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  1. Article ; Online: Harnessing laser technology to create stable metal halide perovskite-rGO conjugates as promising electrodes for Zn-ion capacitors.

    Kostopoulou, Athanasia / Vernardou, Dimitra / Livakas, Nikolaos / Brintakis, Konstantinos / Daskalakis, Stylianos / Stratakis, Emmanuel

    Nanoscale

    2024  Volume 16, Issue 13, Page(s) 6455–6463

    Abstract: We report that the direct conjugation of metal halide perovskite nanocrystals on rGO sheets can provide high performance and stable electrodes for Zn-ion capacitors. It is the first time that metal halide nanocrystals have been used to enhance the energy ...

    Abstract We report that the direct conjugation of metal halide perovskite nanocrystals on rGO sheets can provide high performance and stable electrodes for Zn-ion capacitors. It is the first time that metal halide nanocrystals have been used to enhance the energy storage of 2D materials in capacitors by introducing an additional pseudocapacitance mechanism. In particular, we present a simple, rapid and room temperature laser-induced method to anchor CsPbBr
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr05552c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Laser-Assisted Fabrication for Metal Halide Perovskite-2D Nanoconjugates: Control on the Nanocrystal Density and Morphology.

    Kostopoulou, Athanasia / Brintakis, Konstantinos / Serpetzoglou, Efthymis / Stratakis, Emmanuel

    Nanomaterials (Basel, Switzerland)

    2020  Volume 10, Issue 4

    Abstract: We report on a facile and rapid photo-induced process to conjugate graphene-based materials with metal-halide perovskite nanocrystals. We show that a small number of laser pulses is sufficient to decorate the 2-dimensional (2D) flakes with metal-halide ... ...

    Abstract We report on a facile and rapid photo-induced process to conjugate graphene-based materials with metal-halide perovskite nanocrystals. We show that a small number of laser pulses is sufficient to decorate the 2-dimensional (2D) flakes with metal-halide nanocrystals without affecting their primary morphology. At the same time, the density of anchored nanocrystals could be finely tuned by the number of irradiation pulses. This facile and rapid room temperature method provides unique opportunities for the design and development of perovskite-2D nanoconjugates, exhibiting synergetic functionality by combining nanocrystals of different morphologies and chemical phases with various 2D materials.
    Language English
    Publishing date 2020-04-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano10040747
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Interruption of p53-MDM2 Interaction by Nutlin-3a in Human Lymphoma Cell Models Initiates a Cell-Dependent Global Effect on Transcriptome and Proteome Level.

    Psatha, Konstantina / Kollipara, Laxmikanth / Drakos, Elias / Deligianni, Elena / Brintakis, Konstantinos / Patsouris, Eustratios / Sickmann, Albert / Rassidakis, George Z / Aivaliotis, Michalis

    Cancers

    2023  Volume 15, Issue 15

    Abstract: In most lymphomas, p53 signaling pathway is inactivated by various mechanisms independent to p53 gene mutations or deletions. In many cases, p53 function is largely regulated by alterations in the protein abundance levels by the action of E3 ubiquitin- ... ...

    Abstract In most lymphomas, p53 signaling pathway is inactivated by various mechanisms independent to p53 gene mutations or deletions. In many cases, p53 function is largely regulated by alterations in the protein abundance levels by the action of E3 ubiquitin-protein ligase MDM2, targeting p53 to proteasome-mediated degradation. In the present study, an integrating transcriptomics and proteomics analysis was employed to investigate the effect of p53 activation by a small-molecule MDM2-antagonist, nutlin-3a, on three lymphoma cell models following p53 activation. Our analysis revealed a system-wide nutlin-3a-associated effect in all examined lymphoma types, identifying in total of 4037 differentially affected proteins involved in a plethora of pathways, with significant heterogeneity among lymphomas. Our findings include known p53-targets and novel p53 activation effects, involving transcription, translation, or degradation of protein components of pathways, such as a decrease in key members of PI3K/mTOR pathway, heat-shock response, and glycolysis, and an increase in key members of oxidative phoshosphorylation, autophagy and mitochondrial translation. Combined inhibition of HSP90 or PI3K/mTOR pathway with nutlin-3a-mediated p53-activation enhanced the apoptotic effects suggesting a promising strategy against human lymphomas. Integrated omic profiling after p53 activation offered novel insights on the regulatory role specific proteins and pathways may have in lymphomagenesis.
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15153903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Highly luminescent and ultrastable cesium lead bromide perovskite patterns generated in phosphate glass matrices.

