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Article: A Multi-Residue Analytical Method for Assessing the Effects of Stacking Treatment on Antimicrobial and Coccidiostat Degradation in Broiler Litter.

Efriem, Solomon / Britzi, Malka / Soback, Stefan / Sabastian, Chris / Mabjeesh, Sameer J

2024 Volume 17, Issue 2

Abstract: Antimicrobial drugs and coccidiostat compounds are commonly used in poultry farming. These compounds are subsequently excreted and released into the environment via broiler litter (BL) and can re-enter the food chain as fertilizer or animal feed. Such ... ...

Abstract	Antimicrobial drugs and coccidiostat compounds are commonly used in poultry farming. These compounds are subsequently excreted and released into the environment via broiler litter (BL) and can re-enter the food chain as fertilizer or animal feed. Such residue in animal feed can encourage the appearance of antibiotic-resistant bacteria as well as toxicity. Most analytical methods used to identify and quantitate these drug residues are traditional, and are specific to some antimicrobials and present limitations in assessing complex matrixes like BL. The aim of this study was to develop a multi-residue analytic method for assessing 30 antimicrobial drugs and coccidiostats associated with BL. We investigated the presence and the effects of biotic stack treatment on the degradation of drug residue in BL. Liquid-liquid extraction (LLE) and solid phase extraction (SPE) were replaced by Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) clean-up steps and detected by liquid chromatography mass spectrometry (LC/MS/MS). Results show that a wide spectrum of residues were detected from 0.4 to 8.9 mg kg
Language	English
Publishing date	2024-02-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17020203
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Resistant Bacteria in Broiler Litter Used as Ruminant Feed: Effect of Biotic Treatment.

Efriem, Solomon / Sabastian, Chris / Blum, Shlomo / Fleker, Marcelo / Mabjeesh, Sameer J / Britzi, Malka

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 7

Abstract: The use of antimicrobial drugs and coccidiostats in poultry farming is widespread, with a significant proportion of these drugs being excreted and released into the environment. The residues of such drugs in poultry litter (PL) can result in the ... ...

Abstract	The use of antimicrobial drugs and coccidiostats in poultry farming is widespread, with a significant proportion of these drugs being excreted and released into the environment. The residues of such drugs in poultry litter (PL) can result in the development of antibiotic-resistant bacteria. The impact of different biotic treatments (aerobic, anaerobic, and stacking) on broiler litter (BL) before its use as animal feed has not been studied extensively, nor have the differences between antimicrobial-dependent and independent broiler farms been investigated. This study aimed to determine the resistant bacteria in BL used as ruminant feed before and after litter treatment. The results show that the most resistant bacteria before BL treatment were the Enterococcus species. This study also found that the quantity of amoxicillin-resistant
Language	English
Publishing date	2023-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12071093
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Article ; Online: Ensiling process and pomegranate peel extract as a natural additive in potential prevention of fungal and mycotoxin contamination in silage

Sadhasivam, Sudharsan / Marshi, Rula / Barda, Omer / Zakin, Varda / Britzi, Malka / Gamliel, A. / Sionov, Edward

Toxicology Reports. 2022, v. 9 p.1557-1565

2022

Abstract: A study was conducted on six animal feed centers in Israel where fungal and mycotoxin presence was examined in maize and wheat silages. Fumonisin mycotoxins FB₁ and FB₂ were present in every maize silage sample analyzed. Interestingly, no correlation was ...

