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  1. Article: Hypnose : outil complémentaire chez les adolescent-e-s souffrant d’anorexie mentale.

    Wosinski, Benjy / Le Breton, Julien / Soroken, Cindy

    Revue medicale suisse

    2024  Volume 20, Issue 870, Page(s) 793–796

    Abstract: Anorexia Nervosa (AN) mainly affects adolescent girls and requires specialized, multidisciplinary care. In Geneva, the HUG's AliNEA unit and the pediatric hypnosis consultation have been collaborating since 2021 to integrate hypnosis into the management ... ...

    Title translation Hypnosis: a complementary tool for managing adolescents affected by anorexia nervosa.
    Abstract Anorexia Nervosa (AN) mainly affects adolescent girls and requires specialized, multidisciplinary care. In Geneva, the HUG's AliNEA unit and the pediatric hypnosis consultation have been collaborating since 2021 to integrate hypnosis into the management of AN. Hypnosis is seen as a complementary tool to the Maudsley therapeutic model, but not a miracle solution. It needs to be adapted to each patient's individual needs and to the different phases of treatment : re-association with the body, reinforcement of motivation, exploration of interpersonal relationships and consolidation of progress. Although scientific evidence is limited, patient testimonials underline its beneficial potential as a non-medicinal, individualized form of support.
    MeSH term(s) Female ; Humans ; Adolescent ; Child ; Anorexia Nervosa/therapy ; Hypnosis ; Interdisciplinary Studies ; Interpersonal Relations ; Motivation
    Language French
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type English Abstract ; Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2024.20.870.793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Syndrome de tachycardie posturale chez les adolescent-e-s.

    Soroken, Cindy / Le Breton, Julien

    Revue medicale suisse

    2022  Volume 18, Issue 778, Page(s) 741–745

    Abstract: Postural tachycardia syndrome (PoTS) is a frequent polymorphic clinical syndrome, poorly known and, as a result, underdiagnosed especially in adolescents. It is a form of dysautonomia, but its exact physiopathology remains elusive. It is characterized by ...

    Title translation Postural tachycardia syndrome among adolescents.
    Abstract Postural tachycardia syndrome (PoTS) is a frequent polymorphic clinical syndrome, poorly known and, as a result, underdiagnosed especially in adolescents. It is a form of dysautonomia, but its exact physiopathology remains elusive. It is characterized by heterogeneous symptoms that accompany a disproportionate tachycardia upon the upright position. It can significantly impact adolescents' quality of life. Only a Schellong test is useful to make the diagnosis; however additional testing is frequently performed in order to exclude conditions that may mimic, exacerbate or impact management. Treatment in PoTS is primarily symptomatic. The main goal is to restore the patient's condition as quickly as possible. Its management is multidisciplinary and must involve the parents. The course of the syndrome is sometimes marked by relapses, but the prognosis is mostly favorable.
    MeSH term(s) Adolescent ; Heart Rate ; Humans ; Postural Orthostatic Tachycardia Syndrome/diagnosis ; Postural Orthostatic Tachycardia Syndrome/therapy ; Quality of Life ; Tachycardia
    Language French
    Publishing date 2022-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2022.18.778.741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Dysbiotic Gut Bacteria in Obesity: An Overview of the Metabolic Mechanisms and Therapeutic Perspectives of Next-Generation Probiotics

    Breton, Jonathan / Galmiche, Marie / Déchelotte, Pierre

    Microorganisms. 2022 Feb. 16, v. 10, no. 2

    2022  

    Abstract: Obesity, a worldwide health concern with a constantly rising prevalence, is a multifactorial chronic disease associated with a wide range of physiological disruptions, including energy imbalance, central appetite and food reward dysregulation, and ... ...

