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  1. Article: 28 A comparison among equine boots and legwraps on leg surface temperature during and after exercise

    Brock, L / Spooner, H

    Journal of equine veterinary science. 2021 May, v. 100

    2021  

    Abstract: Boots and legwraps are commonly used to protect the lower limbs of the horse from trauma during exercise. However, previous research suggests such use can result in increased limb temperature that may be detrimental to underlying tendons. This study was ... ...

    Abstract Boots and legwraps are commonly used to protect the lower limbs of the horse from trauma during exercise. However, previous research suggests such use can result in increased limb temperature that may be detrimental to underlying tendons. This study was designed to explore limb surface temperature during and after exercise when common leg protection was applied, hypothesizing that boots and wraps would increase temperature over the bare limb during exercise, yet show differences in the time required to return to baseline temperature. Six clinically-sound, mature horses (age 15 ± 2 yr; mean ± SEM) were used to test 6 boots or wraps: a neoprene boot, a perforated neoprene boot, an alternative neoprene boot, a cross country boot, a combination fleece and elastic wrap, and a polo wrap. The booted forelimb was selected randomly and the other forelimb served as a bare limb control in each test of a 6 × 6 Latin square design. An iButton hygrochron data logger was placed immediately palmar to the midpoint of the lateral splint bone on both the booted and bare limbs. The data logger recorded temperature and humidity every min during a 20-min standard exercise test and 180-min standing recovery during moderate ambient conditions (22.8 ± 0.9°C; humidity: 53.3 ± 4.8%). Data were analyzed using a mixed model design with repeated measures; significance was set at P < 0.05. The bare limb temperature was lowest (27.7 ± 1°C) at min 9 of the SET, then peaked and plateaued (33 ± 1°C; P < 0.05) during recovery. Conversely, treated limbs increased during exercise from 32 ± 1°C (min 0) to 36 ± 1°C at min 15, then plateaued during recovery. All treatment temperatures were greater than the bare limb (P < 0.0001) across all times. The polo wrap was hotter than the alternative neoprene sports medicine boot (P = 0.02), but neither was different from any other treatments. The humidity of the polo wrap was higher (P < 0.05) than all other treatments at 94%. All treatments failed to return to baseline temperature and humidity after 180 min (P = 0.01). The results support the hypothesis that convection cooling is impaired by boots and wraps during exercise. Given that skin temperature of the lower leg has been correlated as to underlying tendon surface temperature, this suggests that even in a moderate intensity exercise bout in moderate ambient conditions, a booted or wrapped limb may reach damaging temperatures. Contrary to our hypothesis, no boot or wrap nor the bare limb returned to baseline temperature in as much as 180 min of recovery, necessitating further research into the time required for passive cooling of the equine limb after exercise and verification of strategies to reduce cooling time.
    Keywords convection ; cooling ; exercise ; exercise test ; fleece ; horses ; humidity ; microprocessors ; skin temperature ; statistical models ; surface temperature ; veterinary medicine
    Language English
    Dates of publication 2021-05
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2102631-2
    ISSN 1542-7412 ; 0737-0806
    ISSN (online) 1542-7412
    ISSN 0737-0806
    DOI 10.1016/j.jevs.2021.103491
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Information from Noise: Measuring Dyslexia Risk Using Rasch-like Matrix Factorization with a Procedure for Equating Instruments.

    Moulton, Mark H / Eide, Brock L

    Entropy (Basel, Switzerland)

    2023  Volume 25, Issue 12

    Abstract: This study examines the psychometric properties of a screening protocol for dyslexia and demonstrates a special form of matrix factorization called Nous based on the Alternating Least Squares algorithm. Dyslexia presents an intrinsically multidimensional ...

