (NCCR) rearrangements and point mutations in virion protein (VP) 1 have been described in both JCPyV and BKPyV infections. In the context of JCPyV infection, molecular evolution at both these loci allows the virus to replicate effectively in the central nervous system, thereby leading to the development of progressive multifocal leukoencephalopathy (PML). In BKPyV infection, NCCR rearrangements have been linked to higher rates of virus replication in the kidney, and are proposed to play a direct causal role in the development of PyV-associated nephropathy. In all three of these infections, therefore, intra-host viral evolution appears to be an essential component of the disease process. This article is part of the theme issue 'Silent cancer agents: multi-disciplinary modelling of human DNA oncoviruses'.
MeSH term(s)	Biological Evolution ; Humans ; Polyomavirus/physiology ; Polyomavirus Infections/virology ; Virus Replication
Language	English
Publishing date	2019-04-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	208382-6
ISSN	1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
ISSN (online)	1471-2970
ISSN	0080-4622 ; 0264-3839 ; 0962-8436
DOI	10.1098/rstb.2018.0301
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Article ; Online: Distinctive phenotype for HLA-E- versus HLA-A2-restricted memory CD8 αβT cells in the course of HCMV infection discloses features shared with NKG2C

Rousselière, Amélie / Gérard, Nathalie / Delbos, Laurence / Guérif, Pierrick / Giral, Magali / Bressollette-Bodin, Céline / Charreau, Béatrice

Frontiers in immunology

2022 Volume 13, Page(s) 1063690

Abstract: The human cytomegalovirus (HCMV) triggers both innate and adaptive immune responses, including protective ... ...

Abstract	The human cytomegalovirus (HCMV) triggers both innate and adaptive immune responses, including protective CD8
MeSH term(s)	Humans ; Cytomegalovirus Infections ; HLA-A2 Antigen/metabolism ; Programmed Cell Death 1 Receptor/metabolism ; Killer Cells, Natural ; Cytomegalovirus ; CD8-Positive T-Lymphocytes ; Phenotype ; HLA-E Antigens
Chemical Substances	HLA-A2 Antigen ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2022-12-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1063690
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Article ; Online: A cluster of broadly neutralizing IgG against BK polyomavirus in a repertoire dominated by IgM.

Nguyen, Ngoc-Khanh / Devilder, Marie-Claire / Gautreau-Rolland, Laetitia / Fourgeux, Cynthia / Sinha, Debajyoti / Poschmann, Jeremie / Hourmant, Maryvonne / Bressollette-Bodin, Céline / Saulquin, Xavier / McIlroy, Dorian

Life science alliance

2023 Volume 6, Issue 4

Abstract: The BK polyomavirus (BKPyV) is an opportunistic pathogen, which is only pathogenic in immunosuppressed individuals, such as kidney transplant recipients, in whom BKPyV can cause significant morbidity. To identify broadly neutralizing antibodies against ... ...

Abstract	The BK polyomavirus (BKPyV) is an opportunistic pathogen, which is only pathogenic in immunosuppressed individuals, such as kidney transplant recipients, in whom BKPyV can cause significant morbidity. To identify broadly neutralizing antibodies against this virus, we used fluorescence-labeled BKPyV virus-like particles to sort BKPyV-specific B cells from the PBMC of KTx recipients, then single-cell RNAseq to obtain paired heavy- and light-chain antibody sequences from 2,106 sorted B cells. The BKPyV-specific repertoire was highly diverse in terms of both V-gene usage and clonotype diversity and included most of the IgM B cells, including many with extensive somatic hypermutation. In two patients where sufficient data were available, IgM B cells in the BKPyV-specific dataset had significant differences in V-gene usage compared with IgG B cells from the same patient. CDR3 sequence-based clustering allowed us to identify and characterize three broadly neutralizing "41F17-like" clonotypes that were predominantly IgG, suggesting that some specific BKPyV capsid epitopes are preferentially targeted by IgG.
MeSH term(s)	Humans ; BK Virus/genetics ; Kidney Transplantation/adverse effects ; Leukocytes, Mononuclear ; Polyomavirus Infections/etiology ; Immunoglobulin G ; Immunoglobulin M
Chemical Substances	Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2023-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2575-1077
ISSN (online)	2575-1077
DOI	10.26508/lsa.202201567
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Article: Cardiomyopathies inflammatoires : diagnostic, corrélations avec l’imagerie, intérêt de la biopsie myocardique et place de la biologie moléculaire.

Bourgade, Raphaël / Piriou, Nicolas / Bressollette-Bodin, Céline / Loussouarn, Delphine / Toquet, Claire

Annales de pathologie

2020 Volume 41, Issue 1, Page(s) 71–84

Abstract: Inflammatory cardiomyopathies, also known as "myocarditis" are inflammatory pathologies affecting the myocardium and characterized by vast etiological and clinical heterogeneity. They can be asymptomatic, particularly in viral forms, or be responsible ... ...

