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  1. Article ; Online: Anti-Inflammatory Effect of Synaptamide in Ischemic Acute Kidney Injury and the Role of G-Protein-Coupled Receptor 110.

    Brezgunova, Anna A / Andrianova, Nadezda V / Saidova, Aleena A / Potashnikova, Daria M / Abramicheva, Polina A / Manskikh, Vasily N / Mariasina, Sofia S / Pevzner, Irina B / Zorova, Ljubava D / Manzhulo, Igor V / Zorov, Dmitry B / Plotnikov, Egor Y

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: The development of drugs for the treatment of acute kidney injury (AKI) that could suppress the excessive inflammatory response in damaged kidneys is an important clinical challenge. Recently, synaptamide (N-docosahexaenoylethanolamine) has been shown to ...

    Abstract The development of drugs for the treatment of acute kidney injury (AKI) that could suppress the excessive inflammatory response in damaged kidneys is an important clinical challenge. Recently, synaptamide (N-docosahexaenoylethanolamine) has been shown to exert anti-inflammatory and neurogenic properties. The aim of this study was to investigate the anti-inflammatory effect of synaptamide in ischemic AKI. For this purpose, we analyzed the expression of inflammatory mediators and the infiltration of different leukocyte populations into the kidney after injury, evaluated the expression of the putative synaptamide receptor G-protein-coupled receptor 110 (GPR110), and isolated a population of CD11b/c
    MeSH term(s) Animals ; Rats ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/metabolism ; Anti-Inflammatory Agents/metabolism ; Ethanolamines ; Interleukins/metabolism ; Kidney/metabolism ; Receptors, G-Protein-Coupled/drug effects ; Receptors, G-Protein-Coupled/metabolism ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism
    Chemical Substances Anti-Inflammatory Agents ; Ethanolamines ; Interleukins ; Receptors, G-Protein-Coupled ; synaptamide
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sex-Specific Effects of Estradiol and Progesterone in Ischemic Kidney Injury.

    Andrianova, Nadezda V / Brezgunova, Anna A / Buyan, Marina I / Makievskaya, Ciara I / Buyan, Andrey I / Cherkesova, Kseniia S / Pevzner, Irina B / Zorova, Ljubava D / Zorov, Dmitry B / Plotnikov, Egor Y / Popkov, Vasily A

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: The positive effects of female sex hormones, particularly estradiol and progesterone, have been observed in treatment of various pathologies. Acute kidney injury (AKI) is a common condition in hospitalized patients in which the molecular mechanisms of ... ...

    Abstract The positive effects of female sex hormones, particularly estradiol and progesterone, have been observed in treatment of various pathologies. Acute kidney injury (AKI) is a common condition in hospitalized patients in which the molecular mechanisms of hormone action are poorly characterized. In this study, we investigated the influence of estradiol and progesterone on renal cells during ischemic injury. We performed both in vivo experiments on female and male rats and in vitro experiments on renal tubular cells (RTCs) obtained from the kidneys of intact animals of different sexes. Since mitochondria play an important role in the pathogenesis of AKI, we analyzed the properties of individual mitochondria in renal cells, including the area, roundness, mitochondrial membrane potential, and mitochondrial permeability transition pore (mPTP) opening time. We found that pre-treatment with progesterone or estradiol attenuated the severity of ischemia/reperfusion (I/R)-induced AKI in female rats, whereas in male rats, these hormones exacerbated renal dysfunction. We demonstrated that the mPTP opening time was higher in RTCs from female rats than that in those from male rats, which may be one of the reasons for the higher tolerance of females to ischemic injury. In RTCs from the kidneys of male rats, progesterone caused mitochondrial fragmentation, which can be associated with reduced cell viability. Thus, therapy with progesterone or estradiol displays quite different effects depending on sex, and could be only effective against ischemic AKI in females.
    MeSH term(s) Humans ; Rats ; Male ; Female ; Animals ; Progesterone/adverse effects ; Estradiol/adverse effects ; Kidney/pathology ; Ischemia/complications ; Reperfusion Injury/pathology ; Acute Kidney Injury/etiology
    Chemical Substances Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2024-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Relationship of Cytotoxic and Antimicrobial Effects of Triphenylphosphonium Conjugates with Various Quinone Derivatives.

