LIVIVO - Search results -

Search results

Result 1 - 10 of total 30

Search options

Article ; Online: CAR-T cells and CAR-Tregs targeting conventional type-1 dendritic cell suppress experimental autoimmune encephalomyelitis.

Moorman, Cody D / Yu, Sherman / Briseno, Carlos G / Phee, Hyewon / Sahoo, Anupama / Ramrakhiani, Ambika / Chaudhry, Ashutosh

Frontiers in immunology

2023 Volume 14, Page(s) 1235222

Abstract: Conventional type 1 dendritic cells (DC1) contribute to the development of pathogenic T helper type 1 (Th1) cells in ... ...

Abstract	Conventional type 1 dendritic cells (DC1) contribute to the development of pathogenic T helper type 1 (Th1) cells in part
MeSH term(s)	Mice ; Animals ; Encephalomyelitis, Autoimmune, Experimental ; CD8-Positive T-Lymphocytes/pathology ; Cytokines/metabolism ; Th1 Cells ; Dendritic Cells
Chemical Substances	Cytokines
Language	English
Publishing date	2023-10-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1235222
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Bcl6

O'Connor, Kevin W / Liu, Tiantian / Kim, Sunkyung / Briseño, Carlos G / Georgopoulos, Katia / Murphy, Theresa L / Murphy, Kenneth M

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 35, Page(s) e2220853120

Abstract: ... ...

Abstract	Ly6C
MeSH term(s)	Monocytes ; Endothelium, Vascular ; Hematopoiesis ; Signal Transduction
Language	English
Publishing date	2023-08-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2220853120
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Development, Diversity, and Function of Dendritic Cells in Mouse and Human.

Anderson, David A / Murphy, Kenneth M / Briseño, Carlos G

Cold Spring Harbor perspectives in biology

2018 Volume 10, Issue 11

Abstract: The study of murine dendritic cell (DC) development has been integral to the identification of specialized DC subsets that have unique requirements for their form and function. Advances in the field have also provided a framework for the identification ... ...

Abstract	The study of murine dendritic cell (DC) development has been integral to the identification of specialized DC subsets that have unique requirements for their form and function. Advances in the field have also provided a framework for the identification of human DC counterparts, which appear to have conserved mechanisms of development and function. Multiple transcription factors are expressed in unique combinations that direct the development of classical DCs (cDCs), which include two major subsets known as cDC1s and cDC2s, and plasmacytoid DCs (pDCs). pDCs are potent producers of type I interferons and thus these cells are implicated in immune responses that depend on this cytokine. Mouse models deficient in the cDC1 lineage have revealed their importance in directing immune responses to intracellular bacteria, viruses, and cancer through the cross-presentation of cell-associated antigen. Models of transcription factor deficiency have been used to identify subsets of cDC2 that are required for T helper (Th)2 and Th17 responses to certain pathogens; however, no single factor is known to be absolutely required for the development of the complete cDC2 lineage. In this review, we will discuss the current state of knowledge of mouse and human DC development and function and highlight areas in the field that remain unresolved.
MeSH term(s)	Animals ; Bone Marrow Cells ; Cell Differentiation ; Cytokines/genetics ; Cytokines/metabolism ; Dendritic Cells/classification ; Dendritic Cells/physiology ; Gene Expression Regulation/physiology ; Humans ; Mice
Chemical Substances	Cytokines
Language	English
Publishing date	2018-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1943-0264
ISSN (online)	1943-0264
DOI	10.1101/cshperspect.a028613
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages.

Gonzalez, Michael A / Lu, Daniel R / Yousefi, Maryam / Kroll, Ashley / Lo, Chen Hao / Briseño, Carlos G / Watson, J E Vivienne / Novitskiy, Sergey / Arias, Vanessa / Zhou, Hong / Plata Stapper, Andres / Tsai, Min K / Ashkin, Emily L / Murray, Christopher W / Li, Chi-Ming / Winslow, Monte M / Tarbell, Kristin V

The Journal of experimental medicine

2023 Volume 220, Issue 6

Abstract: Phagocytosis is a key macrophage function, but how phagocytosis shapes tumor-associated macrophage (TAM) phenotypes and heterogeneity in solid tumors remains unclear. Here, we utilized both syngeneic and novel autochthonous lung tumor models in which ... ...

Abstract	Phagocytosis is a key macrophage function, but how phagocytosis shapes tumor-associated macrophage (TAM) phenotypes and heterogeneity in solid tumors remains unclear. Here, we utilized both syngeneic and novel autochthonous lung tumor models in which neoplastic cells express the fluorophore tdTomato (tdTom) to identify TAMs that have phagocytosed neoplastic cells in vivo. Phagocytic tdTompos TAMs upregulated antigen presentation and anti-inflammatory proteins, but downregulated classic proinflammatory effectors compared to tdTomneg TAMs. Single-cell transcriptomic profiling identified TAM subset-specific and common gene expression changes associated with phagocytosis. We uncover a phagocytic signature that is predominated by oxidative phosphorylation (OXPHOS), ribosomal, and metabolic genes, and this signature correlates with worse clinical outcome in human lung cancer. Expression of OXPHOS proteins, mitochondrial content, and functional utilization of OXPHOS were increased in tdTompos TAMs. tdTompos tumor dendritic cells also display similar metabolic changes. Our identification of phagocytic TAMs as a distinct myeloid cell state links phagocytosis of neoplastic cells in vivo with OXPHOS and tumor-promoting phenotypes.
MeSH term(s)	Humans ; Macrophages/metabolism ; Phagocytosis/genetics ; Lung Neoplasms/pathology ; Myeloid Cells/metabolism ; Oxidative Stress ; Tumor Microenvironment
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20221472
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 45: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Complementary diversification of dendritic cells and innate lymphoid cells.