    Konidakis, Ioannis / Brintakis, Konstantinos / Kostopoulou, Athanasia / Demeridou, Ioanna / Kavatzikidou, Paraskevi / Stratakis, Emmanuel

    Nanoscale

    2020  Volume 12, Issue 25, Page(s) 13697–13707

    Abstract: Owing to their exceptional optoelectronic properties, all-inorganic lead halide perovskites offer enormous potential for next generation photonic, light-emitting, and optoelectronic devices. However, their usage is significantly limited by their poor ... ...

    Abstract Owing to their exceptional optoelectronic properties, all-inorganic lead halide perovskites offer enormous potential for next generation photonic, light-emitting, and optoelectronic devices. However, their usage is significantly limited by their poor stability upon moisture exposure and lead toxicity issues. Moreover, many of the aforementioned applications rely on the development of confined perovskite patterns of various shapes and periodicities. Here we report a simple and low-temperature method enabling the controlled incorporation of photoluminescent all-inorganic metal halide PNCs into a silver phosphate glass (AgPO3) matrix which is transparent in most of the visible range. The developed fabrication protocol is based on a simple melting encapsulation process in which pre-synthesized perovskite crystals are inserted in the glass matrix, following the initial glass quenching. Using this novel approach, two types of composite perovskite glasses are prepared, one that hosts perovskite isles and the second in which a thin perovskite layer is embedded beneath the glass surface. Both types of composite glasses exhibit remarkable photoluminescence stability when compared to the ambient air-exposed perovskite crystals. More importantly, by means of a simple and fast cw-laser processing technique, we demonstrate the development of encapsulated dotted perovskite micropatterns within the composite perovskite glass. The ability of the proposed system to resolve stability and lead toxicity issues, coupled with the facile formation of highly luminescent perovskite patterns pave the way towards the broad exploitation of perovskite crystals in photonic applications.
    Language English
    Publishing date 2020-06-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d0nr03254a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Laser-Induced Morphological and Structural Changes of Cesium Lead Bromide Nanocrystals.

    Kostopoulou, Athanasia / Brintakis, Konstantinos / Sygletou, Maria / Savva, Kyriaki / Livakas, Nikolaos / Pantelaiou, Michaila Akathi / Dang, Zhiya / Lappas, Alexandros / Manna, Liberato / Stratakis, Emmanuel

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 4

    Abstract: Metal halide perovskite nanocrystals, an emerging class of materials for advanced photonic and optoelectronic applications, are mainly fabricated with colloidal chemistry routes. On the quest for new properties according to application needs, new ... ...

    Abstract Metal halide perovskite nanocrystals, an emerging class of materials for advanced photonic and optoelectronic applications, are mainly fabricated with colloidal chemistry routes. On the quest for new properties according to application needs, new perovskite systems of various morphologies and levels of doping and alloying have been developed, often also involving post-synthesis reactions. Recently, laser irradiation in liquids has been utilized as a fast method to synthesize or transform materials and interesting laser-induced transformations on nanocrystals were induced. These studies in general have been limited to small nanocrystals (~15 nm). In the case of halide perovskites, fragmentation or anion exchange have been observed in such laser-based processes, but no crystal structure transformations were actually observed or deliberately studied. Nanocrystals are more sensitive to light exposure compared to the corresponding bulk crystals. Additional factors, such as size, morphology, the presence of impurities, and others, can intricately affect the photon absorption and heat dissipation in nanocrystal suspensions during laser irradiation. All these factors can play an important role in the final morphologies and in the time required for these transformations to unfold. In the present work, we have employed a 513 nm femtosecond (fs) laser to induce different transformations in large nanocrystals, in which two phases coexist in the same particle (Cs
    Language English
    Publishing date 2022-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12040703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Iron Oxide Colloidal Nanoclusters as Theranostic Vehicles and Their Interactions at the Cellular Level.

    Kostopoulou, Athanasia / Brintakis, Konstantinos / Fragogeorgi, Eirini / Anthousi, Amalia / Manna, Liberato / Begin-Colin, Sylvie / Billotey, Claire / Ranella, Anthi / Loudos, George / Athanassakis, Irene / Lappas, Alexandros

    Nanomaterials (Basel, Switzerland)

    2018  Volume 8, Issue 5

    Abstract: Advances in surfactant-assisted chemical approaches have led the way for the exploitation of nanoscale inorganic particles in medical diagnosis and treatment. In this field, magnetically-driven multimodal nanotools that perform both detection and therapy, ...

