LIVIVO - Search results -

Search results

Result 1 - 10 of total 33

Search options

Article ; Online: Looking at the rim in multiple sclerosis: new MRI-based biomarkers may open our eyes to the disease's evolution.

Brisset, Jean-Christophe / Cotton, François

2023 Volume 34, Issue 2, Page(s) 1334–1336

MeSH term(s)	Humans ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/pathology ; Magnetic Resonance Imaging ; Eye ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-12-20
Publishing country	Germany
Document type	Editorial ; Comment
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-10482-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3300: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Update on brain MRI for the diagnosis and follow-up of MS patients.

Brisset, Jean-Christophe / Vukusic, Sandra / Cotton, Francois

Presse medicale (Paris, France : 1983)

2021 Volume 50, Issue 2, Page(s) 104067

Abstract: Over the past decades, MRI has become a major tool in the diagnosis and the follow-up of patients with multiple sclerosis (MS), especially for monitoring the effectiveness of therapy. The recent international recommendations issued for the ... ...

Abstract	Over the past decades, MRI has become a major tool in the diagnosis and the follow-up of patients with multiple sclerosis (MS), especially for monitoring the effectiveness of therapy. The recent international recommendations issued for the standardization of neurological and radiological clinical practices converge on many points. In this setting, recommendations made by the "Observatoire français de la sclérose en plaques", the French MS registry, can be distinguished by its interdisciplinary complementarity, its longevity, its size, and its positions in direct connection with the clinic. Hence, after suspicions of gadolinium deposition in the brain, with multiple warning from the American and European health authorities, a national consultation took place and resulted in limitation to useful injections. The precautionary principle prevailing, the patient receives a limited quantity of contrast product even if no clinically harmful manifestation has been detected to date. The result of this round table bringing together neurologists and neuroradiologists from specialized centers was published in the form of a recommendation in early 2020. The interest of this project also lies in the constant improvement of the management of patients with MS and the possibility of developing advanced techniques to assist the clinician. The aim of this review is to explain to the neurologist, the interest of following this imaging protocol both in his/her clinical practice and in the possibilities that this opens up.
MeSH term(s)	Brain/diagnostic imaging ; Brain/metabolism ; Contrast Media/administration & dosage ; Contrast Media/adverse effects ; Contrast Media/pharmacokinetics ; Follow-Up Studies ; Gadolinium/administration & dosage ; Gadolinium/adverse effects ; Gadolinium/pharmacokinetics ; Humans ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/standards ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/therapy ; Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging ; Multiple Sclerosis, Relapsing-Remitting/therapy ; Practice Guidelines as Topic/standards ; Registries ; Treatment Outcome
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2021-05-11
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2021.104067
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 794: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Ua VI Zs.87: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Emerging MR Imaging and Spectroscopic Methods to Study Brain Tumor Metabolism.

Kumar, Manoj / Nanga, Ravi Prakash Reddy / Verma, Gaurav / Wilson, Neil / Brisset, Jean Christophe / Nath, Kavindra / Chawla, Sanjeev

Frontiers in neurology

2022 Volume 13, Page(s) 789355

Abstract: Proton magnetic resonance spectroscopy ( ...

Abstract	Proton magnetic resonance spectroscopy (
Language	English
Publishing date	2022-03-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.789355
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Contribution of diffusion-weighted imaging to distinguish herpetic encephalitis from auto-immune encephalitis at an early stage.

Bani-Sadr, Alexandre / Ruitton-Allinieu, Marie-Camille / Brisset, Jean-Christophe / Ducray, François / Joubert, Bastien / Picard, Géraldine / Cotton, François

Journal of neuroradiology = Journal de neuroradiologie

2022 Volume 50, Issue 3, Page(s) 288–292

Abstract: Objectives: To determine whether diffusion-weighted imaging (DWI) can help to distinguish early stage autoimmune (AI) and herpes simplex virus (HSV) encephalitides.: Methods: This case-control study included patients from a multi-center cohort of AI ... ...