Abstract	A study was conducted on six animal feed centers in Israel where fungal and mycotoxin presence was examined in maize and wheat silages. Fumonisin mycotoxins FB₁ and FB₂ were present in every maize silage sample analyzed. Interestingly, no correlation was found between the occurrence of specific mycotoxins and the presence of the fungal species that might produce them in maize and wheat silages. We further investigated the effect of pomegranate peel extract (PPE) on Fusarium infection and fumonisin biosynthesis in laboratory-prepared maize silage. PPE had an inhibitory effect on FB₁ and FB₂ biosynthesis by Fusarium proliferatum, which resulted in up to 90 % reduction of fumonisin production in silage samples compared to untreated controls. This finding was supported by qRT-PCR analysis, showing downregulation of key genes involved in the fumonisin-biosynthesis pathway under PPE treatment. Our results present promising new options for the use of natural compounds that may help reduce fungal and mycotoxin contamination in agricultural foodstuff, and potentially replace traditionally used synthetic chemicals.
Keywords	Fusarium proliferatum ; biosynthesis ; corn ; corn silage ; foods ; fumonisins ; fungi ; pomegranates ; toxicology ; wheat ; Israel ; Silage ; Mycotoxin analysis ; Pomegranate peel extract
Language	English
Size	p. 1557-1565.
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2805786-7
ISSN	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2022.07.011
Database	NAL-Catalogue (AGRICOLA)

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Article: Concentration of amikacin sulphate in synovial fluid when given in combination with dexamethasone phosphate in intravenous regional limb perfusion in standing horses

Gustafsson, Kajsa / Tatz, Amos J. / Britzi, Malka / Dahan, Roee / Sutton, Gila A. / Kelmer, Gal

Journal of veterinary pharmacology and therapeutics. 2022 July, v. 45, no. 4

2022

Abstract: Eight horses underwent IVRLP at two occasions through a 23‐gauge 2 cm long butterfly catheter. Regional anaesthesia of the ulnar, median and medial cutaneous antebrachial nerves was performed prior, and an 8 cm rubber tourniquet was placed on the ... ...

Abstract	Eight horses underwent IVRLP at two occasions through a 23‐gauge 2 cm long butterfly catheter. Regional anaesthesia of the ulnar, median and medial cutaneous antebrachial nerves was performed prior, and an 8 cm rubber tourniquet was placed on the proximal radius for 30 minutes following the infusion. The first infusion consisted of 2 g of amikacin sulphate and 10 mg of dexamethasone phosphate diluted with 0.9% NaCl to a total volume of 100 ml. The second perfusion was performed after a 2‐week washout period, the same protocol was used but without dexamethasone phosphate. Synovial fluid samples were collected from the metacarpophalangeal joint at T = 0, 0.5, 2, 12, 24 and 36 h post‐infusion. Synovial fluid amikacin sulphate concentrations were determined by use of liquid chromatography/tandem mass‐spectrometry. All horses (n = 8) remained healthy throughout the study, and no adverse effects associated with the study were encountered. No statistically significant differences were found in synovial fluid amikacin sulphate concentrations between the treatment and the control group at any of the time points. In conclusion, dexamethasone phosphate can be used in IVRLP concomitantly with amikacin sulphate in cases of distal limb inflammation and pain without decreasing the synovial fluid concentration of amikacin sulphate.
Keywords	amikacin ; anesthesia ; catheters ; dexamethasone ; inflammation ; intravenous injection ; liquid chromatography ; pain ; pharmacology ; phosphates ; radius (bone) ; rubber ; sulfates ; synovial fluid
Language	English
Dates of publication	2022-07
Size	p. 409-414.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	435216-6
ISSN	1365-2885 ; 0140-7783
ISSN (online)	1365-2885
ISSN	0140-7783
DOI	10.1111/jvp.13053
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 2226: Show issues

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Article ; Online: Ensiling process and pomegranate peel extract as a natural additive in potential prevention of fungal and mycotoxin contamination in silage.

Sadhasivam, Sudharsan / Marshi, Rula / Barda, Omer / Zakin, Varda / Britzi, Malka / Gamliel, Abraham / Sionov, Edward

Toxicology reports

2022 Volume 9, Page(s) 1557–1565

Abstract: A study was conducted on six animal feed centers in Israel where fungal and mycotoxin presence was examined in maize and wheat silages. Fumonisin mycotoxins ... ...

