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Article ; Online: Development of Biopsy Tract Sealants Based on Shape Memory Polymer Foams.

Touchet, Tyler J / Brinson, Braeden / Jones, McKenzie / Byju, Achu / Fletcher, Grace / Hasan, Sayyeda Marziya / Nash, Landon D / Maitland, Duncan J

Biomedical materials & devices (New York, N.Y.)

2023 Volume 1, Issue 2, Page(s) 853–860

Abstract: Lung biopsies are often used to aid in the diagnosis of cancers. However, the procedure carries the dual risk of air (pneumothorax) or blood (hemothorax) filling the pleural cavity, increasing the risk of a collapsed lung and chest intubation. This work ... ...

Abstract	Lung biopsies are often used to aid in the diagnosis of cancers. However, the procedure carries the dual risk of air (pneumothorax) or blood (hemothorax) filling the pleural cavity, increasing the risk of a collapsed lung and chest intubation. This work demonstrates the effectiveness of a polyurethane-based shape memory polymer foam as a biopsy tract sealant. The impact of diameter, length, pore size, and shape memory effect was evaluated to determine the ideal device design for tract sealing. Characterization in an
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Journal Article
ISSN	2731-4820
ISSN (online)	2731-4820
DOI	10.1007/s44174-023-00064-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Swellable and Thermally Responsive Hydrogel/Shape Memory Polymer Foam Composites for Sealing Lung Biopsy Tracts.

Jungmann, Matthew A / Recalde Phillips, Sarea / Touchet, Tyler J / Brinson, Braeden / Parish, Katherine / Petersen, Corinne / Hasan, Sayyeda Marziya / Nash, Landon D / Maitland, Duncan J / Alge, Daniel L

ACS biomaterials science & engineering

2023 Volume 9, Issue 2, Page(s) 642–650

Abstract: Lung tissue biopsies can result in a leakage of blood (hemothorax) and air (pneumothorax) from the biopsy tract, which threatens the patient with a collapsed lung and other complications. We have developed a lung biopsy tract sealant based on a thiol-ene- ...

Abstract	Lung tissue biopsies can result in a leakage of blood (hemothorax) and air (pneumothorax) from the biopsy tract, which threatens the patient with a collapsed lung and other complications. We have developed a lung biopsy tract sealant based on a thiol-ene-crosslinked PEG hydrogel and polyurethane shape memory polymer (SMP) foam composite. After insertion into biopsy tracts, the PEG hydrogel component contributes to sealing through water-driven swelling, whereas the SMP foam contributes to sealing via thermal actuation. The gelation kinetics, swelling properties, and rheological properties of various hydrogel formulations were studied to determine the optimal formulation for composite fabrication. Composites were then fabricated via vacuum infiltration of the PEG hydrogel precursors into the SMP foam followed by thermal curing. After drying, the composites were crimped to enable insertion into biopsy tracts. Characterization revealed that the composites exhibited a slight delay in shape recovery compared to control SMP foams. However, the composites were still able to recover their shape in a matter of minutes. Cytocompatibility testing showed that leachable byproducts can be easily removed by washing and washed composites were not cytotoxic to mouse lung fibroblasts (L929s). Benchtop testing demonstrated that the composites can be easily deployed through a cannula, and the working time for deployment after exposure to water was 2 min. Furthermore, testing in an in vitro lung model demonstrated that the composites were able to effectively seal a lung biopsy tract and prevent air leakage. Collectively, these results show that the PEG hydrogel/SMP foam composites have the potential to be used as lung biopsy tract sealants to prevent pneumothorax post-lung biopsy.
MeSH term(s)	Animals ; Mice ; Hydrogels ; Smart Materials ; Pneumothorax ; Biocompatible Materials ; Biopsy
Chemical Substances	Hydrogels ; Smart Materials ; Biocompatible Materials ; polyurethane foam (9009-54-5)
Language	English
Publishing date	2023-02-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.2c01369
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Women in medicine at the Medical College of Virginia of Virginia Commonwealth University.