Briseño, Carlos G / Murphy, Theresa L / Murphy, Kenneth M

Current opinion in immunology

2014 Volume 29, Page(s) 69–78

Abstract: Dendritic cells (DCs) are professional antigen presenting cells conventionally thought to mediate cellular adaptive immune responses. Recent studies have led to the recognition of a non-redundant role for DCs in orchestrating innate immune responses, and ...

Abstract	Dendritic cells (DCs) are professional antigen presenting cells conventionally thought to mediate cellular adaptive immune responses. Recent studies have led to the recognition of a non-redundant role for DCs in orchestrating innate immune responses, and in particular, for DC subset-specific interactions with innate lymphoid cells (ILCs). Recently recognized as important effectors of early immune responses, ILCs develop into subsets which mirror the transcriptional and cytokine profile of their T cell subset counterparts. DC diversification into functional subsets provides for modules of pathogen sensing and cytokine production that direct pathogen-appropriate ILC and T cell responses. This review focuses on the recent advances in the understanding of DC development, and their function in orchestrating the innate immune modules.
MeSH term(s)	Animals ; Bone Marrow/immunology ; Cytokines/immunology ; Dendritic Cells/immunology ; Homeostasis ; Humans ; Immunity, Innate ; Lymphocytes/immunology
Chemical Substances	Cytokines
Language	English
Publishing date	2014-05-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2014.04.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2773: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 13: Show issues

Order via subito

Details ▾

Article ; Online: Batf3

Theisen, Derek J / Ferris, Stephen T / Briseño, Carlos G / Kretzer, Nicole / Iwata, Arifumi / Murphy, Kenneth M / Murphy, Theresa L

Cancer immunology research

2018 Volume 7, Issue 1, Page(s) 29–39

Abstract: The BATF3-dependent cDC1 lineage of conventional dendritic cells (cDC) is required for rejection of immunogenic sarcomas and for rejection of progressive sarcomas during checkpoint blockade therapy. One unique function of the cDC1 lineage is the ... ...

Abstract	The BATF3-dependent cDC1 lineage of conventional dendritic cells (cDC) is required for rejection of immunogenic sarcomas and for rejection of progressive sarcomas during checkpoint blockade therapy. One unique function of the cDC1 lineage is the efficient cross-presentation of tumor-derived neoantigens to CD8
MeSH term(s)	Animals ; Basic-Leucine Zipper Transcription Factors/genetics ; Cell Line, Tumor ; Dendritic Cells/immunology ; Female ; Fibrosarcoma/genetics ; Fibrosarcoma/immunology ; Graft Rejection/genetics ; Graft Rejection/immunology ; Interferon Regulatory Factors/genetics ; Lymph Nodes/immunology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Oligonucleotide Array Sequence Analysis ; Repressor Proteins/genetics ; Spleen/immunology
Chemical Substances	Basic-Leucine Zipper Transcription Factors ; Interferon Regulatory Factors ; Repressor Proteins ; SNFT protein, mouse ; interferon regulatory factor-8
Language	English
Publishing date	2018-11-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2732489-8
ISSN	2326-6074 ; 2326-6066
ISSN (online)	2326-6074
ISSN	2326-6066
DOI	10.1158/2326-6066.CIR-18-0138
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 7022: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: cDC1 prime and are licensed by CD4

Ferris, Stephen T / Durai, Vivek / Wu, Renee / Theisen, Derek J / Ward, Jeffrey P / Bern, Michael D / Davidson, Jesse T / Bagadia, Prachi / Liu, Tiantian / Briseño, Carlos G / Li, Lijin / Gillanders, William E / Wu, Gregory F / Yokoyama, Wayne M / Murphy, Theresa L / Schreiber, Robert D / Murphy, Kenneth M

Nature

2020 Volume 584, Issue 7822, Page(s) 624–629

Abstract: Conventional type 1 dendritic cells (cDC1) ...

Abstract	Conventional type 1 dendritic cells (cDC1)
MeSH term(s)	Animals ; Antigen Presentation/immunology ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; CD40 Antigens/immunology ; CD40 Antigens/metabolism ; CD8-Positive T-Lymphocytes/immunology ; Cross-Priming ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Female ; Histocompatibility Antigens Class II/immunology ; Mice ; Neoplasms/immunology ; Signal Transduction
Chemical Substances	CD40 Antigens ; Histocompatibility Antigens Class II
Language	English
Publishing date	2020-08-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-020-2611-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Notch2-dependent DC2s mediate splenic germinal center responses.

Briseño, Carlos G / Satpathy, Ansuman T / Davidson, Jesse T / Ferris, Stephen T / Durai, Vivek / Bagadia, Prachi / O'Connor, Kevin W / Theisen, Derek J / Murphy, Theresa L / Murphy, Kenneth M

Proceedings of the National Academy of Sciences of the United States of America

2018 Volume 115, Issue 42, Page(s) 10726–10731

Abstract: ... ...

Abstract	CD4
MeSH term(s)	Animals ; Antigen Presentation/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Differentiation ; Cells, Cultured ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Erythrocytes/immunology ; Germinal Center/immunology ; Germinal Center/metabolism ; Immunity, Humoral/immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptor, Notch2/physiology ; Sheep ; Signal Transduction ; Spleen/immunology ; Spleen/metabolism ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/metabolism
Chemical Substances	Notch2 protein, mouse ; Receptor, Notch2
Language	English
Publishing date	2018-10-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1809925115
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin.

Satpathy, Ansuman T / Brown, Ryanne A / Gomulia, Ellen / Briseño, Carlos G / Mumbach, Maxwell R / Pan, Zenggang / Murphy, Kenneth M / Natkunam, Yasodha / Chang, Howard Y / Kim, Jinah

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2018 Volume 31, Issue 9, Page(s) 1479–1486

Abstract: Distinguishing classical dendritic cells from other myeloid cell types is complicated by the shared expression of cell surface markers. ZBTB46 is a zinc finger and BTB domain-containing transcription factor, which is expressed by dendritic cells and ... ...

Abstract	Distinguishing classical dendritic cells from other myeloid cell types is complicated by the shared expression of cell surface markers. ZBTB46 is a zinc finger and BTB domain-containing transcription factor, which is expressed by dendritic cells and committed dendritic cell precursors, but not by plasmacytoid dendritic cells, monocytes, macrophages, or other immune cell populations. In this study, we demonstrate that expression of ZBTB46 identifies human dendritic cell neoplasms. We examined ZBTB46 expression in a range of benign and malignant histiocytic disorders and found that ZBTB46 is able to clearly define the dendritic cell identity of many previously unclassified histiocytic disease subtypes. In particular, all examined cases of Langerhans cell histiocytosis and histiocytic sarcoma expressed ZBTB46, while all cases of blastic plasmacytoid dendritic cell neoplasm, chronic myelomonocytic leukemia, juvenile xanthogranuloma, Rosai-Dorfman disease, and Erdheim-Chester disease failed to demonstrate expression of ZBTB46. Moreover, ZBTB46 expression clarified the identity of diagnostically challenging neoplasms, such as cases of indeterminate cell histiocytosis, classifying a fraction of these entities as dendritic cell malignancies. These findings clarify the lineage origins of human histiocytic disorders and distinguish dendritic cell disorders from all other myeloid neoplasms.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Dendritic Cells/metabolism ; Dendritic Cells/pathology ; Diagnosis, Differential ; Female ; Histiocytosis/diagnosis ; Histiocytosis/metabolism ; Histiocytosis/pathology ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Myeloid Cells/metabolism ; Myeloid Cells/pathology ; Transcription Factors/metabolism ; Young Adult
Chemical Substances	Transcription Factors ; Zbtb46 protein, human
Language	English
Publishing date	2018-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1038/s41379-018-0052-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2450: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Altered compensatory cytokine signaling underlies the discrepancy between

Durai, Vivek / Bagadia, Prachi / Briseño, Carlos G / Theisen, Derek J / Iwata, Arifumi / Davidson, Jesse T / Gargaro, Marco / Fremont, Daved H / Murphy, Theresa L / Murphy, Kenneth M

The Journal of experimental medicine

2018 Volume 215, Issue 5, Page(s) 1417–1435

Abstract: The receptor Flt3 and its ligand Flt3L are both critical for dendritic cell (DC) development, but DC deficiency is more severe ... ...

Abstract	The receptor Flt3 and its ligand Flt3L are both critical for dendritic cell (DC) development, but DC deficiency is more severe in
MeSH term(s)	Animals ; Bone Marrow/drug effects ; Bone Marrow/metabolism ; Cytokines/metabolism ; Dendritic Cells/drug effects ; Dendritic Cells/metabolism ; Gene Deletion ; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology ; Membrane Proteins/deficiency ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Proto-Oncogene Proteins c-kit/metabolism ; Receptor, Macrophage Colony-Stimulating Factor/metabolism ; Signal Transduction/drug effects ; Stem Cell Factor/pharmacology ; Stem Cells/cytology ; Stem Cells/drug effects ; Transcription, Genetic/drug effects ; fms-Like Tyrosine Kinase 3/deficiency ; fms-Like Tyrosine Kinase 3/metabolism
Chemical Substances	Cytokines ; Membrane Proteins ; Stem Cell Factor ; flt3 ligand protein ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; Flt3 protein, mouse (EC 2.7.10.1) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1) ; Receptor, Macrophage Colony-Stimulating Factor (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
Language	English
Publishing date	2018-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20171784
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 45: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito