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  1. Article ; Online: Circulating endothelial cells in pathophysiology.

    Brett, Victor Emmanuel / Dignat George, Francoise / James, Chloe

    Current opinion in hematology

    2024  Volume 31, Issue 3, Page(s) 148–154

    Abstract: Purpose of review: The purpose of this review is to synthesize recent insights into the roles and importance of circulating endothelial cells (CECs) as indicators of the severity, progression, and prognosis of vascular-related diseases.: Recent ... ...

    Abstract Purpose of review: The purpose of this review is to synthesize recent insights into the roles and importance of circulating endothelial cells (CECs) as indicators of the severity, progression, and prognosis of vascular-related diseases.
    Recent findings: Recent studies have identified elevated counts of CECs in pathological conditions, notably inflammatory or cardiovascular diseases such as acute myocardial infarction and heart failure, underscoring their potential as sensitive indicators of disease. Furthermore, the rise in CEC levels in cancer patients, particularly with disease advancement, points to their role in cancer-associated angiogenesis and response to treatment.
    Summary: This review underscores the evolving significance of CECs as markers for evaluating the gravity and advancement of diseases with vascular injury, including cardiovascular diseases, cancer, inflammatory conditions, and thromboembolic events. These last years, efforts made to standardize flow cytometry detection of CEC and the development of highly sensitive techniques to isolate, quantify or phenotype rare cells open promising avenues for clinical application. This may yield extensive knowledge regarding the mechanisms by which endothelial cells contribute to a variety of vascular-related disorders and their clinical value as emerging biomarkers.
    MeSH term(s) Humans ; Endothelial Cells/pathology ; Biomarkers ; Myocardial Infarction ; Vascular Diseases/pathology ; Neoplasms/pathology ; Flow Cytometry
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1153887-9
    ISSN 1531-7048 ; 1065-6251
    ISSN (online) 1531-7048
    ISSN 1065-6251
    DOI 10.1097/MOH.0000000000000814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3703: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Principal component analysis yields results comparable to those of an elaborate Boolean strategy: simplifying the assessment of measurable residual disease in chronic lymphocytic leukemia patients.

    Brett, Victor-Emmanuel / Dilhuydy, Marie-Sarah / Lechevalier, Nicolas / Adjibabi, And-Nan / Gros, François-Xavier / Forcade, Édouard / Letestu, Rémi / Vial, Jean-Philippe

    Annales de biologie clinique

    2023  Volume 81, Issue 4, Page(s) 379–387

    Abstract: Introduction: Measurable residual disease (MRD) is becoming increasingly important in the chronic lymphocytic leukemia (CLL) context. It is of independent prognostic significance in terms of favorable progression-free and overall survival. The ... ...

    Abstract Introduction: Measurable residual disease (MRD) is becoming increasingly important in the chronic lymphocytic leukemia (CLL) context. It is of independent prognostic significance in terms of favorable progression-free and overall survival. The standardized methods used to assess CLL MRD are based on flow cytometry and real-time quantitative PCR. We here present a nine-color assay for CLL MRD with the ROR-1 marker antigen as recommended by the European Research Initiative (ERIC) on CLL; the sensitivity is at least 10-5.
    Materials and methods: We used 54 samples to develop a new principal component analysis (PCA) method based on the Kaluza© "radar" presentation mode. We used a Navios flow cytometer (Beckman Coulter©).
    Results: We confirmed the linearity of our method over more than five dilutions. The specificity limit was 1.3×10-6 and the lower limit of detection was 3.6×10-6. Compared to the Boolean method, the sensitivity, specificity, and positive and negative predictive values of our PCA method were 100%. When MRD was detectable, PCA and Boolean assays were in agreement (linear regression, R2 = 0.99).
    Conclusion: We developed a new PCA-based method for detection of CLL MRD. Our method is comparable to that of the consensus method in terms of sensitivity, and it is also much easier and faster.
    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Principal Component Analysis ; Flow Cytometry/methods ; Real-Time Polymerase Chain Reaction ; Neoplasm, Residual/diagnosis
    Language English
    Publishing date 2023-10-20
    Publishing country France
    Document type Journal Article
    ZDB-ID 418098-7
    ISSN 1950-6112 ; 0003-3898
    ISSN (online) 1950-6112
    ISSN 0003-3898
    DOI 10.1684/abc.2023.1826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.203: Show issues Location:
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  3. Article ; Online: An unusual case of cytoplasmic CD3 expressing BPDCN supporting the T-lineage origin of plasmacytoid dendritic cells.