    Nazarov, Pavel A / Zinovkina, Lyudmila A / Brezgunova, Anna A / Lyamzaev, Konstantin G / Golovin, Andrei V / Karakozova, Marina V / Kotova, Elena A / Plotnikov, Egor Yu / Zinovkin, Roman A / Skulachev, Maxim V / Antonenko, Yuri N

    Biochemistry. Biokhimiia

    2024  Volume 89, Issue 2, Page(s) 212–222

    Abstract: Quinone derivatives of triphenylphosphonium have proven themselves to be effective geroprotectors and antioxidants that prevent oxidation of cell components with participation of active free radicals - peroxide ( ... ...

    Abstract Quinone derivatives of triphenylphosphonium have proven themselves to be effective geroprotectors and antioxidants that prevent oxidation of cell components with participation of active free radicals - peroxide (RO
    MeSH term(s) Animals ; Mitochondria/metabolism ; Antioxidants/pharmacology ; Organophosphorus Compounds/pharmacology ; Plastoquinone/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism ; Antineoplastic Agents/pharmacology ; Mammals/metabolism ; Benzoquinones
    Chemical Substances triphenylphosphonium ; Antioxidants ; Organophosphorus Compounds ; quinone (3T006GV98U) ; Plastoquinone (OAC30J69CN) ; Anti-Bacterial Agents ; Antineoplastic Agents ; Benzoquinones
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1109-5
    ISSN 1608-3040 ; 0006-2979 ; 0320-9717
    ISSN (online) 1608-3040
    ISSN 0006-2979 ; 0320-9717
    DOI 10.1134/S0006297924020032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 220: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The effects of antibiotic therapy on neonatal sepsis-associated acute kidney injury.

    Pevzner, Irina B / Brezgunova, Anna A / Popkov, Vasily A / Sintsov, Mikhail Y / Andrianova, Nadezda V / Zorova, Ljubava D / Silachev, Denis N / Burov, Artem A / Podurovskaya, Yulia L / Zorov, Dmitry B / Plotnikov, Egor Y / Sukhikh, Gennady T

    Life sciences

    2023  Volume 338, Page(s) 122359

    Abstract: Aim: Neonatal sepsis remains one of the most dangerous conditions in the neonatal intensive care units. One of the organs affected by sepsis is the kidney, making acute kidney injury (AKI) a common complication of sepsis. Treatment of sepsis almost ... ...

    Abstract Aim: Neonatal sepsis remains one of the most dangerous conditions in the neonatal intensive care units. One of the organs affected by sepsis is the kidney, making acute kidney injury (AKI) a common complication of sepsis. Treatment of sepsis almost always involves antibiotic therapy, which by itself may cause some adverse effects, including nephrotoxicity. We analyzed the mutual effect of antibiotic therapy and sepsis on AKI in an experimental and clinical study in infants and neonatal rats.
    Materials and methods: We evaluated the influence of therapy with different antibiotics on the appearance of AKI markers (blood urea nitrogen (BUN), neutrophil gelatinase-associated lipocalin (NGAL), clusterin, interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), monocyte chemoattractant protein 1 (MCP-1), calbindin, glutation-S-transferase subtype π (GST-π)) and liver injury markers in newborns with or without clinical signs of sepsis in the intensive care unit. In parallel, we analyzed the development of AKI in experimental lipopolysaccharide (LPS)-induced systemic inflammation in newborn rats accompanied by antibiotic therapy.
    Key findings: We showed that therapy with metronidazole or ampicillin in combination with sulbactam had a beneficial effect in children with suspected sepsis, resulting in a decrease in AKI markers levels. However, treatment of newborns with netilmicin, cefepime, linezolid, or imipenem in combination with cilastatin worsened kidney function in these patients.
    Significance: This prospective study indicates which antibiotics are preferable in neonatal sepsis and which should be used with caution in view of the risk of AKI development.
    MeSH term(s) Humans ; Infant ; Child ; Rats ; Animals ; Neonatal Sepsis/complications ; Neonatal Sepsis/drug therapy ; Prospective Studies ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/etiology ; Anti-Bacterial Agents/therapeutic use ; Sepsis/complications ; Sepsis/drug therapy ; Biomarkers
    Chemical Substances Anti-Bacterial Agents ; Biomarkers
    Language English
    Publishing date 2023-12-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.122359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: New experimental model of kidney injury: Photothrombosis-induced kidney ischemia.

