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  1. Article ; Online: Reply to: "Parkinson's Disease, Premature Mortality, and Amygdala".

    Laansma, Max A / Bright, Joanna K / Jahanshad, Neda / Thompson, Paul M / van der Werf, Ysbrand D

    Movement disorders : official journal of the Movement Disorder Society

    2022  Volume 37, Issue 5, Page(s) 1111–1112

    MeSH term(s) Amygdala ; Humans ; Mortality, Premature ; Parkinson Disease
    Language English
    Publishing date 2022-05-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29004
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  2. Article: Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development.

    Bright, Joanna K / Rayner, Christopher / Freeman, Ze / Zavos, Helena M S / Ahmadzadeh, Yasmin I / Viding, Essi / McAdams, Tom A

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Prediction from polygenic scores may be confounded sources of passive gene-environment correlation (rGE; e.g. population stratification, assortative mating, and environmentally mediated effects of parental genotype on child phenotype). Using genomic data ...

    Abstract Prediction from polygenic scores may be confounded sources of passive gene-environment correlation (rGE; e.g. population stratification, assortative mating, and environmentally mediated effects of parental genotype on child phenotype). Using genomic data from 10,000 twin pairs, we asked whether polygenic scores from the recent externalising genome-wide association study predicted conduct problems, ADHD symptomology and callous-unemotional traits, and whether these predictions are biased by rGE. We ran regression models including within-family and between-family polygenic scores, to separate the direct genetic influence on a trait from environmental influences that correlate with genes (indirect genetic effects). Findings suggested that this externalising polygenic score is a good index of direct genetic influence on conduct and ADHD-related symptoms across development, with minimal bias from rGE, although the polygenic score predicted less variance in CU traits. Post-hoc analyses showed some indirect genetic effects acting on a common factor indexing stability of conduct problems across time and contexts.
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.13.23299910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Structural assessment of thalamus morphology in brain disorders: A review and recommendation of thalamic nucleus segmentation and shape analysis.

    Boelens Keun, Jikke T / van Heese, Eva M / Laansma, Max A / Weeland, Cees J / de Joode, Niels T / van den Heuvel, Odile A / Gool, Jari K / Kasprzak, Selina / Bright, Joanna K / Vriend, Chris / van der Werf, Ysbrand D

    Neuroscience and biobehavioral reviews

    2021  Volume 131, Page(s) 466–478

    Abstract: The thalamus is a central brain structure crucially involved in cognitive, emotional, sensory, and motor functions and is often reported to be involved in the pathophysiology of neurological and psychiatric disorders. The functional subdivision of the ... ...

    Abstract The thalamus is a central brain structure crucially involved in cognitive, emotional, sensory, and motor functions and is often reported to be involved in the pathophysiology of neurological and psychiatric disorders. The functional subdivision of the thalamus warrants morphological investigation on the level of individual subnuclei. In addition to volumetric measures, the investigation of other morphological features may give additional insights into thalamic morphology. For instance, shape features offer a higher spatial resolution by revealing small, regional differences that are left undetected in volumetric analyses. In this review, we discuss the benefits and limitations of recent advances in neuroimaging techniques to investigate thalamic morphology in vivo, leading to our proposed methodology. This methodology consists of available pipelines for volume and shape analysis, focussing on the morphological features of volume, thickness, and surface area. We demonstrate this combined approach in a Parkinson's disease cohort to illustrate their complementarity. Considering our findings, we recommend a combined methodology as it allows for more sensitive investigation of thalamic morphology in clinical populations.
    MeSH term(s) Brain ; Humans ; Magnetic Resonance Imaging/methods ; Neuroimaging ; Parkinson Disease ; Thalamus/diagnostic imaging
    Language English
    Publishing date 2021-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2021.09.044
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  4. Article ; Online: International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease.