Abstract	A study was conducted on six animal feed centers in Israel where fungal and mycotoxin presence was examined in maize and wheat silages. Fumonisin mycotoxins FB
Language	English
Publishing date	2022-07-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2805786-7
ISSN	2214-7500 ; 2214-7500
ISSN (online)	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2022.07.011
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Article ; Online: Concentration of amikacin sulphate in synovial fluid when given in combination with dexamethasone phosphate in intravenous regional limb perfusion in standing horses.

Gustafsson, Kajsa / Tatz, Amos J / Britzi, Malka / Dahan, Roee / Sutton, Gila A / Kelmer, Gal

Journal of veterinary pharmacology and therapeutics

2022 Volume 45, Issue 4, Page(s) 409–414

Abstract: Eight horses underwent IVRLP at two occasions through a 23-gauge 2 cm long butterfly catheter. Regional anaesthesia of the ulnar, median and medial cutaneous antebrachial nerves was performed prior, and an 8 cm rubber tourniquet was placed on the ... ...

Abstract	Eight horses underwent IVRLP at two occasions through a 23-gauge 2 cm long butterfly catheter. Regional anaesthesia of the ulnar, median and medial cutaneous antebrachial nerves was performed prior, and an 8 cm rubber tourniquet was placed on the proximal radius for 30 minutes following the infusion. The first infusion consisted of 2 g of amikacin sulphate and 10 mg of dexamethasone phosphate diluted with 0.9% NaCl to a total volume of 100 ml. The second perfusion was performed after a 2-week washout period, the same protocol was used but without dexamethasone phosphate. Synovial fluid samples were collected from the metacarpophalangeal joint at T = 0, 0.5, 2, 12, 24 and 36 h post-infusion. Synovial fluid amikacin sulphate concentrations were determined by use of liquid chromatography/tandem mass-spectrometry. All horses (n = 8) remained healthy throughout the study, and no adverse effects associated with the study were encountered. No statistically significant differences were found in synovial fluid amikacin sulphate concentrations between the treatment and the control group at any of the time points. In conclusion, dexamethasone phosphate can be used in IVRLP concomitantly with amikacin sulphate in cases of distal limb inflammation and pain without decreasing the synovial fluid concentration of amikacin sulphate.
MeSH term(s)	Amikacin/analysis ; Amikacin/chemistry ; Animals ; Anti-Bacterial Agents/analysis ; Dexamethasone/analogs & derivatives ; Forelimb ; Horses ; Perfusion/veterinary ; Synovial Fluid/chemistry
Chemical Substances	Anti-Bacterial Agents ; dexamethasone 21-phosphate (2BP70L44PR) ; Dexamethasone (7S5I7G3JQL) ; Amikacin (84319SGC3C)
Language	English
Publishing date	2022-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	435216-6
ISSN	1365-2885 ; 0140-7783
ISSN (online)	1365-2885
ISSN	0140-7783
DOI	10.1111/jvp.13053
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Zs.A 2226: Show issues

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Article: Synovial Concentration of Trimethoprim-Sulphadiazine Following Regional Limb Perfusion in Standing Horses

Gustafsson, Kajsa / Tatz, Amos J. / Dahan, Roee / Abu Ahmad, Wiessam / Britzi, Malka / Sutton, Gila A. / Kelmer, Gal

Animals. 2021 July 13, v. 11, no. 7

2021

Abstract: The aim of this study was to investigate the safety and pharmacokinetics of trimethoprim-sulphadiazine administered via intravenous regional limb perfusion (IVRLP) into the cephalic vein. According to the hypothesis, the drug could be administered ... ...