Brinson, B / Hampton, C

Virginia medical quarterly : VMQ

1998 Volume 125, Issue 1, Page(s) 49–51

MeSH term(s)	Education, Medical/history ; Female ; History, 17th Century ; History, 19th Century ; History, 20th Century ; Humans ; Physicians, Women/history ; Schools, Medical/history ; Societies, Medical/history ; Virginia
Language	English
Publishing date	1998
Publishing country	United States
Document type	Historical Article ; Journal Article ; Portrait
ZDB-ID	1043265-6
ISSN	1052-4231 ; 0146-3616
ISSN	1052-4231 ; 0146-3616
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Article ; Online: Impurity-induced plasmon damping in individual cobalt-doped hollow Au nanoshells.

Thibodeaux, Christyn A / Kulkarni, Vikram / Chang, Wei-Shun / Neumann, Oara / Cao, Yang / Brinson, Bruce / Ayala-Orozco, Ciceron / Chen, Chih-Wei / Morosan, Emilia / Link, Stephan / Nordlander, Peter / Halas, Naomi J

The journal of physical chemistry. B

2014 Volume 118, Issue 49, Page(s) 14056–14061

Abstract: The optical properties of plasmonic nanoparticles in the size range corresponding to the electrostatic, or dipole, limit have the potential to reveal effects otherwise masked by phase retardation. Here we examine the optical properties of individual, sub- ...

Abstract	The optical properties of plasmonic nanoparticles in the size range corresponding to the electrostatic, or dipole, limit have the potential to reveal effects otherwise masked by phase retardation. Here we examine the optical properties of individual, sub-50 nm hollow Au nanoshells (Co-HGNS), where Co is the initial sacrificial core nanoparticle, using single particle total internal reflection scattering (TIRS) spectroscopy. The residual Co present in the metallic shell induces a substantial broadening of the homogeneous plasmon resonance line width of the Co-HGNS, where the full width at half-maximum (fwhm) broadens proportionately with increasing Co content. This doping-induced line broadening provides a strategy for controlling plasmon line width independent of nanoparticle size, and has the potential to substantially modify the relative decay channels for localized nanoparticle surface plasmons.
Language	English
Publishing date	2014-12-11
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/jp504467j
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Article: Magnolia grandiflora: a propagation guide

Dirr, M.A / Brinson, B

American nurseryman. Nov 1, 1985. v. 162 (9)

1985

Keywords	Magnolia grandiflora ; cultivars ; ornamental woody plants ; methodology ; plant propagation ; United States
Language	English
Dates of publication	1985-1101
Size	p. 38-40, 42-46, 48-51., ill.
Document type	Article
ZDB-ID	408726-4
ISSN	0003-0198 ; 0003-0198
ISSN (online)	0003-0198
ISSN	0003-0198
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Observation of Seven Astrophysical Tau Neutrino Candidates with IceCube.

Abbasi, R / Ackermann, M / Adams, J / Agarwalla, S K / Aguilar, J A / Ahlers, M / Alameddine, J M / Amin, N M / Andeen, K / Anton, G / Argüelles, C / Ashida, Y / Athanasiadou, S / Axani, S N / Bai, X / Balagopal, V A / Baricevic, M / Barwick, S W / Basu, V /