    Laansma, Max A / Bright, Joanna K / Al-Bachari, Sarah / Anderson, Tim J / Ard, Tyler / Assogna, Francesca / Baquero, Katherine A / Berendse, Henk W / Blair, Jamie / Cendes, Fernando / Dalrymple-Alford, John C / de Bie, Rob M A / Debove, Ines / Dirkx, Michiel F / Druzgal, Jason / Emsley, Hedley C A / Garraux, Gäetan / Guimarães, Rachel P / Gutman, Boris A /
    Helmich, Rick C / Klein, Johannes C / Mackay, Clare E / McMillan, Corey T / Melzer, Tracy R / Parkes, Laura M / Piras, Fabrizio / Pitcher, Toni L / Poston, Kathleen L / Rango, Mario / Ribeiro, Letícia F / Rocha, Cristiane S / Rummel, Christian / Santos, Lucas S R / Schmidt, Reinhold / Schwingenschuh, Petra / Spalletta, Gianfranco / Squarcina, Letizia / van den Heuvel, Odile A / Vriend, Chris / Wang, Jiun-Jie / Weintraub, Daniel / Wiest, Roland / Yasuda, Clarissa L / Jahanshad, Neda / Thompson, Paul M / van der Werf, Ysbrand D

    Movement disorders : official journal of the Movement Disorder Society

    2021  Volume 36, Issue 11, Page(s) 2583–2594

    Abstract: Background: Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated.: Objective: Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease stage- ... ...

    Abstract Background: Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated.
    Objective: Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease stage-specific profiles of pathology, as suggested by in vivo neuroimaging.
    Methods: Individual brain MRI and clinical data from 2357 Parkinson's disease patients and 1182 healthy controls were collected from 19 sources. We analyzed regional cortical thickness, cortical surface area, and subcortical volume using mixed-effects models. Patients grouped according to Hoehn and Yahr stage were compared with age- and sex-matched controls. Within the patient sample, we investigated associations with Montreal Cognitive Assessment score.
    Results: Overall, patients showed a thinner cortex in 38 of 68 regions compared with controls (d
    Conclusions: Our findings offer robust and novel imaging signatures that are generally incremental across but in certain regions specific to disease stages. Our findings highlight the importance of adequately powered multicenter collaborations. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
    MeSH term(s) Brain/diagnostic imaging ; Brain/pathology ; Humans ; Magnetic Resonance Imaging ; Neuroimaging ; Parkinson Disease/complications ; Thalamus/pathology
    Language English
    Publishing date 2021-07-20
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.28706
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    Zs.MO 238: Show issues

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  5. Article ; Online: Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium.

    van Velzen, Laura S / Dauvermann, Maria R / Colic, Lejla / Villa, Luca M / Savage, Hannah S / Toenders, Yara J / Zhu, Alyssa H / Bright, Joanna K / Campos, Adrián I / Salminen, Lauren E / Ambrogi, Sonia / Ayesa-Arriola, Rosa / Banaj, Nerisa / Başgöze, Zeynep / Bauer, Jochen / Blair, Karina / Blair, Robert James / Brosch, Katharina / Cheng, Yuqi /
    Colle, Romain / Connolly, Colm G / Corruble, Emmanuelle / Couvy-Duchesne, Baptiste / Crespo-Facorro, Benedicto / Cullen, Kathryn R / Dannlowski, Udo / Davey, Christopher G / Dohm, Katharina / Fullerton, Janice M / Gonul, Ali Saffet / Gotlib, Ian H / Grotegerd, Dominik / Hahn, Tim / Harrison, Ben J / He, Mengxin / Hickie, Ian B / Ho, Tiffany C / Iorfino, Frank / Jansen, Andreas / Jollant, Fabrice / Kircher, Tilo / Klimes-Dougan, Bonnie / Klug, Melissa / Leehr, Elisabeth J / Lippard, Elizabeth T C / McLaughlin, Katie A / Meinert, Susanne / Miller, Adam Bryant / Mitchell, Philip B / Mwangi, Benson / Nenadić, Igor / Ojha, Amar / Overs, Bronwyn J / Pfarr, Julia-Katharina / Piras, Fabrizio / Ringwald, Kai G / Roberts, Gloria / Romer, Georg / Sanches, Marsal / Sheridan, Margaret A / Soares, Jair C / Spalletta, Gianfranco / Stein, Frederike / Teresi, Giana I / Tordesillas-Gutiérrez, Diana / Uyar-Demir, Aslihan / van der Wee, Nic J A / van der Werff, Steven J / Vermeiren, Robert R J M / Winter, Alexandra / Wu, Mon-Ju / Yang, Tony T / Thompson, Paul M / Rentería, Miguel E / Jahanshad, Neda / Blumberg, Hilary P / van Harmelen, Anne-Laura / Schmaal, Lianne

    Molecular psychiatry

    2022  Volume 27, Issue 11, Page(s) 4550–4560

    Abstract: Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and improving early intervention and prevention. The ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) ... ...