Abstract	The aim of this study was to investigate the safety and pharmacokinetics of trimethoprim-sulphadiazine administered via intravenous regional limb perfusion (IVRLP) into the cephalic vein. According to the hypothesis, the drug could be administered without adverse effects and the synovial concentrations would remain above the minimum inhibitory concentration (MIC) for trimethoprim-sulphadiazine (0.5 and 9.5 µg/mL) for 24 h. Ten (n = 10) horses underwent cephalic vein IVRLP with an Esmarch tourniquet applied for 30 min. Four grams (4 g) of trimethoprim-sulphadiazine (TMP-SDZ) were diluted at 0.9% NaCl for a total volume of 100 mL. Synovial fluid and blood samples were obtained immediately before IVRLP and at 0.25, 0.5, 2, 6, 12 and 24 h after the initiation of IVRLP. Trimethoprim and sulphadiazine concentrations were determined using a method based on liquid chromatography/tandem mass spectrometry. The Cₘₐₓ (peak drug concentration) values were 36 ± 31.1 and 275.3 ± 214.4 µg/mL (TMP and SDZ). The respective tₘₐₓ (time to reach Cₘₐₓ) values were 20 ± 7.8 and 26.4 ± 7.2 min. The initial synovial fluid concentrations were high but decreased quickly. No horse had synovial concentrations of trimethoprim-sulphadiazine above the MIC at 12 h. Severe vasculitis and pain shortly after IVRLP, lasting up to one week post-injection, occurred in five out of 10 horses. In conclusion, IVRLP with trimethoprim-sulphadiazine cannot be recommended due to the low concentrations of synovial fluid over time and the frequent severe adverse effects causing pain and discomfort in treated horses. Thus, in cases of septic synovitis with bacteria sensitive to trimethoprim-sulphadiazine, other routes of administration should be considered.
Keywords	blood ; horses ; intravenous injection ; liquid chromatography ; minimum inhibitory concentration ; pain ; pharmacokinetics ; sulfadiazine ; synovial fluid ; synovitis ; tandem mass spectrometry ; trimethoprim ; vasculitis
Language	English
Dates of publication	2021-0713
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani11072085
Database	NAL-Catalogue (AGRICOLA)

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Article: Synovial Concentration of Trimethoprim-Sulphadiazine Following Regional Limb Perfusion in Standing Horses.

Gustafsson, Kajsa / Tatz, Amos J / Dahan, Roee / Abu Ahmad, Wiessam / Britzi, Malka / Sutton, Gila A / Kelmer, Gal

Animals : an open access journal from MDPI

2021 Volume 11, Issue 7

Abstract	The aim of this study was to investigate the safety and pharmacokinetics of trimethoprim-sulphadiazine administered via intravenous regional limb perfusion (IVRLP) into the cephalic vein. According to the hypothesis, the drug could be administered without adverse effects and the synovial concentrations would remain above the minimum inhibitory concentration (MIC) for trimethoprim-sulphadiazine (0.5 and 9.5 µg/mL) for 24 h. Ten (
Language	English
Publishing date	2021-07-13
Publishing country	Switzerland
Document type	Journal Article
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani11072085
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Concentration of Metronidazole in the Distal Interphalangeal Joint following Intravenous Regional Limb Perfusion via the Cephalic Vein in Standing Horses.

Gustafsson, Kajsa / Tatz, Amos J / Dahan, Roee / Britzi, Malka / Soback, Stefan / Ahmad, Wiessam Abu / Prince, Hagar / Kelmer, Gal

Veterinary and comparative orthopaedics and traumatology : V.C.O.T

2021 Volume 34, Issue 4, Page(s) 287–293

Abstract: Objective: The aim of this study was to determine the concentration of metronidazole in the distal interphalangeal joint (DIPJ) of the thoracic limb after administering metronidazole to standing horses by intravenous regional limb perfusion (IVRLP).: ...