    Abstract This study examines the psychometric properties of a screening protocol for dyslexia and demonstrates a special form of matrix factorization called Nous based on the Alternating Least Squares algorithm. Dyslexia presents an intrinsically multidimensional complex of cognitive loads. By building and enforcing a common 6-dimensional space, Nous extracts a multidimensional signal for each person and item from test data that increases the Shannon entropy of the dataset while at the same time being constrained to meet the special objectivity requirements of the Rasch model. The resulting Dyslexia Risk Scale (DRS) yields linear equal-interval measures that are comparable regardless of the subset of items taken by the examinee. Each measure and cell estimate is accompanied by an efficiently calculated standard error. By incorporating examinee age into the calibration process, the DRS can be generalized to all age groups to allow the tracking of individual dyslexia risk over time. The methodology was implemented using a 2019 calibration sample of 828 persons aged 7 to 82 with varying degrees of dyslexia risk. The analysis yielded high reliability (0.95) and excellent receiver operating characteristics (AUC = 0.96). The analysis is accompanied by a discussion of the information-theoretic properties of matrix factorization.
    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e25121580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dexmedetomidine in Adult Patients in Cardiac Surgery Critical Care: An Evidence-Based Review.

    Brock, Lyndsay

    AACN advanced critical care

    2019  Volume 30, Issue 3, Page(s) 259–268

    Abstract: Although several options are available for postoperative sedation in the intensive care unit, the selective α2-adrenoceptor agonist dexmedetomidine may offer advantages for patients after cardiac surgery. The author conducted a review of the literature ... ...

    Abstract Although several options are available for postoperative sedation in the intensive care unit, the selective α2-adrenoceptor agonist dexmedetomidine may offer advantages for patients after cardiac surgery. The author conducted a review of the literature on the use of dexmedetomidine in the cardiac surgery population to determine possible advantages and disadvantages in this patient population. Although the use of dexmedetomidine has not been conclusively shown to change overall morbidity and mortality and may be associated with higher drug cost, its other demonstrated effects offer advantages for postoperative cardiac surgery patients that other forms of sedation cannot match.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cardiac Surgical Procedures/standards ; Critical Care Nursing/standards ; Dexmedetomidine/therapeutic use ; Female ; Humans ; Hypnotics and Sedatives/therapeutic use ; Male ; Middle Aged ; Postoperative Care/standards ; Practice Guidelines as Topic
    Chemical Substances Hypnotics and Sedatives ; Dexmedetomidine (67VB76HONO)
    Language English
    Publishing date 2019-08-27
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 2239949-5
    ISSN 1559-7776 ; 1559-7768
    ISSN (online) 1559-7776
    ISSN 1559-7768
    DOI 10.4037/aacnacc2019888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Information from Noise

    Mark H. Moulton / Brock L. Eide

    Entropy, Vol 25, Iss 12, p

    Measuring Dyslexia Risk Using Rasch-like Matrix Factorization with a Procedure for Equating Instruments

    2023  Volume 1580

    Abstract: This study examines the psychometric properties of a screening protocol for dyslexia and demonstrates a special form of matrix factorization called Nous based on the Alternating Least Squares algorithm. Dyslexia presents an intrinsically multidimensional ...

    Abstract This study examines the psychometric properties of a screening protocol for dyslexia and demonstrates a special form of matrix factorization called Nous based on the Alternating Least Squares algorithm. Dyslexia presents an intrinsically multidimensional complex of cognitive loads. By building and enforcing a common 6-dimensional space, Nous extracts a multidimensional signal for each person and item from test data that increases the Shannon entropy of the dataset while at the same time being constrained to meet the special objectivity requirements of the Rasch model. The resulting Dyslexia Risk Scale (DRS) yields linear equal-interval measures that are comparable regardless of the subset of items taken by the examinee. Each measure and cell estimate is accompanied by an efficiently calculated standard error. By incorporating examinee age into the calibration process, the DRS can be generalized to all age groups to allow the tracking of individual dyslexia risk over time. The methodology was implemented using a 2019 calibration sample of 828 persons aged 7 to 82 with varying degrees of dyslexia risk. The analysis yielded high reliability (0.95) and excellent receiver operating characteristics (AUC = 0.96). The analysis is accompanied by a discussion of the information-theoretic properties of matrix factorization.
    Keywords dyslexia ; matrix factorization ; Rasch model ; alternating least squares ; test ; Science ; Q ; Astrophysics ; QB460-466 ; Physics ; QC1-999
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Towards a Unified Mental Health Service.