    Abstract Obesity, a worldwide health concern with a constantly rising prevalence, is a multifactorial chronic disease associated with a wide range of physiological disruptions, including energy imbalance, central appetite and food reward dysregulation, and hormonal alterations and gut dysbiosis. The gut microbiome is a well-recognized factor in the pathophysiology of obesity, and its influence on host physiology has been extensively investigated over the last decade. This review highlights the mechanisms by which gut dysbiosis can contribute to the pathophysiology of obesity. In particular, we discuss gut microbiota’s contribution to host energy homeostatic changes, low-grade inflammation, and regulation of fat deposition and bile acid metabolism via bacterial metabolites, such as short-chain fatty acids, and bacterial components, such as lipopolysaccharides, among others. Finally, therapeutic strategies based on next-generation probiotics aiming to re-shape the intestinal microbiota and reverse metabolic alterations associated with obesity are described.
    Keywords appetite ; bile acids ; chronic diseases ; digestive system ; dysbiosis ; energy ; inflammation ; intestinal microorganisms ; lipopolysaccharides ; metabolism ; metabolites ; obesity ; pathophysiology ; probiotics ; therapeutics
    Language English
    Dates of publication 2022-0216
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10020452
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Dysbiotic Gut Bacteria in Obesity: An Overview of the Metabolic Mechanisms and Therapeutic Perspectives of Next-Generation Probiotics.

    Breton, Jonathan / Galmiche, Marie / Déchelotte, Pierre

    Microorganisms

    2022  Volume 10, Issue 2

    Abstract: Obesity, a worldwide health concern with a constantly rising prevalence, is a multifactorial chronic disease associated with a wide range of physiological disruptions, including energy imbalance, central appetite and food reward dysregulation, and ... ...

    Abstract Obesity, a worldwide health concern with a constantly rising prevalence, is a multifactorial chronic disease associated with a wide range of physiological disruptions, including energy imbalance, central appetite and food reward dysregulation, and hormonal alterations and gut dysbiosis. The gut microbiome is a well-recognized factor in the pathophysiology of obesity, and its influence on host physiology has been extensively investigated over the last decade. This review highlights the mechanisms by which gut dysbiosis can contribute to the pathophysiology of obesity. In particular, we discuss gut microbiota's contribution to host energy homeostatic changes, low-grade inflammation, and regulation of fat deposition and bile acid metabolism via bacterial metabolites, such as short-chain fatty acids, and bacterial components, such as lipopolysaccharides, among others. Finally, therapeutic strategies based on next-generation probiotics aiming to re-shape the intestinal microbiota and reverse metabolic alterations associated with obesity are described.
    Language English
    Publishing date 2022-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10020452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Nutrition and enhanced recovery programmes in adult surgery.

    Ocón-Bretón, Julia / Rodríguez Ramírez, Jose Manuel

    Endocrinologia, diabetes y nutricion

    2022  Volume 69, Issue 2, Page(s) 81–82

    MeSH term(s) Nutritional Status
    Language English
    Publishing date 2022-02-28
    Publishing country Spain
    Document type Journal Article
    ISSN 2530-0180
    ISSN (online) 2530-0180
    DOI 10.1016/j.endien.2021.12.005
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  6. Article: Targeting the GLP-1/GLP-1R axis to treat osteoarthritis: A new opportunity?

    Meurot, C / Jacques, C / Martin, C / Sudre, L / Breton, J / Rattenbach, R / Bismuth, K / Berenbaum, F

    Journal of orthopaedic translation

    2022  Volume 32, Page(s) 121–129

    Abstract: Osteoarthritis (OA) is a degenerative joint disease affecting millions of people worldwide. In OA, chondrocytes, synovial cells and other joint cells become activated when exposed to an abnormal environment, including mechanical stress, inflammatory ... ...

    Abstract Osteoarthritis (OA) is a degenerative joint disease affecting millions of people worldwide. In OA, chondrocytes, synovial cells and other joint cells become activated when exposed to an abnormal environment, including mechanical stress, inflammatory cytokines or disorganization of matrix proteins. Several analogues of the hormones called incretins have been developed and are used notably for treating type 2 diabetes mellitus. Data has accumulated to suggest that incretinomimetics, which bind to the glucagon-like peptide-1 receptor (GLP-1R), have beneficial pleiotropic effects such as immunomodulation, anti-inflammation and neuronal protection. Thus, because of their anti-inflammatory properties, GLP-1-based therapies could benefit OA patients. This review focuses on the GLP-1R pathway, molecular mechanisms and phenotypes related to OA pathogenesis.
    The translational potential of this article: The search for new therapeutic targets to treat people suffering from OA remains urgent as there is currently no disease-modifyingtherapy available for this disease. This review discusses how GLP-1 analogues could be potential DMOADs for treating OA thanks to their anti-inflammatory, immunoregulatory and differentiation properties.
    Language English
    Publishing date 2022-02-25
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2747531-1
    ISSN 2214-031X
    ISSN 2214-031X
    DOI 10.1016/j.jot.2022.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Liraglutide, a glucagon-like peptide 1 receptor agonist, exerts analgesic, anti-inflammatory and anti-degradative actions in osteoarthritis.

    Meurot, C / Martin, C / Sudre, L / Breton, J / Bougault, C / Rattenbach, R / Bismuth, K / Jacques, C / Berenbaum, F

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 1567

    Abstract: Osteoarthritis (OA) is a common disabling disease worldwide, with no effective and safe disease-modifying drugs (DMOAD) in the market. However, studies suggest that drugs, such as liraglutide, which possess strong potential in decreasing low-grade ... ...

    Abstract Osteoarthritis (OA) is a common disabling disease worldwide, with no effective and safe disease-modifying drugs (DMOAD) in the market. However, studies suggest that drugs, such as liraglutide, which possess strong potential in decreasing low-grade systemic inflammation may be effective in treating OA. Therefore, the aim of this study was to examine the anti-inflammatory, analgesic, and anti-degradative effects in OA using in vitro and in vivo experiments. The results showed that intra-articular injection of liraglutide alleviated pain-related behavior in in vivo sodium monoiodoacetate OA mouse model, which was probably driven by the GLP-1R-mediated anti-inflammatory activity of liraglutide. Moreover, liraglutide treatment significantly decreased IL-6, PGE
    MeSH term(s) Liraglutide
    Chemical Substances Liraglutide (839I73S42A)
    Language English
    Publishing date 2022-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-05323-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cerebral blood flow, tau imaging, and memory associations in cognitively unimpaired older adults.

    Weigand, Alexandra J / Hamlin, Abbey M / Breton, Jordana / Clark, Alexandra L

    Cerebral circulation - cognition and behavior

    2022  Volume 3, Page(s) 100153

    Abstract: Objective: Cerebral blood flow (CBF) has been independently linked to cognitive impairment and traditional Alzheimer's disease (AD) pathology (e.g., amyloid-beta [Aβ], tau) in older adults. However, less is known about the possible interactive effects ... ...

    Abstract Objective: Cerebral blood flow (CBF) has been independently linked to cognitive impairment and traditional Alzheimer's disease (AD) pathology (e.g., amyloid-beta [Aβ], tau) in older adults. However, less is known about the possible interactive effects of CBF, Aβ, and tau on memory performance. The present study examined whether CBF moderates the effect of Aβ and tau on objective and subjective memory within cognitively unimpaired (CU) older adults.
    Methods: Participants included 54 predominately white CU older adults from the Alzheimer's Disease Neuroimaging Initiative. Multiple linear regression models examined meta-temporal CBF associations with (1) meta-temporal tau PET adjusting for cortical Aβ PET and (2) and cortical Aβ PET adjusting for tau PET. The CBF and tau meta region was an average of 5 distinct temporal lobe regions. CBF interactions with Aβ or tau PET on memory performance were also examined. Covariates for all models included age, sex, education, pulse pressure, APOE-ε4 positivity, and imaging acquisition date differences.
    Results: CBF was significantly negatively associated with tau PET (
    Conclusions: Cerebrovascular and tau pathologies may interact to influence cognitive performance. This study highlights the need for future vascular risk interventions, which could offer a scalable and cost-effective method for AD prevention.
    Language English
    Publishing date 2022-10-27
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-2450
    ISSN (online) 2666-2450
    DOI 10.1016/j.cccb.2022.100153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Isolement social et solitude chez la personne âgée en temps de pandémie du Covid-19.