    Brezgunova, Anna A / Andrianova, Nadezda V / Popkov, Vasily A / Tkachev, Sergey Y / Manskikh, Vasily N / Pevzner, Irina B / Zorova, Ljubava D / Timashev, Peter S / Silachev, Denis N / Zorov, Dmitry B / Plotnikov, Egor Y

    Biochimica et biophysica acta. Molecular basis of disease

    2022  Volume 1869, Issue 3, Page(s) 166622

    Abstract: Acute kidney injury (AKI) is a frequent pathology with a high mortality rate after even a single AKI episode and a great risk of chronic kidney disease (CKD) development. To get insight into mechanisms of the AKI pathogenesis, there is a need to develop ... ...

    Abstract Acute kidney injury (AKI) is a frequent pathology with a high mortality rate after even a single AKI episode and a great risk of chronic kidney disease (CKD) development. To get insight into mechanisms of the AKI pathogenesis, there is a need to develop diverse experimental models of the disease. Photothrombosis is a widely used method for inducing ischemia in the brain. In this study, for the first time, we described photothrombosis-induced kidney ischemia as an appropriate model of AKI and obtained comprehensive characteristics of the photothrombotic lesion using micro-computed tomography (micro-CT) and histological techniques. In the ischemic area, we observed destruction of tubules, the loss of brush border and nuclei, connective tissue fibers disorganization, leukocyte infiltration, and hyaline casts formation. In kidney tissue and urine, we revealed increased levels in markers of proliferation and injury. The explicit long-term consequence of photothrombosis-induced kidney ischemia was renal fibrosis. Thus, we establish a new low invasive experimental model of AKI, which provides a reproducible local ischemic injury lesion. We propose our model of photothrombosis-induced kidney ischemia as a useful approach for investigating AKI pathogenesis, studying the mechanisms of kidney regeneration, and development of therapy against AKI and CKD.
    MeSH term(s) Humans ; Kidney/pathology ; X-Ray Microtomography/adverse effects ; Reperfusion Injury/pathology ; Regeneration ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/pathology ; Acute Kidney Injury/pathology ; Ischemia/pathology
    Language English
    Publishing date 2022-12-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2022.166622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Article: Mechanisms of LPS-Induced Acute Kidney Injury in Neonatal and Adult Rats.

    Plotnikov, Egor Y / Brezgunova, Anna A / Pevzner, Irina B / Zorova, Ljubava D / Manskikh, Vasily N / Popkov, Vasily A / Silachev, Denis N / Zorov, Dmitry B

    Antioxidants (Basel, Switzerland)

    2018  Volume 7, Issue 8

    Abstract: Neonatal sepsis is one of the major causes of mortality and morbidity in newborns, greatly associated with severe acute kidney injury (AKI) and failure. Handling of newborns with kidney damage can be significantly different compared to adults, and it is ... ...

    Abstract Neonatal sepsis is one of the major causes of mortality and morbidity in newborns, greatly associated with severe acute kidney injury (AKI) and failure. Handling of newborns with kidney damage can be significantly different compared to adults, and it is necessary to consider the individuality of an organism's response to systemic inflammation. In this study, we used lipopolysaccharide (LPS)-mediated acute kidney injury model to study mechanisms of kidney cells damage in neonatal and adult rats. We found LPS-associated oxidative stress was more severe in adults compared to neonates, as judged by levels of carbonylated proteins and products of lipids peroxidation. In both models, LPS-mediated septic simulation caused apoptosis of kidney cells, albeit to a different degree. Elevated levels of proliferating cell nuclear antigen (PCNA) in the kidney dropped after LPS administration in neonates but increased in adults. Renal fibrosis, as estimated by smooth muscle actin levels, was significantly higher in adult kidneys, whereas these changes were less profound in LPS-treated neonatal kidneys. We concluded that in LPS-mediated AKI model, renal cells of neonatal rats were more tolerant to oxidative stress and suffered less from long-term pathological consequences, such as fibrosis. In addition, we assume that by some features LPS administration simulates the conditions of accelerated aging.
    Language English
    Publishing date 2018-08-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox7080105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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