Abstract	Objectives: To determine whether diffusion-weighted imaging (DWI) can help to distinguish early stage autoimmune (AI) and herpes simplex virus (HSV) encephalitides. Methods: This case-control study included patients from a multi-center cohort of AI encephalitides whose initial MRI including DWI was performed within ten days after symptoms onset. They were compared with patients with HSV encephalitis enrolled prospectively in a single-center from June, 2020 to December, 2020. The final diagnosis of AI encephalitis required a positive autoantibody assay, and that of HSV encephalitis required a positive HSV polymerase chain reaction based on cerebrospinal fluid. Brain MRI were evaluated for restricted diffusion, fluid-inversion recovery (FLAIR) abnormalities, lesion topography, hemorrhagic changes, and contrast enhancement. Results: Forty-nine patients were included of which, 19 (38.8%) had AI encephalitis. Twenty-seven patients (55.1%) were males and the median age was 46.0 years (interquartile range (IQR):[22.0; 65.0]). Brain MRI were performed after a median of 4 days (IQR:[2.0; 7.0]) of symptom onset and time between symptom onset and MRI was not significantly different (p = 0.60). Twenty-six patients had restricted diffusion lesions in the medial temporal lobe, including 25/30 in the HSV encephalitis group (p < 0.001). FLAIR abnormalities were observed in 36 patients, including 29/30 in the HSV encephalitis group (p < 0.001). Lesion topography, hemorrhagic changes, and contrast enhancement did not differ significantly between the two groups. Conclusion: Our results suggest that restricted diffusion lesions in the medial temporal lobe are a hallmark of HSV encephalitis and may help distinguish it from early-stage AI encephalitis.
MeSH term(s)	Male ; Humans ; Middle Aged ; Female ; Encephalitis, Herpes Simplex/diagnostic imaging ; Encephalitis, Herpes Simplex/cerebrospinal fluid ; Case-Control Studies ; Diffusion Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2022-05-31
Publishing country	France
Document type	Journal Article
ZDB-ID	131763-5
ISSN	1773-0406 ; 0150-9861
ISSN (online)	1773-0406
ISSN	0150-9861
DOI	10.1016/j.neurad.2022.05.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1062: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Cerebral vasculitis of medium-sized vessels as a possible mechanism of brain damage in COVID-19 patients.

Lersy, François / Anheim, Mathieu / Willaume, Thibault / Chammas, Agathe / Brisset, Jean-Christophe / Cotton, François / Kremer, Stéphane

Journal of neuroradiology = Journal de neuroradiologie

2020 Volume 48, Issue 3, Page(s) 141–146

Abstract: Background and purpose: Cerebral complications related to COVID-19 were recently reported, and the underlying mechanisms of brain damage remain uncertain, probably multifactorial. Among various hypotheses suggested, a possible vasculitis was issued but ... ...

Abstract	Background and purpose: Cerebral complications related to COVID-19 were recently reported, and the underlying mechanisms of brain damage remain uncertain, probably multifactorial. Among various hypotheses suggested, a possible vasculitis was issued but never confirmed. Herein, we aimed to describe brain MRIs focused on the intracranial vessel wall in a population of COVID-19 patients with neurologic manifestations. Materials and methods: Between March 1 and May 31, 2020, 69 consecutive COVID-19 patients with neurologic manifestations underwent a brain MRI allowing the study of the intracranial vessel wall at Strasbourg University hospitals and were retrospectively included. During the same period, 25 consecutive patients, without suspicion of SARS-CoV-2 infection, underwent a brain MRI urgently, with the same imaging protocols. A vasculitis seemed likely when imaging demonstrated vessel wall thickening with homogeneous and concentric enhancement. Results: Among the 69 COVID-19 patients included, 11 (16%) presented arterial vessel wall thickening with homogeneous and concentric enhancement, compatible with cerebral vasculitis. These neuroimaging findings were not found among the 25 patients without SARS-CoV-2 infection, and the difference was statistically significant (p = 0.03). Middle cerebral arteries, basilar artery, and posterior cerebral arteries were the most frequent vessels involved. For nine of them, imaging demonstrated ischemic or hemorrhagic complications. Conclusion: Cerebral vasculitis of medium-sized vessels seems to be one of the mechanisms at the origin of brain damage related to COVID-19.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Brain/diagnostic imaging ; COVID-19/complications ; COVID-19/diagnostic imaging ; Female ; Humans ; Magnetic Resonance Angiography ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuroimaging ; Retrospective Studies ; Vasculitis, Central Nervous System/diagnostic imaging ; Vasculitis, Central Nervous System/etiology ; Young Adult
Language	English
Publishing date	2020-12-16
Publishing country	France
Document type	Journal Article
ZDB-ID	131763-5
ISSN	1773-0406 ; 0150-9861
ISSN (online)	1773-0406
ISSN	0150-9861
DOI	10.1016/j.neurad.2020.11.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1062: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Susceptibility weighted imaging and quantitative susceptibility mapping of the cerebral vasculature using ferumoxytol.

