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  1. Article ; Online: Correction: Tumour treating fields therapy for glioblastoma: current advances and future directions.

    Rominiyi, Ola / Vanderlinden, Aurelie / Clenton, Susan Jane / Bridgewater, Caroline / Al-Tamimi, Yahia / Collis, Spencer James

    British journal of cancer

    2021  Volume 125, Issue 4, Page(s) 623

    Language English
    Publishing date 2021-06-10
    Publishing country England
    Document type Published Erratum
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-021-01451-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tumour treating fields therapy for glioblastoma: current advances and future directions.

    Rominiyi, Ola / Vanderlinden, Aurelie / Clenton, Susan Jane / Bridgewater, Caroline / Al-Tamimi, Yahia / Collis, Spencer James

    British journal of cancer

    2020  Volume 124, Issue 4, Page(s) 697–709

    Abstract: Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and continues to portend poor survival, despite multimodal treatment using surgery and chemoradiotherapy. The addition of tumour-treating fields (TTFields)-an approach in ... ...

    Abstract Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and continues to portend poor survival, despite multimodal treatment using surgery and chemoradiotherapy. The addition of tumour-treating fields (TTFields)-an approach in which alternating electrical fields exert biophysical force on charged and polarisable molecules known as dipoles-to standard therapy, has been shown to extend survival for patients with newly diagnosed GBM, recurrent GBM and mesothelioma, leading to the clinical approval of this approach by the FDA. TTFields represent a non-invasive anticancer modality consisting of low-intensity (1-3 V/cm), intermediate-frequency (100-300 kHz), alternating electric fields delivered via cutaneous transducer arrays configured to provide optimal tumour-site coverage. Although TTFields were initially demonstrated to inhibit cancer cell proliferation by interfering with mitotic apparatus, it is becoming increasingly clear that TTFields show a broad mechanism of action by disrupting a multitude of biological processes, including DNA repair, cell permeability and immunological responses, to elicit therapeutic effects. This review describes advances in our current understanding of the mechanisms by which TTFields mediate anticancer effects. Additionally, we summarise the landscape of TTFields clinical trials across various cancers and consider how emerging preclinical data might inform future clinical applications for TTFields.
    MeSH term(s) Animals ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Clinical Trials, Phase III as Topic ; Electric Stimulation Therapy/methods ; Glioblastoma/pathology ; Glioblastoma/therapy ; Humans ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2020-11-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-020-01136-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: 'Low grade glioma': an update for radiologists.

    Larsen, Jennifer / Wharton, Steve B / McKevitt, Fiona / Romanowski, Charles / Bridgewater, Caroline / Zaki, Hesham / Hoggard, Nigel

    The British journal of radiology

    2017  Volume 90, Issue 1070, Page(s) 20160600

    Abstract: With the recent publication of a new World Health Organization brain tumour classification that reflects increased understanding of glioma tumour genetics, there is a need for radiologists to understand the changes and their implications for patient ... ...

    Abstract With the recent publication of a new World Health Organization brain tumour classification that reflects increased understanding of glioma tumour genetics, there is a need for radiologists to understand the changes and their implications for patient management. There has also been an increasing trend for adopting earlier, more aggressive surgical approaches to low-grade glioma (LGG) treatment. We will summarize these changes, give some context to the increased role of tumour genetics and discuss the associated implications of their adoption for radiologists. We will discuss the earlier and more radical surgical resection of LGG and what it means for patients undergoing imaging.
    MeSH term(s) Brain/diagnostic imaging ; Brain/pathology ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/pathology ; Diagnostic Imaging/methods ; Glioma/diagnostic imaging ; Glioma/pathology ; Humans ; Neoplasm Grading
    Language English
    Publishing date 2017-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20160600
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  4. Article: Radiotherapy in the HAART era: a cause for concern?

    Bridgewater, Caroline / Cottrill, Chris / Ahmed, Imtiaz

    Journal of HIV therapy

    2006  Volume 11, Issue 3, Page(s) 61–63

    MeSH term(s) HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Neoplasms/complications ; Neoplasms/drug therapy ; Neoplasms/radiotherapy ; Radiotherapy/adverse effects
    Language English
    Publishing date 2006-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075900-9
    ISSN 1462-0308
    ISSN 1462-0308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Oral presentation of malignant mesothelioma.

    Murray, Louise J / Higham, Jon / Suvarna, S Kim / Craig, Geoffrey T / Bridgewater, Caroline H / Fisher, Patricia M / Thornhill, Martin H

    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics

    2011  Volume 111, Issue 1, Page(s) e21–6

    Abstract: We report a case of metastatic mesothelioma presenting as an oral metastasis in a 46-year-old patient. The patient presented with 2 polypoid lesions that appeared to be benign on the dorsum of the tongue. Excisional biopsy showed the presence of ... ...

    Abstract We report a case of metastatic mesothelioma presenting as an oral metastasis in a 46-year-old patient. The patient presented with 2 polypoid lesions that appeared to be benign on the dorsum of the tongue. Excisional biopsy showed the presence of metastatic carcinoma that on further investigation proved to be mesothelioma. The initial presentation of mesothelioma as an oral metastasis is not previously reported. This article highlights the importance of biopsy and histopathological diagnosis in presumed benign lesions and the role of the general dental practitioner in screening for oral neoplasms.
    MeSH term(s) Antimetabolites, Antineoplastic/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cisplatin/therapeutic use ; Diagnosis, Differential ; Female ; Glutamates/therapeutic use ; Guanine/analogs & derivatives ; Guanine/therapeutic use ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Mesothelioma/drug therapy ; Mesothelioma/pathology ; Mesothelioma/secondary ; Middle Aged ; Pemetrexed ; Tongue Neoplasms/drug therapy ; Tongue Neoplasms/pathology ; Tongue Neoplasms/secondary
    Chemical Substances Antimetabolites, Antineoplastic ; Glutamates ; Pemetrexed (04Q9AIZ7NO) ; Guanine (5Z93L87A1R) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2011-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 202468-8
    ISSN 1528-395X ; 0030-4220 ; 1079-2104
    ISSN (online) 1528-395X
    ISSN 0030-4220 ; 1079-2104
    DOI 10.1016/j.tripleo.2010.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul III Zs.121: Show issues Location:
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