    Brock, Laurence

    Mental welfare

    2017  Volume 20, Issue 4, Page(s) 93–97

    Language English
    Publishing date 2017-09-14
    Publishing country England
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Psychiatry and the public-health service.

    BROCK, L

    Lancet (London, England)

    2010  Volume 1, Issue 6393, Page(s) 333–337

    MeSH term(s) Humans ; Psychiatry ; Public Health
    Language English
    Publishing date 2010-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/s0140-6736(46)90284-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Departmental Report on Sterilisation.

    Brock, L G

    Mental welfare

    2017  Volume 15, Issue 3, Page(s) 61–69

    Language English
    Publishing date 2017-09-14
    Publishing country England
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Enteral N-acetylcysteine to reduce serum cobalt concentrations secondary to prosthetic knee-associated metallosis: A case report.

    Floyd, Connor A / Carr, John R / Brock, Logan / Orvin, Dustin L

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2023  Volume 81, Issue 7, Page(s) e159–e165

    Abstract: Purpose: Cobalt metallosis is a rare but dangerous complication of total joint arthroplasty resulting from deterioration of the joint leading to metal-on-metal friction and breakdown. Potential manifestations vary in severity and include dilated ... ...

    Abstract Purpose: Cobalt metallosis is a rare but dangerous complication of total joint arthroplasty resulting from deterioration of the joint leading to metal-on-metal friction and breakdown. Potential manifestations vary in severity and include dilated cardiomyopathy, thyroid dysfunction, cognitive disturbances, neuropathy, fatigue, and weakness. The therapeutic role of N-acetylcysteine in metallosis has been investigated due to its ability to chelate with heavy metal ions, such as cobalt and chromium.
    Summary: Here we report the case of a 71-year-old female who presented with suspected metallosis diagnosed in the outpatient setting due to symptoms of significant weight loss and failure to thrive. This metallosis was secondary to the hardware breakdown of a left knee revision roughly 6 years previously. The patient was not a surgical candidate due to her poor nutrition status and was started on nasojejunal tube feeds along with N-acetylcysteine 600 mg by mouth twice daily for 45 days. The patient's serum cobalt levels decreased from 61.7 µg/L on admission to 16.2 µg/L prior to her undergoing proper revision of the left knee roughly 2 months after admission to the hospital. The patient tolerated treatment well and was able to be discharged the day after surgery, with no further complaints or complications.
    Conclusion: This case report contributes to the body of literature suggesting that administration of N-acetylcysteine can reduce serum cobalt concentrations, without notable adverse effects, in the context of prosthetic knee-associated metallosis.
    MeSH term(s) Aged ; Female ; Humans ; Acetylcysteine/therapeutic use ; Chromium ; Cobalt/blood ; Metals/adverse effects
    Chemical Substances Acetylcysteine (WYQ7N0BPYC) ; Chromium (0R0008Q3JB) ; Cobalt (3G0H8C9362) ; Metals
    Language English
    Publishing date 2023-12-22
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxad312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Robust Fabrication of Polymeric Nanowire with Anodic Aluminum Oxide Templates.

    Brock, Larry / Sheng, Jian

    Micromachines

    2019  Volume 11, Issue 1

    Abstract: Functionalization of a surface with biomimetic nano-/micro-scale roughness (wires) has attracted significant interests in surface science and engineering as well as has inspired many real-world applications including anti-fouling and superhydrophobic ... ...