Liu, Saifeng / Brisset, Jean-Christophe / Hu, Jiani / Haacke, E Mark / Ge, Yulin

Journal of magnetic resonance imaging : JMRI

2017 Volume 47, Issue 3, Page(s) 621–633

Abstract: Purpose: To demonstrate the potential of imaging cerebral arteries and veins with ferumoxytol using susceptibility weighted imaging (SWI) and quantitative susceptibility mapping (QSM).: Materials and methods: The relationships between ferumoxytol ... ...

Abstract	Purpose: To demonstrate the potential of imaging cerebral arteries and veins with ferumoxytol using susceptibility weighted imaging (SWI) and quantitative susceptibility mapping (QSM). Materials and methods: The relationships between ferumoxytol concentration and the apparent susceptibility at 1.5T, 3T, and 7T were determined using phantom data; the ability of visualizing subvoxel vessels was evaluated using simulations; and the feasibility of using ferumoxytol to enhance the visibility of small vessels was confirmed in three healthy volunteers at 7T(with doses 1 mg/kg to 4 mg/kg). The visualization of the lenticulostriate arteries and the medullary veins was assessed by two raters and the contrast-to-noise ratios (CNRs) of these vessels were measured. Results: The relationship between ferumoxytol concentration and susceptibility was linear with a slope 13.3 ± 0.2 ppm·mg Conclusion: The CNR for cerebral vessels with ferumoxytol can be enhanced using SWI, and the apparent susceptibilities of the arteries can be reliably quantified using QSM. This approach improves the imaging of the entire vascular system outside the capillaries and may be valuable for a variety of neurodegenerative diseases which involve the microvasculature. Level of evidence: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:621-633.
MeSH term(s)	Adult ; Brain/blood supply ; Brain/diagnostic imaging ; Brain/physiology ; Cerebral Arteries/diagnostic imaging ; Cerebral Arteries/physiology ; Female ; Ferrosoferric Oxide ; Humans ; Image Enhancement/methods ; Image Processing, Computer-Assisted/methods ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging/methods ; Middle Aged ; Phantoms, Imaging ; Reference Values
Chemical Substances	Ferrosoferric Oxide (XM0M87F357)
Language	English
Publishing date	2017-07-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.25809
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3648: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 236: Show issues

Order via subito

Details ▾

Article ; Online: Longitudinal study of multiple sclerosis lesions using ultra-high field (7T) multiparametric MR imaging.

Chawla, Sanjeev / Kister, Ilya / Sinnecker, Tim / Wuerfel, Jens / Brisset, Jean-Christophe / Paul, Friedemann / Ge, Yulin

PloS one

2018 Volume 13, Issue 9, Page(s) e0202918

Abstract: Pathophysiology of multiple sclerosis (MS) lesions is dynamic and changes over time. The purpose of this exploratory study was to determine the longitudinal changes in MS lesions over time on ultra-high field MR imaging. Nine patients with MS underwent ... ...

