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Article ; Online: Emerging oral drug options for ulcerative colitis.

Salvatori, Silvia / Neri, Benedetto / Marafini, Irene / Brigida, Mattia / Monteleone, Giovanni

2023 Volume 28, Issue 3, Page(s) 191–201

Abstract: Introduction: Despite the availability of a variety of therapeutic compounds and improved management strategies, one-third of UC patients with moderate-to-severe disease do not benefit from the existing treatments or experience drug-related side effects. ...

Abstract	Introduction: Despite the availability of a variety of therapeutic compounds and improved management strategies, one-third of UC patients with moderate-to-severe disease do not benefit from the existing treatments or experience drug-related side effects. This has boosted intensive research focusing on the development of new drugs for UC therapy. This article aims to summarize the available evidence on oral drugs, which are now being explored in clinical trials or are ready to enter the clinics. Areas covered: From May 15 to June 11, we searched on PubMed using the keywords 'oral drugs ulcerative colitis,' 'ulcerative colitis clinical trials,' 'UC phase 2 and 3 trials' excluding case reports, case series, phase 1 and 4 studies, and studies about approved therapies. Expert opinion: The findings discussed in this article suggest that the future treatment of UC patients will be probably characterized by the possibility of using various small-molecule drugs. All these new compounds, even those belonging to the same class, differ in terms of efficacy and safety. Identification of predictors of response could help optimize the efficacy and safety of these treatments, thus improving resource allocation through a pretreatment stratification of patients.
MeSH term(s)	Humans ; Colitis, Ulcerative/drug therapy
Language	English
Publishing date	2023-09-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2061369-6
ISSN	1744-7623 ; 1472-8214
ISSN (online)	1744-7623
ISSN	1472-8214
DOI	10.1080/14728214.2023.2254686
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Article ; Online: LA METÁFORA DE LA LIBERTAD

Brígida M. Pastor

Revista Brasileira do Caribe, Vol 0, Iss

El discurso del cuerpo en la literatura de Zoé Valdés/ THE METAPHOR OF FREEDOM: He body discourse in Zoé Valdés´s writing

2017

Abstract: Este estudo pretende demonstrar a relação entre gênero, sexo e escrita em Nada Cotidiana (1995) da cubana Zoé Valdés (1959-). Desde o exilio e a marginação por ser mulher e escritora, a autora recorre a diferenciadas estratégias femininas/feministas como ...

Abstract	Este estudo pretende demonstrar a relação entre gênero, sexo e escrita em Nada Cotidiana (1995) da cubana Zoé Valdés (1959-). Desde o exilio e a marginação por ser mulher e escritora, a autora recorre a diferenciadas estratégias femininas/feministas como resistência ante qualquer tipo de repressão. Por meio do discurso do corpo, a escritora explora sua identidade genérico-sexual e denuncia o sistema opressor do patriarcado, restaurando sua autêntica identidade. Sem dúvida, a escrita de Valdés e de sua própria experiência vital representa um legado promotor de mudança na situação da mulher: a estratégica consciência discursiva da voz feminina cubana demonstra que o silêncio não existe e a linguagem do corpo é instrumento de liberdade. Palavras-chave: Escrita feminine. Discurso erótico. Corpo feminine. Cuba. Exílio. Zoé Valdés Resumen Este estudio pretende demostrar la relación entre género, sexo y escritura en la Nada Cotidiana (1995) de la cubana Zoé Valdés (1959-). Desde el exilio y la marginación por ser mujer y escritora, la autora recurre a diferenciadas estrategias femeninas/feministas como resistencia ante cualquier tipo de represión. A través del discurso del cuerpo, la escritora explora su identidad genérico-sexual y denuncia el sistema opresor del patriarcado, restaurando su auténtica identidad. En definitiva, la escritura de Valdés y de su propia experiencia vital representa un legado promotor de cambio en la situación de la mujer: la estratégica conciencia discursiva de la voz femenina cubana y demuestra que el silencio no existe y el lenguaje del cuerpo es vehículo de libertad. Palabras clave: Escritura femenina. Discurso erótico. Cuerpo femenino. Cuba. Exilio. Zoé Valdés Abstract This study aims to demonstrate the relationship between gender, sex and writing in La nada cotidiana (1995) by the Cuban writer Zoé Valdés (1959-). From exile and marginalization, as a woman and writer, the author resorts to different feminine/feminist strategies to resist any kind of repression. Through the erotic ...
Keywords	Escrita feminine. Discurso erótico ; Corpo feminine ; Cuba ; Exílio ; Zoé Valdés ; Latin America. Spanish America ; F1201-3799 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	Universidade Federal do Maranhão
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Proximal esophageal impedance baseline increases the yield of impedance-pH monitoring for GERD diagnosis and is associated with heartburn response to PPI.

Ribolsi, Mentore / Frazzoni, Marzio / Marchetti, Lorenzo / Brigida, Mattia / Cicala, Michele / Savarino, Edoardo

Neurogastroenterology and motility

2023 Volume 35, Issue 8, Page(s) e14612

Abstract: Background: Impairment of esophageal mucosal integrity as assessed by low mean nocturnal baseline impedance (MNBI) measured in the distal esophagus increases the diagnostic yield of impedance-pH in patients with inconclusive GERD diagnosis as defined by ...

Abstract	Background: Impairment of esophageal mucosal integrity as assessed by low mean nocturnal baseline impedance (MNBI) measured in the distal esophagus increases the diagnostic yield of impedance-pH in patients with inconclusive GERD diagnosis as defined by Lyon criteria. Aim: To assess the diagnostic yield of MNBI measurement in the proximal esophagus, and its relationship with PPI response. Methods: Expert review of off-therapy impedance-pH tracings from consecutive patients with heartburn, 80 responders and 80 non-responders to label-dose PPI. Data were compared to those from 36 healthy controls using ROC analysis. Multivariate analysis was performed to measure the strength of association of MNBI with PPI response. Results: A threshold value of 2665 Ω was defined for proximal MNBI by ROC analysis, affording 91.7% sensitivity and 86.5% specificity. Proximal and distal MNBI were significantly lower in non-responder cases as compared to responders. Adding proximal MNBI positivity to pathologic (>6%) acid exposure time (AET) and positive symptom-reflux association, the proportion of patients with abnormal impedance-pH findings increased from 74/160 (46%) to 106/160 (66.3%) (p = 0.0016). Among the 12 patients with pathologic proximal MNBI as the only positive impedance-pH finding, 9 cases (75%) were PPI responders. According to multivariate analysis, AET and pathological distal and proximal MNBI were significantly associated with PPI response, the strongest association observed for proximal MNBI. Conclusions: Impedance baseline assessment in the proximal esophagus may increase the diagnostic yield of impedance-pH monitoring. Heartburn response to PPI is directly related to ultrastructural mucosal damage in the distal and in the proximal esophagus as well.
MeSH term(s)	Humans ; Heartburn/diagnosis ; Esophageal pH Monitoring ; Electric Impedance ; Gastroesophageal Reflux/diagnosis ; Hydrogen-Ion Concentration ; Proton Pump Inhibitors/therapeutic use
Chemical Substances	Proton Pump Inhibitors
Language	English
Publishing date	2023-05-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/nmo.14612
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Article ; Online: .

Brígida M. Pastor

Revista Brasileira do Caribe, Vol 0, Iss

2014

Keywords	Latin America. Spanish America ; F1201-3799 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2014-06-01T00:00:00Z
Publisher	Universidade Federal do Maranhão
Document type	Article ; Online
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Article ; Online: JUAN FLORES. FROM BOMBA TO HIP-HOP. PUERTO RICAN CULTURE AND LATINO IDENTITY

Brígida M. Pastor

Revista Brasileira do Caribe, Vol 0, Iss

2014

Abstract: FLORES, Juan. From Bomba to Hip-Hop. Puerto Rican Culture and Latino Identity. NewYork: Columbia University Press, 2000, 265 p. ...

Abstract	FLORES, Juan. From Bomba to Hip-Hop. Puerto Rican Culture and Latino Identity. NewYork: Columbia University Press, 2000, 265 p.
Keywords	Latin America. Spanish America ; F1201-3799 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2014-06-01T00:00:00Z
Publisher	Universidade Federal do Maranhão
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Gastrointestinal Bleeding Due to NOACs Use: Exploring the Molecular Mechanisms.

Saviano, Angela / Brigida, Mattia / Petruzziello, Carmine / Candelli, Marcello / Gabrielli, Maurizio / Ojetti, Veronica

International journal of molecular sciences

2022 Volume 23, Issue 22

Abstract: Novel oral anticoagulants (NOACs) are drugs approved for the prevention and treatment of many thromboembolic cardiovascular conditions as a safer alternative to warfarin. We reviewed studies published in ... ...