    Abstract Functionalization of a surface with biomimetic nano-/micro-scale roughness (wires) has attracted significant interests in surface science and engineering as well as has inspired many real-world applications including anti-fouling and superhydrophobic surfaces. Although methods relying on lithography include soft-lithography greatly increase our abilities in structuring hard surfaces with engineered nano-/micro-topologies mimicking real-world counterparts, such as lotus leaves, rose petals, and gecko toe pads, scalable tools enabling us to pattern polymeric substrates with the same structures are largely absent in literature. Here we present a robust and simple technique combining anodic aluminum oxide (AAO) templating and vacuum-assisted molding to fabricate nanowires over polymeric substrates. We have demonstrated the efficacy and robustness of the technique by successfully fabricating nanowires with large aspect ratios (>25) using several common soft materials including both cross-linking polymers and thermal plastics. Furthermore, a model is also developed to determine the length and molding time based on nanowires material properties (e.g., viscosity and interfacial tension) and operational parameters (e.g., pressure, vacuum, and AAO template dimension). Applying the technique, we have further demonstrated the confinement effects on polymeric crosslinking processes and shown substantial lengthening of the curing time.
    Language English
    Publishing date 2019-12-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi11010046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Incorporating Metacognitive Strategy Training Into Semantic Treatment Promotes Restitutive and Substitutive Gains in Naming: A Single-Subject Investigation.

    Tilton-Bolowsky, Victoria E / Brock, Lauren / Nunn, Kristen / Evans, William S / Vallila-Rohter, Sofia

    American journal of speech-language pathology

    2023  Volume 32, Issue 5, Page(s) 1979–2020

    Abstract: Purpose: This study tested the effectiveness of a modified semantic feature analysis (SFA) treatment protocol that incorporated metacognitive strategy training (MST). Regarding its restitutive component, SFA most reliably results in improved word ... ...

    Abstract Purpose: This study tested the effectiveness of a modified semantic feature analysis (SFA) treatment protocol that incorporated metacognitive strategy training (MST). Regarding its restitutive component, SFA most reliably results in improved word retrieval for treated items and untreated, semantically related items, but evidence of response generalization is often small/inconsistent. Regarding its substitutive component, SFA is thought to facilitate successful communication via habituation of the SFA circumlocution strategy. However, repeated practice with SFA's strategy in the absence of direct MST may not result in independent strategy use and/or generalization. Furthermore, people with aphasia's independent use of the SFA strategy in moments of anomia is presently underreported. To address these limitations, we incorporated MST into SFA and directly measured substitutive outcomes.
    Method: Four people with aphasia participated in 24 treatment sessions of SFA + MST in a single-subject, A-B experimental design with repeated measurements. We measured word retrieval accuracy, strategy use, and explicit strategy knowledge. We calculated effect sizes to measure changes in word retrieval accuracy and strategy use and used visual inspection to assess gains in explicit strategy knowledge from pre- to posttreatment and retention.
    Results: Participants achieved marginally small to medium effects in word retrieval accuracy for treated; untreated, semantically related; and untreated, semantically unrelated items and marginally small to large effects in independent strategy use. Explicit strategy knowledge was variable.
    Conclusions: Across participants, SFA + MST yielded positive changes in word retrieval accuracy or strategy use, or both. Positive changes in word retrieval accuracy were comparable to other SFA studies. Positive changes in strategy use demonstrate preliminary evidence of this treatment's ability to yield restitutive and substitutive gains. Overall, this study offers preliminary evidence of SFA + MST's effectiveness and highlights the importance of directly measuring SFA's substitutive outcomes, which showed that people with aphasia can respond to this treatment in multiple successful ways-not just improved target word production.
    MeSH term(s) Humans ; Semantics ; Language Therapy/methods ; Aphasia/therapy ; Aphasia/psychology ; Anomia/diagnosis ; Anomia/therapy ; Anomia/psychology ; Generalization, Psychological
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1154406-5
    ISSN 1558-9110 ; 1058-0360
    ISSN (online) 1558-9110
    ISSN 1058-0360
    DOI 10.1044/2023_AJSLP-22-00230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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