Abstract	Pathophysiology of multiple sclerosis (MS) lesions is dynamic and changes over time. The purpose of this exploratory study was to determine the longitudinal changes in MS lesions over time on ultra-high field MR imaging. Nine patients with MS underwent high-resolution 3D-susceptibility weighted imaging (SWI) and 2D-gradient-echo-T2-weighted imaging on 7T MRI at baseline and after ~2.4 years of follow-up. Morphologic imaging characteristics, signal intensity patterns and quantitative susceptibility mapping (QSM) values of lesions were recorded at both time points. Lesions were classified as "iron-laden" if they demonstrated hypointense signal on T2-weighted images and/or SWI as well as hyperintense signal on QSM. Lesions were considered "non-iron-laden" if they were hyperintense on T2*/SWI and isointense or hyperintense on QSM. Total of 162 non-iron-laden and 29 iron-laden lesions were observed at baseline. No change in baseline lesion size during follow up was recorded in 92.7%; no change in lesion-vessel relationship in 86.5%; and no change in signal intensity pattern in 96.9% of lesions. Three lesions which were non-iron-laden at baseline, exhibited iron at follow-up. In two iron-laden lesions, redistribution of iron content was observed at follow-up. Two-thirds of these iron-laden lesions showed an increase in QSM at follow-up relative to baseline, and the remaining one-third exhibited decrease in QSM. Most of the newly formed lesions (11/13, 84.6%) at follow-up were iron-laden. 7T multiparametric MRI is a useful tool for tracking the evolution of MS lesions, especially with regard to changes in iron content.
MeSH term(s)	Adult ; Aged ; Brain/diagnostic imaging ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging/instrumentation ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/physiopathology
Language	English
Publishing date	2018-09-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0202918
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: 3D-Morphomics, Morphological Features on CT scans for lung nodule malignancy diagnosis

Munoz, Elias / Baudot, Pierre / Le, Van-Khoa / Voyton, Charles / Renoust, Benjamin / Francis, Danny / Groza, Vladimir / Brisset, Jean-Christophe / Geremia, Ezequiel / Iannessi, Antoine / Liu, Yan / Huet, Benoit

2022

Abstract: Pathologies systematically induce morphological changes, thus providing a major but yet insufficiently quantified source of observables for diagnosis. The study develops a predictive model of the pathological states based on morphological features (3D- ... ...

Abstract	Pathologies systematically induce morphological changes, thus providing a major but yet insufficiently quantified source of observables for diagnosis. The study develops a predictive model of the pathological states based on morphological features (3D-morphomics) on Computed Tomography (CT) volumes. A complete workflow for mesh extraction and simplification of an organ's surface is developed, and coupled with an automatic extraction of morphological features given by the distribution of mean curvature and mesh energy. An XGBoost supervised classifier is then trained and tested on the 3D-morphomics to predict the pathological states. This framework is applied to the prediction of the malignancy of lung's nodules. On a subset of NLST database with malignancy confirmed biopsy, using 3D-morphomics only, the classification model of lung nodules into malignant vs. benign achieves 0.964 of AUC. Three other sets of classical features are trained and tested, (1) clinical relevant features gives an AUC of 0.58, (2) 111 radiomics gives an AUC of 0.976, (3) radiologist ground truth (GT) containing the nodule size, attenuation and spiculation qualitative annotations gives an AUC of 0.979. We also test the Brock model and obtain an AUC of 0.826. Combining 3D-morphomics and radiomics features achieves state-of-the-art results with an AUC of 0.978 where the 3D-morphomics have some of the highest predictive powers. As a validation on a public independent cohort, models are applied to the LIDC dataset, the 3D-morphomics achieves an AUC of 0.906 and the 3D-morphomics+radiomics achieves an AUC of 0.958, which ranks second in the challenge among deep models. It establishes the curvature distributions as efficient features for predicting lung nodule malignancy and a new method that can be applied directly to arbitrary computer aided diagnosis task. Comment: 10 pages, 7 figures
Keywords	Electrical Engineering and Systems Science - Image and Video Processing ; Computer Science - Computer Vision and Pattern Recognition ; Quantitative Biology - Quantitative Methods
Publishing date	2022-07-27
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Critical illness-associated cerebral microbleeds for patients with severe COVID-19: etiologic hypotheses.

Lersy, François / Willaume, Thibault / Brisset, Jean-Christophe / Collange, Olivier / Helms, Julie / Schneider, Francis / Chammas, Agathe / Willaume, Alexandre / Meyer, Nicolas / Anheim, Mathieu / Cotton, François / Kremer, Stéphane

Journal of neurology

2020 Volume 268, Issue 8, Page(s) 2676–2684

Abstract: Background and purpose: During the COVID-19 outbreak, the presence of extensive white matter microhemorrhages was detected by brain MRIs. The goal of this study was to investigate the origin of this atypical hemorrhagic complication.: Methods: ... ...