Abstract	Objective: The aim of this study was to determine the concentration of metronidazole in the distal interphalangeal joint (DIPJ) of the thoracic limb after administering metronidazole to standing horses by intravenous regional limb perfusion (IVRLP). Methods: Eleven healthy horses had a wide rubber tourniquet applied to the proximal aspect of the antebrachium for 0.5 hours and 500 mg of metronidazole diluted in physiologic saline solution to a total volume of 108 mL was administered by cephalic IVRLP. Synovial fluid samples were collected from the DIPJ before perfusion and at 0.25, 0.5, 2, 12 and 24 hours. Blood samples were obtained at the same time points for serum analysis. Concentrations of metronidazole were determined by liquid chromatography/tandem mass spectrometry. Results: Four horses were excluded due to low synovial fluid concentrations and not completing the full tourniquet application time. The Conclusion: Metronidazole administered by IVRLP reached high concentrations in the synovial fluid at 0.5 hours. However, the concentrations rapidly decreased below the minimum inhibitory concentration of potential target pathogens. Effectiveness of metronidazole administered by IVRLP as a sole therapy against anaerobic infections of synovial structures of the distal limb cannot be determined by a pharmacokinetic study. However, the present study serves as the basis for future carefully planned clinical trials.
MeSH term(s)	Administration, Intravenous/veterinary ; Amikacin ; Animals ; Anti-Bacterial Agents ; Forelimb ; Horses ; Metronidazole ; Perfusion/veterinary ; Synovial Fluid
Chemical Substances	Anti-Bacterial Agents ; Metronidazole (140QMO216E) ; Amikacin (84319SGC3C)
Language	English
Publishing date	2021-05-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	286750-3
ISSN	2567-6911 ; 0932-0814
ISSN (online)	2567-6911
ISSN	0932-0814
DOI	10.1055/s-0041-1726083
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Zs.A 2352: Show issues

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Article ; Online: A survey of arsenic, mercury, cadmium, and lead residues in seafood (fish, crustaceans, and cephalopods) from the south-eastern Mediterranean Sea.

Ramon, Debra / Morick, Danny / Croot, Peter / Berzak, Ran / Scheinin, Aviad / Tchernov, Dan / Davidovich, Nadav / Britzi, Malka

Journal of food science

2021 Volume 86, Issue 3, Page(s) 1153–1161

Abstract: Seafood is capable of bioaccumulating heavy metals (HM), making it a potentially major dietary source of HM for humans. Presently, little data exists on seafood from the eastern-most boundary of the Mediterranean Sea. This study aims to provide exposure ... ...

Abstract	Seafood is capable of bioaccumulating heavy metals (HM), making it a potentially major dietary source of HM for humans. Presently, little data exists on seafood from the eastern-most boundary of the Mediterranean Sea. This study aims to provide exposure insight of the Israeli population to HM through the consumption of locally caught seafood by assessing the levels of arsenic, mercury, cadmium, and lead in raw tissues of seafood. A wide survey of local fisheries was conducted providing 296 samples from 11 different species, including seven fish, two crustacean, and two cephalopod species. Total arsenic, cadmium, and lead were analyzed by graphite-furnace atomic absorption. Total mercury was measured by cold-vapor mercury analyzer. Arsenic speciation was performed by anion chromatography-inductively coupled plasma sector field mass spectrometry. Results suggested that the total arsenic concentrations were significantly higher in crustaceans and cephalopods than fish. Arsenic speciation revealed two samples that exceed 1 mg/kg of inorganic arsenic, whereas methylated arsenic was below the detection limit. Elevated mercury levels were detected in the commercial benthic species Mullus barbatus (red mullet), cadmium was detected in one-third of the samples, and lead detected in eight samples. Comparing the results to health guidelines, 99.4% of seafood tested in this study abide with acceptable levels of heavy metals in seafood, as defined by both Israeli and European Union guidelines.
MeSH term(s)	Animals ; Arsenic/analysis ; Cadmium/analysis ; Cephalopoda/metabolism ; Decapoda/metabolism ; Fishes/metabolism ; Food Contamination/analysis ; Humans ; Mediterranean Sea ; Mercury/analysis
Chemical Substances	Cadmium (00BH33GNGH) ; Mercury (FXS1BY2PGL) ; Arsenic (N712M78A8G)
Language	English
Publishing date	2021-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	241615-3
ISSN	1750-3841 ; 0022-1147
ISSN (online)	1750-3841
ISSN	0022-1147
DOI	10.1111/1750-3841.15627
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