    Abstract Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and improving early intervention and prevention. The ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites to examine brain morphology associated with STBs in youth. We performed analyses in three separate stages, in samples ranging from most to least homogeneous in terms of suicide assessment instrument and mental disorder. First, in a sample of 577 young people with mood disorders, in which STBs were assessed with the Columbia Suicide Severity Rating Scale (C-SSRS). Second, in a sample of young people with mood disorders, in which STB were assessed using different instruments, MRI metrics were compared among healthy controls without STBs (HC; N = 519), clinical controls with a mood disorder but without STBs (CC; N = 246) and young people with current suicidal ideation (N = 223). In separate analyses, MRI metrics were compared among HCs (N = 253), CCs (N = 217), and suicide attempters (N = 64). Third, in a larger transdiagnostic sample with various assessment instruments (HC = 606; CC = 419; Ideation = 289; HC = 253; CC = 432; Attempt=91). In the homogeneous C-SSRS sample, surface area of the frontal pole was lower in young people with mood disorders and a history of actual suicide attempts (N = 163) than those without a lifetime suicide attempt (N = 323; FDR-p = 0.035, Cohen's d = 0.34). No associations with suicidal ideation were found. When examining more heterogeneous samples, we did not observe significant associations. Lower frontal pole surface area may represent a vulnerability for a (non-interrupted and non-aborted) suicide attempt; however, more research is needed to understand the nature of its relationship to suicide risk.
    MeSH term(s) Adolescent ; Humans ; Suicidal Ideation ; Suicide, Attempted ; Brain ; Neuroimaging/methods ; Mood Disorders
    Language English
    Publishing date 2022-09-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-022-01734-0
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  6. Article ; Online: Genetic variants associated with longitudinal changes in brain structure across the lifespan.

    Brouwer, Rachel M / Klein, Marieke / Grasby, Katrina L / Schnack, Hugo G / Jahanshad, Neda / Teeuw, Jalmar / Thomopoulos, Sophia I / Sprooten, Emma / Franz, Carol E / Gogtay, Nitin / Kremen, William S / Panizzon, Matthew S / Olde Loohuis, Loes M / Whelan, Christopher D / Aghajani, Moji / Alloza, Clara / Alnæs, Dag / Artiges, Eric / Ayesa-Arriola, Rosa /
    Barker, Gareth J / Bastin, Mark E / Blok, Elisabet / Bøen, Erlend / Breukelaar, Isabella A / Bright, Joanna K / Buimer, Elizabeth E L / Bülow, Robin / Cannon, Dara M / Ciufolini, Simone / Crossley, Nicolas A / Damatac, Christienne G / Dazzan, Paola / de Mol, Casper L / de Zwarte, Sonja M C / Desrivières, Sylvane / Díaz-Caneja, Covadonga M / Doan, Nhat Trung / Dohm, Katharina / Fröhner, Juliane H / Goltermann, Janik / Grigis, Antoine / Grotegerd, Dominik / Han, Laura K M / Harris, Mathew A / Hartman, Catharina A / Heany, Sarah J / Heindel, Walter / Heslenfeld, Dirk J / Hohmann, Sarah / Ittermann, Bernd / Jansen, Philip R / Janssen, Joost / Jia, Tianye / Jiang, Jiyang / Jockwitz, Christiane / Karali, Temmuz / Keeser, Daniel / Koevoets, Martijn G J C / Lenroot, Rhoshel K / Malchow, Berend / Mandl, René C W / Medel, Vicente / Meinert, Susanne / Morgan, Catherine A / Mühleisen, Thomas W / Nabulsi, Leila / Opel, Nils / de la Foz, Víctor Ortiz-García / Overs, Bronwyn J / Paillère Martinot, Marie-Laure / Redlich, Ronny / Marques, Tiago Reis / Repple, Jonathan / Roberts, Gloria / Roshchupkin, Gennady V / Setiaman, Nikita / Shumskaya, Elena / Stein, Frederike / Sudre, Gustavo / Takahashi, Shun / Thalamuthu, Anbupalam / Tordesillas-Gutiérrez, Diana / van der Lugt, Aad / van Haren, Neeltje E M / Wardlaw, Joanna M / Wen, Wei / Westeneng, Henk-Jan / Wittfeld, Katharina / Zhu, Alyssa H / Zugman, Andre / Armstrong, Nicola J / Bonfiglio, Gaia / Bralten, Janita / Dalvie, Shareefa / Davies, Gail / Di Forti, Marta / Ding, Linda / Donohoe, Gary / Forstner, Andreas J / Gonzalez-Peñas, Javier / Guimaraes, Joao P O F T / Homuth, Georg / Hottenga, Jouke-Jan / Knol, Maria J / Kwok, John B J / Le Hellard, Stephanie / Mather, Karen A / Milaneschi, Yuri / Morris, Derek W / Nöthen, Markus M / Papiol, Sergi / Rietschel, Marcella / Santoro, Marcos L / Steen, Vidar M / Stein, Jason L / Streit, Fabian / Tankard, Rick M / Teumer, Alexander / van 't Ent, Dennis / van der Meer, Dennis / van Eijk, Kristel R / Vassos, Evangelos / Vázquez-Bourgon, Javier / Witt, Stephanie H / Adams, Hieab H H / Agartz, Ingrid / Ames, David / Amunts, Katrin / Andreassen, Ole A / Arango, Celso / Banaschewski, Tobias / Baune, Bernhard T / Belangero, Sintia I / Bokde, Arun L W / Boomsma, Dorret I / Bressan, Rodrigo A / Brodaty, Henry / Buitelaar, Jan K / Cahn, Wiepke / Caspers, Svenja / Cichon, Sven / Crespo-Facorro, Benedicto / Cox, Simon R / Dannlowski, Udo / Elvsåshagen, Torbjørn / Espeseth, Thomas / Falkai, Peter G / Fisher, Simon E / Flor, Herta / Fullerton, Janice M / Garavan, Hugh / Gowland, Penny A / Grabe, Hans J / Hahn, Tim / Heinz, Andreas / Hillegers, Manon / Hoare, Jacqueline / Hoekstra, Pieter J / Ikram, Mohammad A / Jackowski, Andrea P / Jansen, Andreas / Jönsson, Erik G / Kahn, Rene S / Kircher, Tilo / Korgaonkar, Mayuresh S / Krug, Axel / Lemaitre, Herve / Malt, Ulrik F / Martinot, Jean-Luc / McDonald, Colm / Mitchell, Philip B / Muetzel, Ryan L / Murray, Robin M / Nees, Frauke / Nenadić, Igor / Oosterlaan, Jaap / Ophoff, Roel A / Pan, Pedro M / Penninx, Brenda W J H / Poustka, Luise / Sachdev, Perminder S / Salum, Giovanni A / Schofield, Peter R / Schumann, Gunter / Shaw, Philip / Sim, Kang / Smolka, Michael N / Stein, Dan J / Trollor, Julian N / van den Berg, Leonard H / Veldink, Jan H / Walter, Henrik / Westlye, Lars T / Whelan, Robert / White, Tonya / Wright, Margaret J / Medland, Sarah E / Franke, Barbara / Thompson, Paul M / Hulshoff Pol, Hilleke E

    Nature neuroscience

    2022  Volume 25, Issue 4, Page(s) 421–432

    Abstract: Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect ... ...

    Abstract Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.
    MeSH term(s) Aging/genetics ; Brain ; Genome-Wide Association Study ; Humans ; Longevity/genetics ; Magnetic Resonance Imaging
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-022-01042-4
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