Title translation	Inflammatory cardiomyopathies: Diagnosis, correlations with imaging, interest of myocardial biopsy and place of molecular biology.
Abstract	Inflammatory cardiomyopathies, also known as "myocarditis" are inflammatory pathologies affecting the myocardium and characterized by vast etiological and clinical heterogeneity. They can be asymptomatic, particularly in viral forms, or be responsible for sudden death, particularly in subjects under 35 years olds. Due to insufficient sensitivity and specificity of imaging and biology, the gold standard is histopathological and is performed on an endomyocardial biopsy or on explanted heart samples in a transplant context. Their classification has considerably evolved and is now based on the identification of a predominant cell pattern such as lymphocytic, neutrophilic or eosinophilic polynuclear, giant cell or granulomatous myocarditis. These different patterns will guide the etiological diagnosis, prognosis and the therapies to be implemented. Due to the importance of viral etiologies, this morphological analysis must be complemented by a virological analysis based on PCR with viral load quantification. In addition, some authors have been able to demonstrate the occurrence of myocarditis in patients with arrhythmogenic cardiomyopathy of genetic origin. The aim of this chapter is to review the current state of knowledge on inflammatory cardiomyopathies and their management.
MeSH term(s)	Biopsy ; Cardiomyopathies/diagnosis ; Humans ; Molecular Biology ; Myocarditis/diagnosis ; Myocardium
Language	French
Publishing date	2020-12-30
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	225720-8
ISSN	0242-6498
ISSN	0242-6498
DOI	10.1016/j.annpat.2020.10.007
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Article: Quantification of APOBEC3 Mutation Rates Affecting the VP1 Gene of BK Polyomavirus In Vivo

McIlroy, Dorian / Peltier, Cécile / Nguyen, My-Linh / Manceau, Louise / Mobuchon, Lenha / Le Baut, Nicolas / Nguyen, Ngoc-Khanh / Tran, Minh-Chau / Nguyen, The-Cuong / Bressollette-Bodin, Céline

Viruses. 2022 Sept. 19, v. 14, no. 9

2022

Abstract: Mutations in the BK polyomavirus (BKPyV) capsid accumulate in kidney transplant (KTx) recipients with persistent virus replication. They are associated with neutralization escape and appear to arise as a result of cytosine deamination by host cell ... ...

Abstract	Mutations in the BK polyomavirus (BKPyV) capsid accumulate in kidney transplant (KTx) recipients with persistent virus replication. They are associated with neutralization escape and appear to arise as a result of cytosine deamination by host cell APOBEC3A/B enzymes. To study the mutagenic processes occurring in patients, we amplified the typing region of the VP1 gene, sequenced the amplicons to a depth of 5000–10,000×, and identified rare mutations, which were fitted to COSMIC mutational signatures. Background mutations were identified in amplicons from plasmids carrying the BKPyV genome and compared to mutations observed in 148 samples from 23 KTx recipients in France and in Vietnam. Three mutational signatures were consistently observed in urine, serum, and kidney biopsy samples, two of which, SBS2 and SBS13, corresponded to APOBEC3A/B activity. In addition, a third signature with no known etiology, SBS89, was detected both in patient samples, and in cells infected in vitro with BKPyV. Quantitatively, APOBEC3A/B mutation rates in urine samples were strongly correlated with urine viral load, and also appeared to vary between individuals. These results confirm that APOBEC3A/B is a major, but not the only, source of BKPyV genome mutations in patients.
Keywords	Human polyomavirus 1 ; biopsy ; blood serum ; capsid ; cytosine ; deamination ; etiology ; genes ; kidney transplant ; kidneys ; mutagens ; mutation ; neutralization ; patients ; plasmids ; urine ; viral load ; virus replication ; France ; Vietnam
Language	English
Dates of publication	2022-0919
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v14092077
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Changes in HCMV immune cell frequency and phenotype are associated with chronic lung allograft dysfunction.

Rousselière, Amélie / Delbos, Laurence / Foureau, Aurore / Reynaud-Gaubert, Martine / Roux, Antoine / Demant, Xavier / Le Pavec, Jérôme / Kessler, Romain / Mornex, Jean-François / Messika, Jonathan / Falque, Loïc / Le Borgne, Aurélie / Boussaud, Véronique / Tissot, Adrien / Hombourger, Sophie / Bressollette-Bodin, Céline / Charreau, Béatrice

Frontiers in immunology

2023 Volume 14, Page(s) 1143875

Abstract: Background: Human cytomegalovirus (HCMV) infection is common and often severe in lung transplant recipients (LTRs), and it is a risk factor associated with chronic lung allograft dysfunction (CLAD). The complex interplay between HCMV and allograft ... ...

Abstract	Background: Human cytomegalovirus (HCMV) infection is common and often severe in lung transplant recipients (LTRs), and it is a risk factor associated with chronic lung allograft dysfunction (CLAD). The complex interplay between HCMV and allograft rejection is still unclear. Currently, no treatment is available to reverse CLAD after diagnosis, and the identification of reliable biomarkers that can predict the early development of CLAD is needed. This study investigated the HCMV immunity in LTRs who will develop CLAD. Methods: This study quantified and phenotyped conventional (HLA-A2pp65) and HLA-E-restricted (HLA-EUL40) anti-HCMV CD8 Results: At M18 post-transplantation, HLA-EUL40 CD8 T responses were less frequently found in HCMV Conclusions: CLAD is associated with significant changes in anti-HCMV immune cell responses. Our findings propose that the presence of dysfunctional HCMV-specific HLA-E-restricted CD8 T cells together with post-infection changes in the immune cell distribution affecting NK and γδT cells defines an early immune signature for CLAD in HCMV
MeSH term(s)	Humans ; Cytomegalovirus ; Cytomegalovirus Infections ; Killer Cells, Natural ; Phenotype ; Lung/metabolism ; Allografts/metabolism
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1143875
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