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  1. Article ; Online: Response.

    Gordon, Louisa G / Mayne, George C / Bright, Timothy / Whiteman, David C / Watson, David I

    Gastrointestinal endoscopy

    2014  Volume 80, Issue 1, Page(s) 191

    MeSH term(s) Barrett Esophagus/pathology ; Esophagoscopy/economics ; Female ; Health Care Costs/standards ; Humans ; Male ; SEER Program/economics
    Language English
    Publishing date 2014-07
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2014.02.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus.

    Sreedharan, Loveena / Mayne, George C / Watson, David I / Bright, Timothy / Lord, Reginald V / Ansar, Alfiya / Wang, Tingting / Kist, Jakob / Astill, David StJ / Hussey, Damian J

    World journal of gastroenterology

    2017  Volume 23, Issue 30, Page(s) 5508–5518

    Abstract: Aim: To investigate the microRNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.: Methods: High throughput screening using TaqMan: Results: Forty-four microRNAs were ... ...

    Abstract Aim: To investigate the microRNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.
    Methods: High throughput screening using TaqMan
    Results: Forty-four microRNAs were differentially expressed between control squamous mucosa
    Conclusion: Neosquamous mucosa arising after ablation of Barrett's esophagus expresses microRNAs that may contribute to decreased barrier function and microRNAs that may be involved in the regulation of survival signaling pathways.
    Language English
    Publishing date 2017-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v23.i30.5508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cost-effectiveness of endoscopic surveillance of non-dysplastic Barrett's esophagus.

    Gordon, Louisa G / Mayne, George C / Hirst, Nicholas G / Bright, Timothy / Whiteman, David C / Watson, David I

    Gastrointestinal endoscopy

    2014  Volume 79, Issue 2, Page(s) 242–56.e6

    Abstract: Background: Endoscopic surveillance for non-dysplastic Barrett's esophagus (BE) is contentious and its cost effectiveness unclear.: Objective: To perform an economic analysis of endoscopic surveillance strategies.: Design: Cost-utility analysis by ...

    Abstract Background: Endoscopic surveillance for non-dysplastic Barrett's esophagus (BE) is contentious and its cost effectiveness unclear.
    Objective: To perform an economic analysis of endoscopic surveillance strategies.
    Design: Cost-utility analysis by using a simulation Markov model to synthesize evidence from large epidemiologic studies and clinical data for surveillance, based on international guidelines, applied in a coordinator-managed surveillance program.
    Setting: Tertiary care hospital, South Australia.
    Patients: A total of 2040 patient-years of follow-up.
    Intervention: (1) No surveillance, (2) 2-yearly endoscopic surveillance of patients with non-dysplastic BE and 6-monthly surveillance of patients with low-grade dysplasia, (3) a hypothetical strategy of biomarker-modified surveillance.
    Main outcome measurements: U.S. cost per quality-adjusted life year (QALY) ratios.
    Results: Compared with no surveillance, surveillance produced an estimated incremental cost per QALY ratio of $60,858. This was reduced to $38,307 when surveillance practice was modified by a hypothetical biomarker-based strategy. Sensitivity analyses indicated that the likelihood that surveillance alone was cost-effective compared with no surveillance was 16.0% and 60.6% if a hypothetical biomarker-based strategy was added to surveillance, at an acceptability threshold of $100,000 per QALY gained.
    Limitations: Treatment options for BE that overlap those for symptomatic GERD were omitted.
    Conclusion: By using best available estimates of the malignant potential of BE, endoscopic surveillance of patients with non-dysplastic BE is unlikely to be cost-effective for the majority of patients and depends heavily on progression rates between dysplasia grades. However, strategies that modify surveillance according to cancer risk might be cost-effective, provided that high-risk individuals can be identified and prioritized for surveillance.
    MeSH term(s) Barrett Esophagus/economics ; Barrett Esophagus/pathology ; Cost-Benefit Analysis ; Decision Support Techniques ; Disease Progression ; Esophagoscopy/economics ; Esophagoscopy/standards ; Female ; Health Care Costs/standards ; Humans ; Male ; Middle Aged ; Precancerous Conditions ; SEER Program/economics ; United States
    Language English
    Publishing date 2014-02
    Publishing country United States
    Document type Journal Article ; Practice Guideline ; Research Support, Non-U.S. Gov't
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2013.07.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Dr. Timothie Bright

    Keynes, Geoffrey

    1550 - 1615 ; a survey of his life with a bibliography of his writings

    (Publications of the Wellcome Historical Medical Library ; N.S., 1)

    1962  

    Author's details Geoffrey Keynes
    Series title Publications of the Wellcome Historical Medical Library ; N.S., 1
    Collection
    Keywords Bright, Timothie
    Language English
    Size 47 S. ; 4-o
    Publisher Wellcome Histor. Med. Library
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT009345238
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1965 A 784 order for loan Magazin

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  5. Article ; Online: Modeling the cost-effectiveness of strategies for treating esophageal adenocarcinoma and high-grade dysplasia.

    Gordon, Louisa G / Hirst, Nicholas G / Mayne, George C / Watson, David I / Bright, Timothy / Cai, Wang / Barbour, Andrew P / Smithers, Bernard M / Whiteman, David C / Eckermann, Simon

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2012  Volume 16, Issue 8, Page(s) 1451–1461

    Abstract: Objective: This study aims to synthesize cost and health outcomes for current treatment pathways for esophageal adenocarcinoma and high-grade dysplasia (HGD) and to model comparative net clinical and economic benefits of alternative management scenarios. ...

    Abstract Objective: This study aims to synthesize cost and health outcomes for current treatment pathways for esophageal adenocarcinoma and high-grade dysplasia (HGD) and to model comparative net clinical and economic benefits of alternative management scenarios.
    Methods: A decision-analytic model of real-world practices for esophageal adenocarcinoma treatment by tumor stage was constructed and validated. The model synthesized treatment probabilities, survival, quality of life, and resource use extracted from epidemiological datasets, published literature, and expert opinion. Comparative analyses between current practice and five hypothetical scenarios for modified treatment were undertaken.
    Results: Over 5 years, outcomes across T stage ranged from 4.06 quality-adjusted life-years and costs of $3,179 for HGD to 1.62 quality-adjusted life-years and costs of $50,226 for stage T4. Greater use of endoscopic mucosal resection for stage T1 and measures to reduce esophagectomy mortality to 0-3 % produced modest gains, whereas a 20 % reduction in the proportion of patients presenting at stage T3 produced large incremental net benefits of $4,971 (95 % interval, $1,560-8,368).
    Conclusion: These findings support measures that promote earlier diagnosis, such as developing risk assessment processes or endoscopic surveillance of Barrett's esophagus. Incremental net monetary benefits for other strategies are relatively small in comparison to predicted gains from early detection strategies.
    MeSH term(s) Adenocarcinoma/economics ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Australia ; Barrett Esophagus/economics ; Barrett Esophagus/mortality ; Barrett Esophagus/pathology ; Barrett Esophagus/therapy ; Combined Modality Therapy/economics ; Combined Modality Therapy/mortality ; Cost-Benefit Analysis ; Decision Support Techniques ; Esophageal Neoplasms/economics ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/therapy ; Esophagectomy/economics ; Esophagectomy/mortality ; Esophagoscopy/economics ; Health Care Costs ; Humans ; Models, Economic ; Neoplasm Staging ; Quality of Life ; Quality-Adjusted Life Years ; Survival Analysis ; Treatment Outcome
    Language English
    Publishing date 2012-05-30
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1007/s11605-012-1911-9
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