Abstract	Background and purpose: During the COVID-19 outbreak, the presence of extensive white matter microhemorrhages was detected by brain MRIs. The goal of this study was to investigate the origin of this atypical hemorrhagic complication. Methods: Between March 17 and May 18, 2020, 80 patients with severe COVID-19 infections were admitted for acute respiratory distress syndrome to intensive care units at the University Hospitals of Strasbourg for whom a brain MRI for neurologic manifestations was performed. 19 patients (24%) with diffuse microhemorrhages were compared to 18 control patients with COVID-19 and normal brain MRI. Results: The first hypothesis was hypoxemia. The latter seemed very likely since respiratory failure was longer and more pronounced in patients with microhemorrhages (prolonged endotracheal intubation (p = 0.0002), higher FiO Conclusions: Blood-brain barrier dysfunction secondary to hypoxemia and high concentration of uremic toxins seems to be the main mechanism leading to critical illness-associated cerebral microbleeds, and this complication remains to be frequently described in severe COVID-19 patients.
MeSH term(s)	COVID-19 ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/epidemiology ; Critical Illness ; Extracorporeal Membrane Oxygenation ; Humans ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-11-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-020-10313-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui II Zs.40: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: New OFSEP recommendations for MRI assessment of multiple sclerosis patients: Special consideration for gadolinium deposition and frequent acquisitions.

Brisset, Jean-Christophe / Kremer, Stephane / Hannoun, Salem / Bonneville, Fabrice / Durand-Dubief, Francoise / Tourdias, Thomas / Barillot, Christian / Guttmann, Charles / Vukusic, Sandra / Dousset, Vincent / Cotton, Francois

Journal of neuroradiology = Journal de neuroradiologie

2020 Volume 47, Issue 4, Page(s) 250–258

Abstract: Purpose: New multiple sclerosis (MS) disease-modifying therapies (DMTs), which exert beneficial effects through prevention of relapse, limitation of disability progression, and improvement of patients' quality of life, have recently emerged. Nonetheless, ...

Abstract	Purpose: New multiple sclerosis (MS) disease-modifying therapies (DMTs), which exert beneficial effects through prevention of relapse, limitation of disability progression, and improvement of patients' quality of life, have recently emerged. Nonetheless, these DMTs are not without associated complications (severe adverse events like. progressive multifocal leukoencephalopathy). Patient follow-up requires regular clinical evaluations and close monitoring with magnetic resonance imaging (MRI). Detection of new T2 lesions and potential brain atrophy measurements contribute to the evaluation of treatment effectiveness. Current MRI protocols for MS recommend the acquisition of an annual gadolinium (Gd) enhanced MRI, resulting in administration of high volume of contrast agents over time and Gd accumulation in the brain. Methods: A consensus report was established by neuroradiologists and neurologists from the French Observatory of MS, which aimed at reducing the number of Gd injections required during MS patient follow-up. Recommendations: The French Observatory of MS recommends the use of macrocyclic Gd enhancement at time of diagnosis, when a new DMT is introduced, at 6-month re-baseline, and when previous scans are unavailable for comparison. Gd administration can be performed as an option in case of relapse or suspicion of intercurrent disease such as progressive multifocal leukoencephalopathy. Other follow-up MRIs do not require contrast enhancement, provided current and previous MRI acquisitions follow the same standardized protocol including 3D FLAIR sequences.
MeSH term(s)	Brain/diagnostic imaging ; Consensus ; Contrast Media/adverse effects ; Gadolinium/adverse effects ; Humans ; Image Enhancement ; Magnetic Resonance Imaging ; Multiple Sclerosis/diagnostic imaging
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2020-01-31
Publishing country	France
Document type	Guideline ; Journal Article ; Review
ZDB-ID	131763-5
ISSN	1773-0406 ; 0150-9861
ISSN (online)	1773-0406
ISSN	0150-9861
DOI	10.1016/j.neurad.2020.01.083
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1062: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito