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Article ; Online: Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.

Williamson, Alice / Norris, Dougall M / Yin, Xianyong / Broadaway, K Alaine / Moxley, Anne H / Vadlamudi, Swarooparani / Wilson, Emma P / Jackson, Anne U / Ahuja, Vasudha / Andersen, Mette K / Arzumanyan, Zorayr / Bonnycastle, Lori L / Bornstein, Stefan R / Bretschneider, Maxi P / Buchanan, Thomas A / Chang, Yi-Cheng / Chuang, Lee-Ming / Chung, Ren-Hua / Clausen, Tine D /
Damm, Peter / Delgado, Graciela E / de Mello, Vanessa D / Dupuis, Josée / Dwivedi, Om P / Erdos, Michael R / Fernandes Silva, Lilian / Frayling, Timothy M / Gieger, Christian / Goodarzi, Mark O / Guo, Xiuqing / Gustafsson, Stefan / Hakaste, Liisa / Hammar, Ulf / Hatem, Gad / Herrmann, Sandra / Højlund, Kurt / Horn, Katrin / Hsueh, Willa A / Hung, Yi-Jen / Hwu, Chii-Min / Jonsson, Anna / Kårhus, Line L / Kleber, Marcus E / Kovacs, Peter / Lakka, Timo A / Lauzon, Marie / Lee, I-Te / Lindgren, Cecilia M / Lindström, Jaana / Linneberg, Allan / Liu, Ching-Ti / Luan, Jian'an / Aly, Dina Mansour / Mathiesen, Elisabeth / Moissl, Angela P / Morris, Andrew P / Narisu, Narisu / Perakakis, Nikolaos / Peters, Annette / Prasad, Rashmi B / Rodionov, Roman N / Roll, Kathryn / Rundsten, Carsten F / Sarnowski, Chloé / Savonen, Kai / Scholz, Markus / Sharma, Sapna / Stinson, Sara E / Suleman, Sufyan / Tan, Jingyi / Taylor, Kent D / Uusitupa, Matti / Vistisen, Dorte / Witte, Daniel R / Walther, Romy / Wu, Peitao / Xiang, Anny H / Zethelius, Björn / Ahlqvist, Emma / Bergman, Richard N / Chen, Yii-Der Ida / Collins, Francis S / Fall, Tove / Florez, Jose C / Fritsche, Andreas / Grallert, Harald / Groop, Leif / Hansen, Torben / Koistinen, Heikki A / Komulainen, Pirjo / Laakso, Markku / Lind, Lars / Loeffler, Markus / März, Winfried / Meigs, James B / Raffel, Leslie J / Rauramaa, Rainer / Rotter, Jerome I / Schwarz, Peter E H / Stumvoll, Michael / Sundström, Johan / Tönjes, Anke / Tuomi, Tiinamaija / Tuomilehto, Jaakko / Wagner, Robert / Barroso, Inês / Walker, Mark / Grarup, Niels / Boehnke, Michael / Wareham, Nicholas J / Mohlke, Karen L / Wheeler, Eleanor / O'Rahilly, Stephen / Fazakerley, Daniel J / Langenberg, Claudia

Nature genetics

2023  Volume 55, Issue 6, Page(s) 973–983

Abstract: Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic ... ...

Abstract Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new loci (P < 5 × 10
MeSH term(s) Humans ; Insulin/genetics ; Genome-Wide Association Study ; Insulin Resistance/genetics ; Diabetes Mellitus, Type 2/genetics ; Glucose/metabolism ; Blood Glucose/genetics
Chemical Substances Insulin ; Glucose (IY9XDZ35W2) ; Blood Glucose
Language English
Publishing date 2023-06-08
Publishing country United States
Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID 1108734-1
ISSN 1546-1718 ; 1061-4036
ISSN (online) 1546-1718
ISSN 1061-4036
DOI 10.1038/s41588-023-01408-9
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Zs.A 3613: Show issues Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)
Zs.MG 46: Show issues

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