Bay, R / Beatty, J J / Becker Tjus, J / Beise, J / Bellenghi, C / Benning, C / BenZvi, S / Berley, D / Bernardini, E / Besson, D Z / Blaufuss, E / Blot, S / Bontempo, F / Book, J Y / Boscolo Meneguolo, C / Böser, S / Botner, O / Böttcher, J / Bourbeau, E / Braun, J / Brinson, B / Brostean-Kaiser, J / Burley, R T / Busse, R S / Butterfield, D / Campana, M A / Carloni, K / Carnie-Bronca, E G / Chattopadhyay, S / Chau, N / Chen, C / Chen, Z / Chirkin, D / Choi, S / Clark, B A / Classen, L / Coleman, A / Collin, G H / Connolly, A / Conrad, J M / Coppin, P / Correa, P / Cowen, D F / Dave, P / De Clercq, C / DeLaunay, J J / Delgado, D / Deng, S / Deoskar, K / Desai, A / Desiati, P / de Vries, K D / de Wasseige, G / DeYoung, T / Diaz, A / Díaz-Vélez, J C / Dittmer, M / Domi, A / Dujmovic, H / DuVernois, M A / Ehrhardt, T / Eller, P / Ellinger, E / El Mentawi, S / Elsässer, D / Engel, R / Erpenbeck, H / Evans, J / Evenson, P A / Fan, K L / Fang, K / Farrag, K / Fazely, A R / Feigl, N / Fiedlschuster, S / Fienberg, A T / Finley, C / Fischer, L / Fox, D / Franckowiak, A / Fritz, A / Fürst, P / Gallagher, J / Ganster, E / Garcia, A / Gerhardt, L / Ghadimi, A / Glaser, C / Glauch, T / Glüsenkamp, T / Goehlke, N / Gonzalez, J G / Goswami, S / Grant, D / Gray, S J / Gries, O / Griffin, S / Griswold, S / Groth, K M / Günther, C / Gutjahr, P / Haack, C / Hallgren, A / Halliday, R / Halve, L / Halzen, F / Hamdaoui, H / Ha Minh, M / Hanson, K / Hardin, J / Harnisch, A A / Hatch, P / Haungs, A / Helbing, K / Hellrung, J / Henningsen, F / Heuermann, L / Heyer, N / Hickford, S / Hidvegi, A / Hill, C / Hill, G C / Hoffman, K D / Hori, S / Hoshina, K / Hou, W / Huber, T / Hultqvist, K / Hünnefeld, M / Hussain, R / Hymon, K / In, S / Ishihara, A / Jacquart, M / Janik, O / Jansson, M / Japaridze, G S / Jeong, M / Jin, M / Jones, B J P / Kang, D / Kang, W / Kang, X / Kappes, A / Kappesser, D / Kardum, L / Karg, T / Karl, M / Karle, A / Katz, U / Kauer, M / Kelley, J L / Khatee Zathul, A / Kheirandish, A / Kiryluk, J / Klein, S R / Kochocki, A / Koirala, R / Kolanoski, H / Kontrimas, T / Köpke, L / Kopper, C / Koskinen, D J / Koundal, P / Kovacevich, M / Kowalski, M / Kozynets, T / Krishnamoorthi, J / Kruiswijk, K / Krupczak, E / Kumar, A / Kun, E / Kurahashi, N / Lad, N / Lagunas Gualda, C / Lamoureux, M / Larson, M J / Latseva, S / Lauber, F / Lazar, J P / Lee, J W / Leonard DeHolton, K / Leszczyńska, A / Lincetto, M / Liu, Q R / Liubarska, M / Lohfink, E / Love, C / Lozano Mariscal, C J / Lucarelli, F / Luszczak, W / Lyu, Y / Madsen, J / Mahn, K B M / Makino, Y / Manao, E / Mancina, S / Marie Sainte, W / Mariş, I C / Marka, S / Marka, Z / Marsee, M / Martinez-Soler, I / Maruyama, R / Mayhew, F / McElroy, T / McNally, F / Mead, J V / Meagher, K / Mechbal, S / Medina, A / Meier, M / Merckx, Y / Merten, L / Micallef, J / Mitchell, J / Montaruli, T / Moore, R W / Morii, Y / Morse, R / Moulai, M / Mukherjee, T / Naab, R / Nagai, R / Nakos, M / Naumann, U / Necker, J / Negi, A / Neumann, M / Niederhausen, H / Nisa, M U / Noell, A / Novikov, A / Nowicki, S C / Obertacke Pollmann, A / O'Dell, V / Oehler, M / Oeyen, B / Olivas, A / Orsoe, R / Osborn, J / O'Sullivan, E / Pandya, H / Pankova, D V / Park, N / Parker, G K / Paudel, E N / Paul, L / Pérez de Los Heros, C / Peterson, J / Philippen, S / Pizzuto, A / Plum, M / Pontén, A / Popovych, Y / Prado Rodriguez, M / Pries, B / Procter-Murphy, R / Przybylski, G T / Raab, C / Rack-Helleis, J / Rawlins, K / Rechav, Z / Rehman, A / Reichherzer, P / Renzi, G / Resconi, E / Reusch, S / Rhode, W / Riedel, B / Rifaie, A / Roberts, E J / Robertson, S / Rodan, S / Roellinghoff, G / Rongen, M / Rott, C / Ruhe, T / Ruohan, L / Ryckbosch, D / Safa, I / Saffer, J / Salazar-Gallegos, D / Sampathkumar, P / Sanchez Herrera, S E / Sandrock, A / Santander, M / Sarkar, S / Savelberg, J / Savina, P / Schaufel, M / Schieler, H / Schindler, S / Schlickmann, L / Schlüter, B / Schlüter, F / Schmeisser, N / Schmidt, T / Schneider, J / Schröder, F G / Schumacher, L / Schwefer, G / Sclafani, S / Seckel, D / Seikh, M / Seunarine, S / Shah, R / Sharma, A / Shefali, S / Shimizu, N / Silva, M / Skrzypek, B / Smithers, B / Snihur, R / Soedingrekso, J / Søgaard, A / Soldin, D / Soldin, P / Sommani, G / Spannfellner, C / Spiczak, G M / Stamatikos, M / Stanev, T / Stezelberger, T / Stürwald, T / Stuttard, T / Sullivan, G W / Taboada, I / Ter-Antonyan, S / Thiesmeyer, M / Thompson, W G / Thwaites, J / Tilav, S / Tollefson, K / Tönnis, C / Toscano, S / Tosi, D / Trettin, A / Tung, C F / Turcotte, R / Twagirayezu, J P / Ty, B / Unland Elorrieta, M A / Upadhyay, A K / Upshaw, K / Valtonen-Mattila, N / Vandenbroucke, J / van Eijndhoven, N / Vannerom, D / van Santen, J / Vara, J / Veitch-Michaelis, J / Venugopal, M / Vereecken, M / Verpoest, S / Veske, D / Vijai, A / Walck, C / Weaver, C / Weigel, P / Weindl, A / Weldert, J / Wen, A Y / Wendt, C / Werthebach, J / Weyrauch, M / Whitehorn, N / Wiebusch, C H / Willey, N / Williams, D R / Witthaus, L / Wolf, A / Wolf, M / Wrede, G / Xu, X W / Yanez, J P / Yildizci, E / Yoshida, S / Young, R / Yu, F / Yu, S / Zhang, Z / Zhelnin, P / Zilberman, P / Zimmerman, M