    Brett, Victor-Emmanuel / Menguy, Sarah / Arcourt, Agathe / Bidet, Audrey / Lechevalier, Nicolas / Leguay, Thibaut / Klein, Emilie / Garnache-Ottou, Francine / Vial, Jean-Philippe

    Cytometry. Part B, Clinical cytometry

    2021  Volume 102, Issue 2, Page(s) 175–177

    MeSH term(s) Dendritic Cells ; Flow Cytometry ; Hematologic Neoplasms ; Humans
    Language English
    Publishing date 2021-11-17
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 2099657-3
    ISSN 1552-4957 ; 1552-4949 ; 0196-4763
    ISSN (online) 1552-4957
    ISSN 1552-4949 ; 0196-4763
    DOI 10.1002/cyto.b.22039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1688: Show issues Location:
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  4. Article ; Online: The presence of a chromosomal abnormality in cytopenia without dysplasia identifies a category of high-risk clonal cytopenia of unknown significance.

    Brett, Victor-Emmanuel / Lechevalier, Nicolas / Trimoreau, Franck / Dussiau, Charles / Dimicoli-Salazar, Sophie / Coster, Lucie / Luquet, Isabelle / Nadal, Nathalie / Ribourtout, Bénédicte / Chapiro, Elise / Lefebvre, Christine / Tondeur, Sylvie / Balducci, Estelle / Nguyen-Khac, Florence / Borie, Claire / Radford-Weiss, Isabelle / Barin, Carole / Eclache, Virginie / Mansier, Olivier /
    Bidet, Audrey

    Genes, chromosomes & cancer

    2022  Volume 62, Issue 3, Page(s) 139–151

    Abstract: Myelodysplastic syndromes (MDS) are hematological malignancies classically defined by the presence of cytopenia(s) and dysmorphic myeloid cells. It is now known that MDS can be preceded by a pre-malignant condition called clonal cytopenia of unknown ... ...

    Abstract Myelodysplastic syndromes (MDS) are hematological malignancies classically defined by the presence of cytopenia(s) and dysmorphic myeloid cells. It is now known that MDS can be preceded by a pre-malignant condition called clonal cytopenia of unknown significance (CCUS), which associates a clonality marker with cytopenia in the absence of criteria of dysplasia. However, to date, it is not clear whether chromosomal abnormalities should be considered in the definition of CCUS or if they carry a prognostic impact in CCUS patients. In this study, we analyzed the clinico-biological features and outcomes of 34 patients who presented with one or more cytopenias, an absence of significant dysplasia, and a presence of a chromosomal abnormality (CA). We named this entity chromosomal abnormality with cytopenia of undetermined significance (CACtUS). We show that these patients are slightly older than MDS patients and that they more frequently presented with normocytic anemia. Most CACtUS patients exhibited only one unbalanced CA. The number and type of mutations were comparable between CACtUS patients and MDS patients. Regardless of the cytogenetic abnormality, the clinicobiological characteristics, overall survival, and risk of progression to high-risk (HR) MDS were similar between CACtUS patients and low-risk MDS patients. Thus, we suggest that CACtUS patients can be considered as HR-CCUS and should receive the follow-up regimen recommended for MDS patients.
    MeSH term(s) Humans ; Chromosome Aberrations ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/pathology ; Mutation ; Hematologic Neoplasms ; Chromosome Disorders ; Anemia
    Language English
    Publishing date 2022-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1018988-9
    ISSN 1098-2264 ; 1045-2257
    ISSN (online) 1098-2264
    ISSN 1045-2257
    DOI 10.1002/gcc.23107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2966: Show issues Location:
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