Abstract	Novel oral anticoagulants (NOACs) are drugs approved for the prevention and treatment of many thromboembolic cardiovascular conditions as a safer alternative to warfarin. We reviewed studies published in PubMed
MeSH term(s)	Humans ; Anticoagulants/adverse effects ; Warfarin/adverse effects ; Administration, Oral ; Dabigatran/adverse effects ; Gastrointestinal Hemorrhage/chemically induced ; Gastrointestinal Hemorrhage/drug therapy
Chemical Substances	Anticoagulants ; Warfarin (5Q7ZVV76EI) ; Dabigatran (I0VM4M70GC)
Language	English
Publishing date	2022-11-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232213955
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Article ; Online: Randomized control trial on the efficacy of Limosilactobacillus reuteri ATCC PTA 4659 in reducing inflammatory markers in acute uncomplicated diverticulitis.

Ojetti, Veronica / Saviano, Angela / Brigida, Mattia / Petruzziello, Carmine / Caronna, Martina / Gayani, Gunawardena / Franceschi, Francesco

European journal of gastroenterology & hepatology

2022 Volume 34, Issue 5, Page(s) 496–502

Abstract: Introduction: Recent guidelines suggest treating acute uncomplicated diverticulitis (AUD) without antibiotics. We tested the efficacy of Limosilactobacillus reuteri ATCC PTA 4659 in AUD. Primary outcome was the reduction of abdominal pain and ... ...

Abstract	Introduction: Recent guidelines suggest treating acute uncomplicated diverticulitis (AUD) without antibiotics. We tested the efficacy of Limosilactobacillus reuteri ATCC PTA 4659 in AUD. Primary outcome was the reduction of abdominal pain and inflammatory markers [C-reactive protein (C-RP) and calprotectin]. Secondary outcome was the reduction of hours of hospitalization. Patients and methods: A double-blind, randomized controlled trial was conducted in 119 patients with AUD. The probiotic group (61 patients) was treated with fluids, bowel rest and L. reuteri/b.i.d. for 10 days. The placebo group (58 patients) was treated with the same therapy and placebo/b.i.d. for 10 days. All patients completed a daily visual analogue scale (VAS) for abdominal pain. Results: Both groups showed a mean VAS score of 7 at enrolment and a reduction of 4 points after 3 days. C-RP value, after 72 h, decreased by 58.8% in the probiotic group and by only 40% in the placebo group (P < 0.05). Calprotectin levels, after 72 h, decreased by 17% in the probiotic group and by only 10.6% in the control group (P < 0.05). In the probiotic group, the hospitalization was done for 75.5 h compared to 83.5 in the placebo group. Conclusions: The supplementation with L. reuteri 4659 together with bowel rest and fluids significantly reduced both blood and faecal inflammatory markers compared to the placebo group.
MeSH term(s)	Abdominal Pain/etiology ; C-Reactive Protein/metabolism ; Diverticulitis/therapy ; Double-Blind Method ; Humans ; Limosilactobacillus reuteri/metabolism ; Leukocyte L1 Antigen Complex ; Probiotics/adverse effects ; Treatment Outcome
Chemical Substances	Leukocyte L1 Antigen Complex ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2022-01-13
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000002342
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Article: Reversibility of Frail Phenotype in Patients with Inflammatory Bowel Diseases.

Salvatori, Silvia / Marafini, Irene / Franchin, Martina / Lavigna, Diletta / Brigida, Mattia / Venuto, Chiara / Biancone, Livia / Calabrese, Emma / Giannarelli, Diana / Monteleone, Giovanni

Journal of clinical medicine

2023 Volume 12, Issue 7

Abstract: It was recently reported that frailty status can negatively influence the clinical course of patients with inflammatory bowel diseases (IBDs). Our recent study demonstrated that 20% of patients with an IBD are frail, and disease activity increases the ... ...