Physical review letters

2024 Volume 132, Issue 15, Page(s) 151001

Abstract: We report on a measurement of astrophysical tau neutrinos with 9.7 yr of IceCube data. Using convolutional neural networks trained on images derived from simulated events, seven candidate ν_{τ} events were found with visible energies ranging from roughly ...

Abstract	We report on a measurement of astrophysical tau neutrinos with 9.7 yr of IceCube data. Using convolutional neural networks trained on images derived from simulated events, seven candidate ν_{τ} events were found with visible energies ranging from roughly 20 TeV to 1 PeV and a median expected parent ν_{τ} energy of about 200 TeV. Considering backgrounds from astrophysical and atmospheric neutrinos, and muons from π^{±}/K^{±} decays in atmospheric air showers, we obtain a total estimated background of about 0.5 events, dominated by non-ν_{τ} astrophysical neutrinos. Thus, we rule out the absence of astrophysical ν_{τ} at the 5σ level. The measured astrophysical ν_{τ} flux is consistent with expectations based on previously published IceCube astrophysical neutrino flux measurements and neutrino oscillations.
Language	English
Publishing date	2024-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.132.151001
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Article: Functionalization and extraction of large fullerenes and carbon-coated metal formed during the synthesis of single wall carbon nanotubes by laser oven, direct current arc, and high-pressure carbon monoxide production methods.