    Manzanares, Oana / Tran, Quang Duy / Le Breton, Julien

    Revue medicale suisse

    2021  Volume 17, Issue 757, Page(s) 1878–1882

    Abstract: The sanitary crisis due to the Covid-19 pandemic limited the social network of elderly people, already at risk of social isolation and loneliness (SIL). Isolated and lonely people have a higher mortality risk and suffer from severe health repercussions. ... ...

    Title translation Social isolation and loneliness among old people during Covid-19 pandemic.
    Abstract The sanitary crisis due to the Covid-19 pandemic limited the social network of elderly people, already at risk of social isolation and loneliness (SIL). Isolated and lonely people have a higher mortality risk and suffer from severe health repercussions. The management of SIL faces multiple difficulties, such as the lack of consensus on the definitions, as well as the absence of reliable screening tools and intervention strategies. SIL have a significant impact on individual health and the overall health system, they should be considered as a distinct geriatric syndrome. Taking care of this condition is necessary and should include the development of preventive strategies to limit its deleterious consequences.
    MeSH term(s) Aged ; COVID-19 ; Humans ; Loneliness ; Pandemics ; SARS-CoV-2 ; Social Isolation
    Language French
    Publishing date 2021-11-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Evaluation of DNA double-strand break repair capacity in human cells: Critical overview of current functional methods.

    Tatin, Xavier / Muggiolu, Giovanna / Sauvaigo, Sylvie / Breton, Jean

    Mutation research. Reviews in mutation research

    2021  Volume 788, Page(s) 108388

    Abstract: DNA double-strand breaks (DSBs) are highly deleterious lesions, responsible for mutagenesis, chromosomal translocation or cell death. DSB repair (DSBR) is therefore a critical part of the DNA damage response (DDR) to restore molecular and genomic ... ...

    Abstract DNA double-strand breaks (DSBs) are highly deleterious lesions, responsible for mutagenesis, chromosomal translocation or cell death. DSB repair (DSBR) is therefore a critical part of the DNA damage response (DDR) to restore molecular and genomic integrity. In humans, this process is achieved through different pathways with various outcomes. The balance between DSB repair activities varies depending on cell types, tissues or individuals. Over the years, several methods have been developed to study variations in DSBR capacity. Here, we mainly focus on functional techniques, which provide dynamic information regarding global DSB repair proficiency or the activity of specific pathways. These methods rely on two kinds of approaches. Indirect techniques, such as pulse field gel electrophoresis (PFGE), the comet assay and immunofluorescence (IF), measure DSB repair capacity by quantifying the time-dependent decrease in DSB levels after exposure to a DNA-damaging agent. On the other hand, cell-free assays and reporter-based methods directly track the repair of an artificial DNA substrate. Each approach has intrinsic advantages and limitations and despite considerable efforts, there is currently no ideal method to quantify DSBR capacity. All techniques provide different information and can be regarded as complementary, but some studies report conflicting results. Parameters such as the type of biological material, the required equipment or the cost of analysis may also limit available options. Improving currently available methods measuring DSBR capacity would be a major step forward and we present direct applications in mechanistic studies, drug development, human biomonitoring and personalized medicine, where DSBR analysis may improve the identification of patients eligible for chemo- and radiotherapy.
    MeSH term(s) Comet Assay/methods ; DNA Breaks, Double-Stranded ; Electrophoresis, Gel, Pulsed-Field/methods ; Fluorescent Antibody Technique/methods ; Humans ; Recombinational DNA Repair
    Language English
    Publishing date 2021-06-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2727833-5
    ISSN 1388-2139 ; 1383-5742
    ISSN (online) 1388-2139
    ISSN 1383-5742
    DOI 10.1016/j.mrrev.2021.108388
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