Abstract	It was recently reported that frailty status can negatively influence the clinical course of patients with inflammatory bowel diseases (IBDs). Our recent study demonstrated that 20% of patients with an IBD are frail, and disease activity increases the risk of frailty. In the present study, we prospectively monitored this subgroup of frail patients, assessed whether the frailty status was reversible, and analyzed factors associated with frailty reversibility. Of the sixty-four frail patients with IBD enrolled, five (8%) were lost during the follow-up period and one (2%) underwent a colectomy. Eleven out of the fifty-eight (19%) patients maintained a frail phenotype during a median follow-up of 8 months (range 6-19 months), and thirty-five (60%) and twelve (21%) became pre-frail or fit, respectively. A comparison of the 58 patients at baseline and at the end of the study showed that frail phenotype reversibility occurred more frequently in patients who achieved clinical remission. A multivariate analysis showed that the improvement of the frail phenotype was inversely correlated with the persistence of clinically active disease (OR:0.1; 95% CI: 0.02-0.8) and a history of extra-intestinal manifestations (OR:0.1; 95% CI: 0.01-0.6) and positively correlated with the use of biologics (OR: 21.7; 95% CI: 3.4-263). Data indicate that the frail phenotype is a reversible condition in most IBD patients, and such a change relies on the improvement in disease activity.
Language	English
Publishing date	2023-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12072658
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Article: Intestinal Damage, Inflammation and Microbiota Alteration during COVID-19 Infection.

Saviano, Angela / Brigida, Mattia / Petruzziello, Carmine / Zanza, Christian / Candelli, Marcello / Morabito Loprete, Maria Rita / Saleem, Faiz / Ojetti, Veronica

Biomedicines

2023 Volume 11, Issue 4

Abstract: Background: The virus SARS-CoV-2 is responsible for respiratory disorders due to the fact that it mainly infects the respiratory tract using the Angiotensin-converting enzyme 2 (ACE2) receptors. ACE2 receptors are also highly expressed on intestinal ... ...

Abstract	Background: The virus SARS-CoV-2 is responsible for respiratory disorders due to the fact that it mainly infects the respiratory tract using the Angiotensin-converting enzyme 2 (ACE2) receptors. ACE2 receptors are also highly expressed on intestinal cells, representing an important site of entry for the virus in the gut. Literature studies underlined that the virus infects and replicates in the gut epithelial cells, causing gastrointestinal symptoms such as diarrhea, abdominal pain, nausea/vomiting and anorexia. Moreover, the SARS-CoV-2 virus settles into the bloodstream, hyperactivating the platelets and cytokine storms and causing gut-blood barrier damage with an alteration of the gut microbiota, intestinal cell injury, intestinal vessel thrombosis leading to malabsorption, malnutrition, an increasing disease severity and mortality with short and long-period sequelae. Conclusion: This review summarizes the data on how SARS-CoV-2 effects on the gastrointestinal systems, including the mechanisms of inflammation, relationship with the gut microbiota, endoscopic patterns, and the role of fecal calprotectin, confirming the importance of the digestive system in clinical practice for the diagnosis and follow-up of SARS-CoV-2 infection.
Language	English
Publishing date	2023-03-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11041014
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Article: Gut Microbiota Alteration and Its Modulation with Probiotics in Celiac Disease.

Saviano, Angela / Petruzziello, Carmine / Brigida, Mattia / Morabito Loprete, Maria Rita / Savioli, Gabriele / Migneco, Alessio / Ojetti, Veronica

Biomedicines

2023 Volume 11, Issue 10

Abstract: Celiac disease (CD) is a chronic inflammation of the small intestine triggered by gluten ingestion in genetically predisposed people. Recent literature studies highlight the possible role of the gut microbiota in the pathogenesis of this disease. The gut ...

Abstract	Celiac disease (CD) is a chronic inflammation of the small intestine triggered by gluten ingestion in genetically predisposed people. Recent literature studies highlight the possible role of the gut microbiota in the pathogenesis of this disease. The gut microbiota is a complex community of microorganisms that can interact with the innate and adaptative immune systems. A condition of dysbiosis, which refers to an alteration in the composition and function of the human gut microbiota, can lead to a dysregulated immune response. This condition may contribute to triggering gluten intolerance, favoring the development and/or progression of CD in genetically susceptible patients. Interestingly, studies on children and adults with CD showed a different microbiome profile in fecal samples, with a different degree of "activity" for the disease. From this point of view, our review aimed to collect and discuss modern evidence about the alteration of the gut microbiota and its modulation with probiotics, with possible future indications in the management of patients affected by CD.
Language	English
Publishing date	2023-09-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11102638
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