Sadana, Anil K / Liang, Feng / Brinson, Bruce / Arepalli, Sivaram / Farhat, Samir / Hauge, Robert H / Smalley, Richard E / Billups, W E

The journal of physical chemistry. B

2005 Volume 109, Issue 10, Page(s) 4416–4418

Abstract: Large fullerenes and carbon-coated metal nanoparticles that are formed during the synthesis of carbon nanotubes have been functionalized by the addition of alkyl radicals and isolated by extraction into chloroform. The soluble, functionalized fullerenes ... ...

Abstract	Large fullerenes and carbon-coated metal nanoparticles that are formed during the synthesis of carbon nanotubes have been functionalized by the addition of alkyl radicals and isolated by extraction into chloroform. The soluble, functionalized fullerenes have been isolated from raw single-wall carbon nanotube (SWNT) material prepared by laser oven, direct current arc, and high-pressure carbon monoxide production methods. Analyses of the extracted large fullerenes were carried out by thermogravimetric analysis, UV-vis-near-IR, laser desorption ionization mass spectrometry, and high-resolution transmission electron microscopy.
Language	English
Publishing date	2005-03-17
Publishing country	United States
Document type	Journal Article
ISSN	1520-6106
ISSN	1520-6106
DOI	10.1021/jp045582b
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of decompressive craniectomy on functional outcome after severe traumatic brain injury.

Williams, Regan F / Magnotti, Louis J / Croce, Martin A / Hargraves, Brinson B / Fischer, Peter E / Schroeppel, Thomas J / Zarzaur, Ben L / Muhlbauer, Michael / Timmons, Shelly D / Fabian, Timothy C

The Journal of trauma

2009 Volume 66, Issue 6, Page(s) 1570–4; discussion 1574–6

Abstract: Background: The beneficial effect of decompressive craniectomy (DC) in the treatment of traumatic brain injury (TBI) remains controversial. In many centers, it is used as a salvage procedure for uncontrollable intracranial pressure (ICP). It is our ... ...

Abstract	Background: The beneficial effect of decompressive craniectomy (DC) in the treatment of traumatic brain injury (TBI) remains controversial. In many centers, it is used as a salvage procedure for uncontrollable intracranial pressure (ICP). It is our contention that DC represents a viable early option for head trauma patients. The purpose of this study was to evaluate the efficacy of DC on functional outcome after severe TBI in the largest single institutional series reported in the literature. Methods: Patients with severe TBI (Abbreviated Injury Score 4-5) treated with DC for the management of increased ICP during 6-year period were identified from the trauma registry. Functional outcome was measured 1 year to 6 years postinjury using the Glasgow Outcome Score Extended (GOSE) via telephone interview and classified as good (GOSE 5-8) or poor (GOSE 1-4, including death). Outcomes were compared using Wilcoxon rank-sum and chi2 tests where appropriate. Results: One hundred and seventy-one patients were identified: 137 (80%) men and 34 (20%) women. Overall mortality (all in-hospital) was 32% (head-related = 22%). Of the 117 survivors, follow-up was obtained in all but 6 (95%). Good outcome was achieved in 96 patients (56% overall, 82% of survivors). Those with good outcome were younger (26 years vs. 43 years, p = 0.0028) and experienced a greater change in predecompression to postdecompression ICP (ICP reduced by 23 mm Hg vs. 10 mm Hg, p < 0.0001). Not surprisingly, unchanged ICP (predecompression to postdecompression) was associated with poor outcome (p = 0.0031). There was no difference in immediate predecompression ICP between survivors versus nonsurvivors. However, immediate predecompression Glasgow Coma Score was significantly higher in survivors compared with nonsurvivors (7 vs. 5, p < 0.0001). Conclusions: DC resulted in good functional outcome in >50% of patients with severe TBI. The greatest benefit was observed in younger patients with a demonstrable reduction in ICP after decompression. The prospect of improved functional outcome offered by this procedure in the treatment of severe TBI warrants prospective investigation.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Brain Injuries/surgery ; Craniotomy/methods ; Decompression, Surgical ; Female ; Humans ; Male ; Middle Aged ; Recovery of Function ; Registries ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2009-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	219302-4
ISSN	1529-8809 ; 0022-5282 ; 1079-6061
ISSN (online)	1529-8809
ISSN	0022-5282 ; 1079-6061
DOI	10.1097/TA.0b013e3181a594c4
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Article ; Online: Observation of high-energy neutrinos from the Galactic plane.