    Abstract Advances in surfactant-assisted chemical approaches have led the way for the exploitation of nanoscale inorganic particles in medical diagnosis and treatment. In this field, magnetically-driven multimodal nanotools that perform both detection and therapy, well-designed in size, shape and composition, are highly advantageous. Such a theranostic material—which entails the controlled assembly of smaller (maghemite) nanocrystals in a secondary motif that is highly dispersible in aqueous media—is discussed here. These surface functionalized, pomegranate-like ferrimagnetic nanoclusters (40⁻85 nm) are made of nanocrystal subunits that show a remarkable magnetic resonance imaging contrast efficiency, which is better than that of the superparamagnetic contrast agent Endorem
    Language English
    Publishing date 2018-05-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano8050315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Vacancy-driven non-cubic local structure and magnetic anisotropy tailoring in Fe$_x$O-Fe$_{3-\delta}$O$_4$ nanocrystals

    Lappas, Alexandros / Antonaropoulos, George / Brintakis, Konstantinos / Vasilakaki, Marianna / Trohidou, Kalliopi N. / Iannotti, Vincenzo / Ausanio, Giovanni / Kostopoulou, Athanasia / Abeykoon, Milinda / Robinson, Ian K. / Bozin, Emil S.

    2020  

    Abstract: In contrast to bulk materials, nanoscale crystal growth is critically influenced by size- and shape-dependent properties. However, it is challenging to decipher how stoichiometry, in the realm of mixed-valence elements, can act to control physical ... ...

    Abstract In contrast to bulk materials, nanoscale crystal growth is critically influenced by size- and shape-dependent properties. However, it is challenging to decipher how stoichiometry, in the realm of mixed-valence elements, can act to control physical properties, especially when complex bonding is implicated by short and long-range ordering of structural defects. Here, solution-grown iron-oxide nanocrystals (NCs) of the pilot wustite system are found to convert into iron-deficient rock-salt and ferro-spinel sub-domains, but attain a surprising tetragonally distorted local structure. Cationic vacancies within chemically uniform NCs are portrayed as the parameter to tweak the underlying properties. These lattice imperfections are shown to produce local exchange-anisotropy fields that reinforce the nanoparticles magnetization and overcome the influence of finite-size effects. The concept of atomic-scale defect control in subcritical size NCs, aspires to become a pathway to tailor-made properties with improved performance for hyperthermia heating over defect-free NCs.

    Comment: 20 pages, 9 figures, Supplemental Material
    Keywords Condensed Matter - Materials Science
    Subject code 530
    Publishing date 2020-05-16
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Colloidal assemblies of oriented maghemite nanocrystals and their NMR relaxometric properties.

    Kostopoulou, Athanasia / Velu, Sabareesh K P / Thangavel, Kalaivani / Orsini, Francesco / Brintakis, Konstantinos / Psycharakis, Stylianos / Ranella, Anthi / Bordonali, Lorenzo / Lappas, Alexandros / Lascialfari, Alessandro

    Dalton transactions (Cambridge, England : 2003)

    2014  Volume 43, Issue 22, Page(s) 8395–8404

    Abstract: An elevated-temperature polyol-based colloidal-chemistry approach allows for the development of size-tunable (50 and 86 nm) assemblies of maghemite iso-oriented nanocrystals, with enhanced magnetization. (1)H-nuclear magnetic resonance (NMR) relaxometric ...

    Abstract An elevated-temperature polyol-based colloidal-chemistry approach allows for the development of size-tunable (50 and 86 nm) assemblies of maghemite iso-oriented nanocrystals, with enhanced magnetization. (1)H-nuclear magnetic resonance (NMR) relaxometric experiments show that the ferrimagnetic cluster-like colloidal entities exhibit a remarkable enhancement (4-5 times) in transverse relaxivity when compared to that of the superparamagnetic contrast agent Endorem®, over an extended frequency range (1-60 MHz). The marked increase in the transverse relaxivity r2 at a clinical magnetic field strength (∼1.41 T), which is 405.1 and 508.3 mM(-1) s(-1) for small and large assemblies, respectively, makes it possible to relate the observed response to the raised intra-aggregate magnetic material volume fraction. Furthermore, cell tests with a murine fibroblast culture medium confirmed cell viability in the presence of the clusters. We discuss the NMR dispersion profiles on the basis of relaxivity models to highlight the magneto-structural characteristics of the materials for improved T2-weighted magnetic resonance images.
    MeSH term(s) Animals ; Cell Culture Techniques ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Colloids ; Ferric Compounds/chemistry ; Ferric Compounds/toxicity ; Hydrophobic and Hydrophilic Interactions ; Magnetic Phenomena ; Magnetic Resonance Spectroscopy ; Mice ; Microscopy, Electron, Transmission ; NIH 3T3 Cells ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Particle Size ; Surface Properties
    Chemical Substances Colloids ; Ferric Compounds ; ferric oxide (1K09F3G675)
    Language English
    Publishing date 2014-06-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c4dt00024b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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