Abbasi, R / Ackermann, M / Adams, J / Aguilar, J A / Ahlers, M / Ahrens, M / Alameddine, J M / Alves, A A / Amin, N M / Andeen, K / Anderson, T / Anton, G / Argüelles, C / Ashida, Y / Athanasiadou, S / Axani, S / Bai, X / Balagopal V, A / Barwick, S W /

Basu, V / Baur, S / Bay, R / Beatty, J J / Becker, K-H / Tjus, J Becker / Beise, J / Bellenghi, C / Benda, S / BenZvi, S / Berley, D / Bernardini, E / Besson, D Z / Binder, G / Bindig, D / Blaufuss, E / Blot, S / Boddenberg, M / Bontempo, F / Book, J Y / Borowka, J / Böser, S / Botner, O / Böttcher, J / Bourbeau, E / Bradascio, F / Braun, J / Brinson, B / Bron, S / Brostean-Kaiser, J / Burley, R T / Busse, R S / Campana, M A / Carnie-Bronca, E G / Chen, C / Chen, Z / Chirkin, D / Choi, K / Clark, B A / Clark, K / Classen, L / Coleman, A / Collin, G H / Connolly, A / Conrad, J M / Coppin, P / Correa, P / Cowen, D F / Cross, R / Dappen, C / Dave, P / De Clercq, C / DeLaunay, J J / López, D Delgado / Dembinski, H / Deoskar, K / Desai, A / Desiati, P / de Vries, K D / de Wasseige, G / DeYoung, T / Diaz, A / Díaz-Vélez, J C / Dittmer, M / Dujmovic, H / Dunkman, M / DuVernois, M A / Ehrhardt, T / Eller, P / Engel, R / Erpenbeck, H / Evans, J / Evenson, P A / Fan, K L / Fazely, A R / Fedynitch, A / Feigl, N / Fiedlschuster, S / Fienberg, A T / Finley, C / Fischer, L / Fox, D / Franckowiak, A / Friedman, E / Fritz, A / Fürst, P / Gaisser, T K / Gallagher, J / Ganster, E / Garcia, A / Garrappa, S / Gerhardt, L / Ghadimi, A / Glaser, C / Glauch, T / Glüsenkamp, T / Goehlke, N / Goldschmidt, A / Gonzalez, J G / Goswami, S / Grant, D / Grégoire, T / Griswold, S / Günther, C / Gutjahr, P / Haack, C / Hallgren, A / Halliday, R / Halve, L / Halzen, F / Minh, M Ha / Hanson, K / Hardin, J / Harnisch, A A / Haungs, A / Helbing, K / Henningsen, F / Hettinger, E C / Hickford, S / Hignight, J / Hill, C / Hill, G C / Hoffman, K D / Hoshina, K / Hou, W / Huang, F / Huber, M / Huber, T / Hultqvist, K / Hünnefeld, M / Hussain, R / Hymon, K / In, S / Iovine, N / Ishihara, A / Jansson, M / Japaridze, G S / Jeong, M / Jin, M / Jones, B J P / Kang, D / Kang, W / Kang, X / Kappes, A / Kappesser, D / Kardum, L / Karg, T / Karl, M / Karle, A / Katz, U / Kauer, M / Kellermann, M / Kelley, J L / Kheirandish, A / Kin, K / Kiryluk, J / Klein, S R / Kochocki, A / Koirala, R / Kolanoski, H / Kontrimas, T / Köpke, L / Kopper, C / Kopper, S / Koskinen, D J / Koundal, P / Kovacevich, M / Kowalski, M / Kozynets, T / Krupczak, E / Kun, E / Kurahashi, N / Lad, N / Gualda, C Lagunas / Lanfranchi, J L / Larson, M J / Lauber, F / Lazar, J P / Lee, J W / Leonard, K / Leszczyńska, A / Li, Y / Lincetto, M / Liu, Q R / Liubarska, M / Lohfink, E / Mariscal, C J Lozano / Lu, L / Lucarelli, F / Ludwig, A / Luszczak, W / Lyu, Y / Ma, W Y / Madsen, J / Mahn, K B M / Makino, Y / Mancina, S / Mariş, I C / Martinez-Soler, I / Maruyama, R / McHale, S / McElroy, T / McNally, F / Mead, J V / Meagher, K / Mechbal, S / Medina, A / Meier, M / Meighen-Berger, S / Merckx, Y / Micallef, J / Mockler, D / Montaruli, T / Moore, R W / Morik, K / Morse, R / Moulai, M / Mukherjee, T / Naab, R / Nagai, R / Nahnhauer, R / Naumann, U / Necker, J / Nguyen, L V / Niederhausen, H / Nisa, M U / Nowicki, S C / Nygren, D / Pollmann, A Obertacke / Oehler, M / Oeyen, B / Olivas, A / O'Sullivan, E / Pandya, H / Pankova, D V / Park, N / Parker, G K / Paudel, E N / Paul, L / de Los Heros, C Pérez / Peters, L / Peterson, J / Philippen, S / Pieper, S / Pizzuto, A / Plum, M / Popovych, Y / Porcelli, A / Rodriguez, M Prado / Pries, B / Przybylski, G T / Raab, C / Rack-Helleis, J / Raissi, A / Rameez, M / Rawlins, K / Rea, I C / Rechav, Z / Rehman, A / Reichherzer, P / Reimann, R / Renzi, G / Resconi, E / Reusch, S / Rhode, W / Richman, M / Riedel, B / Roberts, E J / Robertson, S / Roellinghoff, G / Rongen, M / Rott, C / Ruhe, T / Ryckbosch, D / Cantu, D Rysewyk / Safa, I / Saffer, J / Salazar-Gallegos, D / Sampathkumar, P / Herrera, S E Sanchez / Sandrock, A / Santander, M / Sarkar, S / Satalecka, K / Schaufel, M / Schieler, H / Schindler, S / Schmidt, T / Schneider, A / Schneider, J / Schröder, F G / Schumacher, L / Schwefer, G / Sclafani, S / Seckel, D / Seunarine, S / Sharma, A / Shefali, S / Shimizu, N / Silva, M / Skrzypek, B / Smithers, B / Snihur, R / Soedingrekso, J / Sogaard, A / Soldin, D / Spannfellner, C / Spiczak, G M / Spiering, C / Stamatikos, M / Stanev, T / Stein, R / Stettner, J / Stezelberger, T / Stokstad, B / Stürwald, T / Stuttard, T / Sullivan, G W / Taboada, I / Ter-Antonyan, S / Thwaites, J / Tilav, S / Tischbein, F / Tollefson, K / Tönnis, C / Toscano, S / Tosi, D / Trettin, A / Tselengidou, M / Tung, C F / Turcati, A / Turcotte, R / Turley, C F / Twagirayezu, J P / Ty, B / Elorrieta, M A Unland / Valtonen-Mattila, N / Vandenbroucke, J / van Eijndhoven, N / Vannerom, D / van Santen, J / Veitch-Michaelis, J / Verpoest, S / Walck, C / Wang, W / Watson, T B / Weaver, C / Weigel, P / Weindl, A / Weiss, M J / Weldert, J / Wendt, C / Werthebach, J / Weyrauch, M / Whitehorn, N / Wiebusch, C H / Willey, N / Williams, D R / Wolf, M / Wrede, G / Wulff, J / Xu, X W / Yanez, J P / Yildizci, E / Yoshida, S / Yu, S / Yuan, T / Zhang, Z / Zhelnin, P

Science (New York, N.Y.)

2023 Volume 380, Issue 6652, Page(s) 1338–1343

Abstract: The origin of high-energy cosmic rays, atomic nuclei that continuously impact Earth's atmosphere, is unknown. Because of deflection by interstellar magnetic fields, cosmic rays produced within the Milky Way arrive at Earth from random directions. However, ...

Abstract	The origin of high-energy cosmic rays, atomic nuclei that continuously impact Earth's atmosphere, is unknown. Because of deflection by interstellar magnetic fields, cosmic rays produced within the Milky Way arrive at Earth from random directions. However, cosmic rays interact with matter near their sources and during propagation, which produces high-energy neutrinos. We searched for neutrino emission using machine learning techniques applied to 10 years of data from the IceCube Neutrino Observatory. By comparing diffuse emission models to a background-only hypothesis, we identified neutrino emission from the Galactic plane at the 4.5σ level of significance. The signal is consistent with diffuse emission of neutrinos from the Milky Way but could also arise from a population of unresolved point sources.
Language	English
Publishing date	2023-06-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.adc9818
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Virginia generalist initiative: lessons learned in a statewide consortium.

Morse, R M / Plungas, G S / Duke, D / Rollins, L K / Barnes, H V / Brinson, B K / Martindale, J R / Marsland, D W

Academic medicine : journal of the Association of American Medical Colleges

1999 Volume 74, Issue 1 Suppl, Page(s) S24–9

Abstract: In response to Virginia's need for an increased supply of generalist physicians, the state's three medical schools--Eastern Virginia Medical School, Virginia Commonwealth University School of Medicine, and the University of Virginia School of Medicine-- ... ...

Abstract	In response to Virginia's need for an increased supply of generalist physicians, the state's three medical schools--Eastern Virginia Medical School, Virginia Commonwealth University School of Medicine, and the University of Virginia School of Medicine--have formed a partnership with key governmental stakeholders in the Virginia Generalist Initiative funded by The Robert Wood Johnson Foundation's Generalist Physician Initiative. These state-supported medical schools historically have functioned independently, with little cooperative effort. This paper describes the consortium, its activities, its successes, and its unmet objectives, and uses a series of cases in point to illustrate relevant lessons learned. Some of these lessons are that (1) stakeholders must be involved from the beginning of planning to identify mutual goals and establish consortium protocols; (2) all partners must share a philosophical commitment to the consortium's mission, as well as the time and resources needed; (3) an atmosphere that enables risk-taking behavior must be created; (4) stakeholders must be willing to revise goals and sustain an environment conductive to change; and (5) trust is essential and must be vigilantly maintained. The paper concludes that the Virginia Generalist Initiative has dramatically altered the goals, objectives and programs of the three schools and has succeeded in aligning the schools' strategic objectives with the state's priorities.
MeSH term(s)	Databases as Topic ; Education, Medical, Undergraduate ; Family Practice/education ; Humans ; Internship and Residency ; Organizational Objectives ; Rural Population ; Schools, Medical/organization & administration ; Virginia
Language	English
Publishing date	1999-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/00001888-199901001-00027
Database	MEDical Literature Analysis and Retrieval System OnLINE

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